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Journal Articles

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142284

Published: 2020

Journal Articles

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, MSc, Hirotaka Takahasi, PhD, Tatsuya Sawasaki, PhD, Toshio Kitamura, MD PhD, Susumu Goyama, MD PhD

Blood (2019) 134 (Supplement_1): 1252.

https://doi.org/10.1182/blood-2019-126264

Published: 2019

Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 2514.

https://doi.org/10.1182/blood-2019-125472

Published: 2019

Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Blood (2019) 134 (Supplement_1): 2525.

https://doi.org/10.1182/blood-2019-126663

Published: 2019

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 821.

https://doi.org/10.1182/blood-2019-127904

Published: 2019

Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD

Blood (2019) 134 (Supplement_1): 1240.

https://doi.org/10.1182/blood-2019-125207

Published: 2019

Journal Articles

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

Shuhei Asada, MD, Susumu Goyama, MD PhD, Daichi Inoue, MD PhD, Reina Takeda, MD, Masahito Kawazu, Hiroyuki Mano, MDPhD, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 562.

https://doi.org/10.1182/blood.V130.Suppl_1.562.562

Published: 2017

Journal Articles

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

Susumu Goyama, MD PhD, Yasutaka Hayashi, XiaoXiao Liu, Shiori Shikata, Yosuke Tanaka, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Toshio Kitamura, MD PhD

Blood (2017) 130 (Supplement 1): 796.

https://doi.org/10.1182/blood.V130.Suppl_1.796.796

Published: 2017

Journal Articles

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Blood (2017) 130 (Supplement 1): 104.

https://doi.org/10.1182/blood.V130.Suppl_1.104.104

Published: 2017

Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD

Blood (2016) 128 (22): 2730.

https://doi.org/10.1182/blood.V128.22.2730.2730

Published: 2016

Journal Articles

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Kazuya Miyashita, Noritaka Kagaya, PhD, Miho Izumikawa, PhD, Kenji Kitajima, PhD, Kyoko Watakabe-Inamoto, MD, Yuho Najima, Noriko Doki, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Kazuteru Ohashi, Kazuo Shin-ya, PhD, Takahiko Hara, PhD

Blood (2016) 128 (22): 2813.

https://doi.org/10.1182/blood.V128.22.2813.2813

Published: 2016

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Kimihito Cojin Kawabata, MD PhD, Daichi Inoue, MD PhD, Jiro Kitaura, MD PhD, Yuka Harada, MD PhD, Susumu Goyama, MD PhD, Hironori Harada, MD PhD, Hiroyuki Aburatani, MD PhD, Toshio Kitamura, MD PhD

Blood (2015) 126 (23): 4116.

https://doi.org/10.1182/blood.V126.23.4116.4116

Published: 2015

Journal Articles

Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells

Yue Zhang, MD, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, PhD, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, MD, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, H. Leighton Grimes, PhD, Michael A. Caligiuri, M.D., Gang Huang

Blood (2012) 120 (21): 3501.

https://doi.org/10.1182/blood.V120.21.3501.3501

Published: 2012

Journal Articles

C-CBL Inactivation Promotes Cytokine-Driven Growth of Human CD34+ Cells and AML1-ETO Expressing Cells

Susumu Goyama, MD, PhD, Janet Schibler, James C. Mulloy, PhD

Blood (2011) 118 (21): 2464.

https://doi.org/10.1182/blood.V118.21.2464.2464

Published: 2011

Journal Articles

MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion

Yue Zhang, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan P. Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, David Witte, MD, Qian-fei Wang, MD, Daniel G. Tenen, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, Michael A Caligiuri, MD, Gang Huang

Blood (2011) 118 (21): 2801.

https://doi.org/10.1182/blood.V118.21.2801.2801

Published: 2011

Journal Articles

Pro-Survival Role of RUNX1 in Acute Myeloid Leukemia with Common Fusion Proteins

Susumu Goyama, MD, PhD, Janet Schibler, Yalan Rao, PhD, Mark Wunderlich, MS, Kevin A. Link, PhD, Gang Huang, James C. Mulloy, PhD

Blood (2011) 118 (21): 870.

https://doi.org/10.1182/blood.V118.21.870.870

Published: 2011

Journal Articles

Pbx-1 Is a Direct Target of Evi-1 in Hematopoietic Stem/Progenitors and Leukemic Cells.

Munetake Shimabe, Susumu Goyama, MD, PhD, Motoshi Ichikawa, MD, PhD, Yoichi Imai, MD, PhD, Tsuyoshi Takahashi, MD, PhD, Akira Hangaishi, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2008) 112 (11): 1192.

https://doi.org/10.1182/blood.V112.11.1192.1192

Published: 2008

Journal Articles

Phosphorylation of AML1/Runx1 Is Essential for T Cell Differentiation and Early Hematopoietic Development.

Mayumi Yoshimi, MD, Susumu Goyama, MD, PhD, Masahiro Nakagawa, MD, PhD, Takashi Asai, MD, PhD, Motoshi Ichikawa, MD, PhD, Mineo Kurokawa, MD, PhD

Blood (2007) 110 (11): 2189.

https://doi.org/10.1182/blood.V110.11.2189.2189

Published: 2007

NARROW

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Growth Suppressing Activity of Lhx2 in Human T Cell Acute Lymphoblastic Leukemia (T-ALL)-Derived Cells and Large-Scale Screening of a Lead Compounds Targeting T-ALL

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells

C-CBL Inactivation Promotes Cytokine-Driven Growth of Human CD34+ Cells and AML1-ETO Expressing Cells

MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion

Pro-Survival Role of RUNX1 in Acute Myeloid Leukemia with Common Fusion Proteins

Pbx-1 Is a Direct Target of Evi-1 in Hematopoietic Stem/Progenitors and Leukemic Cells.

Phosphorylation of AML1/Runx1 Is Essential for T Cell Differentiation and Early Hematopoietic Development.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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