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Journal Articles

Impact of Idelalisib Treatment Interruption with or without Dose Reduction on Outcomes in Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Shuo Ma, MD PhD, Rebecca J Chan, MD PhD, Lin Gu, MS, Guan Xing, PhD, Nishan Rajakumaraswamy, MD, Bianca Ruzicka, PhD, Nina D. Wagner-Johnston, MD

Blood (2019) 134 (Supplement_1): 5468.

https://doi.org/10.1182/blood-2019-124541

Published: 2019

Journal Articles

Treatment Patterns and Outcomes of Patients with Relapsed or Refractory Follicular Lymphoma Treated with Idelalisib in a Community Oncology Setting

David Andorsky, MD, Rebecca J Chan, MD PhD, Jamyia Clark, MPH, Bianca Ruzicka, PhD, Nicholas James Robert, MD, Farrukh T. Awan, MD

Blood (2019) 134 (Supplement_1): 2810.

https://doi.org/10.1182/blood-2019-124013

Published: 2019

Journal Articles

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Roshni Patel, BS, Baskar Ramdas, PhD, Lisa Deng, PhD, Victoria Jideonwo-Auman, PhD, Rebecca J Chan, MD PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 2623.

https://doi.org/10.1182/blood-2018-99-118802

Published: 2018

Journal Articles

Patient Co-Morbidity Profile Should Drive PI3K Inhibitor Selection for Relapsed Follicular Lymphoma

Farrukh T. Awan, MD MS, Rebecca J Chan, MD PhD, Wei Ye, PhD, Guan Xing, PhD, Caroline Roudet, PharmD, MBA, Bianca Ruzicka, PhD, Martin Dreyling, MD PhD, Pier Luigi Zinzani, MD, Ajay K. Gopal, MD

Blood (2018) 132 (Supplement 1): 5322.

https://doi.org/10.1182/blood-2018-99-110477

Published: 2018

Journal Articles

Idelalisib Plus Anti-CD20 Used Second Line Shows Improved PFS and Comparable Safety Compared to Later Line Therapy of Relapsed CLL

Jennifer R. Brown, MD PhD, Rebecca J Chan, MD PhD, Wei Ye, PhD, Guan Xing, PhD, Caroline Roudet, PharmD, MBA, Bianca Ruzicka, PhD, Susan M. O'Brien, MD

Blood (2018) 132 (Supplement 1): 5564.

https://doi.org/10.1182/blood-2018-99-110853

Published: 2018

Journal Articles

Survival Outcomes Following Idelalisib Interruption in the Treatment of Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Shuo Ma, MD PhD, Rebecca J Chan, MD PhD, Wei Ye, PhD, Guan Xing, PhD, Carrie Ellen Brubaker, PhD, Caroline Roudet, PharmD, MBA, Bianca Ruzicka, PhD, Nina D. Wagner-Johnston, MD

Blood (2018) 132 (Supplement 1): 3149.

https://doi.org/10.1182/blood-2018-99-110655

Published: 2018

Journal Articles

Pharmacologic Inhibition of PI3Kδ Prolongs Survival of Mutant Shp2 E76K -Expressing Mice

Lisa Deng, Elizabeth L Virts, PhD, Rebecca J Chan, MD PhD

Blood (2017) 130 (Supplement 1): 1240.

https://doi.org/10.1182/blood.V130.Suppl_1.1240.1240

Published: 2017

Journal Articles

PTPN11 D61Y/+ ; Vavcre+ Animals Commonly Succumb to Leukemia Relapse Despite Robust Engraftment of Transplanted Wild-Type Hematopoietic Stem and Progenitor Cells

Stefan P. Tarnawsky, BS, Mervin C. Yoder, MD, Rebecca J. Chan, MD, PhD

Blood (2016) 128 (22): 496.

https://doi.org/10.1182/blood.V128.22.496.496

Published: 2016

Journal Articles

Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function

XingJun Li, MD PhD, Charles Goodwin, BS, Zhenyun Yang, Sarah C Nabinger, PhD, Briana Richine, Gordon Chan, Helmut Hanenberg, Hiroaki Ohnishi, MD, Takashi Matozaki, MD PhD, Jamel El Benna, Gen-Sheng Feng, PhD, Benjamin Neel, MD PhD, Rebecca J. Chan, MD PhD

Blood (2014) 124 (21): 1397.

https://doi.org/10.1182/blood.V124.21.1397.1397

Published: 2014

Journal Articles

HSC-Independent Yolk Sac Progenitors Bear Hallmarks of JMML in a PTPN11 D61Y Mouse Model

Stefan Pasichnyk Tarnawsky, B.Sc., Momoko Yoshimoto, MD PhD, Gordon Chan, PhD, Benjamin Neel, MD PhD, Rebecca J. Chan, MD PhD, Mervin C. Yoder, MD

Blood (2014) 124 (21): 3236.

https://doi.org/10.1182/blood.V124.21.3236.3236

Published: 2014

Journal Articles

Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression

Lili Chen, PhD, Wei Chen, PhD, Maria Mysliwski, Justin Serio, James Ropa, Fardokht Abulwerdi, Rebecca J. Chan, MD PhD, Jay P. Patel, Martin S. Tallman, MD, Elisabeth M. Paietta, PhD, Ari M Melnick, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Zaneta Nikolovska-Coleska, PhD, Andrew G. Muntean, PhD

Blood (2014) 124 (21): 3565.

https://doi.org/10.1182/blood.V124.21.3565.3565

Published: 2014

Journal Articles

Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11 -Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia

Charles B Goodwin, Raghuveer Mali, Ph.D., Gordon Chan, Benjamin Neel, Brian Lannutti, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2013) 122 (21): 3678.

https://doi.org/10.1182/blood.V122.21.3678.3678

Published: 2013

Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2012) 120 (21): 2420.

https://doi.org/10.1182/blood.V120.21.2420.2420

Published: 2012

Journal Articles

Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis

Anindya Chatterjee, MS, PhD, Joydeep Ghosh, Baskar Ramdas, Ph.D., Sasidhar Vemula, PhD, Holly Martin, Raghuveer Mali, Ph.D., Sarah C Nabinger, PhD, Charles B Goodwin, H. Scott Boswell, MD, Rebecca J. Chan, MD, PhD, Reuben Kapur, PhD

Blood (2012) 120 (21): 858.

https://doi.org/10.1182/blood.V120.21.858.858

Published: 2012

Journal Articles

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Peilin Ma, MD, PhD, Raghuveer Mali, Ph.D., Li-Fan Zeng, PhD, Holly Martin, Baskar Ramdas, Ph.D., Yantao He, PhD, Emily Sims, Joydeep Ghosh, Ph.D, Sarah C Nabinger, Shuo Li, Veerendra Munugalavadla, PhD, Anindya Chatterjee, PhD, George Sandusky, MD, Andrew Craig, PhD, Kevin D. Bunting, PhD, Gen-Sheng Feng, Rebecca J. Chan, MD, PhD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD

Blood (2011) 118 (21): 868.

https://doi.org/10.1182/blood.V118.21.868.868

Published: 2011

Journal Articles

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Sarah C Nabinger, Yantao He, Fuqin Yin, Xian Zhang, Linda Senbanjo, Seiji Fukuda, MD, PhD, Menggang Yu, Gen-Sheng Feng, Zhong-Yin Zhang, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2009) 114 (22): 827.

https://doi.org/10.1182/blood.V114.22.827.827

Published: 2009

Journal Articles

Genetic Disruption of the PI3K Regulatory Subunit, p85α Partially Normalizes Gain-of-Function PTPN11-Induced Hypersensitivity to GM-CSF in Hematopoietic Progenitors.

Charles B Goodwin, Zhenyun Yang, Sasidhar Vemula, Fuqin Yin, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2009) 114 (22): 3968.

https://doi.org/10.1182/blood.V114.22.3968.3968

Published: 2009

Journal Articles

Genetic Disruption of the Scaffolding Protein, Kinase Suppressor of Ras 1 (Ksr1), Differentially Regulates GM-CSF-Stimulated Hyperproliferation in Hematopoietic Progenitors Expressing Activating PTPN11 Mutants D61Y and E76K.

Zhenyun Yang, Sarah Sitarski, Tirajeh Saadatzadeh, Fuqin Yin, Rebecca J. Chan, MD, PhD

Blood (2009) 114 (22): 1895.

https://doi.org/10.1182/blood.V114.22.1895.1895

Published: 2009

Journal Articles

MOZ and MOZ-CBP Cooperate with NFκB To Induce Expression of NFκB-Dependent Genes.

Edward M. Chan, MD, Rebecca J. Chan, MD-PhD, Elisha M. Comer, JD, Robert J. Goulet, III, MD, Colin D. Crean, Zachary D. Brown, Amy M. Fruehwald, Zhenyun Yang, PhD, Howard S. Boswell, MD, Harikrishna Nakshatri, PhD, Theodore G. Gabig, MD

Blood (2007) 110 (11): 887.

https://doi.org/10.1182/blood.V110.11.887.887

Published: 2007

Journal Articles

PTPN11 Mutations E76K, D61V, and D61Y Induce Hypersensitivity of Hematopoietic Progenitors to GM-CSF and IL-3.

Rebecca J. Chan, MD-PhD, Yanjun Li, MD, Melissa B. Leedy, BS

Blood (2004) 104 (11): 2559.

https://doi.org/10.1182/blood.V104.11.2559.2559

Published: 2004

NARROW

Impact of Idelalisib Treatment Interruption with or without Dose Reduction on Outcomes in Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Treatment Patterns and Outcomes of Patients with Relapsed or Refractory Follicular Lymphoma Treated with Idelalisib in a Community Oncology Setting

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Patient Co-Morbidity Profile Should Drive PI3K Inhibitor Selection for Relapsed Follicular Lymphoma

Idelalisib Plus Anti-CD20 Used Second Line Shows Improved PFS and Comparable Safety Compared to Later Line Therapy of Relapsed CLL

Survival Outcomes Following Idelalisib Interruption in the Treatment of Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Pharmacologic Inhibition of PI3Kδ Prolongs Survival of Mutant Shp2 E76K -Expressing Mice

PTPN11 D61Y/+ ; Vavcre+ Animals Commonly Succumb to Leukemia Relapse Despite Robust Engraftment of Transplanted Wild-Type Hematopoietic Stem and Progenitor Cells

Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function

HSC-Independent Yolk Sac Progenitors Bear Hallmarks of JMML in a PTPN11 D61Y Mouse Model

Hyperactive Ptpn11 Mutations Alters Leukemic Stem Cell Frequency through Mcl-1 Overexpression

Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11 -Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Genetic Disruption of the PI3K Regulatory Subunit, p85α Partially Normalizes Gain-of-Function PTPN11-Induced Hypersensitivity to GM-CSF in Hematopoietic Progenitors.

Genetic Disruption of the Scaffolding Protein, Kinase Suppressor of Ras 1 (Ksr1), Differentially Regulates GM-CSF-Stimulated Hyperproliferation in Hematopoietic Progenitors Expressing Activating PTPN11 Mutants D61Y and E76K.

MOZ and MOZ-CBP Cooperate with NFκB To Induce Expression of NFκB-Dependent Genes.

PTPN11 Mutations E76K, D61V, and D61Y Induce Hypersensitivity of Hematopoietic Progenitors to GM-CSF and IL-3.

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American Society of Hematology

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American Society of Hematology

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