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John P Manis
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Journal Articles

Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression

Ryan P. Jajosky, Kashyap R. Patel, Jerry William L. Allen, Patricia E. Zerra, Satheesh Chonat, Diyoly Ayona, Cheryl L. Maier, Dominique Morais, Shang-Chuen Wu, C. John Luckey, Stephanie C. Eisenbarth, John D. Roback, Ross M. Fasano, Cassandra D. Josephson, John P. Manis, Li Chai, Jeanne E. Hendrickson, Krystalyn E. Hudson, Connie M. Arthur, Sean R. Stowell
Journal: Blood
Blood (2023) 142 (12): 1082–1098.
https://doi.org/10.1182/blood.2022018591
Published: 2023
Includes: Supplemental data
Journal Articles

Therapeutic Gene Editing of HSCs Ex Vivo without in Vitro Culture Avoids Genotoxicity, Simplifies Procedures, and Preserves Efficiency and Stemness

Jing Zeng, My Anh Nguyen, Marioara-Felicia Ciuculescu, Esther Mintzer, Pengpeng Liu, Linda Yingqi Lin, Tolulope O Rosanwo, Archana Verma, Nola Neri, Stacy A. Maitland, Alden Richter, David G. Justus, Kendell Clement, Christian Brendel, Luca Pinello, John P Manis, Myriam Armant, Scot A. Wolfe, Daniel E. Bauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 10671–10672.
https://doi.org/10.1182/blood-2022-169900
Published: 2022
Journal Articles

Altered Cellular Sedimentation during Apheresis Impacts Outcomes of Peripheral Blood Stem Cell Collection Efficiency in Patients with Sickle Cell Disease

David G. Justus, Erica B. Esrick, Matthew M. Heeney, Ellen Proeung, Carly Howard, Carlo Brugnara, David A. Williams, John P Manis
Journal: Blood
Blood (2022) 140 (Supplement 1): 5715–5716.
https://doi.org/10.1182/blood-2022-170450
Published: 2022
Journal Articles

Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model

Michael J. Peters, Anna Deck, April Hu, Yuko Fujiwara, Jinkuk Kim, Aubrie Soucy, Kevin Zhang, Julianna Kenny, Linda Y. Lin, Alyssa L. Kennedy, Caitlin Bowers, Chad E. Harris, Chi Yuan Zhang, Karthik Ponnienselvan, Pengpeng Liu, Kevin Luk, Davide Seruggia, R. Coleman Lindsley, John P. Manis, Christian Brendel, Scot A. Wolfe, Stuart H. Orkin, Timothy Yu, Akiko Shimamura, Daniel E. Bauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2944–2945.
https://doi.org/10.1182/blood-2022-169379
Published: 2022
Journal Articles

Induction of Fetal Hemoglobin and Reduction of Clinical Manifestations in Patients with Severe Sickle Cell Disease Treated with Shmir-Based Lentiviral Gene Therapy for Post-Transcriptional Gene Editing of BCL11A: Updated Results from Pilot and Feasibility Trial

Erica B. Esrick, Amy Federico, Daniela Abriss, Myriam Armant, Kari Boardman, Christian Brendel, Marioara-Felicia Ciuculescu, Heather Daley, Colleen Dansereau, Augustine Fernandes, Matthew M. Heeney, David G. Justus, Pei-Chi Kao, Annette S. Kim, Donald B. Kohn, Leslie E. Lehmann, Donghui Liu, Wendy B. London, John P Manis, Theodore B. Moore, Emily Morris, Danilo Pellin, Ellen Proeung, Shanna Richard, Gavin D. Roach, Kit L. Shaw, Dayna Terrazas, Shanna L White, David A. Williams
Journal: Blood
Blood (2022) 140 (Supplement 1): 10665–10667.
https://doi.org/10.1182/blood-2022-169089
Published: 2022
Journal Articles

Antibody-Mediated Antigen Loss Can Switch an Augmented Immune Response to Antibody-Mediated Immunosuppression

Ryan Philip Jajosky, Jerry W. Allen, Patricia E Zerra, Cheryl L Maier, Satheesh Chonat, Chance John Luckey, John D. Roback, Ross M. Fasano, Cassandra D. Josephson, John P Manis, Li Chai, Jeanne E. Hendrickson, Krystalyn E Hudson, Connie M. Arthur, Sean R. Stowell
Journal: Blood
Blood (2022) 140 (Supplement 1): 73–74.
https://doi.org/10.1182/blood-2022-170081
Published: 2022
Journal Articles

A Phase 2, Open-Label Study to Evaluate the Efficacy and Safety of Mgta-145 in Combination with Plerixafor for the Mobilization of Hematopoietic Stem Cells in Patients with Sickle Cell Anemia

Akshay Sharma, John P Manis, David G. Justus, David A. Williams, Sergey Efuni, Ji Hyun Lee, Erin Conlin, Shawn Rose, Jeffrey Humphrey, Kirk Bertelsen, Nicole Henry, June Li, Donald Pardy, David Santos, Christian Zdybowicz, Alexis Leonard, John Tisdale
Journal: Blood
Blood (2022) 140 (Supplement 1): 8263–8264.
https://doi.org/10.1182/blood-2022-159728
Published: 2022
Journal Articles

Combined +58 and +55 BCL11A enhancer Editing Yields Exceptional Efficiency, Specificity and HbF Induction in Human and NHP Preclinical Models

Jing Zeng, Selami Demirci, My Anh Nguyen, Linda Yingqi Lin, Stacy A. Maitland, Esther Mintzer, Yuxuan Wu, Danilo Pellin, Amornrat Tangprasittipap, Chokdee Vong, Shaina N. Porter, Kevin Luk, Pengpeng Liu, Varun Katta, Marioara-Felicia Ciuculescu, Daniela Abriss, Jonathan Hsu, Naoya Uchida, Khaled Essawi, Robert Donahue, Karl Petri, Vikram Pattanayak, Luca Pinello, Christian Brendel, David A Williams, John P Manis, Shengdar Q. Tsai, Shondra M. Pruett-Miller, J. Keith Joung, Duantida Songdej, Suradej Hongeng, Myriam Armant, Scot A. Wolfe, John F. Tisdale, Daniel E. Bauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2021-152634
Published: 2021
Journal Articles

Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Erica B. Esrick, MD, Maureen Achebe, MD MPH, Myriam Armant, PhD, Pablo Bartolucci, MD PhD, Marioara Felicia Ciuculescu, MD, Heather Daley, Colleen Dansereau, MSN, RN, CPN, Giuseppe Di Caprio, PhD, Bronner Goncalves, MD PhD, Nicolas Hebert, Matthew M Heeney, MD, John M. Higgins, MD PhD, Leslie E. Lehmann, MD, John P Manis, MD, Olivier Negre, PhD, Sarah Nikiforow, MD PhD, Ethan Schonbrun, PhD, David K. Wood, PhD, David A. Williams, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-5.
https://doi.org/10.1182/blood-2019-132745
Published: 2019
Journal Articles

Therapeutic Base Editing of Human Hematopoietic Stem Cells

Jing Zeng, MD, Yuxuan Wu, PhD, Chunyan Ren, PhD, Jasmine Bonanno, Anne H. Shen, Devlin Shea, Jason M Gehrke, PhD, John P Manis, MD, J. Keith Gehrke, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 612.
https://doi.org/10.1182/blood-2019-129173
Published: 2019
Journal Articles

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Jing Zeng, MD, Daniel E. Bauer, MD PhD, Yuxuan Wu, PhD, Benjamin P Roscoe, Pengpeng Liu, Qiuming Yao, PhD, Cicera Lazzarrotto, M. Kendell Clement, Mitchel A. Cole, BS, Kevin Luk, Cristina Baricordi, Erica B. Esrick, MD, John P Manis, MD, David Dorfma, David A. Williams, MD, Alessandra Biffi, MD PhD, Carlo Brugnara, MD, Luca Biasco, Christian Brendel, PhD, Luca Pinello, PhD, Shengdar Tsai, PhD, Scot A. Wolfe
Journal: Blood
Blood (2018) 132 (Supplement 1): 3482.
https://doi.org/10.1182/blood-2018-99-119365
Published: 2018
Journal Articles

Flipping the Switch: Initial Results of Genetic Targeting of the Fetal to Adult Globin Switch in Sickle Cell Patients

Erica B. Esrick, MD, Christian Brendel, PhD, John P Manis, MD, Myriam A Armant, PhD, Helene Negre, PhD, Colleen Dansereau, MSN, RN, CPN, Marioara Felicia Ciuculescu, MD, Stephanie Patriarca, Brenda Mackinnon, BSN, RN, Heather Daley, BS, Shanna Richard, Daniela Abriss, Renee Maxwell, Stephen Braunewell, BS, Lauryn Christiansen, BS, Sarah Nikiforow, MD PhD, Jerome Ritz, MD PhD, Maureen Achebe, MD, Olivier Negre, PhD, Leslie E. Lehmann, MD, Matthew M Heeney, MD, Alessandra Biffi, MD PhD, David A. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1023.
https://doi.org/10.1182/blood-2018-99-116733
Published: 2018
Journal Articles

Platelet refractoriness: it’s not the B-all and end-all

John P. Manis, Leslie E. Silberstein
Journal: Blood
Blood (2016) 127 (14): 1740–1741.
https://doi.org/10.1182/blood-2016-02-695437
Published: 2016