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Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Carla Casu, PhD, Pedro Ramos, PhD, Luca Melchiori, PhD, Ella Guy, Eliezer A. Rachmilewitz, Patricia Giardina, MD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 3187.

https://doi.org/10.1182/blood.V118.21.3187.3187

Published: 2011

Journal Articles

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

Pedro Ramos, Ella Guy, Nan Chen, Catia C. Proenca, Sara Gardenghi, Carla Casu, Antonia Follenzi, Nico Van Rooijen, Robert W. Grady, Maria de Sousa, Stefano Rivella

Blood (2011) 117 (4): 1379–1389.

https://doi.org/10.1182/blood-2010-09-307462

Published: 2011

Includes: Supplemental data

Journal Articles

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Pedro Ramos, Sara Gardenghi, PhD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 2063.

https://doi.org/10.1182/blood.V116.21.2063.2063

Published: 2010

Journal Articles

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Pedro Ramos, PhD, Ella Guy, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 4251.

https://doi.org/10.1182/blood.V116.21.4251.4251

Published: 2010

Journal Articles

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Pedro Ramos, Ella Guy, Nan Chen, Robert W. Grady, PhD, Barry S. Coller, MD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2023.

https://doi.org/10.1182/blood.V114.22.2023.2023

Published: 2009

Journal Articles

Hepcidin: A Clue for a New Role for Lymphocytes.

Jorge P Pinto, PhD, Vera Dias, Heinz Zoller, MD, Pedro N Rodrigues, PhD, Helena Carmo, Pedro Ramos, Félix Carvalho, PhD, Graça Porto, MD, PhD, Maria de Sousa, MD, PhD

Blood (2009) 114 (22): 1999.

https://doi.org/10.1182/blood.V114.22.1999.1999

Published: 2009

Journal Articles

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Nan Chen, Sara Gardenghi, Robert W. Grady, PhD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 4044.

https://doi.org/10.1182/blood.V114.22.4044.4044

Published: 2009

Journal Articles

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Luca Melchiori, Ella Guy, Ilaria Libani, Ph.D, Raffaella Schirò, MD, Ph.D, Pedro Ramos, Laura Breda, Ph.D, Amy Chadburn, MD, Yi-Fang Liu, Maria De Sousa, MD, Eliezer Rachmilewitz, M.D, Patricia J Giardina, MD, Robert W Grady, Ph.D, Stefano Rivella, Ph.D

Blood (2008) 112 (11): 1877.

https://doi.org/10.1182/blood.V112.11.1877.1877

Published: 2008

Journal Articles

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Laura Breda, PhD, Sara Gardenghi, PhD, Robert W Grady, Ph.D, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2008) 112 (11): 3848.

https://doi.org/10.1182/blood.V112.11.3848.3848

Published: 2008

Journal Articles

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia

Blood (2008) 112 (3): 875–885.

https://doi.org/10.1182/blood-2007-12-126938

Published: 2008

Includes: Supplemental data

Journal Articles

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ella Guy, Ilaria Libani, PhD, Luca Melchiori, Thomas Scholzen, PhD, Raffaella Schiro, MD, Pedro Ramos, Margrit Kernbach, Bettina Baron-Luehr, Laura Breda, PhD, Matteo Porotto, PhD, Maria de Sousa, MD, Maria Domenica Cappellini, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Johannes Gerdes, PhD, Stefano Rivella, PhD

Blood (2007) 110 (11): 275.

https://doi.org/10.1182/blood.V110.11.275.275

Published: 2007

Journal Articles

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi, Maria F. Marongiu, Pedro Ramos, Ella Guy, Laura Breda, Amy Chadburn, YiFang Liu, Ninette Amariglio, Gideon Rechavi, Eliezer A. Rachmilewitz, William Breuer, Z. Ioav Cabantchik, Diedra M. Wrighting, Nancy C. Andrews, Maria de Sousa, Patricia J. Giardina, Robert W. Grady, Stefano Rivella

Blood (2007) 109 (11): 5027–5035.

https://doi.org/10.1182/blood-2006-09-048868

Published: 2007

Includes: Supplemental data

Journal Articles

Role of HFE in Hepatic Iron Overload: Novel Findings Demonstrate Direct Effects of Mutant C282Y on Hepcidin and Calreticulin mRNA Expression.

Jorge P. Pinto, PhD, Pedro Ramos, Sergio de Almeida, Susana Oliveira, Laura Breda, PhD, Marek Michalak, PhD, Stefano Rivella, PhD, Maria de Sousa, MD, PhD

Blood (2006) 108 (11): 1549.

https://doi.org/10.1182/blood.V108.11.1549.1549

Published: 2006

Journal Articles

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Sara Gardenghi, PhD, Maria Marongiu, Pedro Ramos, Ella Guy, Laura Breda, PhD, Amy Chadburn, MD, Yifang Liu, Gideon Rechavi, MD, Ninette Amariglio, PhD, E.A. Rachmilewitz, MD, Diedra Wrighting, PhD, Nancy C. Andrews, MD, Maria de Sousa, MD, Patricia Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2006) 108 (11): 1543.

https://doi.org/10.1182/blood.V108.11.1543.1543

Published: 2006

Journal Articles

HFE cross-talks with the MHC class I antigen presentation pathway

Sérgio F. de Almeida, Isabel F. Carvalho, Carla S. Cardoso, João V. Cordeiro, Jorge E. Azevedo, Jacques Neefjes, Maria de Sousa

Blood (2005) 106 (3): 971–977.

https://doi.org/10.1182/blood-2004-12-4640

Published: 2005

Includes: Supplemental data

Journal Articles

HFE mutations in the pathobiology of hemophilic arthropathy

Eugenia Cruz, Graça Porto, Sara Morais, Manuel Campos, Maria de Sousa

Blood (2005) 105 (8): 3381–3382.

https://doi.org/10.1182/blood-2004-11-4342

Published: 2005

Journal Articles

Increased hepatic iron in mice lacking classical MHC class I molecules

Elsa M. Cardoso, Maria G. Macedo, Pierre Rohrlich, Eduarda Ribeiro, Manuel T. Silva, François A. Lemonnier, Maria de Sousa

Blood (2002) 100 (12): 4239–4241.

https://doi.org/10.1182/blood-2002-05-1565

Published: 2002

Journal Articles

Transferrin receptor 2 ( TfR2 ) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation

Andre Mattman, David Huntsman, Gillian Lockitch, Sylvie Langlois, Noel Buskard, Diana Ralston, Yaron Butterfield, Pedro Rodrigues, Steven Jones, Graça Porto, Marco Marra, Maria De Sousa, Greg Vatcher

Blood (2002) 100 (3): 1075–1077.

https://doi.org/10.1182/blood-2002-01-0133

Published: 2002

Journal Articles

Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deficiency, and Iron Loading in β2-Microglobulin Knockout Mice

Manuela Santos, Hans Clevers, Maria de Sousa, J.J.M. Marx

Blood (1998) 91 (8): 3059–3065.

https://doi.org/10.1182/blood.V91.8.3059.3059_3059_3065

Published: 1998

NARROW

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Hepcidin: A Clue for a New Role for Lymphocytes.

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Role of HFE in Hepatic Iron Overload: Novel Findings Demonstrate Direct Effects of Mutant C282Y on Hepcidin and Calreticulin mRNA Expression.

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

HFE cross-talks with the MHC class I antigen presentation pathway

HFE mutations in the pathobiology of hemophilic arthropathy

Increased hepatic iron in mice lacking classical MHC class I molecules

Transferrin receptor 2 ( TfR2 ) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation

Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deficiency, and Iron Loading in β2-Microglobulin Knockout Mice

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American Society of Hematology

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American Society of Hematology

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