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James Rottman
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Journal Articles

Targeted lnp delivery of an RNA gene writer In Vivo enables generation of functional CAR-T cells

Free
Cecilia Cotta-Ramusino, Albert De Iaco, James Rottman, Jason Rodriguez, Donghui Li, Kartika Venugopal, Jessica Desmond, Christina Ferren, Mohit Gupta, Rebecca Levy, Rahul Palchaudhuri, Z. Jane Wang, William Querbes, Hari Pujar, Michael C Holmes
Journal: Blood
Blood (2025) 146 (Supplement 1): 6097.
https://doi.org/10.1182/blood-2025-6097
Published: 2025
Journal Articles

In Vivo correction of the sickle cell disease mutation in hematopoietic stem cells using RNA gene writers

Free
Yaser Heshmati, Giulia Schiroli, Lorenzo Tozzi, Michael Monte, Nouhaila Beytour, Apiwat Wangweerawong, James Rottman, William E. Salomon, Rahul Palchaudhuri, Z. Jane Wang, Anne Bothmer, Kim Vanuytsel, John Manis, Lev Gorfinkel, Francesca Alvarez Calderon, Ulrike Gerdemann, Leslie Kean, Hari Pujar, Cecilia Cotta-Ramusino, Raja Prince-Eladnani, Michael C Holmes
Journal: Blood
Blood (2025) 146 (Supplement 1): 2536.
https://doi.org/10.1182/blood-2025-2536
Published: 2025
Journal Articles

In Vivo RNA delivery by targeted lipid nanoparticles enable gene editing in hematopoietic stem cells and T cells

Free
Rahul Palchaudhuri, Michael Monte, Mohit Gupta, Giulia Schiroli, Lorenzo Tozzi, Lei Liu, Han Gu, Rebecca Goldman, Apiwat Wangweerawong, Aaron Zannini, Yaser Heshmati, Christina Ferren, Alyssa Sanfilippo, Tiffany Morales, Jessica Desmond, Kartika Venugopal, Jason Rodriguez, Albert De Iaco, Cecilia Cotta-Ramusino, William E. Salomon, James Rottman, William Querbes, Hari Pujar, Michael C Holmes, Z. Jane Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 4318.
https://doi.org/10.1182/blood-2025-4318
Published: 2025