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Journal Articles

The Pro-Mobilizing Effects of UDP-Glucose-P2Y14 Purinergic Receptor Signaling Are Explained By Promoting Membrane Lipid Raft Formation to Optimize Hspcs' Responsiveness to Chemoattractants-a Potential Strategy to Optimize Hematopoietic Transplantation and Improve Transplant Outcomes

Kamila Bujko, Mateusz Admiak, Kannathasan Thetchinamoorthy, Arjun Thapa, Diana Wierzbicka, Magdalena Molenda, Mariusz Z Ratajczak, Magdalena Kucia

Blood (2024) 144 (Supplement 1): 4034.

https://doi.org/10.1182/blood-2024-204825

Published: 2024

Journal Articles

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Vira Chumak, Andrzej Ciechanowicz, Mateusz Adamiak, Arjun Thapa, Ahmed Abdelbaset-Ismail, Kamila Bujko, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 1987–1988.

https://doi.org/10.1182/blood-2022-158573

Published: 2022

Journal Articles

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Kamila Bujko, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2022) 140 (Supplement 1): 7567.

https://doi.org/10.1182/blood-2022-158594

Published: 2022

Journal Articles

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Kamila Bujko, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak

Blood (2022) 140 (Supplement 1): 11397.

https://doi.org/10.1182/blood-2022-159672

Published: 2022

Journal Articles

Novel Evidence That By Employing a Two-Step Differentiation Protocol in the Presence of UM171 and Nicotinamide Acid Human Very Small Embryonic like Stem Cells (VSELs) Differentiate into Functional Endothelial Cells (ECs)

Alison Domingues, Elisa Rossi, Kamila Bujko, Grégoire Detriche, Janina Ratajczak, Ulysse Richez, Adeline Blandinieres, Magda Kucia, David M Smadja, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 2070.

https://doi.org/10.1182/blood-2021-149822

Published: 2021

Journal Articles

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 3809.

https://doi.org/10.1182/blood-2021-148733

Published: 2021

Journal Articles

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

Mateusz Adamiak, Andrzej Ciechanowicz, Kamila Bujko, Katarzyna Brzeźniakiewicz-Janus, Janina Ratajczak, Magda Kucia, Mariusz Z Ratajczak

Blood (2021) 138 (Supplement 1): 1683.

https://doi.org/10.1182/blood-2021-148818

Published: 2021

Journal Articles

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Katarzyna Sielatycka, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-137083

Published: 2020

Journal Articles

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Mateusz Adamiak, PhD, Arjun Thapa, Kamila Bujko, MSc, Valentina Pensato, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-137123

Published: 2020

Journal Articles

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Arjun Thapa, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-137102

Published: 2020

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Kamila Bujko, MS, Mateusz Adamiak, PhD, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4472.

https://doi.org/10.1182/blood-2019-125858

Published: 2019

Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4882.

https://doi.org/10.1182/blood-2019-125819

Published: 2019

Journal Articles

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Mateusz Adamiak, PhD, Kamila Bujko, MS, Monika Plonka, MD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 4528.

https://doi.org/10.1182/blood-2018-99-110634

Published: 2018

Journal Articles

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Mateusz Adamiak, PhD, Kamila Bujko, MS, Anna Lenkiewicz, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2018-99-110631

Published: 2018

Journal Articles

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Kamila Bujko, MS, Sylwia Rzeszotek, PhD, Janina Ratajczak, MD PhD DSci, Kai Hoehlig, PhD, Axel Vater, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 1188.

https://doi.org/10.1182/blood.V130.Suppl_1.1188.1188

Published: 2017

Journal Articles

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

Janina Ratajczak, MD PhD DSci, Malwina Suszynska, PhD, Kamila Bujko, MS, Donald M Miller, MD PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3761.

https://doi.org/10.1182/blood.V130.Suppl_1.3761.3761

Published: 2017

NARROW

The Pro-Mobilizing Effects of UDP-Glucose-P2Y14 Purinergic Receptor Signaling Are Explained By Promoting Membrane Lipid Raft Formation to Optimize Hspcs' Responsiveness to Chemoattractants-a Potential Strategy to Optimize Hematopoietic Transplantation and Improve Transplant Outcomes

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Novel Evidence That the P2X1 Purinergic Receptor - Nlrp3 Inflammasome Axis Orchestrates Optimal Trafficking of Hematopoietic Stem Progenitors Cells (HSPCs)

Novel Evidence That NADPH Oxidase 2 (Nox-2) Enhances Trafficking of Hematopoietic Stem Progenitor Cells (HSPCs) By Involving ROS Mediated Activation of Nlrp3 Inflammasome

Novel Evidence That By Employing a Two-Step Differentiation Protocol in the Presence of UM171 and Nicotinamide Acid Human Very Small Embryonic like Stem Cells (VSELs) Differentiate into Functional Endothelial Cells (ECs)

Modulation of Purinergic Signaling Prior to Transplantation Both in Hematopoietic Stem Progenitor Cells (HSPCs) or Recipient Bone Marrow (BM) Microenvironment - As Novel Strategies to Accelerate and Facilitate HSPCs Homing and Engraftment

Novel Evidence That Alternative Activation Pathway of Complement Cascade (ComC) Regulates Optimal Homing and Engraftment of Hematopoietic Stem/Progenitor Cells (HSPCs) in Reactive Oxygen Species (ROS) - Nlrp3 Inflammasome-Dependent Manner

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

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American Society of Hematology

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