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Andrzej Ciechanowicz
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Journal Articles

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Vira Chumak, Andrzej Ciechanowicz, Mateusz Adamiak, Arjun Thapa, Ahmed Abdelbaset-Ismail, Kamila Bujko, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak
Journal: Blood
Blood (2022) 140 (Supplement 1): 1987–1988.
https://doi.org/10.1182/blood-2022-158573
Published: 2022
Journal Articles

Novel Observation That Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) Involves Activation of Nlrp3 Inflammasome That Provides Cholesterol and Sphingolipids for the Formation of Lipid Rafts on the Outer Cell Membrane That Are Crucial for Proper Responsiveness of HSPCs to Chemoattractant and Hematopoietic Cytokines/Growth Factors

Andrzej Ciechanowicz, Ahmed Abdelbaset-Ismail, Magda Kucia, Mariusz Z Ratajczak
Journal: Blood
Blood (2022) 140 (Supplement 1): 4470–4471.
https://doi.org/10.1182/blood-2022-158560
Published: 2022
Journal Articles

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

Mateusz Adamiak, Andrzej Ciechanowicz, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak
Journal: Blood
Blood (2021) 138 (Supplement 1): 1683.
https://doi.org/10.1182/blood-2021-148818
Published: 2021
Journal Articles

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Katarzyna Sielatycka, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 8.
https://doi.org/10.1182/blood-2020-137083
Published: 2020
Journal Articles

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Mateusz Adamiak, PhD, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Marta Skoda, PhD, Mariusz Z Ratajczak, MD PhD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1033.
https://doi.org/10.1182/blood-2019-125853
Published: 2019