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Journal Articles

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Pedro Ramos, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Laura Breda, Ph.D, Bart J Crielaard, PhD, Ritama Gupta, Undergraduate student, Ella Guy, Maria F Mariongiu, PhD, Ross L. Levine, Omar Abdel-Wahab, PhD, Benjamin L. Ebert, Nico van Rooijen, PhD, Saghi Ghaffari, MD, PhD, Robert W Grady, PhD, Patricia Giardina, MD, Stefano Rivella, PhD

Blood (2012) 120 (21): 81.

https://doi.org/10.1182/blood.V120.21.81.81

Published: 2012

Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Carla Casu, PhD, Pedro Ramos, PhD, Luca Melchiori, PhD, Ella Guy, Eliezer A. Rachmilewitz, Patricia Giardina, MD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 3187.

https://doi.org/10.1182/blood.V118.21.3187.3187

Published: 2011

Journal Articles

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Carla Casu, PhD, Pedro Ramos, PhD, Ella Guy, Nico van Rooijen, PhD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 1035.

https://doi.org/10.1182/blood.V118.21.1035.1035

Published: 2011

Journal Articles

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

Pedro Ramos, Ella Guy, Nan Chen, Catia C. Proenca, Sara Gardenghi, Carla Casu, Antonia Follenzi, Nico Van Rooijen, Robert W. Grady, Maria de Sousa, Stefano Rivella

Blood (2011) 117 (4): 1379–1389.

https://doi.org/10.1182/blood-2010-09-307462

Published: 2011

Includes: Supplemental data

Journal Articles

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Pedro Ramos, PhD, Ella Guy, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 4251.

https://doi.org/10.1182/blood.V116.21.4251.4251

Published: 2010

Journal Articles

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Pedro Ramos, Ella Guy, Nan Chen, Robert W. Grady, PhD, Barry S. Coller, MD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2023.

https://doi.org/10.1182/blood.V114.22.2023.2023

Published: 2009

Journal Articles

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Nan Chen, Sara Gardenghi, Robert W. Grady, PhD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 4044.

https://doi.org/10.1182/blood.V114.22.4044.4044

Published: 2009

Journal Articles

The Effect of Dietary Iron on Tissue Iron Levels in Intact and Splenectomized Mice Affected by β-Thalassemia.

Maria Franca Marongiu, Kristen Muirhead, Sara Gardenghi, Ella Guy, Stefano Rivella, Robert W Grady

Blood (2008) 112 (11): 1876.

https://doi.org/10.1182/blood.V112.11.1876.1876

Published: 2008

Journal Articles

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Luca Melchiori, Ella Guy, Ilaria Libani, Ph.D, Raffaella Schirò, MD, Ph.D, Pedro Ramos, Laura Breda, Ph.D, Amy Chadburn, MD, Yi-Fang Liu, Maria De Sousa, MD, Eliezer Rachmilewitz, M.D, Patricia J Giardina, MD, Robert W Grady, Ph.D, Stefano Rivella, Ph.D

Blood (2008) 112 (11): 1877.

https://doi.org/10.1182/blood.V112.11.1877.1877

Published: 2008

Journal Articles

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Laura Breda, PhD, Sara Gardenghi, PhD, Robert W Grady, Ph.D, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2008) 112 (11): 3848.

https://doi.org/10.1182/blood.V112.11.3848.3848

Published: 2008

Journal Articles

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ella Guy, Ilaria Libani, PhD, Luca Melchiori, Thomas Scholzen, PhD, Raffaella Schiro, MD, Pedro Ramos, Margrit Kernbach, Bettina Baron-Luehr, Laura Breda, PhD, Matteo Porotto, PhD, Maria de Sousa, MD, Maria Domenica Cappellini, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Johannes Gerdes, PhD, Stefano Rivella, PhD

Blood (2007) 110 (11): 275.

https://doi.org/10.1182/blood.V110.11.275.275

Published: 2007

Journal Articles

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi, Maria F. Marongiu, Pedro Ramos, Ella Guy, Laura Breda, Amy Chadburn, YiFang Liu, Ninette Amariglio, Gideon Rechavi, Eliezer A. Rachmilewitz, William Breuer, Z. Ioav Cabantchik, Diedra M. Wrighting, Nancy C. Andrews, Maria de Sousa, Patricia J. Giardina, Robert W. Grady, Stefano Rivella

Blood (2007) 109 (11): 5027–5035.

https://doi.org/10.1182/blood-2006-09-048868

Published: 2007

Includes: Supplemental data

Journal Articles

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Enhanced Survival Mechanisms That Reduce P21-Mediated Cell Death.

Ilaria Libani, Raffaella Schiro, Thomas Scholzen, Pedro Ramos, Ella Guy, Margrit Kernbach, Bettina Baron-Luehr, Laura Breda, Matteo Porotto, Maria Domenica Cappellini, Patricia Giardina, Johannes Gerdes, Stefano Rivella

Blood (2006) 108 (11): 649.

https://doi.org/10.1182/blood.V108.11.649.649

Published: 2006

Journal Articles

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Sara Gardenghi, PhD, Maria Marongiu, Pedro Ramos, Ella Guy, Laura Breda, PhD, Amy Chadburn, MD, Yifang Liu, Gideon Rechavi, MD, Ninette Amariglio, PhD, E.A. Rachmilewitz, MD, Diedra Wrighting, PhD, Nancy C. Andrews, MD, Maria de Sousa, MD, Patricia Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2006) 108 (11): 1543.

https://doi.org/10.1182/blood.V108.11.1543.1543

Published: 2006

Journal Articles

Oxidative Stress of RBC in a Murine Model of Beta-Thalassemia Can Be Reversed by Treatment with Antioxidants.

Eitan Fibach, PhD, Johnny Amer, M.Sc., Eliezer Rachmilewitz, M.D, Ella Guy, M.Sc., Stefano Rivella, Ph.D

Blood (2005) 106 (11): 3643.

https://doi.org/10.1182/blood.V106.11.3643.3643

Published: 2005

Journal Articles

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

Laura Breda, PhD, Sara Gardenghi, PhD, Ella Guy, Ninette Amariglio, PhD, Konstantin Adamsky, PhD, Orly Weizer-Stern, PhD, Eliezer Rachmilewitz, MD, Gideon Rechavi, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2005) 106 (11): 3846.

https://doi.org/10.1182/blood.V106.11.3846.3846

Published: 2005

NARROW

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Enhanced erythropoiesis in Hfe -KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

The Effect of Dietary Iron on Tissue Iron Levels in Intact and Splenectomized Mice Affected by β-Thalassemia.

Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.

Absence of the Hemochromatosis Gene HFE Confers Protection Under Conditions of Stress Erythropoiesis.

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Enhanced Survival Mechanisms That Reduce P21-Mediated Cell Death.

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Oxidative Stress of RBC in a Murine Model of Beta-Thalassemia Can Be Reversed by Treatment with Antioxidants.

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

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American Society of Hematology

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American Society of Hematology

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