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Journal Articles

Reprogramming glutamine metabolism enhances BCMA -CAR T-cell fitness and therapeutic efficacy in multiple myeloma

Open Access
Flor Navarro, Teresa Lozano, Andrea Fuentes-García, Inés Sánchez-Moreno, Marta Larrayoz, Pedro Justicia, Beatriz Perucha, Maialen Martinez-Tabar, Rebeca Martinez-Turrillas, Noelia Casares, Celia Martín-Otal, Marta Gorraiz, Erin W. Meermeier, Marta Chesi, Douglas Lake, P. Leif Bergsagel, Eva Santamaría, María Eréndira Calleja-Cervantes, Patxi San Martín-Uriz, Lorea Jordana-Urriza, Xabier Agirre, Sandra Hervás-Stubbs, Juan Roberto Rodriguez-Madoz, José Ángel Martinez-Climent, Felipe Prosper, Juan José Lasarte
Journal: Blood
Blood (2025) 146 (24): 2931–2944.
https://doi.org/10.1182/blood.2024027496
Published: 2025
Includes: Supplemental data
Journal Articles

Transcriptional stratification reveals distinct molecular subtypes with treatment-specific outcomes in multiple myeloma patients from the GEM2017FIT trial

Free
Antonio Porlan, Beñat Ariceta, Paula Aguirre-Ruiz, Joana De Las Heras, Alejandro Medina, Alicia Gimenez, Patxi San Martin-Uriz, Maria Jose Larrayoz, Joaquin Martinez-Lopez, Veronica Gonzalez-Calle, Noemí Puig, Maria Calasanz, Norma Gutierrez, Anna Sureda Balarí, Maria Teresa Cedena Romero, Albert Oriol, Enrique Ocio, Laura Rosiñol Dachs, Joan Bargay, María-Jesús Blanchard, Valentin Cabanas Perianes, Juan-Jose Lahuerta Palacios, Joan Batista Blade Creixenti, Jesus San-Miguel, Paula Rodriguez-Otero, María-Victoria Mateos, Felipe Prosper
Journal: Blood
Blood (2025) 146 (Supplement 1): 496.
https://doi.org/10.1182/blood-2025-496
Published: 2025
Journal Articles

Targeted long-read sequencing with adaptive sampling in multiple myeloma: A pilot study toward a unified diagnostic platform

Free
Beñat Ariceta, Paula Aguirre-Ruiz, Andrea Castro, Patxi San Martin-Uriz, Saioa Vicente, Maria Jose Larrayoz, Luis-Esteban Tamariz-Amador, Ana Alfonso-Pierola, Jesus San-Miguel, Maria Calasanz, Paula Rodriguez-Otero, Felipe Prosper
Journal: Blood
Blood (2025) 146 (Supplement 1): 6121.
https://doi.org/10.1182/blood-2025-6121
Published: 2025
Journal Articles

Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation

Free
Sofia Huerga, Beñat Ariceta, Paula Aguirre-Ruiz, Patxi San Martin-Uriz, Sarai Sarvide, Álvaro López-Janeiro, Diego Alignani, Aitziber López, Teresa Ezponda, Maria Rocio Figueroa Mora, Carlos Grande, Ana Alfonso, Esther Pena, Santiago Browne, Marta Abengozar, Ramón Robledano, Amaia Vilas-Zornoza, Sergio Roa, Jose A. Martinez-Climent, Felipe Prosper, Miguel Ángel Canales Albendea
Journal: Blood
Blood (2025) 146 (Supplement 1): 3539.
https://doi.org/10.1182/blood-2025-3539
Published: 2025
Journal Articles

Single-cell multiomic dissection of human hematopoietic stem cells reveals novel transcriptional fingerprints and regulatory programs in bone marrow and mobilized peripheral blood

Free
Daniel Mouzo, Asier Ortega-Legarreta, Ana Rosa Lopez-Perez, Nuria Planell, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Paula Aguirre-Ruiz, Patricia Jauregui, Rebeca Martinez-Turrillas, José Rifón, Vincenzo Lagani, Robert Lehman, Jesper Tegner, Marta Perez-Rodriguez, Susana Navarro, Juan Antonio Bueren, Paula Rio, Juan Roberto Rodriguez-Madoz, David Gomez-Cabrero, Felipe Prosper
Journal: Blood
Blood (2025) 146 (Supplement 1): 1377.
https://doi.org/10.1182/blood-2025-1377
Published: 2025
Journal Articles

BCMA CAR-T Cell Phenotype and Functionality Is Affected By Disease Stage of Multiple Myeloma Patients

Free
Angel Martin-Mallo, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Aintzane Zabaleta, Diego Alignani, Paula Rodríguez-Márquez, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Maria Luisa Palacios-Berraquero, Candela Ceballos, Jorge Illarramendi Esteban, Diana Gisell Gabaldon Limas, Maria Cruz Viguria, Ana Margarita Redondo, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernandez de Larrea, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Teresa Lozano, Juan Jose Lasarte, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 12708–12710.
https://doi.org/10.1182/blood-2022-163149
Published: 2022
Journal Articles

Characterization of Transcriptional Alterations Leading to Aberrant Myeloid Differentiation in Myelodysplastic Syndromes

Free
Aintzane Diaz-Mazkiaran, Jesús De la Fuente, Guillermo Serrano, Paula Garcia-Olloqui, Nerea Berastegui, Marina Ainciburu, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Jose Maria Lamo De Espinosa, Mikel San Julián, Pamela Acha, Francesc Solé, Tamara Jimenez, Félix López Cadenas, Maria Diez-Campelo, Antonieta Molero, Maria Julia Montoro, David Valcarcel, Teresa Ezponda, Mikel Hernáez, Felipe Prosper
Journal: Blood
Blood (2022) 140 (Supplement 1): 5852–5854.
https://doi.org/10.1182/blood-2022-166921
Published: 2022
Journal Articles

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Free
Lorea Jordana-Urriza, Guillermo Serrano, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabañas, Almudena Navarro-Bailón, Aina Oliver-Caldes, Marta Español-Rego, Mariona Pascal, Manel Juan, Álvaro Urbano-Ispizua, Juan Luis Reguera, Jose Maria Moraleda, Maria-Victoria Mateos, Fermin Sanchez-Guijo, Ana Alfonso Pierola, José J. Rifón Roca, Paula Rodríguez-Otero, Carlos Fernandez de Larrea, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Juan Jose Lasarte, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Mikel Hernáez, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 7366–7368.
https://doi.org/10.1182/blood-2022-163082
Published: 2022
Journal Articles

Deep Deconvolution of the Hematopoietic Stem Cell Regulatory Microenvironment Reveals a High Degree of Specialization and Conservation between Mouse and Human

Free
Jin Ye, Isabel A Calvo, Itziar Cenzano, Amaia Vilas-Zornoza, Xabier Martinez-de-Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C Viñado, Patxi San Martin-Uriz, Juan P Romero, Delia Quilez Agreda, Marta Miñana Barrios, Ignacio Sancho González, Gabriele Todisco, Luca Malcovati, Nuria Planell, Borja Saez, Jesper Tegner, Felipe Prosper, David Gomez Cabrero
Journal: Blood
Blood (2021) 138 (Supplement 1): 2168.
https://doi.org/10.1182/blood-2021-150612
Published: 2021
Journal Articles

CAR Density Influences Antitumoral Efficacy of BCMA CAR-T Cells and Correlates with Clinical Outcome

Free
Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Guillermo Serrano, Maria Luisa Palacios-Berraquero, Diego Alignani, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Candela Ceballos, Angel Martin-Mallo, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Susana Inogés, Ascensión López-Diaz de Cerio, Aina Oliver-Caldés, Marta Español-Rego, Mariona Pascal, Beatriz Martin-Antonio, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernández De Larrea, Maria Cruz Viguria, Ana Margarita Redondo, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Juan Jose Lasarte, Teresa Lozano, Bruno Paiva, Jesús F. San-Miguel, Mikel Hernáez, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood
Blood (2021) 138 (Supplement 1): 735.
https://doi.org/10.1182/blood-2021-148578
Published: 2021
Journal Articles

Single-Cell Transcriptomics Study of Human Hematopoietic Progenitors Reveals Alterations Associated with Aging and Myeloid Malignancies

Free
Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Maria Lamo De Espinosa, Mikel San Julián, Tamara Jimenez, Felix López Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero Yordi, María Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, Gomez-Cabrero David, Maria Diez-Campelo, David Valcarcel, Mikel Hernáez, Juan P. Romero, Felipe Prosper
Journal: Blood
Blood (2021) 138 (Supplement 1): 1082.
https://doi.org/10.1182/blood-2021-153550
Published: 2021
Journal Articles

Transcriptional Regulation of Hematopoietic Stem Cells in Aging and Myelodysplastic Syndrome Reveals DDIT3 As a Potential Driver of Transformation

Free
Teresa Ezponda, Juan P. Romero, Marina Ainciburu, Ana Alfonso, Nerea Berastegui, Amaia Vilas-Zornoza, PhD, Patxi San Martin-Uriz, Laura Castro, Victoria Riego, Tamara Jimenez, Félix López Cadenas, MD, Jesus M Hernández-Sánchez, Antonieta Molero, MD, Julia Montoro, Bárbara Tazón, PhD, Bruno Paiva, PhD, María Díez-Campelo, MD PhD, David Valcarcel, David Lara-Astiaso, Felipe Prosper
Journal: Blood
Blood (2019) 134 (Supplement_1): 3764.
https://doi.org/10.1182/blood-2019-122686
Published: 2019