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Journal Articles

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Mateusz Adamiak, MS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Ahmed Abdel-Latif, MD PhD, Joseph B Moore, IV, MS, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3372.

https://doi.org/10.1182/blood.V128.22.3372.3372

Published: 2016

Journal Articles

Heme Oxygenase 1 (HO-1) Is a Novel Negative Regulator of Normal and Malignant Hematopoietic Cell Trafficking

Mateusz Adamiak, MS, Ahmed Abdelbaset-Ismail, PhD, Joseph B Moore, IV, MS, Ahmed Abdel-Latif, MD PhD, Marcin Wysoczynski, PhD, Magdalena Kucia, PhD, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 2150.

https://doi.org/10.1182/blood.V128.22.2150.2150

Published: 2016

Journal Articles

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

Mateusz Adamiak, MS, Joseph B Moore IV, PhD, John Zhao, BS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2015) 126 (23): 4272.

https://doi.org/10.1182/blood.V126.23.4272.4272

Published: 2015

Journal Articles

Further Evidence That HO-1 Regulates SDF-1 Expression in the Bone Marrow Microenvironment and That HO-1-Deficient Mice Show a Defect in the SDF-1–CXCR4 Retention Axis of Hematopoietic Stem/Progenitor Cells in Bone Marrow and Thus Are Easy Mobilizers - Studies in HO-1 Mutant Mice, Irradiation Chimeras, and the Effect of in Vivo Pharmacological Inhibition of HO-1

Marcin Wysoczynski, PhD, Janina Ratajczak, MD, PhD, Gregg Rokosh, Ph.D., Roberto Bolli, MD, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2012) 120 (21): 344.

https://doi.org/10.1182/blood.V120.21.344.344

Published: 2012

Journal Articles

A Novel Observation That Heme Oxygenase-1 (HO-1) Deficient Mice Are Easy Mobilizers and That HO-1 Plays An Important Role in Maintaining Expression of SDF-1 in Bone Marrow (BM) Stroma and Promotes Retention of Hematopoietic Stem/Progenitor Cells (HSPCs) in the Bone Marrow Microenvironment

Marcin Wysoczynski, PhD, Janina Ratajczak, MD, PhD, Gregg Rokosh, Ph.D., Roberto Bolli, MD, PhD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 315.

https://doi.org/10.1182/blood.V118.21.315.315

Published: 2011

Journal Articles

Evidence That a Bioactive Lipid, Ceramide-1 Phosphate (C1P), Is Upregulated In Bone Marrow Microenvironment After Myeloablative Therapy and Is a Potential Novel Homing Factor for Hematopoietic Stem Cells

Chihwa Kim, Ph.D, Wu Wan, MS, Ahmed Abdel-Latif, MD, Marcin Wysoczynski, PhD, Magdalena Kucia, PhD, Janina Ratajczak, MD, PhD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2010) 116 (21): 401.

https://doi.org/10.1182/blood.V116.21.401.401

Published: 2010

Journal Articles

Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).

HakMo Lee, PhD, Wan Wu, Marcin Wysoczynski, Magdalena Kucia, Ph.D., Mary J. Laughlin, MD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 371.

https://doi.org/10.1182/blood.V114.22.371.371

Published: 2009

Journal Articles

Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.

Marcin Wysoczynski, PhD, HakMo Lee, PhD, Rui Liu, M.D., Wan Wu, Janina Ratajczak,, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 367.

https://doi.org/10.1182/blood.V114.22.367.367

Published: 2009

Journal Articles

Novel Pleiotropic Effects of Thrombin in Regulation of Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells – Identification of Negative PAR1 and PAR3 Receptor Crosstalk.

Marcin Wysoczynski, PhD, Rui Liu, M.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 336.

https://doi.org/10.1182/blood.V114.22.336.336

Published: 2009

Journal Articles

In Vitro and In Vivo Evidence That Umbilical Cord Blood (UCB)-Derived CD45-/SSEA-4+/OCT-4+/CD133+/CXCR4+/Lin- Very Small Embryonic/Epiblast Like Stem Cells (VSELs) Do Not Contain Clonogenic Hematopoietic Progenitors but Are Highly Enriched in More Primitive Stem Cells - Novel View On Hierarchy of UCB Stem Cell Compartment.

Ewa K. Zuba-Surma, PhD, Izabela Klich, Ph.D., Marcin Wysoczynski, PhD, Nicholas J Greco, PhD, Mary J. Laughlin, MD, Mariusz Z Ratajczak, MD, PhD, Janina Ratajczak, M.D., Ph.D.

Blood (2009) 114 (22): 35.

https://doi.org/10.1182/blood.V114.22.35.35

Published: 2009

Journal Articles

Novel Mechanistic Insight Into Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs): Complement Cascade and Membrane Attack Complex Activated in Bone Marrow Sinusoids During Mobilization Release From Erythrocytes Sphingosine-1 Phosphate – An Underappreciated Chemoattractant Executing Egress of HSPCs.

HakMo Lee, PhD, Marcin Wysoczynski, PhD, Wan Wu, Rui Liu, M.D., Magdalena Kucia, Ph.D., Anna Janowska-Wieczorek, MD, PhD, Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 31.

https://doi.org/10.1182/blood.V114.22.31.31

Published: 2009

Journal Articles

Novel Observation That Mice Lacking the Fifth Complement Cascade Protein Component (C5) Are Very Poor Stem Cell Mobilizers Explained by Defective Egress of Granulocytes: A Novel Role for Bone Marrow Granulocytes to Act as “ice Breaker” Cells in Facilitating Egress of Hematopoietic Stem/Progenitor Cells

Wan Wu, MS, Hakmoo Lee, Ph.D., Marcin Wysoczynski, MS, Magdalena Kucia, Ph.D., Janina Ratajczak, M.D., Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.

Blood (2008) 112 (11): 67.

https://doi.org/10.1182/blood.V112.11.67.67

Published: 2008

Journal Articles

Novel Pleiotropic Effects of Thrombin in Regulation of the Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells.

Marcin Wysoczynski, MS, Mariusz Z Ratajczak, M.D., Ph.D.

Blood (2008) 112 (11): 2270.

https://doi.org/10.1182/blood.V112.11.2270.2270

Published: 2008

Journal Articles

An In Vitro and In Vivo Evidence That Interleukin-8 Is a Pivotal Hypoxia-Regulated Pro-Angiopoietic Factor Secreted by Human Rhabdomyosarcomas (RMS) - Therapeutic Implications.

Marcin Wysoczynski, Wu Wan, Magda Kucia, PhD, Janina Ratajczak, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 3720.

https://doi.org/10.1182/blood.V110.11.3720.3720

Published: 2007

Journal Articles

Complement Cascade (CC) Cleavage Fragments - C3a and C5a Anaphylatoxins - As New Unexpected Hypoxia-Related Stimulators of Erythropoiesis.

Janina Ratajczak, MD, PhD, Marcin Wysoczynski, Bogdan Machalinski, MD, PhD, Anna Janowska-Wieczorek, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 2220.

https://doi.org/10.1182/blood.V110.11.2220.2220

Published: 2007

Journal Articles

An In Vivo Evidence That the CD45 negative Adult Marrow-Derived CXCR4 + SSEA-1 + OCT-4 + Very Small Embryonic-Like (VSEL) Stem Cells May Differentiate into CD45 positive Long Term Repopulating Hematopoietic Stem Cells.

Marcin Wysoczynski, Magda Kucia, PhD, Ewa K. Zuba-Surma, PhD, Wu Wan, Mariusz Z. Ratajczak, MD, PhD, Janina Ratajczak, MD, PhD

Blood (2007) 110 (11): 505.

https://doi.org/10.1182/blood.V110.11.505.505

Published: 2007

Journal Articles

Novel Direct Evidence That Adult Bone Marrow-Derived Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood - Leukopheresis as a Potential Tool To Isolate Pluripotent Stem Cells for Therapeutic Pruposes.

Magda Kucia, PhD, Marcin Wysoczynski, Wu Wan, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 1205.

https://doi.org/10.1182/blood.V110.11.1205.1205

Published: 2007

Journal Articles

The Studies in Various Murine Strains with Defects in Activation of Complement Cascade (CC) Reveal Both Pivotal and Pleiotropic Role of CC in Mobilization of Hematopoietic Stem/Progenitor Cells.

Marcin Wysoczynski, Ryan Reca, PhD, Wu Wan, Magda Kucia, PhD, Marina Botto, MD, PhD, Janina Ratajczak, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2007) 110 (11): 774.

https://doi.org/10.1182/blood.V110.11.774.774

Published: 2007

Journal Articles

An In Vitro and In Vivo Evidence That Downregulation of Leukemia Inhibitory Factor (LIF) Receptor (LIF-R) Decreases the Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells.

Marcin Wysoczynski, Katarzyna Miekus, Anna Marcinkowska, MD, Anna Janowska-Wieczorek, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2006) 108 (11): 2561.

https://doi.org/10.1182/blood.V108.11.2561.2561

Published: 2006

Journal Articles

Mobilization Studies in Immunodeficient Mice Support a Role of Complement in Modulating the Trafficking of Hematopoietic Stem Cells (HSC) - A Pivotal Role of C3 Cleavage Fragments in Retention and C5 Fragments in Mobilization/Egress of HSC.

Ryan Reca, PhD, Marcin Wysoczynski, Kucia Magda, PhD, Anna Janowska-Wieczorek, MD, PhD, Janina Ratajczak, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2006) 108 (11): 3375.

https://doi.org/10.1182/blood.V108.11.3375.3375

Published: 2006

NARROW

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Heme Oxygenase 1 (HO-1) Is a Novel Negative Regulator of Normal and Malignant Hematopoietic Cell Trafficking

Transient Ex Vivo Inhibition of Heme Oxygenase 1 (HO-1) in Hematopoietic Stem/Progenitor Cells (HSPCs) By Small-Molecule Inhibitors Enhances Their Migratory Responsiveness to Bone Marrow (BM)-Secreted Chemoattractants a Novel and Simple Strategy to Improve Homing of HSPCs

A Novel Observation That Heme Oxygenase-1 (HO-1) Deficient Mice Are Easy Mobilizers and That HO-1 Plays An Important Role in Maintaining Expression of SDF-1 in Bone Marrow (BM) Stroma and Promotes Retention of Hematopoietic Stem/Progenitor Cells (HSPCs) in the Bone Marrow Microenvironment

Evidence That a Bioactive Lipid, Ceramide-1 Phosphate (C1P), Is Upregulated In Bone Marrow Microenvironment After Myeloablative Therapy and Is a Potential Novel Homing Factor for Hematopoietic Stem Cells

Granulocyte-Derived Cationic Peptides (GDCPs) Present in Leucophoresis Products Enhance Homing of Hematopoietic Stem Cells (HSCs) to SDF-1 Gradient; Potential Implications for Accelerated Recovery of Hematopoiesis After Transplantation of Mobilized Peripheral Blood Stem Cells (PBSC).

Mobilization Studies in Complement-Deficient Mice Reveal That AMD3100 Mobilization Depends On Complement Cascade Activation and Suggest Involvement of “Membrane Attack Complex - MAC” in Egress of Hematopoietic Stem/Progenitor Cells.

Novel Pleiotropic Effects of Thrombin in Regulation of Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells – Identification of Negative PAR1 and PAR3 Receptor Crosstalk.

Novel Pleiotropic Effects of Thrombin in Regulation of the Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells.

An In Vitro and In Vivo Evidence That Interleukin-8 Is a Pivotal Hypoxia-Regulated Pro-Angiopoietic Factor Secreted by Human Rhabdomyosarcomas (RMS) - Therapeutic Implications.

Complement Cascade (CC) Cleavage Fragments - C3a and C5a Anaphylatoxins - As New Unexpected Hypoxia-Related Stimulators of Erythropoiesis.

An In Vivo Evidence That the CD45 negative Adult Marrow-Derived CXCR4 + SSEA-1 + OCT-4 + Very Small Embryonic-Like (VSEL) Stem Cells May Differentiate into CD45 positive Long Term Repopulating Hematopoietic Stem Cells.

Novel Direct Evidence That Adult Bone Marrow-Derived Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood - Leukopheresis as a Potential Tool To Isolate Pluripotent Stem Cells for Therapeutic Pruposes.

The Studies in Various Murine Strains with Defects in Activation of Complement Cascade (CC) Reveal Both Pivotal and Pleiotropic Role of CC in Mobilization of Hematopoietic Stem/Progenitor Cells.

An In Vitro and In Vivo Evidence That Downregulation of Leukemia Inhibitory Factor (LIF) Receptor (LIF-R) Decreases the Metastatic Potential of Human Rhabdomyosarcoma (RMS) Cells.

Mobilization Studies in Immunodeficient Mice Support a Role of Complement in Modulating the Trafficking of Hematopoietic Stem Cells (HSC) - A Pivotal Role of C3 Cleavage Fragments in Retention and C5 Fragments in Mobilization/Egress of HSC.

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American Society of Hematology

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American Society of Hematology

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