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Journal Articles

ISB 2001: Accelerating Patient Benefits through Quantitative Systems Pharmacology (QSP) Guided First-in-Human (FIH) Starting Dose Selection

Vinu Menon, Lida Pacaud, Beata Holkova, Sunitha Gn, Andrew Garton, Maria Pihlgren, Tomomi Matsuura, Piet H van der Graft, Mario Perro, Cyril Konto
Journal: Blood
Blood (2024) 144 (Supplement 1): 6854.
https://doi.org/10.1182/blood-2024-209580
Published: 2024
Journal Articles

First Results of a Phase 1, First-in-Human, Dose Escalation Study of ISB 2001, a BCMAxCD38xCD3 Targeting Trispecific Antibody in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Hang Quach, Bradley Augustson, Hanlon Sia, Nishi Shah, Eben I Lichtman, Michaela Liedtke, Camille Martinet, Vinu Menon, Andrew Garton, Maria Pihlgren, Beata Holkova, Cyril Konto, Lida Pacaud, Amit Khot
Journal: Blood
Blood (2024) 144 (Supplement 1): 1026.
https://doi.org/10.1182/blood-2024-208189
Published: 2024
Journal Articles

Dose Escalation of ISB 1442, a Novel CD38 Biparatopic x CD47 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma

Binod Dhakal, Hang Quach, Phoebe Joy Ho, Andrew Spencer, Mark A. Schroeder, Peter Tan, Tara Cochrane, Hanlon Sia, Jeffrey A. Zonder, Camille Martinet, Dominique Duchesne, Andrew Garton, Vinu Menon, Beata Holkova, Cyril Konto, Lida Pacaud, Dickran Kazandjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3364.
https://doi.org/10.1182/blood-2024-209952
Published: 2024
Journal Articles

Dose Escalation of ISB 1342, a Novel CD38xCD3 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Prashant Kapoor, Don A. Stevens, Xavier Leleu, Karim Belhadj Merzoug, Lionel Karlin, Salomon Manier, Thomas Chalopin, Cyrille Hulin, Aurore Perrot, Jésus G Berdeja, Cristiana Costa Chase, Cyrille Touzeau, Philippe Moreau, Sanjay Mohan, Alexander Lesokhin, Carol Huff, David H. Vesole, Joshua Richter, Jeffrey Matous, Eileen Wolff, Tejas Shah, Jeppe Koch-Olsen, Andrew Garton, Vinu Menon, Sunitha Gn, Mario Perro, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Mohamad Mohty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2023-186664
Published: 2023
Journal Articles

A Phase 1, First-in-Human, Dose Escalation and Dose-Expansion Study of a BCMAxCD38xCD3 Targeting Trispecific Antibody ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma

Hanlon Sia, Vinu Menon, Andrew Garton, Eileen Wolff, Tejas Shah, Colleen Charpentier, Dominique Duchesne, Maria Pihlgren, Jeppe Koch-Olsen, Adam Drake, Mario Perro, Eugene Zhukovsky, Lida Pacaud, Cyril Konto
Journal: Blood
Blood (2023) 142 (Supplement 1): 3396.
https://doi.org/10.1182/blood-2023-187106
Published: 2023
Journal Articles

Integrated Preclinical Data Analysis of ISB 2001 Enables Optimal Starting Dose Selection for a First-in-Class Trispecific T Cell Engager Phase1 Study in Multiple Myeloma

Adam Drake, Maria Pihlgren, Vinu Menon, Daniela Pais, Laura Carretero-Iglesia, Jeremy Berret, Olivia Hall, Julie Macoin, Isabelle Gruber, Elodie Stainnack, Carole Estoppey, Cyrille Dreyfus, Girish Gudi, Tomomi Matsuura, Piet H van der Graft, Michael Dyson, Cyril Konto, Lida Pacaud, Ankita Srivastava, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2023) 142 (Supplement 1): 6574.
https://doi.org/10.1182/blood-2023-181546
Published: 2023
Journal Articles

Initial Dose Escalation of ISB 1442, a Novel CD38 Biparatopic x CD47 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Dickran Kazandjian, Hang Quach, Hanlon Sia, Phoebe Joy Ho, Andrew Spencer, Mark A. Schroeder, Binod Dhakal, Tara Cochrane, Jeffrey A. Zonder, Nancy Yi, Dominique Duchesne, Tejas Shah, Andrew Garton, Vinu Menon, Sunitha Gn, Stefano Sammicheli, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Peter Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4707.
https://doi.org/10.1182/blood-2023-186241
Published: 2023
Journal Articles

Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma

Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jérémy Berret, Maria Pihlgren, Marie-Agnès Doucey, Girish S. Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, M. Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M. Edwards, James R. Edwards, Emmanuelle Menoret, Charlotte Kervoëlen, Catherine Pellat-Deceunynck, Philippe Moreau, Eugene Zhukovsky, Mario Perro, Myriam Chimen
Journal: Blood
Blood (2023) 142 (3): 260–273.
https://doi.org/10.1182/blood.2022019451
Published: 2023
Includes: Supplemental data
Journal Articles

Initial Results of Dose Escalation of ISB 1342, a Novel CD3xCD38 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Sanjay R Mohan, Cristiana Costa Chase, Jesus G Berdeja, Lionel Karlin, Karim Belhadj, Aurore Perrot, Philippe Moreau, Cyrille Touzeau, Thomas Chalopin, Alexander M Lesokhin, Carol Ann Huff, David H. Vesole, Joshua Richter, Jeffrey V. Matous, Igor Proscurshim, Eileen Wolff, Girish Gudi, Andrew Garton, Vinu Menon, Sunitha Gn, Yacine Salhi, Eric J. Feldman, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 7264–7266.
https://doi.org/10.1182/blood-2022-157525
Published: 2022
Journal Articles

ISB 1442, a First-in-Class CD38 and CD47 Bispecific Antibody Innate Cell Modulator for the Treatment of Relapsed Refractory Multiple Myeloma

Sammicheli Stefano, Camille Grandclement, Elie Dehilly, Maria Panagopoulou, Evangelia Martini, Rosa Castillo, Perrine Suere, Blandine Pouleau, Carole Estoppey, Julia Frei, Jeremy Loyau, Thierry Monney, Rebecca Wood, Amelie Croset, Alain Rubod, Girish Gudi, Venkatesha Udupa, Sunitha Gn, Vinu Menon, Daniel Rasmussen, Jeppe Koch Olsen, Roberto Giovannini, Aravind Chakrapani, Stanislas Blein, Marie-Agnes Doucey, Adam Drake, Alessandro Riva, Cyril Konto, Mario Perro, Lamine Mbow
Journal: Blood
Blood (2021) 138 (Supplement 1): 73.
https://doi.org/10.1182/blood-2021-145586
Published: 2021