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Journal Articles

Differential in Vitro Sensitivity of BCR::ABL1 Kinase Domain Mutations to Tyrosine Kinase Inhibitors Depending on the p190 or p210 Background

Chantal Lucini, Isabella Sponseiler, Julia Senkiv, Anna-Maria Bandian, Thomas Lion

Blood (2024) 144 (Supplement 1): 2829.

https://doi.org/10.1182/blood-2024-200428

Published: 2024

Journal Articles

New Insights in Current Practice in the Management of DNA Viruses in Children Following Allogeneic HSCT at EBMT Centers

Elif Ince, Petr Sedlacek, Tobias Feuchtinger, Jérôme Le Goff, Tony H Truong, Thomas Lion, Jan Styczynski, Mouad Abouqateb, Arnaud Dalissier, Rafael De La Camara, Dina Averbuch, Krzysztof Kalwak

Blood (2024) 144 (Supplement 1): 7273.

https://doi.org/10.1182/blood-2024-194116

Published: 2024

Journal Articles

Combinatorial Treatment Options for Highly Resistant Compound Mutations in the Kinase Domain of the BCR::ABL1 Fusion Gene

Isabella Sponseiler, Anna-Maria Bandian, Petra Pusic, Thomas Lion

Blood (2023) 142 (Supplement 1): 5746.

https://doi.org/10.1182/blood-2023-174154

Published: 2023

Journal Articles

Hydroxyurea Induces Growth Inhibition in BCR-ABL1 T315I+ Clones and Synergizes with Ponatinib in Killing TKI-Resistant CML Cells

Mathias A Schneeweiss, MD, Konstantin Byrgazov, PhD, Chantal B Lucini, PhD, Susanne Herndlhofer, Wolfgang R. Sperr, MD, Thomas Lion, PhD, Gregor Hoermann, Michael W. Deininger, MD PhD, Peter Valent, MD, Karoline V Gleixner, MD

Blood (2016) 128 (22): 5425.

https://doi.org/10.1182/blood.V128.22.5425.5425

Published: 2016

Journal Articles

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Karoline V Gleixner, MD, Mathias A Schneeweiss, MD, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Daniela Berger, Gregor Eisenwort, MD PhD, Georg Greiner, MD, Konstantin Byrgazov, PhD, Gregor Hoermann, Marina Konopleva, MD PhD, Islam Waliul, Patrick T Gunning, PhD, Hiroshi Maeda, PhD, Richard Moriggl, PhD, Michael W. Deininger, MD PhD, Thomas Lion, PhD, Michael Andreeff, MD PhD, Peter Valent, MD

Blood (2016) 128 (22): 4241.

https://doi.org/10.1182/blood.V128.22.4241.4241

Published: 2016

Journal Articles

Hypomorphic mutation in TTC7A causes combined immunodeficiency with mild structural intestinal defects

Stavroula Woutsas, Caner Aytekin, Elisabeth Salzer, Cecilia Domínguez Conde, Sema Apaydin, Herbert Pichler, Nima Memaran-Dadgar, Ferda Ozbay Hosnut, Elisabeth Förster-Waldl, Susanne Matthes, Wolf-Dietrich Huber, Thomas Lion, Wolfgang Holter, Ivan Bilic, Kaan Boztug

Blood (2015) 125 (10): 1674–1676.

https://doi.org/10.1182/blood-2014-08-595397

Published: 2015

Includes: Supplemental data

Journal Articles

A Novel Fusion Gene NDEL1-Pdgfrb in a Patient with JMML with a New Variant of TKI-Resistant Mutation in the Kinase Domain of PDGFRβ

Konstantin Byrgazov, PhD, Renate Kastner, PhD, Michael Dworzak, MD, Gregor Hoermann, MD PhD, Oskar A. Haas, MD, Raphael Ulreich, MD, Christian E. Urban, MD, Oliver D. Hantschel, PhD, Peter Valent, MD, Thomas Lion, MD PhD

Blood (2014) 124 (21): 613.

https://doi.org/10.1182/blood.V124.21.613.613

Published: 2014

Journal Articles

Sensitivity, Reproducibility and Clinical Utility Of Next-Generation Sequencing (NGS) for BCR-ABL1 Kinase Domain Mutation Screening: Results From The CML Work Package Of The Iron-II (Interlaboratory RObustness Of Next-Generation Sequencing) International Study

Blood (2013) 122 (21): 3824.

https://doi.org/10.1182/blood.V122.21.3824.3824

Published: 2013

Journal Articles

Rapid Identification Of Compound Mutations In Patients With Ph-Positive Leukemias By Long-Range Next Generation Sequencing

Sandra Preuner, MSc, Renate Kastner, Agnes Zopf, MSc, Proell Johannes, PhD, Pierre Foskett, PhD, Peter Valent, Christian Gabriel, MD, Thomas Lion, MD, PhD

Blood (2013) 122 (21): 1373.

https://doi.org/10.1182/blood.V122.21.1373.1373

Published: 2013

Journal Articles

The Interlaboratory Robustness Of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses Of Hematological Malignancies Performed In 8,867 Cases By An International Network Involving 27 Laboratories

Blood (2013) 122 (21): 743.

https://doi.org/10.1182/blood.V122.21.743.743

Published: 2013

Journal Articles

The Interlaboratory Robustness of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses of Hematological Malignancies Performed by an International Network Involving 26 Laboratories

Blood (2012) 120 (21): 1399.

https://doi.org/10.1182/blood.V120.21.1399.1399

Published: 2012

Journal Articles

International Standardization of Minimal Residual Disease Assessment for in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Expressing m-BCR-ABL Transcripts: Updated Results of Quality Control Procedures by the EWALL and ESG-MRD-ALL Consortia

Blood (2011) 118 (21): 2535.

https://doi.org/10.1182/blood.V118.21.2535.2535

Published: 2011

Journal Articles

Stability of Conversion Factors for BCR-ABL Monitoring -– Implications for the Frequency of Validation Rounds

Martin C. Müller, MD, Umang Munjal, PhD, Philipp Erben, MD, Thomas Lion, MD, PhD, Gerlinde Mitterbauer-Hohendanner, MD, Hakim El Housni, MD, Nancy Boeckx, Renata Zadro, MD, PhD, Jiri Mayer, MD, PhD, Peter Rohon, MD, Jana Rulcova, PhD, Lykke Grubach, Kadri Raudsepp, MD, Veli Kairisto, MD, PhD, Francois-Xavier Mahon, MD, PhD, Claude Preudhomme, MD, Sandrine Hayette, MD, Jean Gabert, MD, Jean-Michel Cayuela, MD, PhD, Christian Thiede, Lars Galonska, MD, Heike Pfeifer, MD, Carsten Hirt, MD, Philippe Schafhausen, MD, Nils von Neuhoff, PhD, Martin Roskos, MD, Christiane Pott, MD, Thoralf Lange, MD, Georg Hess, MD, Susanne Schnittger, PhD, Annika Dufour, MD, Steffen Koschmieder, MD, Frank Stegelmann, MD, Katerina Zoi, MD, PhD, Kostas Stamatopoulos, Hajnalka Andrikovics, MD, PhD, Tali Tohami, MD, PhD, Giovanni Martinelli, MD, Barbara Izzo, PhD, Enrico Gottardi, MD, Mindaugas Stoskus, Dag Andre Nymoen, MD, Tomasz Sacha, MD, Joana Diamond, MD, PhD, Rodica Talmaci, PhD, Andrey Misyurin, MD, Michael V. Dubina, MD, Tadej Pajic, MD, PhD, Josep F. Nomdedeu, MD, Dolors Colomer, MD, PhD, Gisela Barbany-Bustinza, MD, Hans Ehrencrona, MD, Elisabeth Oppliger Leibundgut, PhD, Jeroen Janssen, MD, Vincent H. J. van der elden, MD, Peter J.M. Valk, MD, PhD, Ugur Ozbek, MD, PhD, Lihui Wang, Gareth Gerrard, PhD, Helen E White, PhD, Thomas Schenk, MD, Thomas Ernst, MD, Rüdiger Hehlmann, MD, Giuseppe Saglio, MD, PhD, Andreas Hochhaus, MD, Nicholas C. P. Cross, PhD

Blood (2010) 116 (21): 893.

https://doi.org/10.1182/blood.V116.21.893.893

Published: 2010

Journal Articles

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Blood (2010) 116 (21): 894.

https://doi.org/10.1182/blood.V116.21.894.894

Published: 2010

Journal Articles

Proliferation Kinetics of Subclones Carrying Point Mutations In the BCR-ABL TKD During TKI Treatment In CML Patients: Quantitative Monitoring by LD-PCR

Sandra Preuner, Margit Bernroitner, PhD, Gerlinde Mitterbauer, MD, Christine Mannhalter, PhD, Susanne Herndlhofer, MD, Wolfgang R Sperr, MD, Gerald Webersinke, PhD, Peter Valent, MD, Thomas Lion, MD, PhD

Blood (2010) 116 (21): 2269.

https://doi.org/10.1182/blood.V116.21.2269.2269

Published: 2010

Journal Articles

High Dose Imatinib Induction Therapy (800 mg/day, 6 Months) In Pre-Treated Chronic Phase CML Patients Improves Cytogenetic and Molecular Responses but Does Not Improve Overall and Progression Free Survival – Final Results of the CELSG Phase III CML11 “ISTAHIT” Trial

Blood (2010) 116 (21): 2271.

https://doi.org/10.1182/blood.V116.21.2271.2271

Published: 2010

Journal Articles

Diagnosis of Invasive Fungal Infections by a Real-Time Panfungal PCR Assay in Pediatric Patients Undergoing Intensive Chemotherapy or Allogeneic Stem Cell Transplantion.

Christine Landlinger, PhD, Lenka Baskova, Sandra Preuner, Martine Van Grotel, MD, Nico G. Hartwig, Marry M. van den Heuvel, MD, PhD, Thomas Lion, MD, PhD

Blood (2009) 114 (22): 343.

https://doi.org/10.1182/blood.V114.22.343.343

Published: 2009

Journal Articles

Selective engraftment of donor CD4 + 25 high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation

Markus G. Seidel, Gerhard Fritsch, Thomas Lion, Birgit Jürgens, Andreas Heitger, Rosa Bacchetta, Anita Lawitschka, Christina Peters, Helmut Gadner, Susanne Matthes-Martin

Blood (2009) 113 (22): 5689–5691.

https://doi.org/10.1182/blood-2009-02-206359

Published: 2009

Journal Articles

Rapid Detection of Invasive Fungal Infections in Hemato-Oncological Patients.

Christine Landlinger, Lenka Baskova, Sandra Preuner, Martine Van Grotel, MD, Nico G. Hartwig, Marry M. van den Heuvel-Eibrink, Thomas Lion

Blood (2008) 112 (11): 1468.

https://doi.org/10.1182/blood.V112.11.1468.1468

Published: 2008

Journal Articles

Monitoring of Adenovirus Load in Stool by Real-Time PCR Permits Early Detection of Impending Invasive Infection in Patients after Allogeneic Stem Cell Transplantation

Thomas Lion, MD, Karin Kosulin, Christine Landlinger, Margit Rauch, Dragana Jugovic, Ulrike Pötschger, Anita Lawitschka, Christina Peters, Gerhard Fritsch, Susanne Matthes-Martin

Blood (2008) 112 (11): 1162.

https://doi.org/10.1182/blood.V112.11.1162.1162

Published: 2008

NARROW

Differential in Vitro Sensitivity of BCR::ABL1 Kinase Domain Mutations to Tyrosine Kinase Inhibitors Depending on the p190 or p210 Background

New Insights in Current Practice in the Management of DNA Viruses in Children Following Allogeneic HSCT at EBMT Centers

Combinatorial Treatment Options for Highly Resistant Compound Mutations in the Kinase Domain of the BCR::ABL1 Fusion Gene

Hydroxyurea Induces Growth Inhibition in BCR-ABL1 T315I+ Clones and Synergizes with Ponatinib in Killing TKI-Resistant CML Cells

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Hypomorphic mutation in TTC7A causes combined immunodeficiency with mild structural intestinal defects

A Novel Fusion Gene NDEL1-Pdgfrb in a Patient with JMML with a New Variant of TKI-Resistant Mutation in the Kinase Domain of PDGFRβ

Sensitivity, Reproducibility and Clinical Utility Of Next-Generation Sequencing (NGS) for BCR-ABL1 Kinase Domain Mutation Screening: Results From The CML Work Package Of The Iron-II (Interlaboratory RObustness Of Next-Generation Sequencing) International Study

Rapid Identification Of Compound Mutations In Patients With Ph-Positive Leukemias By Long-Range Next Generation Sequencing

The Interlaboratory Robustness Of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses Of Hematological Malignancies Performed In 8,867 Cases By An International Network Involving 27 Laboratories

The Interlaboratory Robustness of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses of Hematological Malignancies Performed by an International Network Involving 26 Laboratories

International Standardization of Minimal Residual Disease Assessment for in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Expressing m-BCR-ABL Transcripts: Updated Results of Quality Control Procedures by the EWALL and ESG-MRD-ALL Consortia

Stability of Conversion Factors for BCR-ABL Monitoring -– Implications for the Frequency of Validation Rounds

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Proliferation Kinetics of Subclones Carrying Point Mutations In the BCR-ABL TKD During TKI Treatment In CML Patients: Quantitative Monitoring by LD-PCR

High Dose Imatinib Induction Therapy (800 mg/day, 6 Months) In Pre-Treated Chronic Phase CML Patients Improves Cytogenetic and Molecular Responses but Does Not Improve Overall and Progression Free Survival – Final Results of the CELSG Phase III CML11 “ISTAHIT” Trial

Diagnosis of Invasive Fungal Infections by a Real-Time Panfungal PCR Assay in Pediatric Patients Undergoing Intensive Chemotherapy or Allogeneic Stem Cell Transplantion.

Selective engraftment of donor CD4 + 25 high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation

Rapid Detection of Invasive Fungal Infections in Hemato-Oncological Patients.

Monitoring of Adenovirus Load in Stool by Real-Time PCR Permits Early Detection of Impending Invasive Infection in Patients after Allogeneic Stem Cell Transplantation

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American Society of Hematology

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American Society of Hematology

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