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Therapy Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Is Predictive of Individual Acute Myeloid Leukemia (AML) Patient Probability of Clinical Response (CR) and Overall Survival (OS): Mycare-023

Scott C Howard, Drew Watson, Michael Castro, Shweta Kapoor, Prashant Ramachandran Nair, Samiksha Avinash Prasad, Swaminathan Rajagopalan, Aftab Alam, Kunal Ghosh Roy, Diwyanshu Sahu, Deepak Anil Lala, Kabya Basu, Yashaswini S Ullal, Yugandhara Narvekar, Adity Ghosh, Mohammed Sauban, Poornachandra G, Ashish Kumar Agrawal, Anuj Tyagi, Rakhi Purushothaman Suseela, Karthik Sundara Raju, Anusha Pampana, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 689.
https://doi.org/10.1182/blood-2021-154023
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Genomic and Molecular Markers for Decitabine (DAC) Plus Valproic-Acid (VPA) Treatment Response in Patients with Myelodysplastic Syndromes (MDS)

Michael Castro, Ansu Kumar, Himanshu Grover, Vivek Patil, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Samiksha Avinash Prasad, Kabya Basu, Rakhi Purushothaman Suseela, Chandan Kumar, Prashant Ramachandran Nair, Pallavi Kumari, Anusha Pampana, Yashaswini S Ullal, Humera Azam, Nagendra Prasad, Anish Raju R Amara, Diwyanshu Sahu, Nithya T Raveendaran, Archana Palillam Veedu, Nirjhar Mundkur, Sanjana Patel, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 2615.
https://doi.org/10.1182/blood-2021-153220
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Predicted Novel Biomarkers for Hyper-CVAD (CVAD) Treatment Response and Combination of Rituximab and Cladribine (RC) in CVAD Resistant Cases of Mantle Cell Lymphoma (MCL)

Guido Marcucci, Ansu Kumar, Michael Castro, Swati Khandelwal, Subrat Mohapatra, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Kabya Basu, Vijayashree P Shyamasundar, Deepak Anil Lala, Karthik Sundara Raju, Naga Ganesh Palaniyeppa, Yashaswini S Ullal, Vishwas Joseph, Liptimayee Behura, Diwyanshu Sahu, Annapoorna Prakash, Upasana Mitra, Ashokraja Balla, Mamatha Patil, Jharana Mohanty, Sanjana Patel, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3550.
https://doi.org/10.1182/blood-2021-152423
Published: 2021
Journal Articles

Superior Therapy Response Predictions for Patients with Myelodysplastic Syndrome (MDS) Using Cellworks Singula™: Mycare-020-02

Anthony S. Stein, MD, Drew Watson, PhD, Prashant Ramachandran Nair, B.Tech., Kabya Basu, M.Sc., Yashaswini S Ullal, M.Tech., Adity Ghosh, M.Sc., Yugandhara Narvekar, M.Sc., Himanshu Grover, M.S., Diwyanshu Sahu, M.Sc., Annapoorna Prakash, M.Tech., Liptimayee Behura, B.E., Veena Balakrishnan, M.Sc., Kunal Ghosh Roy, M.Sc., Swaminathan Rajagopalan, M.Tech., Aftab Alam, M.Sc., Rajan Parashar, B.Tech., Nirjhar Mundkur, James Christie, B.S., Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Guido Marcucci, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-142214
Published: 2020
Journal Articles

Assessment of Cellworks Omics Biosimulation Therapy Response Predictions for Patients with Acute Myeloid Leukemia (AML) Using Cellworks Singula™: Mycare-020-01

Guido Marcucci, MD, Drew Watson, PhD, Prashant Ramachandran Nair, B.Tech., Kabya Basu, M.Sc., Yashaswini S Ullal, M.Tech., Adity Ghosh, M.Sc., Yugandhara Narvekar, M.Sc., Himanshu Grover, M.S., Diwyanshu Sahu, M.Sc., Anish Raju R Amara, B.E., Anusha Pampana, M.Sc., Kunal Ghosh Roy, M.Sc., Swaminathan Rajagopalan, M.Tech., Aftab Alam, M.Sc., Rajan Parashar, B.Tech., Nirjhar Mundkur, James Christie, B.S., Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Anthony S. Stein, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35.
https://doi.org/10.1182/blood-2020-142184
Published: 2020
Journal Articles

Digital Drug Screening and Computational Modeling Identifies Treatment Opportunities Despite Lack of Directly Actionable Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)

Leylah M. Drusbosky, PhD, Kimberly E. Hawkins, PhD BS, Madeleine Turcotte, MS, Hemant S. Murthy, MD, Helen L. Leather, Nosha Farhadfar, MD, Maxim Norkin, MD, John R. Wingard, MD, John W. Hiemenz, MD, Paul Castillo, MD, Randy A. Brown, MD, William Slayton, MD, Biljana N. Horn, MD, Sumanth Vasista, BE, Kabya Basu, MS, Shahabuddin Usmani, MS, Kunal Ghosh Roy, MS, Deepak Anil Lala, BT, Saumya Radhakrishnan, BT, Rajeev Kumar, BT, Swaminathan Rajagopalan, MT, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3910.
https://doi.org/10.1182/blood.V130.Suppl_1.3910.3910
Published: 2017
Journal Articles

The Oral Proteasome Inhibitor Ixazomib, Alone and in Combination with Ibrutinib, Induces Lethality in Waldenstrom Macroglobulinemia Cells That Are Resistant to Ibrutinib

Aneel Paulus, MD, Alak Manna, PhD, Sharoon Akhtar, MPhil, Neeraj Kumar Singh, B.Tech, Ansu Kumar, MS, Kabya Basu, MS, Akshita Trivedi, B.Tech, Debapriya Majumdar, M.Sc., Taher Abbasi, MS, MBA, Shireen Vali, PhD, Vivek Roy, MD, Peter Martin, FRCPC, MD MS, Morton Coleman, MD, Anne J Novak, PhD, Stephen M Ansell, MD PhD, Sikander Ailawadhi, Asher A. Chanan-Khan, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1260.
https://doi.org/10.1182/blood.V130.Suppl_1.1260.1260
Published: 2017
Journal Articles

Icare 1: A Prospective Clinical Trial to Predict Treatment Response Based on Mutanome-Informed Computational Biology in Patients with AML and MDS

Leylah Drusbosky, PhD, Elizabeth Wise, BS, Shireen Vali, PhD, Taher Abbasi, Ansu Kumar, Neeraj Kumar Singh, Kabya Basu, Chandan Kumar, Amjad Husain, Fei Zou, PhD, Caitlin Tucker, BS, Randy A Brown, MD, Maxim Norkin, MD PhD, John Hiemenz, MD, John R. Wingard, MD, Jack W Hsu, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2016) 128 (22): 594.
https://doi.org/10.1182/blood.V128.22.594.594
Published: 2016
Journal Articles

Therapy Personalization Using Predictive Simulation Approach with Ex-Vivo Clinical Validations

Nicole A Doudican, PhD, Ravi Vij, MD, Mark A Fiala, BS, CCRP, Justin King, Shireen Vali, PhD, Kabya Basu, Ansu Kumar, Neeraj Kumar Singh, Zeba Sultana, Taher Abbasi, MS, Amitabha Mazumder, MD
Journal: Blood
Blood (2014) 124 (21): 2232.
https://doi.org/10.1182/blood.V124.21.2232.2232
Published: 2014
Journal Articles

A Novel Method of Using Molecular Profiling in Myelodysplastic Syndromes to Predict Patient-Specific Potential Therapeutics

Christopher R. Cogle, MD, Gaurav Trikha, MBBS, MD, Peter P. Sayeski, PhD, Shireen Vali, PhD, Ansu Kumar, Neeraj Kumar Singh, Prashant R Nair, Deepak Anil Lala, Kabya Basu, Taher Abbasi, MS, Maher Albitar, MD
Journal: Blood
Blood (2014) 124 (21): 5591.
https://doi.org/10.1182/blood.V124.21.5591.5591
Published: 2014