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Journal Articles

A Six-Protein Activity Signature Defines Favorable Response to Selinexor Treatment for Patients with Diffuse Large B-Cell Lymphoma (DLBCL)

Christopher J. Walker, PhD, Yao Shen, PhD, Mariano Alvarez, PhD, Hua Chang, PhD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Andrea Califano, Dr, Yosef Landesman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-142004
Published: 2020
Journal Articles

Effect of Prior Treatment with Proteasome Inhibitors on the Efficacy and Safety of Once-Weekly Selinexor, Bortezomib, and Dexamethasone in Comparison with Twice-Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Subgroup Analysis from the Boston Study

Maria Mateos, MD PhD, Maria Gavriatopoulou, Thierry Facon, MD, Holger W Auner, MD PhD, Xavier Leleu, MD, Roman Hajek, MD, Meletios A Dimopoulos, Sosana Delimpasi, MD, Maryana Simonova, MD, Ivan Spicka, MD PhD, Ludek Pour, MD, Irina Kryachok, MD, Halyna Pylypenko, MD, Vadim A Doronin, MD, Ganna Usenko, MD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD, Tuphan Kanti Dolai, MBBS, MD DNB, DM, Dinesh Kumar Sinha, MD, Christopher P. Venner, MD, Mamta Garg, MD FRCP, FRCPath, Don A. Stevens, MD, Hang Quach, MD, Sundar Jagannath, MD, Philippe Moreau, MD, Moshe Levy, MD, Ashraf Z. Badros, MD, Larry D. Anderson, Jr., MD PhD, Nizar J. Bahlis, MD, Michele Cavo, Yi Chai, Melina Arazy, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Paul G. Richardson, MD, Sebastian Grosicki, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 48–50.
https://doi.org/10.1182/blood-2020-138391
Published: 2020
Journal Articles

Selinexor, Lenalidomide and Dexamethasone (SRd) for Patients with Relapsed/Refractory and Newly Diagnosed Multiple Myeloma

Darrell J White, MD, Richard LeBlanc, MD FRCPC, Muhamed Baljevic, MD, Nizar J. Bahlis, MD, Suzanne Lentzsch, MD PhD, Christopher P. Venner, MD, Cristina Gasparetto, MD, Christine I Chen, MD, Brea Lipe, MD, Sascha A Tuchman, MD, Heather J Sutherland, MD PhD, Rami Kotb, MD, Michael Sebag, MD PhD FRCPC, Natalie S. Callander, MD, William I Bensinger, MD, Adriana C Rossi, MD MSc, Heidi Sheehan, Dane Van Domelen, PhD, Tianjun Zhou, MD PhD, Kai Kazuharu, MD PhD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Gary J. Schiller, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-140141
Published: 2020
Journal Articles

Once Weekly Selinexor, Bortezomib, and Dexamethasone (SVd) Versus Twice Weekly Bortezomib and Dexamethasone (Vd) in Relapsed or Refractory Multiple Myeloma: High-Risk Cytogenetic Risk Planned Subgroup Analyses from the Phase 3 Boston Study

Shambavi Richard, MD, Ajai Chari, MD, Sosana Delimpasi, MD, Maryana Simonova, MD, Ivan Spicka, MD PhD, Ludek Pour, MD, Irina Kryachok, MD, Meletios A Dimopoulos, Halyna Pylypenko, MD, Holger W Auner, MD PhD, Xavier Leleu, MD, Vadim A Doronin, MD, Ganna Usenko, MD, Roman Hajek, MD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD, Tuphan Kanti Dolai, MBBS, MD DNB, DM, Dinesh Kumar Sinha, MD, Christopher P. Venner, MD, Mamta Garg, MD FRCP, FRCPath, Don A. Stevens, MD, Hang Quach, MDFRACP,FRCPA,MBBS, Sundar Jagannath, MD, Philippe Moreau, MD, Moshe Y. Levy, MD, Ashraf Z. Badros, MD, Larry D. Anderson, Jr., MD PhD, Nizar J. Bahlis, MD, Thierry Facon, MD, Maria-Victoria Mateos, MD PhD, Michele Cavo, Hua Chang, PhD, Yosef Landesman, PhD, Anita A. Joshi, Yi Chai, Melina Arazy, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Sebastian Grosicki, MD PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-137154
Published: 2020
Journal Articles

Once Weekly Selinexor, Bortezomib, and Dexamethasone Versus Twice Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Age and Frailty Subgroup Analyses from the Phase 3 Boston Study

Holger W Auner, MD PhD, Maria Gavriatopoulou, Sosana Delimpasi, MD, Maryana Simonova, MD, Ivan Spicka, MD PhD, Ludek Pour, MD, Meletios A Dimopoulos, Irina Kryachok, Professor, Halyna Pylypenko, MD, Xavier Leleu, MD, Vadim A Doronin, MD, Ganna Usenko, MD, Roman Hajek, MD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD, Tuphan Kanti Dolai, MBBS, MD DNB, DM, Dinesh Kumar Sinha, MD, Christopher P. Venner, MD, Mamta Garg, MD FRCP, FRCPath, Don A. Stevens, MD, Hang Quach, MDFRACP,FRCPA,MBBS, Sundar Jagannath, MD, Philippe Moreau, MD, Moshe Y. Levy, MD, Ashraf Z. Badros, MD, Larry D. Anderson, Jr., MD PhD, Nizar J. Bahlis, MD, Thierry Facon, MD, Maria Mateos, MD PhD, Michele Cavo, Anita A. Joshi, Yi Chai, Melina Arazy, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Paul G. Richardson, MD, Sebastian Grosicki, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-137303
Published: 2020
Journal Articles

Impact of Prior Therapies on the Safety and Efficacy of Once Weekly Selinexor, Bortezomib, and Dexamethasone Compared with Twice Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Results from the Boston Study

Maria Mateos, MD PhD, Sundar Jagannath, MD, Sosana Delimpasi, MD, Maryana Simonova, MD, Ivan Spicka, MD PhD, Ludek Pour, MD, Irina Kryachok, MD, Maria Gavriatopoulou, Meletios A Dimopoulos, Halyna Pylypenko, MD, Holger W Auner, MD PhD, Xavier Leleu, MD, Vadim A Doronin, MD, Ganna Usenko, MD, Reuben Benjamin, MD, Tuphan Kanti Dolai, MBBS, MD DNB, DM, Dinesh Kumar Sinha, MD, Christopher P. Venner, MD, Mamta Garg, MD FRCP, FRCPath, Don A. Stevens, MD, Hang Quach, MDFRACP,FRCPA,MBBS, Philippe Moreau, MD, Moshe Y. Levy, MD, Ashraf Z. Badros, MD, Larry D. Anderson, Jr., MD PhD, Nizar J. Bahlis, MD, Thierry Facon, MD, Michele Cavo, Yi Chai, Melina Arazy, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Paul G. Richardson, MD, Sebastian Grosicki, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50–52.
https://doi.org/10.1182/blood-2020-137574
Published: 2020
Journal Articles

Selinexor in Combination with Pomalidomide and Dexamethasone (SPd) for Treatment of Patients with Relapsed Refractory Multiple Myeloma (RRMM)

Christine I Chen, MD, Nizar J. Bahlis, MD, Cristina Gasparetto, MD, Sascha A Tuchman, MD, Brea Lipe, MD, Muhamed Baljevic, MD, Rami Kotb, MD, Heather J Sutherland, MD PhD, William I Bensinger, MD, Michael Sebag, MD PhD FRCPC, Richard LeBlanc, MD FRCPC, Christopher P. Venner, MD, Gary J. Schiller, MD, Suzanne Lentzsch, MD PhD, Natalie S. Callander, MD, Adriana C Rossi, MD MSc, Heidi Sheehan, Dane Van Domelen, PhD, Kai Kazuharu, MD PhD, Hongwei Wang, MD PhD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G Kauffman, MD PhD, Darrell J White, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-139858
Published: 2020
Journal Articles

Influence of Cytogenetics in Patients with Relapsed Refractory Multiple Myeloma Treated with Oral Selinexor and Dexamethasone: A Post-Hoc Analysis of the STORM Study

Ajay K Nooka, MDMPH, Andrew J. Yee, MD, Carol Ann Huff, MD, Dan T. Vogl, MD, Maria Gavriatopoulou, MD, Ajai Chari, MD, Philippe Moreau, MD, David Dingli, MD PhD, Craig E. Cole, MD, Sagar Lonial, Meletios A. Dimopoulos, MD, Joshua R Richter, MD, Ravi Vij, MBBS, Sascha A Tuchman, MD, Marc S Raab, MD PhD, Noa Biran, MD, David S. Siegel, Paul G. Richardson, MD, Jianjun Liu, Anita Joshi, PhD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G. Kauffman, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1872.
https://doi.org/10.1182/blood-2019-122908
Published: 2019
Journal Articles

Safety and Efficacy of the Combination of Selinexor, Lenalidomide and Dexamethasone (SRd) in Patients with Newly Diagnosed Multiple Myeloma

Darrell J White, MD, Suzanne Lentzsch, MD PhD, Cristina Gasparetto, MD, Nizar Bahlis, MD, Christine I Chen, MD, Brea C. Lipe, MD, Gary J. Schiller, MD, Sascha A Tuchman, MD, Heather J. Sutherland, MD PhD, Rami Kotb, MD, Richard Leblanc, MDFRCPC, Michael Sebag, MD PhD, Christopher P Venner, MD, Natalie Scott Callander, MD, William I. Bensinger, Heidi Sheehan, Yi Chai, Kazuharu Kai, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G. Kauffman, MD PhD, Muhamed Baljevic, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3165.
https://doi.org/10.1182/blood-2019-124370
Published: 2019
Journal Articles

A US Budget Impact Model for Selinexor in Combination with Dexamethasone for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma (RRMM)

Ian Gould, PhD, Jan Bassali, PharmD, Jyotsna Mehta, Jatin Shah, MD, Dee Dee Mladsi, BA
Journal: Blood
Blood (2019) 134 (Supplement_1): 5824.
https://doi.org/10.1182/blood-2019-125997
Published: 2019
Journal Articles

Selinexor, Pomalidomide, and Dexamethasone (SPd) in Patients with Relapsed or Refractory Multiple Myeloma

Christine I Chen, MD, Nizar Bahlis, MD, Cristina Gasparetto, MD, Sascha A Tuchman, MD, Brea C. Lipe, MD, Muhamed Baljevic, MD, Rami Kotb, MD, Heather J. Sutherland, MD PhD, William I. Bensinger, Michael Sebag, MD PhD, Richard Leblanc, MDFRCPC, Christopher P Venner, MD, Gary J. Schiller, MD, Suzanne Lentzsch, MD PhD, Natalie Scott Callander, MD, Heidi Sheehan, Yi Chai, Kazuharu Kai, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G. Kauffman, MD PhD, Darrell J White, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 141.
https://doi.org/10.1182/blood-2019-122907
Published: 2019
Journal Articles

Effect of Prior Therapy on the Efficacy and Safety of Oral Selinexor in Patients with Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): A Post-Hoc Analysis of the Sadal Study

Federica Cavallo, MD PhD, George A Follows, MD PhD, Andre Goy, MD, Joost Vermaat, MD PhD, Rene-Olivier Casasnovas, MD, Orly Lavee, MD, Marie Maerevoet, MD, Josée M Zijlstra, MD PhD, Sameer Bakhshi, MD, Reda Bouabdallah, Sylvain Choquet, MD, Ronit Gurion, MD, Brian T. Hill, MD, Ulrich Jaeger, MD, Juan-Manuel Sancho, MD PhD, Michael W. Schuster, MD, Catherine Thieblemont, MD PhD, Fatima De la Cruz, MD, Miklos Egyed, MD PhD, Sourav Mishra, Fritz Offner, MD, Theodoros P. Vassilakopoulos, MD PhD, Krzysztof Warzocha, Daniel McCarthy, Xiwen Ma, Kelly Corona, Jean-Richard Saint-Martin, Anita Joshi, PhD, Jatin Shah, MD, Eric Van Den Neste, MD, Miguel A Canales, MD PhD, Nagesh Kalakonda, FRCPath PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5333.
https://doi.org/10.1182/blood-2019-122900
Published: 2019
Journal Articles

A Phase 1b/2 Study of Selinexor, Carfilzomib, and Dexamethasone (SKd) in Relapsed/ Refractory Multiple Myeloma (RRMM)

Cristina Gasparetto, MD, Gary J. Schiller, MD, Natalie Scott Callander, MD, Suzanne Lentzsch, MD PhD, Sascha A Tuchman, MD, Nizar Bahlis, MD, Darrell J White, MD, Christine I Chen, MD, Heather J. Sutherland, MD PhD, Muhamed Baljevic, MD, Rami Kotb, MD, Richard Leblanc, MDFRCPC, Michael Sebag, MD PhD, Christopher P Venner, MD, William I. Bensinger, Heidi Sheehan, Yi Chai, Kazuharu Kai, MD, Jatin Shah, MD, Sharon Shacham, PhD MBA, Michael G. Kauffman, MD PhD, Brea C. Lipe, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3157.
https://doi.org/10.1182/blood-2019-122902
Published: 2019
Journal Articles

Selinexor-Containing Regimens for the Treatment of Patients with Multiple Myeloma Refractory to Chimeric Antigen Receptor T-Cell (CAR-T) Therapy

Ajai Chari, MD, Dan T. Vogl, MD, Sundar Jagannath, MD, Jagoda K. Jasielec, MD, Andrew DeCastro, PhD, TJ Unger, PhD, Jatin Shah, MD, Andrzej Jakubowiak, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1854.
https://doi.org/10.1182/blood-2019-128887
Published: 2019
Journal Articles

Response to Therapy and the Effectiveness of Treatment with Selinexor and Dexamethasone in Patients with Penta-Exposed Triple-Class Refractory Myeloma Who Had Plasmacytomas

Andrew J. Yee, MD, Carol Ann Huff, MD, Ajai Chari, MD, Dan T. Vogl, MD, Maria Gavriatopoulou, MD, Ajay K Nooka, MDMPH, Philippe Moreau, MD, David Dingli, MD PhD, Craig E. Cole, MD, Sagar Lonial, Meletios A. Dimopoulos, MD, Joshua R Richter, MD, Ravi Vij, MBBS, Sascha A Tuchman, MD, James E. Hoffman, MD, Luciano J. Costa, MD PhD, Terri L Parker, MD, Philip Vlummens, MD, Chantal Doyen, MD, Noa Biran, MD, David S. Siegel, Jatin Shah, MD, Carla Picklesimer, Jean-Richard Saint-Martin, Lingling Li, Michael G. Kauffman, MD PhD, Sharon Shacham, PhD MBA, Paul G. Richardson, MD, Sundar Jagannath, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3140.
https://doi.org/10.1182/blood-2019-129038
Published: 2019
Journal Articles

A Phase Ib/II Trial of Selinexor Combined with Lenalidomide and Low Dose Dexamethasone in Patients with Relapsed / Refractory Multiple Myeloma

Darrell J White, MD, Nizar J. Bahlis, MD, Christopher P. Venner, MD, Gary J Schiller, MD, Cristina J. Gasparetto, MD, Heather J. Sutherland, MD PhD FRCPC, Michael Sebag, MD PhD, Suzanne Lentzsch, MD PhD, Rami Kotb, MD, William Bensinger, MD, Brea C. Lipe, MD, Christine I Chen, MD FRCP(C), Aldo Del Col, BSPharm, MBA, Michael G. Kauffman, MD PhD, Sharon Shacham, PhD MBA, Jacqueline Jeha, Jean-Richard Saint-Martin, Jatin Shah, MD, Richard LeBlanc, MDFRCPC
Journal: Blood
Blood (2017) 130 (Supplement 1): 1861.
https://doi.org/10.1182/blood.V130.Suppl_1.1861.1861
Published: 2017
Journal Articles

A Phase 1b Study to Assess the Combination of Selinexor and Daratumumab in Patients with Relapsed / Refractory Multiple Myeloma Previously Exposed to Proteasome Inhibitors (PI) and Immunomodulatory Drugs (IMiDs)

Cristina J. Gasparetto, MD, Suzanne Lentzsch, MD PhD, Gary J Schiller, MD, William Bensinger, MD, Nizar J. Bahlis, MD, Heather J. Sutherland, MD PhD FRCPC, Darrell J White, MD, Michael Sebag, MD PhD, Rami Kotb, MD, Christopher P. Venner, MD, Richard LeBlanc, MDFRCPC, Christine I Chen, MD FRCP(C), Aldo Del Col, BSPharm, MBA, Michael G. Kauffman, MD PhD, Sharon Shacham, PhD MBA, Jacqueline Jeha, Jean-Richard Saint-Martin, Jatin Shah, MD, Brea C. Lipe, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3100.
https://doi.org/10.1182/blood.V130.Suppl_1.3100.3100
Published: 2017
Journal Articles

Selinexor in Combination with Weekly Low Dose Bortezomib and Dexamethasone (SVd) Induces a High Response Rate with Durable Responses in Patients with Refractory Multiple Myeloma (MM)

Nizar J. Bahlis, MD, Heather Sutherland, MD, Darrell J White, MD, Michael Sebag, MD PhD, Suzanne Lentzsch, MD PhD, Rami Kotb, MD, Christopher P. Venner, MD, Cristina J. Gasparetto, MD, Gary J Schiller, MD, Richard LeBlanc, MDFRCPC, William Bensinger, MD, Brea Lipe, MD, Aldo Del Col, BSPharm, MBA, Michael G. Kauffman, MD PhD, Sharon Shacham, PhD MBA, Jacqueline Jeha, Jean-Richard Saint-Martin, BS, Jatin Shah, MD, Christine I Chen, MD FRCP(C)
Journal: Blood
Blood (2017) 130 (Supplement 1): 3135.
https://doi.org/10.1182/blood.V130.Suppl_1.3135.3135
Published: 2017
Journal Articles

Selinexor in Combination with Pomalidomide and Low Dose Dexamethasone in a Relapsed / Refractory Multiple Myeloma Patient Population with Prior Proteasome Inhibitor and Lenalidomide Exposure

Christine I Chen, MD FRCP(C), Heather J. Sutherland, MD PhD FRCPC, Rami Kotb, MD, Michael Sebag, MD PhD, Darrell J White, MD, William Bensinger, MD, Cristina J. Gasparetto, MD, Richard LeBlanc, MDFRCPC, Christopher P. Venner, MD, Suzanne Lentzsch, MD PhD, Gary J. Schiller, Brea C. Lipe, MD, Aldo Del Col, BSPharm, MBA, Michael G. Kauffman, MD PhD, Sharon Shacham, PhD MBA, Jacqueline Jeha, Jean-Richard Saint-Martin, Jatin Shah, MD, Nizar J. Bahlis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3136.
https://doi.org/10.1182/blood.V130.Suppl_1.3136.3136
Published: 2017
Journal Articles

Global, Prospective, Non-Interventional, Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Patients: The Insight-MM Study

Robert M Rifkin, Faith E Davies, MD, Antonio Palumbo, MD, Jeffrey Zonder, MD, Saulius K Girnius, MD, Caitlin L Costello, MD, Saad Z Usmani, MD FACP, Jesus G. Berdeja, MD, Jim Omel, Michael A Thompson, MD PhD, Jatin Shah, MD, J Sanford Schwartz, Roman Hajek, MD, Evangelos Terpos, MD PhD, Vânia Hungria, MD PhD, Maria-Victoria Mateos, MD PhD, Gordon Cook, Xavier Leleu, Andrew Spencer, Hartmut Goldschmidt, MD, Brian Seal, RPh, MBA, PhD, Chris L Pashos, PhD, Dawn Marie Stull, PharmD, FRACP, Dorothy Romanus, RPh, MSc, PhD, Roxanne Cacioppo, Jill A Bell, PhD, Shawn Yu, Katarina Luptakova, Liviu Niculescu, MD PhD, Stephen J Noga, Tomas Skacel, Ajai Chari, MD
Journal: Blood
Blood (2016) 128 (22): 5681.
https://doi.org/10.1182/blood.V128.22.5681.5681
Published: 2016