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Journal Articles

First Results of a Phase 1, First-in-Human, Dose Escalation Study of ISB 2001, a BCMAxCD38xCD3 Targeting Trispecific Antibody in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Hang Quach, Bradley Augustson, Hanlon Sia, Nishi Shah, Eben I Lichtman, Michaela Liedtke, Camille Martinet, Vinu Menon, Andrew Garton, Maria Pihlgren, Beata Holkova, Cyril Konto, Lida Pacaud, Amit Khot
Journal: Blood
Blood (2024) 144 (Supplement 1): 1026.
https://doi.org/10.1182/blood-2024-208189
Published: 2024
Journal Articles

Dose Escalation of ISB 1442, a Novel CD38 Biparatopic x CD47 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma

Binod Dhakal, Hang Quach, Phoebe Joy Ho, Andrew Spencer, Mark A. Schroeder, Peter Tan, Tara Cochrane, Hanlon Sia, Jeffrey A. Zonder, Camille Martinet, Dominique Duchesne, Andrew Garton, Vinu Menon, Beata Holkova, Cyril Konto, Lida Pacaud, Dickran Kazandjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3364.
https://doi.org/10.1182/blood-2024-209952
Published: 2024
Journal Articles

ISB 2001: Accelerating Patient Benefits through Quantitative Systems Pharmacology (QSP) Guided First-in-Human (FIH) Starting Dose Selection

Vinu Menon, Lida Pacaud, Beata Holkova, Sunitha Gn, Andrew Garton, Maria Pihlgren, Tomomi Matsuura, Piet H van der Graft, Mario Perro, Cyril Konto
Journal: Blood
Blood (2024) 144 (Supplement 1): 6854.
https://doi.org/10.1182/blood-2024-209580
Published: 2024
Journal Articles

Initial Dose Escalation of ISB 1442, a Novel CD38 Biparatopic x CD47 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Dickran Kazandjian, Hang Quach, Hanlon Sia, Phoebe Joy Ho, Andrew Spencer, Mark A. Schroeder, Binod Dhakal, Tara Cochrane, Jeffrey A. Zonder, Nancy Yi, Dominique Duchesne, Tejas Shah, Andrew Garton, Vinu Menon, Sunitha Gn, Stefano Sammicheli, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Peter Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4707.
https://doi.org/10.1182/blood-2023-186241
Published: 2023
Journal Articles

A Phase 1, First-in-Human, Dose Escalation and Dose-Expansion Study of a BCMAxCD38xCD3 Targeting Trispecific Antibody ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma

Hanlon Sia, Vinu Menon, Andrew Garton, Eileen Wolff, Tejas Shah, Colleen Charpentier, Dominique Duchesne, Maria Pihlgren, Jeppe Koch-Olsen, Adam Drake, Mario Perro, Eugene Zhukovsky, Lida Pacaud, Cyril Konto
Journal: Blood
Blood (2023) 142 (Supplement 1): 3396.
https://doi.org/10.1182/blood-2023-187106
Published: 2023
Journal Articles

Dose Escalation of ISB 1342, a Novel CD38xCD3 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Prashant Kapoor, Don A. Stevens, Xavier Leleu, Karim Belhadj Merzoug, Lionel Karlin, Salomon Manier, Thomas Chalopin, Cyrille Hulin, Aurore Perrot, Jésus G Berdeja, Cristiana Costa Chase, Cyrille Touzeau, Philippe Moreau, Sanjay Mohan, Alexander Lesokhin, Carol Huff, David H. Vesole, Joshua Richter, Jeffrey Matous, Eileen Wolff, Tejas Shah, Jeppe Koch-Olsen, Andrew Garton, Vinu Menon, Sunitha Gn, Mario Perro, Eugene Zhukovsky, Cyril Konto, Lida Pacaud, Mohamad Mohty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2023-186664
Published: 2023
Journal Articles

Integrated Preclinical Data Analysis of ISB 2001 Enables Optimal Starting Dose Selection for a First-in-Class Trispecific T Cell Engager Phase1 Study in Multiple Myeloma

Adam Drake, Maria Pihlgren, Vinu Menon, Daniela Pais, Laura Carretero-Iglesia, Jeremy Berret, Olivia Hall, Julie Macoin, Isabelle Gruber, Elodie Stainnack, Carole Estoppey, Cyrille Dreyfus, Girish Gudi, Tomomi Matsuura, Piet H van der Graft, Michael Dyson, Cyril Konto, Lida Pacaud, Ankita Srivastava, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2023) 142 (Supplement 1): 6574.
https://doi.org/10.1182/blood-2023-181546
Published: 2023
Journal Articles

Preclinical Evaluation of ISB 1442, a First-in-Class CD38 and CD47 Bispecific Antibody Innate Cell Modulator for the Treatment of AML and T-ALL

Sammicheli Stefano, Camille Grandclement, Valentina Labanca, Stefania De Angelis, Carole Estoppey, Myriam Chimen, Blandine Pouleau, Perrine Suere, Emilie Nallet, Ankita Srivastava, Eric J. Feldman, Igor Proscurshim, Cyril Konto, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2022) 140 (Supplement 1): 6237–6238.
https://doi.org/10.1182/blood-2022-162201
Published: 2022
Journal Articles

ISB 2001, a First-in-Class Trispecific BCMA and CD38 T Cell Engager Designed to Overcome Mechanisms of Escape from Treatments for Multiple Myeloma By Targeting Two Antigens

Maria Pihlgren, Olivia Hall, Laura Carretero, Carole Estoppey, Adam Drake, Daniela Pais, Jeremy Loyau, Jeremy Berret, Isabelle Gruber, Perrine Suere, Vincent Schnorhk, Emilie Nallet, Blandine Pouleau, Myriam Chimen, Julie Macoin, Elodie Stainnack, Thierry Monney, Aurore Delachat, Cyrille Dreyfus, Thomas Matthes, Cyril Konto, Michael Dyson, Stanislas Blein, Lamine Mbow, Rebecca Wood, Ankita Srivastava, Eugene Zhukovsky, Mario Perro
Journal: Blood
Blood (2022) 140 (Supplement 1): 858–859.
https://doi.org/10.1182/blood-2022-159353
Published: 2022
Journal Articles

ISB 1442, a First-in-Class CD38 and CD47 Bispecific Antibody Innate Cell Modulator for the Treatment of Relapsed Refractory Multiple Myeloma

Sammicheli Stefano, Camille Grandclement, Elie Dehilly, Maria Panagopoulou, Evangelia Martini, Rosa Castillo, Perrine Suere, Blandine Pouleau, Carole Estoppey, Julia Frei, Jeremy Loyau, Thierry Monney, Rebecca Wood, Amelie Croset, Alain Rubod, Girish Gudi, Venkatesha Udupa, Sunitha Gn, Vinu Menon, Daniel Rasmussen, Jeppe Koch Olsen, Roberto Giovannini, Aravind Chakrapani, Stanislas Blein, Marie-Agnes Doucey, Adam Drake, Alessandro Riva, Cyril Konto, Mario Perro, Lamine Mbow
Journal: Blood
Blood (2021) 138 (Supplement 1): 73.
https://doi.org/10.1182/blood-2021-145586
Published: 2021
Journal Articles

Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Reuben Benjamin, Charlotte Graham, MRCP, BSc, MBBS, Deborah Yallop, MBBS FRCP FRCPath PhD, Agnieszka Jozwik, Oana Ciocarlie, Nitin Jain, MD, Elias J. Jabbour, MD, Marcela V. Maus, MD PhD, Matthiew Frigault, MD MSc, Nicolas Boissel, MD PhD, Jerome Larghero, PharmD, PhD, Andre Baruchel, MD, Mohamad Mohty, MD PhD, Barbara De Moerloose, MD PhD, Adrian Bloor, MA MB BChir PhDFCRP FRCPath, Noelle V. Frey, MD, Amina Zinaï, MD, Svetlana Balandraud, MD, Anne Philippe, Pharm D, Sylvain Fouliard, Ludiane Gauthier, Jeanne Pauly, PharmD, Cyril Konto, MD, Candy Bermingham, PhD, Paul Veys, MD PhD, Waseem Qasim, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 896.
https://doi.org/10.1182/blood-2018-99-111356
Published: 2018
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a First-in-Human Trial (CALM) in Adult Patients with CD19 + Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Charlotte Graham, MRCP, BSc, MBBS, Deborah Yallop, MBBS FRCP FRCPath PhD, Agnieszka Jozwik, Piers Patten, BSc, MRCP, MRCPath, PhD, Alan Dunlop, Rose Ellard, Orla Stewart, Victoria Potter, Victoria Metaxa, Shireen Kassam, Farzin Farzaneh, PhD, Stephen Devereux, FRCP, FRCPath, PhD, Antonio Pagliuca, MD, Amina Zinai, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Anne Philippe, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Ghulam Mufti, DM, FRCP, FRCPath, Reuben Benjamin
Journal: Blood
Blood (2017) 130 (Supplement 1): 887.
https://doi.org/10.1182/blood.V130.Suppl_1.887.887
Published: 2017
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product in a First-in-Human Trial (PALL) in Pediatric Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Waseem Qasim, MD PhD, Oana Ciocarlie, Stuart Adams, PhD, Sarah Inglott, Claire Murphy, Christine Rivat, Gary Wright, Giovanna Lucchini, MD, Juliana Silva, MD, Kanchan Rao, Amina Zinaï, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Jeanne Pauly, PharmD, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Robert Chiesa, Sujith Samarasinghe, Havinder Hara, Alayna Boyle, Jan Chu, Danielle Pinner, Persis J Amrolia, Ajay Vora, MD, Anupama Rao, Philip Ancliffe, MD, Paul Veys, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1271.
https://doi.org/10.1182/blood.V130.Suppl_1.1271.1271
Published: 2017