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Martin C Müller
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Journal Articles

Absolute BCR-ABL Transcript Levels At 3 Months but Not At Diagnosis Predict Survival of Chronic Myeloid Leukemia (CML) Patients On Imatinib Therapy

Benjamin Hanfstein, MD, Valeria Shlyakhto, Michael Lauseker, Philipp Erben, MD, Susanne Saussele, MD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, Joerg Schubert, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, Joerg Hasford, Wolf-Karsten Hofmann, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2012) 120 (21): 3761.
https://doi.org/10.1182/blood.V120.21.3761.3761
Published: 2012
Journal Articles

Secondary Malignancies in CML Patients – Data From the German CML Study IV

Manuel Barreto Miranda, MD, Michael Lauseker, Ulrike Proetel, MD, Annette Schreiber, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, Martin C. Müller, MD, Markus Pfirrmann, Andreas Hochhaus, MD, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 3746.
https://doi.org/10.1182/blood.V120.21.3746.3746
Published: 2012
Journal Articles

Impact of Balanced or Unbalanced Karyotype At Diagnosis On Prognosis of CML: Long-Term Observation From 1346 Patients of the Randomized CML Study IV

Alice Fabarius, PhD, Claudia Haferlach, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, Martine Jotterrand, MD, Ulrike Proetel, MD, Wolf-Karsten Hofmann, Stefan W. Krause, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 913.
https://doi.org/10.1182/blood.V120.21.913.913
Published: 2012
Journal Articles

Complete Molecular Remission (CMR 4.5) of CML Is Induced Faster by Dose – Optimized Imatinib and Predicts Better Survival - Results From the Randomized CML-Study IV

Rüdiger Hehlmann, MD, Michael Lauseker, Benjamin Hanfstein, MD, Martin C. Müller, MD, Annette Schreiber, MD, Ulrike Proetel, MD, Markus Pfirrmann, Claudia Haferlach, MD, Susanne Schnittger, PhD, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, Dominik Heim, MD, Hermann Heimpel, Christoph Nerl, MD, Stefan W. Krause, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Andreas Hochhaus, MD, Joerg Hasford, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 67.
https://doi.org/10.1182/blood.V120.21.67.67
Published: 2012
Journal Articles

Genomic Instability in CML-CP originates From the Most Primitive Imatinib-Refractory Leukemia Stem Cells

Elisabeth Bolton, Mirle Schemionek, PhD, Hans-Urlich Klein, Grazyna Hoser, PhD, Sylwia Flis, Thoralf Lange, Linda Kerstiens, Margaret Nieborowska-Skorska, MD, PhD, Martin C. Müller, MD, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 909.
https://doi.org/10.1182/blood.V120.21.909.909
Published: 2012
Journal Articles

Equivalence of BCR-ABL Transcript Levels <1% According to the International Scale with Complete Cytogenetic Response in Chronic Phase CML Patients.

Michael Lauseker, Benjamin Hanfstein, MD, Claudia Haferlach, MD, Susanne Schnittger, PhD, Markus Pfirrmann, Alice Fabarius, PhD, Brigitte Schlegelberger, Susanne Saussele, Philipp Erben, MD, Rüdiger Hehlmann, Joerg Hasford, Andreas Hochhaus, MD, Martin C Müller, MD
Journal: Blood
Blood (2012) 120 (21): 2495.
https://doi.org/10.1182/blood.V120.21.2495.2495
Published: 2012
Journal Articles

Nilotinib in Imatinib-Resistant or -Intolerant Patients (pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): 48-Month Follow-up Results of a Phase 2 Study,

Philipp D. le Coutre, MD, Francis J. Giles, MB, MD, FRCPI, FRCPath, Javier Pinilla-Ibarz, MD, PhD, Richard A. Larson, MD, Norbert Gattermann, MD, Oliver G. Ottmann, MD, PhD, Andreas Hochhaus, MD, Jerald P. Radich, MD, Giuseppe Saglio, MD, Timothy P. Hughes, MD, MBBS, Giovanni Martinelli, MD, Dong-Wook Kim, MD, PhD, Susan Branford, PhD, Martin C. Müller, MD, Yaping Shou, MD, PhD, Steven Novick, MD, PhD, Xiaolin Fan, PhD, Jorge E. Cortes, Michele Baccarani, MD, Hagop M. Kantarjian
Journal: Blood
Blood (2011) 118 (21): 3770.
https://doi.org/10.1182/blood.V118.21.3770.3770
Published: 2011
Journal Articles

Distinct Characteristics of e13a2 versus e14a2 BCR-ABL Chronic Myeloid Leukemia under Upfront Treatment with Imatinib – an Analysis of the German CML Study IV,

Benjamin Hanfstein, MD, Philipp Erben, MD, Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Sven Haag, Susanne Schnittger, PhD, Claudia Haferlach, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Jörg E. A. Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, for The German CML Study Group, for The SAKK
Journal: Blood
Blood (2011) 118 (21): 3773.
https://doi.org/10.1182/blood.V118.21.3773.3773
Published: 2011
Journal Articles

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Annette Schreiber, MD, Florian Nolte, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, MD, Dominik Heim, MD, Dieter K. Hossfeld, MD, PhD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf Karsten Hofmann, MD, PhD, Jörg Hasford, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Rüdiger Hehlmann, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 781.
https://doi.org/10.1182/blood.V118.21.781.781
Published: 2011
Journal Articles

Impact of Additional Cytogenetic Alterations At Diagnosis on Prognosis of CML: Long-Term Observation From 1151 Patients of the Randomized CML Study IV

Alice Fabarius, PhD, Armin Leitner, MD, Andreas Hochhaus, MD, Martin C Müller, MD, Claudia Haferlach, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD, Martine Jotterand, MD, Andreas Reiter, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Juliana Schwaab, MD, Wolf-Karsten Hofmann, Joerg E. A. Schubert, MD, Hermann Einsele, Anthony D. Ho, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Wolfgang Hiddemann, PhD, Gabriela M. Baerlocher, MD, Michael Lauseker, Markus Pfirrmann, PhD, Susanne Saussele, MD, Rüdiger Hehlmann, MD, Joerg Hasford, MD
Journal: Blood
Blood (2011) 118 (21): 782.
https://doi.org/10.1182/blood.V118.21.782.782
Published: 2011
Journal Articles

Molecular and Cytogenetic Response After 3 Months of Imatinib Treatment Is Predictive for the Risk of Disease Progression and Death in Newly Diagnosed Chronic Myeloid Leukemia Patients – a Follow-up Analysis of the German CML Study IV

Benjamin Hanfstein, MD, Martin C. Müller, MD, Philipp Erben, MD, Michael Lauseker, Susanne Saussele, MD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Claudia Haferlach, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Jörg E. A. Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 783.
https://doi.org/10.1182/blood.V118.21.783.783
Published: 2011
Journal Articles

Prediction of Molecular Response of Chronic Phase CML Patients by the EUTOS Score: Results of the Randomized CML-Study IV,

Susanne Saussele, MD, Michael Lauseker, Verena Hoffmann, MA., Ulrike Proetel, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Jörg Hasford, MD, Rüdiger Hehlmann, MD, Martin C Müller, MD, for The SAKK, The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 3762.
https://doi.org/10.1182/blood.V118.21.3762.3762
Published: 2011
Journal Articles

Identification of Recurrent Submicroscopic Deletions of chromosome1q31.3 As Possible Molecular Prognostic Markers in Acute Promyelocytic Leukemia (APL)

Daniel Nowak, MD, Marion Klaumuenzer, Benjamin Hanfstein, MD, Maximilian Mossner, Florian Nolte, MD, Verena Nowak, Julia Oblaender, Anna Hecht, Gero Hütter, MD, Seishi Ogawa, MD, PhD, Alexander Kohlmann, PhD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, Jan Braess, MD, Wolfgang Seifarth, PhD, Alice Fabarius, PhD, Philipp Erben, MD, Susanne Saussele, MD, Martin C. Müller, MD, Thomas Buechner, MD, PhD, Christel Weiss, Dr., Wolf-Karsten Hofmann, Eva Lengfelder, MD
Journal: Blood
Blood (2011) 118 (21): 420.
https://doi.org/10.1182/blood.V118.21.420.420
Published: 2011
Journal Articles

Absolute Quantification of Mutant T315I BCR-ABL Transcripts At 6 Months Identifies Imatinib Resistant CML Patients with a Low Probability to Achieve MMR After 12 Months on Second Line Tyrosine Kinase Therapy

Thoralf Lange, MD, Thomas Ernst, MD, Markus Pfirrmann, PhD, Jacqueline Maier, PhD, Martin C. Müller, MD, Franz Gruber, MD, Dietger Niederwieser, MD, Andreas Hochhaus, MD
Journal: Blood
Blood (2011) 118 (21): 1679.
https://doi.org/10.1182/blood.V118.21.1679.1679
Published: 2011
Journal Articles

Time-Related Interpretation of Molecular Response Levels According to Long Term Overall and Progression-Free Survival of CML Patients on First-Line Imatinib Treatment

Martin C. Müller, MD, Benjamin Hanfstein, MD, Michael Lauseker, Philipp Erben, MD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Susanne Saussele, MD, Andreas Hochhaus, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 1681.
https://doi.org/10.1182/blood.V118.21.1681.1681
Published: 2011
Journal Articles

Patients with Chronic Myeloid Leukemia In Chronic Phase Carrying More Than One BCR-ABL Kinase Domain Mutation Exhibit Poorer Response Rates and Outcomes to Second-Line Dasatinib Compared to Those with No or Only One BCR-ABL Mutation

Alfonso Quintás-Cardama, Hagop Kantarjian, Neil P. Shah, Charles A. Schiffer, Philipp le Coutre, Giuseppe Saglio, Francois Guilhot, Andreas Hochhaus, Martin C. Müller, Erkut Bahceci, Alexandre Lambert, Jorge E. Cortes
Journal: Blood
Blood (2010) 116 (21): 2297.
https://doi.org/10.1182/blood.V116.21.2297.2297
Published: 2010
Journal Articles

Molecular Predictors for the Response to Nilotinib Treatment After Acquired Imatinib Failure In Ph+ Chronic Myeloid Leukemia

Mridul Agrawal, Philipp Erben, MD, Benjamin Hanfstein, MD, Armin Leitner, MD, John Reynolds, Richard C. Woodman, MD, Laura Robin, Wolf-Karsten Hofmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2010) 116 (21): 2283.
https://doi.org/10.1182/blood.V116.21.2283.2283
Published: 2010
Journal Articles

The Presence of the BCR-ABL T315I Mutation In Chronic Phase Chronic Myelogenous Leukemia Resistant to Tyrosine Kinase Inhibitors Profoundly Compromises Overall Survival and Progression Free Survival. Preliminary Results of a Matched Pair Analysis.

Franck E Nicolini, MD, PhD, Stephane Morisset, Stat., Andreas Hochhaus, Giovanni Martinelli, MD, Dong-Wook Kim, MD, PhD, Inge Dufva, MD, Michael Mauro, MD, Jorge E. Cortes, MD, Charles Chuah, MBChB, FRCPE, MD, Jane Apperley, MBChB, FRCP, FRCPath, Francois Guilhot, Giuseppe Saglio, MD, PhD, Martin C. Müller, Simona Soverini, Selim Corm, MD, PhD, Isabelle Tigaud, MD, Madeleine Etienne, CRA, Catherine Roche-Lestienne, PhD, Sandrine Hayette, PhD, Senaka Peter, MPH, Wei Zhou, MD, PhD, Mauricette Michallet, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3410.
https://doi.org/10.1182/blood.V116.21.3410.3410
Published: 2010
Journal Articles

Therapy with Imatinib In Elderly CML Patients (>65years): Results of the German CML-Study IV.

Susanne Saussele, MD, Nadine Pletsch, MD, Michael Lauseker, Armin Leitner, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Martin C. Müller, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, PhD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Stefan W. Krause, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Anthony D. Ho, MD, FRCPC, Christiane Falge, MD, Matthias Hänel, MD, M. Pfreundschuh, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, MD, Karsten Spiekermann, MD, Steffen Koschmieder, MD, Cornelius F. Waller, MD, Martin Bentz, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, Jörg Hasford, MD, Rüdiger Hehlmann, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 3411.
https://doi.org/10.1182/blood.V116.21.3411.3411
Published: 2010
Journal Articles

Superior CMR-Rates with Tolerability-Adapted Imatinib 800 Mg Vs. 400 Mg Vs. 400 Mg + IFN In CML: The Randomized German CML-Study IV

Rüdiger Hehlmann, MD, Susanne Jung-Munkwitz, MD, Michael Lauseker, Martin C. Müller, MD, Armin Leitner, MD, Nadine Pletsch, MD, Ulrike Proetel, MD, Alois Gratwohl, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Christiane Falge, MD, Anthony D. Ho, MD, FRCPC, Matthias Hänel, MD, Michael Pfreundschuh, MD, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, CA, MD, Karsten Spiekermann, MD, Steffen Koschmieder, Cornelius F. Waller, MD, Martin Bentz, MD, Stefan W. Krause, MD, Benjamin Hanfstein, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Andreas Hochhaus, Susanne Saussele, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 357.
https://doi.org/10.1182/blood.V116.21.357.357
Published: 2010