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Journal Articles

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Vira Chumak, Andrzej Ciechanowicz, Mateusz Adamiak, Arjun Thapa, Ahmed Abdelbaset-Ismail, Kamila Bujko, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 1987–1988.

https://doi.org/10.1182/blood-2022-158573

Published: 2022

Journal Articles

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Kamila Bujko, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 7567.

https://doi.org/10.1182/blood-2022-158594

Published: 2022

Journal Articles

Novel Evidence That Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) By Inhibiting Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) - Implications to Understand Better Diurnal Trafficking of HSPCs and Anti-Inflammatory Effects of Melatonin

Ahmed Abdelbaset-Ismail, Arjun Thapa, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 2842–2843.

https://doi.org/10.1182/blood-2022-158581

Published: 2022

Journal Articles

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Kamila Bujko, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak

Blood (2022) 140 (Supplement 1): 11397.

https://doi.org/10.1182/blood-2022-159672

Published: 2022

Journal Articles

Novel Observation That Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) Involves Activation of Nlrp3 Inflammasome That Provides Cholesterol and Sphingolipids for the Formation of Lipid Rafts on the Outer Cell Membrane That Are Crucial for Proper Responsiveness of HSPCs to Chemoattractant and Hematopoietic Cytokines/Growth Factors

Andrzej Ciechanowicz, Ahmed Abdelbaset-Ismail, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 4470–4471.

https://doi.org/10.1182/blood-2022-158560

Published: 2022

Journal Articles

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

Mateusz Adamiak, Andrzej Ciechanowicz, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 1683.

https://doi.org/10.1182/blood-2021-148818

Published: 2021

Journal Articles

Novel Evidence That By Employing a Two-Step Differentiation Protocol in the Presence of UM171 and Nicotinamide Acid Human Very Small Embryonic like Stem Cells (VSELs) Differentiate into Functional Endothelial Cells (ECs)

Alison Domingues, Elisa Rossi, Kamila Bujko, Grégoire Detriche, Janina Ratajczak, Ulysse Richez, Adeline Blandinieres, Magda Kucia, David M Smadja, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 2070.

https://doi.org/10.1182/blood-2021-149822

Published: 2021

Journal Articles

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 3809.

https://doi.org/10.1182/blood-2021-148733

Published: 2021

Journal Articles

Novel View on Stem Cell Compartment and Aging - a Number of Pluripotent Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells in Murine Bone Marrow Is High in Several Long-Living and Reduced in Short-Living Murine Strains and Unexpectedly Inversely Correlates in These Animals with Plasma Growth Hormone/Insulin-Like Growth Factor-1 Level

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Rui Liu, MB, BS, Dong-Myung Shin, PhD, Michal Masternak, PhD, Andrzej Bartke, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2011) 118 (21): LBA-5–LAB-5.

https://doi.org/10.1182/blood.V118.21.LBA-5.LBA-5

Published: 2011

Journal Articles

Novel View on Unwanted Side Effects of Radio-Chemotherapy on Bone Marrow (BM) Microenvironment - Radio-Chemotherapy Upregulates BM-Level of Bioactive Lipids, Sphingosine-1- Phosphate (S1P) and Ceramide-1-Phosphate (C1P), That Chemoattract Metastasizing Cancer Cells

Gabriela Schneider, Ph.D., Bryndza Ewa, MS, Chihwa Kim, Ph.D, Janina Ratajczak, MD, PhD, Magda Kucia, Ph.D., Mariusz Z Ratajczak

Blood (2011) 118 (21): 726.

https://doi.org/10.1182/blood.V118.21.726.726

Published: 2011

Journal Articles

A Novel Perspective on Stem Cell Homing – Emerging Interplay Between Bioactive Lipids As Potent Chemoattractants and Cationic Peptides As Underappreciated Modulators of Responsiveness to SDF-1 Gradients

Chihwa Kim, Ph.D, Wu Wan, MS, Nicholas J. Greco, PhD, Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Mary J. Laughlin, MD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 2957.

https://doi.org/10.1182/blood.V118.21.2957.2957

Published: 2011

Journal Articles

Single Cell Level Genome-Wide Gene Expression Analysis of Bone Marrow-Derived Oct-4 + very Small Embryonic-Like Stem Cells (VSELs) Revealed That a Polycomb Group Protein Ezh2 Regulates VSELs Pluripotency by Maintaining Bivalent Domains At Promoters of Important Homeodomain-Containing Developmental Transcription Factors

Magda Kucia, Ph.D., Rui Liu, Ph.D., Kasia Mierzejewska, MS, Wan Wu, Ph.D., Janina Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Mariusz Z Ratajczak

Blood (2011) 118 (21): 2345.

https://doi.org/10.1182/blood.V118.21.2345.2345

Published: 2011

Journal Articles

New Evidence That the Bioactive Lipid Ceramide-1-Phosphate (C1P) Is a Potent Chemoattractant for Mesenchymal Stromal Cells (MSC), Endothelial Progenitor Cells (EPCs) and Very Small Embryonic-Like Stem Cells (VSELs), Demonstrating Its Potential Involvement in Tissue/Organ Repair and Angiogenesis

ChiHwa Kim, Ph.D., Rui Liu, MB, BS, Magda Kucia, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.

Blood (2011) 118 (21): 2387.

https://doi.org/10.1182/blood.V118.21.2387.2387

Published: 2011

Journal Articles

Long-Term In Vivo Studies in Mice Unexpectedly Reveal That Prolonged Growth Hormone (GH) and Insulin/Insulin-Like Growth Factor-1 (IGF-1) Signaling Have a Negative Effect on Normal Bone Marrow Hematopoiesis – Implications for GH-Based “rejuvenation” Therapies,

Janina Ratajczak, MD, PhD, Rui Liu, Ph.D., Magda Kucia, Ph.D., Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 3422.

https://doi.org/10.1182/blood.V118.21.3422.3422

Published: 2011

Journal Articles

A Novel Perspective on Stem Cells, Tissue Senescence and Aging: Pluripotent Very Small Embryonic-Like Stem Cells (VSELs) and Hematopoietic Stem Cells (HSCs) Are Prematurely Depleted in Adult Bone Marrow (BM) in Response to Prolonged Growth Hormone/Insulin-Like Growth Factor-1 Signaling (IIS) and Chronic Increase in Caloric Uptake

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Rui Liu, Ph.D., Michal Masternak, Ph.D., Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.

Blood (2011) 118 (21): 4818.

https://doi.org/10.1182/blood.V118.21.4818.4818

Published: 2011

Journal Articles

An In Vivo Evidence That the CD45 negative Adult Marrow-Derived CXCR4 + SSEA-1 + OCT-4 + Very Small Embryonic-Like (VSEL) Stem Cells May Differentiate into CD45 positive Long Term Repopulating Hematopoietic Stem Cells.

Marcin Wysoczynski, Magda Kucia, PhD, Ewa K. Zuba-Surma, PhD, Wu Wan, Mariusz Z. Ratajczak, MD, PhD, Janina Ratajczak, MD, PhD

Blood (2007) 110 (11): 505.

https://doi.org/10.1182/blood.V110.11.505.505

Published: 2007

Journal Articles

Novel Direct Evidence That Adult Bone Marrow-Derived Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood - Leukopheresis as a Potential Tool To Isolate Pluripotent Stem Cells for Therapeutic Pruposes.

Magda Kucia, PhD, Marcin Wysoczynski, Wu Wan, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 1205.

https://doi.org/10.1182/blood.V110.11.1205.1205

Published: 2007

Journal Articles

An In Vivo Evidence That Murine Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood after Acute Myocardial Infarction (AMI) and Contribute to Myocardiac Regeneration.

Ewa K. Zuba-Surma, PhD, Magda Kucia, PhD, Yiru Guo, MD, Buddhadeb Dawn, MD, Roberto Bolli, MD, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 3694.

https://doi.org/10.1182/blood.V110.11.3694.3694

Published: 2007

Journal Articles

Pluripotent SSEA-1 + OCT-4 + CXCR4 + Sca-1 + lin − CD45 − Very Small Embryonic Like (VSEL) Stem Cells Reside in Multiple Murine Organs - Are VSEL Epiblast-Derived Functional Pluripotent Precursors for Tissue Committed Stem Cells or Merely Quesiscent Remants from Embryonic Development?.

Magda Kucia, PhD, Ewa K. Zuba, PhD, Wu Wan, Boguslaw Machalinski, MD, PhD, Wojtek Wojakowski, MD, PhD, Mariusz Ratajczak, MD, PhD

Blood (2007) 110 (11): 3698.

https://doi.org/10.1182/blood.V110.11.3698.3698

Published: 2007

Journal Articles

Clincial Evidence That Very Small Embryonic Like (VSEL) Stem Cells Are Mobilizaed into Peripheral Blood in Patents after Stroke.

Magda Kucia, PhD, Edyta Paczkowska, MD, PhD, Dorota Koziarska, MD, Maciej Halasa, MD, PhD, Krzysztof Safranow, MD, PhD, Anna Karbicka, MD, Marta Nowik, MD, Przemyslaw Nowacki, MD, PhD, Mariusz Z. Ratajczak, MD, PhD, Boguslaw Machalinski, MD, PhD

Blood (2007) 110 (11): 3705.

https://doi.org/10.1182/blood.V110.11.3705.3705

Published: 2007

NARROW

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Novel Evidence That Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) By Inhibiting Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) - Implications to Understand Better Diurnal Trafficking of HSPCs and Anti-Inflammatory Effects of Melatonin

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

Novel Evidence That By Employing a Two-Step Differentiation Protocol in the Presence of UM171 and Nicotinamide Acid Human Very Small Embryonic like Stem Cells (VSELs) Differentiate into Functional Endothelial Cells (ECs)

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Novel View on Unwanted Side Effects of Radio-Chemotherapy on Bone Marrow (BM) Microenvironment - Radio-Chemotherapy Upregulates BM-Level of Bioactive Lipids, Sphingosine-1- Phosphate (S1P) and Ceramide-1-Phosphate (C1P), That Chemoattract Metastasizing Cancer Cells

A Novel Perspective on Stem Cell Homing – Emerging Interplay Between Bioactive Lipids As Potent Chemoattractants and Cationic Peptides As Underappreciated Modulators of Responsiveness to SDF-1 Gradients

New Evidence That the Bioactive Lipid Ceramide-1-Phosphate (C1P) Is a Potent Chemoattractant for Mesenchymal Stromal Cells (MSC), Endothelial Progenitor Cells (EPCs) and Very Small Embryonic-Like Stem Cells (VSELs), Demonstrating Its Potential Involvement in Tissue/Organ Repair and Angiogenesis

Long-Term In Vivo Studies in Mice Unexpectedly Reveal That Prolonged Growth Hormone (GH) and Insulin/Insulin-Like Growth Factor-1 (IGF-1) Signaling Have a Negative Effect on Normal Bone Marrow Hematopoiesis – Implications for GH-Based “rejuvenation” Therapies,

An In Vivo Evidence That the CD45 negative Adult Marrow-Derived CXCR4 + SSEA-1 + OCT-4 + Very Small Embryonic-Like (VSEL) Stem Cells May Differentiate into CD45 positive Long Term Repopulating Hematopoietic Stem Cells.

Novel Direct Evidence That Adult Bone Marrow-Derived Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood - Leukopheresis as a Potential Tool To Isolate Pluripotent Stem Cells for Therapeutic Pruposes.

An In Vivo Evidence That Murine Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood after Acute Myocardial Infarction (AMI) and Contribute to Myocardiac Regeneration.

Pluripotent SSEA-1 + OCT-4 + CXCR4 + Sca-1 + lin − CD45 − Very Small Embryonic Like (VSEL) Stem Cells Reside in Multiple Murine Organs - Are VSEL Epiblast-Derived Functional Pluripotent Precursors for Tissue Committed Stem Cells or Merely Quesiscent Remants from Embryonic Development?.

Clincial Evidence That Very Small Embryonic Like (VSEL) Stem Cells Are Mobilizaed into Peripheral Blood in Patents after Stroke.

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American Society of Hematology

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American Society of Hematology

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