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Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 2856.

https://doi.org/10.1182/blood-2019-126827

Published: 2019

Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD

Blood (2019) 134 (Supplement_1): 2862.

https://doi.org/10.1182/blood-2019-125754

Published: 2019

Journal Articles

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Giulia Guerra, Denis Baev, PhD, Catherine Hoofd, PhD, Marta Coscia, MD PhD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, Richard R. Furman, MD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 5454.

https://doi.org/10.1182/blood-2019-128308

Published: 2019

Journal Articles

CD79b Expression in Richter's Transformation

John N. Allan, MD, Erica B Bhavsar, BS, Tiziana Vaisitti, PhD, Vincent Sarno, Yifang Liu, Francesca Arruga, PhD, Maureen Joyce, Mathias Schulz, MD MBA, Silvia Deaglio, MD PhD, Richard R. Furman, MD, Amy Chadburn, MD

Blood (2019) 134 (Supplement_1): 4279.

https://doi.org/10.1182/blood-2019-128305

Published: 2019

Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD

Blood (2018) 132 (Supplement 1): 240.

https://doi.org/10.1182/blood-2018-99-118057

Published: 2018

Journal Articles

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Valeria Bracciamà, Alison Yeomans, PhD, Annalisa D'Avola, PhD, Marta Coscia, MD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Graham Packham, PhD, Silvia Deaglio, MD PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2018) 132 (Supplement 1): 1832.

https://doi.org/10.1182/blood-2018-99-118064

Published: 2018

Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Blood (2016) 128 (22): 969.

https://doi.org/10.1182/blood.V128.22.969.969

Published: 2016

Journal Articles

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Tiziana Vaisitti, PhD, Federica Gaudino, Samedy Ouk, Sara Serra, PhD, Johannes L. Zakrzewski, MD, Erica B. Bhavsar, John N. Allan, MD, Hsiou-Chi Liou, PhD, Richard R. Furman, Silvia Deaglio, MD PhD

Blood (2016) 128 (22): 304.

https://doi.org/10.1182/blood.V128.22.304.304

Published: 2016

Journal Articles

Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Luciana De Luca, Giovanni D'Arena, MD, Vittorio Simeon, PhD, Stefania Trino, PhD, Ilaria Laurenzana, PhD, Antonella Caivano, Francesco La Rocca, Oreste Villani, MD, Giovanna Mansueto, MD, Silvia Deaglio, MD PhD, Idanna Innocenti, MD, Luca Laurenti, Stefano Molica, MD, Giuseppe Pietrantuono, MD, Angelo De Stradis, Luigi Del Vecchio, MD, Pellegrino Musto, MD

Blood (2016) 128 (22): 4375.

https://doi.org/10.1182/blood.V128.22.4375.4375

Published: 2016

Journal Articles

Adenosine Signaling Mediates Hypoxic Responses in the Chronic Lymphocytic Leukemia Microenvironment

Sara Serra, PhD, Davide Brusa, PhD, Tiziana Vaisitti, PhD, Roberta Buonincontri, PhD, Valentina Audrito, PhD, Marta Coscia, MD PhD, Davide Rossi, MD PhD, Erica B. Bhavsar, Richard R. Furman, MD, Gianluca Gaidano, MD PhD, Silvia Deaglio, MD PhD

Blood (2015) 126 (23): 4145.

https://doi.org/10.1182/blood.V126.23.4145.4145

Published: 2015

Journal Articles

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Blood (2014) 124 (21): 3308.

https://doi.org/10.1182/blood.V124.21.3308.3308

Published: 2014

Journal Articles

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Blood (2014) 124 (21): 296.

https://doi.org/10.1182/blood.V124.21.296.296

Published: 2014

Journal Articles

Regulation Of CLL Growth and Trafficking By The Enzymatic Functions Of CD38: Implications For Therapeutic Targeting

Tiziana Vaisitti, PhD, Valentina Audrito, Sara Serra, Giovanna Sociali, Antonella Zucchetto, Erika Tissino, Andrea Pagnani, Candida Vitale, MD, Marta Coscia, MD, PhD, Valter Gattei, Santina Bruzzone, Silvia Deaglio, MD, PhD

Blood (2013) 122 (21): 4112.

https://doi.org/10.1182/blood.V122.21.4112.4112

Published: 2013

Journal Articles

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Francesca Arruga, PhD, Branimir Gizdic, Sara Serra, Tiziana Vaisitti, PhD, Davide Rossi, Marta Coscia, MD, PhD, Luca Laurenti, MD, Giovanni D'Arena, Ozren Jaksic, MD, PhD, Giorgio Inghirami, Gianluca Gaidano, Silvia Deaglio, MD, PhD

Blood (2013) 122 (21): 4117.

https://doi.org/10.1182/blood.V122.21.4117.4117

Published: 2013

Journal Articles

Slamf-1/CD150 Is a Signaling Receptor Expressed by a Subset of Chronic Lymphocytic Leukemia Patients Characterized by a Favorable Prognosis

Cinzia Bologna, Roberta Buonincontri, Sara Serra, Tiziana Vaisitti, PhD, Valentina Audrito, Davide Brusa, Davide Rossi, MD, PhD, Marta Coscia, MD, PhD, Gianluca Gaidano, MD, PhD, Cox Terhorst, PhD, Silvia Deaglio, MD, PhD

Blood (2012) 120 (21): 1770.

https://doi.org/10.1182/blood.V120.21.1770.1770

Published: 2012

Journal Articles

The Elastin Microfibril Interfacer-1 (EMILIN-1) Is a Ligand for CD49d in Chronic Lymphocytic Leukemia Cells

Erika Tissino, Dania Benedetti, Riccardo Bomben, Michele Dal Bo, Tiziana Vaisitti, PhD, Silvia Deaglio, MD, PhD, Davide Rossi, MD, Francesco Zaja, MD, Gabriele Pozzato, MD, Francesco Di Raimondo, Gianluca Gaidano, Giovanni Del Poeta, Alberto Zamò, Paola Spessotto, Roberto Doliana, Antonella Zucchetto, Alfonso Colombatti, Valter Gattei, MD

Blood (2012) 120 (21): 1772.

https://doi.org/10.1182/blood.V120.21.1772.1772

Published: 2012

Journal Articles

The PD-1/PD-L1 Axis Contributes to T Cell Dysfunction in Chronic Lymphocytic Leukemia

Davide Brusa, Sara Serra, Marta Coscia, MD, PhD, Davide Rossi, MD, PhD, Gianluca Gaidano, MD, PhD, Giorgio Inghirami, Tiziana Vaisitti, PhD, Silvia Deaglio, MD, PhD

Blood (2012) 120 (21): 1778.

https://doi.org/10.1182/blood.V120.21.1778.1778

Published: 2012

Journal Articles

Circulating CLL Cells Expressing CD49d Display a Phospho-Proteomic Profile Consistent with a Constitutive Receptor Engagement by Blood-Borne Ligands

Dania Benedetti, Erika Tissino, Daniela Marconi, Michele Dal Bo, Riccardo Bomben, Tiziana Vaisitti, PhD, Silvia Deaglio, MD, PhD, Davide Rossi, MD, Gianluca Gaidano, MD, PhD, Gabriele Pozzato, MD, Francesco Di Raimondo, Giovanni Del Poeta, Amy VanMeter, Antonella Zucchetto, Virginia Espina, Lance Liotta, Valter Gattei, MD

Blood (2012) 120 (21): 930.

https://doi.org/10.1182/blood.V120.21.930.930

Published: 2012

Journal Articles

CD38 Induces Homing of Chronic Lymphocytic Leukemia Cells to the Lymphoid Organs through a Functional Interplay with CXCR4.

Silvia Deaglio, MD, PhD, Semra Aydin, MD, Tiziana Vaisitti, PhD, Luciana Bergui, MD, PhD, Davide Rossi, MD, Giovanni D'Arena, MD, Lisa Bonello, PhD, Maurizia Mello Grand, PhD, Giovanna Chiorino, Alberto Horenstein, PhD, Gianluca Gaidano, MD, PhD, Fabio Malavasi, MD

Blood (2009) 114 (22): 2328.

https://doi.org/10.1182/blood.V114.22.2328.2328

Published: 2009

Journal Articles

Host Genetic Background and Risk of Richter Syndrome: The Genotype of LRP4 Is An Independent Predictor of Chronic Lymphocytic Leukemia Transformation to Aggressive Lymphoma.

Davide Rossi, MD, Silvia Rasi, PhD, Claudio Tripodo, MD, Francesco Forconi, MD, PhD, Luca Laurenti, MD, Alessio Bruscaggin, PhD, Marco Fangazio, MD, Alessia Puma, MD, Elisa Sozzi, BSci, Jeffrey T. Malik, MD, Josep F. Nomdedeu, MD, Roberto Marasca, MD, Valter Gattei, MD, Ken H. Young, MD, PhD, Stefano A. Pileri, MD, Francesco Lauria, MD, Fabio Malavasi, MD, PhD, Silvia Deaglio, MD, PhD, Gianluca Gaidano, MD, PhD

Blood (2009) 114 (22): 2340.

https://doi.org/10.1182/blood.V114.22.2340.2340

Published: 2009

NARROW

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

CD79b Expression in Richter's Transformation

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Adenosine Signaling Mediates Hypoxic Responses in the Chronic Lymphocytic Leukemia Microenvironment

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Regulation Of CLL Growth and Trafficking By The Enzymatic Functions Of CD38: Implications For Therapeutic Targeting

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Slamf-1/CD150 Is a Signaling Receptor Expressed by a Subset of Chronic Lymphocytic Leukemia Patients Characterized by a Favorable Prognosis

The Elastin Microfibril Interfacer-1 (EMILIN-1) Is a Ligand for CD49d in Chronic Lymphocytic Leukemia Cells

The PD-1/PD-L1 Axis Contributes to T Cell Dysfunction in Chronic Lymphocytic Leukemia

Circulating CLL Cells Expressing CD49d Display a Phospho-Proteomic Profile Consistent with a Constitutive Receptor Engagement by Blood-Borne Ligands

CD38 Induces Homing of Chronic Lymphocytic Leukemia Cells to the Lymphoid Organs through a Functional Interplay with CXCR4.

Host Genetic Background and Risk of Richter Syndrome: The Genotype of LRP4 Is An Independent Predictor of Chronic Lymphocytic Leukemia Transformation to Aggressive Lymphoma.

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American Society of Hematology

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