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Kartika Venugopal
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Journal Articles

In Vivo RNA delivery by targeted lipid nanoparticles enable gene editing in hematopoietic stem cells and T cells

Free
Rahul Palchaudhuri, Michael Monte, Mohit Gupta, Giulia Schiroli, Lorenzo Tozzi, Lei Liu, Han Gu, Rebecca Goldman, Apiwat Wangweerawong, Aaron Zannini, Yaser Heshmati, Christina Ferren, Alyssa Sanfilippo, Tiffany Morales, Jessica Desmond, Kartika Venugopal, Jason Rodriguez, Albert De Iaco, Cecilia Cotta-Ramusino, William E. Salomon, James Rottman, William Querbes, Hari Pujar, Michael C Holmes, Z. Jane Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 4318.
https://doi.org/10.1182/blood-2025-4318
Published: 2025
Journal Articles

Targeted lnp delivery of an RNA gene writer In Vivo enables generation of functional CAR-T cells

Free
Cecilia Cotta-Ramusino, Albert De Iaco, James Rottman, Jason Rodriguez, Donghui Li, Kartika Venugopal, Jessica Desmond, Christina Ferren, Mohit Gupta, Rebecca Levy, Rahul Palchaudhuri, Z. Jane Wang, William Querbes, Hari Pujar, Michael C Holmes
Journal: Blood
Blood (2025) 146 (Supplement 1): 6097.
https://doi.org/10.1182/blood-2025-6097
Published: 2025
Journal Articles

Intravenously administered LV-169 delivers a functional BCMA-CAR transgene to niche-resident T cells and leads to elimination of disseminated myeloma in MHC-deficient NSG mice

Free
Stephen Russell, Gopal Naik Nenavath, Nandakumar Packiriswamy, Timothy Carey, Md Yeashin Gazi, Aaron Hawkes, Collin Gwilt, Chia-Hsuan Chin, Christian Kinney, Hamid Salimi, Thipparat Suwanmanee, Darren Phung, Karina Krotova, Rianna Vandergaast, Kartika Venugopal, Edward Briercheck, Eric Smith, Yi Lin, Kah-Whye Peng
Journal: Blood
Blood (2025) 146 (Supplement 1): 5896.
https://doi.org/10.1182/blood-2025-5896
Published: 2025
Journal Articles

Targeted Lipid Nanoparticle Delivery of an RNA Gene Writer In Vivo Enables Generation of CAR-T Cells in a Humanized Mouse Model

Free
Jason Rodriguez, Alberto De Iaco, James B. Rottman, Donghui Liu, Kartika Venugopal, Xin Qiao, Yu Cao, Rebecca Levy, Mohit Gupta, Rahul Palchaudhuri, Bill Querbes, Cecilia Cotta-Ramusino, Hari Pujar, Madhusudan V Peshwa, Michael C Holmes
Journal: Blood
Blood (2024) 144 (Supplement 1): 4799.
https://doi.org/10.1182/blood-2024-208176
Published: 2024
Journal Articles

Dnmt3a Mutations in the Hematopoietic System Promote Colitis-Associated Colon Cancer: A Model of Clonal Hematopoiesis in Solid Tumors

Free
Yang Feng, Rachel Newsome, Troy Robinson, Robert L. Bowman, Ashley Zuniga, Kendra Hall, Cassandra Bernsten, Daniil Shabashvili, Kathryn Krajcik, Chamara Gunaratne, Zachary Zaroogian, Kartika Venugopal, Heidi Casellas Roman, Ross L. Levine, Alberto Riva, Daniel Kopinke, Christian Jobin, Dorina Avram, Olga A Guryanova
Journal: Blood
Blood (2021) 138 (Supplement 1): 2161.
https://doi.org/10.1182/blood-2021-149740
Published: 2021
Journal Articles

DNMT3A with Leukemia-Associated R882 Mutations Promotes Fitness Advantage through Functional Heterogeneity within HSCs

Free
Zachary Zaroogian, Chamara Gunaratne, Daniil Shabashvili, Cassandra Berntsen, Yang Feng, Kartika Venugopal, Santhi Pondugula, Olga A Guryanova
Journal: Blood
Blood (2021) 138 (Supplement 1): 2151.
https://doi.org/10.1182/blood-2021-151007
Published: 2021
Journal Articles

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Free
Kartika Venugopal, MS, Daniil E Shabashvili, PhD, Jianping Li, MD, Luisa M Posada, Richard Lynn Bennett, PhD, Yang Feng, MS, Daphne Dupere Richer, PhD, Alberto Riva, PhD, Santhi Pondugula, PhD, Jonathan E. Bird, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 535.
https://doi.org/10.1182/blood-2019-128213
Published: 2019
Journal Articles

Cells with DNMT3A Mutations Are More Sensitive to Cytarabine-Induced DNA Damage

Free
Kartika Venugopal, MS, Jianping Li, MD, Daniil E Shabashvili, PhD, Luisa M Posada, Yang Feng, MS, Daphne Dupere-Richer, PhD, Aditya Bele, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2643.
https://doi.org/10.1182/blood-2018-99-118708
Published: 2018