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Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Blood (2019) 134 (Supplement_1): 4142.

https://doi.org/10.1182/blood-2019-126500

Published: 2019

Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Blood (2019) 134 (Supplement_1): 4204.

https://doi.org/10.1182/blood-2019-126538

Published: 2019

Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

Blood (2018) 132 (Supplement 1): 1726.

https://doi.org/10.1182/blood-2018-99-112908

Published: 2018

Journal Articles

MDM2 and Aurora Kinase a Contribute to SETD2 Loss of Function in Advanced Systemic Mastocytosis: Implications for Pathogenesis and Treatment

Blood (2018) 132 (Supplement 1): 1779.

https://doi.org/10.1182/blood-2018-99-113278

Published: 2018

Journal Articles

SETD2 Non-Genomic Loss of Function and p53 Functional Inactivation in Advanced Systemic Mastocytosis (SM): Pathogenetic and Therapeutic Implications

Blood (2017) 130 (Supplement 1): 2944.

https://doi.org/10.1182/blood.V130.Suppl_1.2944.2944

Published: 2017

Journal Articles

Polo-like Kinase-1 and Aurora Kinase A As Novel Therapeutic Targets in Neoplastic Mast Cells

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Roberta Zanotti, MD, Livio Pagano, MD, Michele Cavo, MD, Peter Valent, MD, Giovanni Martinelli, MD, Simona Soverini, PhD

Blood (2017) 130 (Supplement 1): 5290.

https://doi.org/10.1182/blood.V130.Suppl_1.5290.5290

Published: 2017

Journal Articles

Targeting WEE1 Kinase after G2/M Checkpoint Arrest Induces Apoptosis in Chronic Myeloid Leukemia Progenitors

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Fausto Castagnetti, MD PhD, Luana Bavaro, Margherita Martelli, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Elena Tenti, PhD, Maria Alessandr Santucci, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD

Blood (2017) 130 (Supplement 1): 1588.

https://doi.org/10.1182/blood.V130.Suppl_1.1588.1588

Published: 2017

Journal Articles

SETD2 Loss of Function Is a Recurrent Event in Advanced-Phase Chronic Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 43.

https://doi.org/10.1182/blood.V130.Suppl_1.43.43

Published: 2017

Journal Articles

Genome-Wide Molecular Portrait of Aggressive Systemic Mastocytosis and Mast Cell Leukemia Depicted By Whole Exome Sequencing and Copy Number Variation Analysis

Blood (2015) 126 (23): 4085.

https://doi.org/10.1182/blood.V126.23.4085.4085

Published: 2015

Journal Articles

Aurora Kinase a: A New Component of Imatinib Resistance in Chronic Myeloid Leukemia

Manuela Mancini, PhD, Simona Soverini, Elisa Leo, PhD, Fausto Castagnetti, PhD, Caterina De Benedittis, PhD, Gabriele Gugliotta, PhD, Gianantonio Rosti, MD, Maria Alessandra Santucci, MD, Michele Cavo, Giovanni Martinelli, MD PhD

Blood (2015) 126 (23): 1573.

https://doi.org/10.1182/blood.V126.23.1573.1573

Published: 2015

Journal Articles

BCR-ABL Mutations in Chronic Myeloid Leukemia (CML) Patients (pts) with Failure and Warning to First- and Second-Line Tyrosine Kinase Inhibitor (TKI) Therapy: What Is the Advantage of Next-Generation Sequencing (NGS) over Conventional Sequencing?

Blood (2015) 126 (23): 346.

https://doi.org/10.1182/blood.V126.23.346.346

Published: 2015

Journal Articles

Clinical Relevance of Low Burden BCR-ABL1 Mutations Detectable By Amplicon Deep Sequencing (DS) in Philadelphia-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients (pts): The Type of Mutation Matters

Simona Soverini, PhD, Caterina De Benedittis, PhD, Claudia Venturi, PhD, Cristina Papayannidis, MD PhD, Manuela Mancini, PhD, Katerina Machova Polakova, Domenico Russo, MD PhD, Paola Bresciani, MD, Alessandra Iurlo, MD PhD, Elisabetta Abruzzese, MD, Federica Sorà, MD PhD, Michele Baccarani, Michele Cavo, MD, Torsten Haferlach, Giovanni Martinelli, MD PhD

Blood (2015) 126 (23): 2489.

https://doi.org/10.1182/blood.V126.23.2489.2489

Published: 2015

Journal Articles

FOXM1 Transcription Factor Is a Component of Beta Catenin Signaling in Hematopoietic Progenitors of Chronic Myeloid Leukemia

Elisa Leo, PhD, Giorgia Simonetti, PhD, Manuela Mancini, PhD, Nevena Veljkovic, PhD, Virginia Campi, Fausto Castagnetti, MD, Gabriele Gugliotta, MD, Caterina De Benedittis, Maria Alessandra Santucci, MD, Giovanni Martinelli, MD

Blood (2014) 124 (21): 3125.

https://doi.org/10.1182/blood.V124.21.3125.3125

Published: 2014

Journal Articles

Inactivation of the SETD2 Tumor Suppressor Gene in Mast Cell Leukemia

Blood (2014) 124 (21): 1881.

https://doi.org/10.1182/blood.V124.21.1881.1881

Published: 2014

Journal Articles

SIRT Regulates the Molecular Interaction Between c-MYC and HIF-1α in Multiple Myeloma

Enrica Borsi, Giulia Perrone, MD, Carolina Terragna, PhD, Marina Martello, Manuela Mancini, PhD, Elisa Leo, PhD, Elena Zamagni, MD, Paola Tacchetti, MD, Annamaria Brioli, MD, Lucia Pantani, MD, Beatrice Anna Zannetti, MD, Giovanni Martinelli, MD, Michele Cavo, MD

Blood (2012) 120 (21): 574.

https://doi.org/10.1182/blood.V120.21.574.574

Published: 2012

Journal Articles

C22 orf2 Gene (22q13.1) Translocation Downstream of Bcr Breakpoint (22q11) to the Derivative 9 Chromosome Is Associated with Reduced Expression of Its Protein, the Beta-Catenin Antagonist Chibby, in Chronic Myeloid Leukemia Progenitors

Michela Aluigi, PhD, Manuela Mancini, PhD, Elisa Leo, PhD, Fausto Castagnetti, Carmen Baldazzi, Enza Barbieri, MD, Maria Alessandra Santucci, MD

Blood (2011) 118 (21): 1676.

https://doi.org/10.1182/blood.V118.21.1676.1676

Published: 2011

Journal Articles

HIF 1 Alpha: A Suitable Target for Multiple Myeloma

Giulia Perrone, MD, Enrica Borsi, PhD, Carolina Terragna, PhD, Sandra Durante, Marina Martello, Michela Aluigi, PhD, Manuela Mancini, PhD, Elena Zamagni, MD, Paola Tacchetti, MD, Annamaria Brioli, MD, Lucia Pantani, MD, Beatrice Anna Zannetti, MD, Giovanni Martinelli, MD, Maria Alessandra Santucci, MD, Michele Baccarani, MD, Michele Cavo, MD

Blood (2011) 118 (21): 2901.

https://doi.org/10.1182/blood.V118.21.2901.2901

Published: 2011

Journal Articles

Apoptotic Death of Bcr-Abl-Expressing Myeloid Progenitors in Response to the m-Tor Inhibitor RAD001 (Everolimus) Is Promoted by the Nuclear Import of c-Abl.

Manuela Mancini, PhD, Elisa Zuffa, PhD, Patrizia Corrado, BS, Gianluca Brusa, PhD, Sara Petta, BS, Eleonora Pagnotta, PhD, Maria Alessandra Santucci, MD

Blood (2006) 108 (11): 2133.

https://doi.org/10.1182/blood.V108.11.2133.2133

Published: 2006

Journal Articles

P210 Tyrosine Kinase Regulates the Expression of 14-3-3sigma in Hematopoietic Progenitors Expressing the bcr-abl Fusion Gene.

Maria Alessandra Santucci, MD, Manuela Mancini, PhD, Elisa Zuffa, BS, Gianluca Brusa, PhD, Enza Barbieri, MD

Blood (2005) 106 (11): 4847.

https://doi.org/10.1182/blood.V106.11.4847.4847

Published: 2005

NARROW

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

MDM2 and Aurora Kinase a Contribute to SETD2 Loss of Function in Advanced Systemic Mastocytosis: Implications for Pathogenesis and Treatment

SETD2 Non-Genomic Loss of Function and p53 Functional Inactivation in Advanced Systemic Mastocytosis (SM): Pathogenetic and Therapeutic Implications

Polo-like Kinase-1 and Aurora Kinase A As Novel Therapeutic Targets in Neoplastic Mast Cells

Targeting WEE1 Kinase after G2/M Checkpoint Arrest Induces Apoptosis in Chronic Myeloid Leukemia Progenitors

SETD2 Loss of Function Is a Recurrent Event in Advanced-Phase Chronic Myeloid Leukemia

Genome-Wide Molecular Portrait of Aggressive Systemic Mastocytosis and Mast Cell Leukemia Depicted By Whole Exome Sequencing and Copy Number Variation Analysis

Aurora Kinase a: A New Component of Imatinib Resistance in Chronic Myeloid Leukemia

BCR-ABL Mutations in Chronic Myeloid Leukemia (CML) Patients (pts) with Failure and Warning to First- and Second-Line Tyrosine Kinase Inhibitor (TKI) Therapy: What Is the Advantage of Next-Generation Sequencing (NGS) over Conventional Sequencing?

Clinical Relevance of Low Burden BCR-ABL1 Mutations Detectable By Amplicon Deep Sequencing (DS) in Philadelphia-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients (pts): The Type of Mutation Matters

FOXM1 Transcription Factor Is a Component of Beta Catenin Signaling in Hematopoietic Progenitors of Chronic Myeloid Leukemia

Inactivation of the SETD2 Tumor Suppressor Gene in Mast Cell Leukemia

SIRT Regulates the Molecular Interaction Between c-MYC and HIF-1α in Multiple Myeloma

C22 orf2 Gene (22q13.1) Translocation Downstream of Bcr Breakpoint (22q11) to the Derivative 9 Chromosome Is Associated with Reduced Expression of Its Protein, the Beta-Catenin Antagonist Chibby, in Chronic Myeloid Leukemia Progenitors

HIF 1 Alpha: A Suitable Target for Multiple Myeloma

Apoptotic Death of Bcr-Abl-Expressing Myeloid Progenitors in Response to the m-Tor Inhibitor RAD001 (Everolimus) Is Promoted by the Nuclear Import of c-Abl.

P210 Tyrosine Kinase Regulates the Expression of 14-3-3sigma in Hematopoietic Progenitors Expressing the bcr-abl Fusion Gene.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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