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Journal Articles

In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair

Xavier M. Anguela, PhD, Rajiv Sharma, PhD, Yannick Doyon, PhD, Thomas Wechsler, PhD, David Paschon, PhD, Robert J. Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD

Blood (2015) 126 (23): 4422.

https://doi.org/10.1182/blood.V126.23.4422.4422

Published: 2015

Journal Articles

NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD

Sara Mastaglio, MD, Pietro Genovese, PhD, Zulma Magnani, MSc, Elisa Landoni, Barbara Camisa, BSc, Giulia Schiroli, Elena Provasi, PhD, Angelo Lombardo, PhD, Andreas Reik, PhD, Nicoletta Cieri, MD PhD, Maurilio Ponzoni, Fabio Ciceri, MD, Claudio Bordignon, MD, Michael C. Holmes, PhD, Philip D Gregory, PhD, Luigi Naldini, MD PhD, Chiara Bonini, MD

Blood (2014) 124 (21): 308.

https://doi.org/10.1182/blood.V124.21.308.308

Published: 2014

Journal Articles

HPRT As a Selectable Safe Harbor for Transgenesis

Anthony Conway, PhD, Josée Laganière, PhD, David E Paschon, PhD, Katrin Hacke, PhD, Noriyuki Kasahara, MD PhD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Gregory J Cost, PhD

Blood (2014) 124 (21): 4796.

https://doi.org/10.1182/blood.V124.21.4796.4796

Published: 2014

Journal Articles

Gene Editing of CCR5 in Hematopoietic Stem Cells in a Nonhuman Primate Model of HIV/AIDS

Christopher W. Peterson, PhD, Jianbin Wang, PhD, Patricia Polacino, PhD, Michael C. Holmes, PhD, Shiu-Lok Hu, PhD, Philip D Gregory, PhD, Hans-Peter Kiem, MD

Blood (2014) 124 (21): 4802.

https://doi.org/10.1182/blood.V124.21.4802.4802

Published: 2014

Journal Articles

TCR Gene Editing Achieved In a Single Round Of T Cell Activation Is Sufficient To Redirect T Cell Specificity and Prevent GvHD

Sara Mastaglio, MD, Pietro Genovese, PhD, Zulma Magnani, MSc, Elena Provasi, PhD, Angelo Lombardo, PhD, Andreas Reik, Nicoletta Cieri, MD, Fabio Ciceri, Claudio Bordignon, MD, Michael C. Holmes, PhD, Philip D Gregory, PhD, Luigi Naldini, MD, PhD, Chiara Bonini, MD

Blood (2013) 122 (21): 2898.

https://doi.org/10.1182/blood.V122.21.2898.2898

Published: 2013

Journal Articles

Zinc Finger Nucleases Targeting The β-Globin Locus Drive Efficient Correction Of The Sickle Mutation In CD34 + Cells

Megan D Hoban, BS, Alok V Joglekar, PhD, David Gray, BS, Michael L Kaufman, MS, Fabrizia Urbinati, PhD, Shantha Senadheera, MS, Gregory Cost, PhD, Andreas Reik, PhD, Michael C. Holmes, PhD, Philip D Gregory, PhD, Roger P. Hollis, PhD, Donald B. Kohn, MD

Blood (2013) 122 (21): 2904.

https://doi.org/10.1182/blood.V122.21.2904.2904

Published: 2013

Journal Articles

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

Hiroki Torikai, Tiejuan Mi, Sonny O Ang, PhD, Loren Gragert, Martin Maiers, Sourindra Maiti, PHD, Kirsten Switzer, Helen Huls, BS, Andreas Reik, Michael C. Holmes, PhD, Philip D Gregory, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 1655.

https://doi.org/10.1182/blood.V122.21.1655.1655

Published: 2013

Journal Articles

Using Forced Chromatin Looping To Overcome Developmental Silencing Of Embryonic and Fetal β-Type Globin Genes In Adult Erythroid Cells

Jeremy W Rupon, MD, PHD, Wulan Deng, PhD, Hongxin Wang, Philip D Gregory, PhD, Andreas Reik, PhD, Ann Dean, PhD, Gerd A. Blobel, MD, PhD

Blood (2013) 122 (21): 433.

https://doi.org/10.1182/blood.V122.21.433.433

Published: 2013

Journal Articles

Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia

Blood (2013) 122 (21): 434.

https://doi.org/10.1182/blood.V122.21.434.434

Published: 2013

Journal Articles

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Thomas Wechsler, PhD, David E Paschon, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Edward J Rebar, PhD, Katherine A. High, MD

Blood (2013) 122 (21): 720.

https://doi.org/10.1182/blood.V122.21.720.720

Published: 2013

Journal Articles

Controlling Long-Range Genomic Interactions to Reprogram the β-Globin Locus

Wulan Deng, Graduate student, Jeremy W Rupon, MD, PhD, Hongxin Wang, Andreas Reik, Philip D. Gregory, PhD, Gerd A Blobel, MD, PhD

Blood (2012) 120 (21): 280.

https://doi.org/10.1182/blood.V120.21.280.280

Published: 2012

Journal Articles

In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Sunnie Y Wong, David E Paschon, Hojun Li, MD PhD, Virginia Haurigot, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Edward Rebar, PhD, Katherine A. High, MD

Blood (2012) 120 (21): 751.

https://doi.org/10.1182/blood.V120.21.751.751

Published: 2012

Journal Articles

TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD

Blood (2011) 118 (21): 667.

https://doi.org/10.1182/blood.V118.21.667.667

Published: 2011

Journal Articles

Robust Factor IX Expression Following ZFN-Mediated Genome Editing in An Adult Mouse Model of Hemophilia B

Xavier M Anguela, Rajiv Sharma, Hojun Li, Virginia Haurigot, Anand Bhagwat, Robert J Davidson, Shangzhen Zhou, Yannick Doyon, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD

Blood (2011) 118 (21): 668.

https://doi.org/10.1182/blood.V118.21.668.668

Published: 2011

Journal Articles

Phenotypic Correction of a Mouse Model of Hemophilia B by In Vivo Genetic Correction of the F9 Gene

Hojun Li, Virginia Haurigot, Yannick Doyon, James Li, Anand Bhagwat, Sunnie Wong, Xavier Anguela, Rajiv Sharma, Lacramioara Ivanciu, Samuel Murphy, Shangzhen Zhou, David Paschon, Edward Rebar, Philip D. Gregory, PhD, Michael C. Holmes, Katherine A. High, MD

Blood (2010) 116 (21): LBA-5.

https://doi.org/10.1182/blood.V116.21.LBA-5.LBA-5

Published: 2010

Journal Articles

Manipulating Higher Order Chromatin Structure of the β-Globin Locus by Targeted Tethering of a “looping” Factor

Wulan Deng, Graduate, student, Philip D Gregory, PhD, Andreas Reik, PhD, Gerd Blobel, MD, PhD

Blood (2010) 116 (21): 647.

https://doi.org/10.1182/blood.V116.21.647.647

Published: 2010

Journal Articles

Targeted Killing of Glioblastoma Multiforme In Vivo by IL-13 Zetakine Redirected CTLs Made Glucocorticoid Resistant with Zinc Finger Nucleases.

Andreas Reik, PhD, Michael C. Holmes, PhD, Yuanyue Zhou, Matthew Mendel, Pei-Qi Liu, PhD, Gary Lee, PhD, David Paschon, PhD, Edward Rebar, PhD, Dale Ando, MD, David DiGiusto, PhD, Philip D. Gregory, PhD, Michael C. Jensen, MD

Blood (2007) 110 (11): 2597.

https://doi.org/10.1182/blood.V110.11.2597.2597

Published: 2007

NARROW

In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair

NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD

HPRT As a Selectable Safe Harbor for Transgenesis

Gene Editing of CCR5 in Hematopoietic Stem Cells in a Nonhuman Primate Model of HIV/AIDS

TCR Gene Editing Achieved In a Single Round Of T Cell Activation Is Sufficient To Redirect T Cell Specificity and Prevent GvHD

Zinc Finger Nucleases Targeting The β-Globin Locus Drive Efficient Correction Of The Sickle Mutation In CD34 + Cells

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

Using Forced Chromatin Looping To Overcome Developmental Silencing Of Embryonic and Fetal β-Type Globin Genes In Adult Erythroid Cells

Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Controlling Long-Range Genomic Interactions to Reprogram the β-Globin Locus

In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9

TCR Gene Editing Results in Effective Immunotherapy of Leukemia without the Development of GvHD

Robust Factor IX Expression Following ZFN-Mediated Genome Editing in An Adult Mouse Model of Hemophilia B

Phenotypic Correction of a Mouse Model of Hemophilia B by In Vivo Genetic Correction of the F9 Gene

Manipulating Higher Order Chromatin Structure of the β-Globin Locus by Targeted Tethering of a “looping” Factor

Targeted Killing of Glioblastoma Multiforme In Vivo by IL-13 Zetakine Redirected CTLs Made Glucocorticoid Resistant with Zinc Finger Nucleases.

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American Society of Hematology

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American Society of Hematology

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