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Journal Articles

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Tyler W. Stratton, MSc, Guangheng Zhu, MD, Yiming Wang, MD PhD, Pingguo Chen, PhD, Miguel A. D. Neves, PhD MSc, Reid C. Gallant, MSc, Peter A. A. Norris, BSc, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2018) 132 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2018-99-119964

Published: 2018

Journal Articles

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Jade Sullivan, BSc, Brigitta Elaine Oswald, B.Sc, Brian Vadasz, BSc, June Li, MSc, Pingguo Chen, PhD, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2017) 130 (Supplement 1): 233.

https://doi.org/10.1182/blood.V130.Suppl_1.233.233

Published: 2017

Journal Articles

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

June Li, MSc, Dianne Evertdina van der Wal, PhD, Guangheng Zhu, MD, Miao Xu, MSc, MD, Issaka Yougbare, PhD, Li Ma, PhD, Brian Vadasz, BSc, Renata Grozovsky, PhD, Min Ruan, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, Lili Tao, MD, Zhi-min Zhai, MD, Jun Peng, MD, Ming Hou, MD, Valery Leytin, PhD, John J. Freedman, MD, Karin M Hoffmeister, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 467.

https://doi.org/10.1182/blood.V124.21.467.467

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

Novel AKT Inhibitor GSK2110183 Shows Favorable Safety, Pharmacokinetics, and Clinical Activity in Multiple Myeloma. Preliminary Results From a Phase I First-Time-In-Human Study

Andrew Spencer, MD, Sung-Soo Yoon, Simon J. Harrison, MBBS MRCP (uk) MRCPath (uk) PhD, Shannon Morris, MD, PhD, Deborah Smith, PharmD, Steven J. Freedman, MD, PhD, Richard Brigandi, MD, PhD, Allen Oliff, MD, Joanna B. Opalinska, MD, PhD, Christine Chen, MD

Blood (2011) 118 (21): 1856.

https://doi.org/10.1182/blood.V118.21.1856.1856

Published: 2011

Journal Articles

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Li Guo, Rukhsana Aslam, Edwin R Speck, Heyu Ni, Ming Hou, John J. Freedman, MD, FRCPC, John W. Semple, PhD

Blood (2010) 116 (21): 3686.

https://doi.org/10.1182/blood.V116.21.3686.3686

Published: 2010

Journal Articles

Plasma Fibronectin In Thrombosis and Hemostasis: Exploring the Fibrin Dependent and Independent Mechanisms

Yiming Wang, MD, Adili Reheman, MD, Jalil Kalantari, BSc, Wuxun Jin, MD, PhD, Peter L. Gross, MD, FRCPC, Margaret L. Rand, PhD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 484.

https://doi.org/10.1182/blood.V116.21.484.484

Published: 2010

Journal Articles

The Role of ABO Blood Group In TTP Prevalence and Disease Outcome

Katerina Pavenski, MD, FRCP, Jordana Boro, John J. Freedman, MD, FRCPC, Marie B. Garvey, MD, Jerome M. Teitel, MD, FRCPC, Lisa Hicks, MD, MSc, FRCPC

Blood (2010) 116 (21): 4671.

https://doi.org/10.1182/blood.V116.21.4671.4671

Published: 2010

Journal Articles

Pregnancy-associated Thrombotic Thrombocytopenic Purpura: A Single Institution's Experience

Jordana Boro, Katerina Pavenski, MD, FRCP, John J. Freedman, MD, FRCPC, Marie B. Garvey, MD, Lisa K Hicks, MD, MSc, FRCPC

Blood (2010) 116 (21): 4675.

https://doi.org/10.1182/blood.V116.21.4675.4675

Published: 2010

Journal Articles

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

Yan Yang, MD, PhD, Zhenyin Shi, MD, Adili Reheman, MD, Wuxun Jin, MD, PhD, Conglei Li, MD, Guangheng Zhu, MD, Yiming Wang, MD, John J. Freedman, MD, Wenhua Ling, MD, PhD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 3197.

https://doi.org/10.1182/blood.V116.21.3197.3197

Published: 2010

Journal Articles

The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Yuhan Chen, Michael Kim, Arata Tabuchi, Wolfgang M. Kuebler, MD, PhD, Rukhsana Aslam, PhD, John J. Freedman, MD, FRCPC, John W. Semple, PhD

Blood (2010) 116 (21): 3351.

https://doi.org/10.1182/blood.V116.21.3351.3351

Published: 2010

Journal Articles

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Elisa K. Simpson, H.B.Sc., Guangheng Zhu, MD, Conglei Li, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, John W. Semple, PhD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 1433.

https://doi.org/10.1182/blood.V116.21.1433.1433

Published: 2010

Journal Articles

Platelet Apoptosis in Fluid-Phase and Adherent Platelets and Thrombi-Like Platelet Aggregates.

Valery Leytin, David J. Allen, Elena Lyubimov, Anna Chavlovski, Mingyu She, Sergiy Mykhaylov, Sergey P. Domogatsky, John J. Freedman

Blood (2007) 110 (11): 2102.

https://doi.org/10.1182/blood.V110.11.2102.2102

Published: 2007

Journal Articles

MK-0457, a Novel Aurora Kinase and BCR-ABL Inhibitor, Is Active Against BCR-ABL T315I Mutant Chronic Myelogenous Leukemia (CML).

Francis Giles, MD, Jorge Cortes, MD, Donald A. Bergstrom, MD, PhD, Alan Xiao, PhD, Penny Bristow, Dan Jones, MD, PhD, Srdan Verstovsek, MD, PhD, Deborah Thomas, MD, Hagop Kantarjian, MD, Steven J. Freedman, MD, PhD

Blood (2006) 108 (11): 163.

https://doi.org/10.1182/blood.V108.11.163.163

Published: 2006

Journal Articles

MK-0457, a Novel Multikinase Inhibitor, Is Active in Patients with Chronic Myeloid Leukemia (CML) and Acute Lymphocytic Leukemia (ALL) with the T315I BCR-ABL Resistance Mutation and Patients with Refractory JAK-2 Positive Myeloproliferative Diseases (MPD).

Francis Giles, MD, Jorge Cortes, MD, Donald A. Bergstrom, MD, PhD, Alan Xiao, PhD, Dan Jones, MD, PhD, Srdan Verstovsek, MD, PhD, Deborah Thomas, MD, Hagop M. Kantarjian, MD, Steven J. Freedman, MD, PhD

Blood (2006) 108 (11): 253.

https://doi.org/10.1182/blood.V108.11.253.253

Published: 2006

Journal Articles

MK-0457, a Novel Multikinase Inhibitor, Has Activity in Refractory AML, Including Transformed JAK2 Positive Myeloproliferative Disease (MPD), and in Philadelphia-Positive ALL.

Francis Giles, MD, Steven J. Freedman, MD,PhD, Alan Xiao, Gautam Borthakur, MD, Guillermo Garcia-Manero, MD, William Wierda, MD,PhD, Steven M. Kornblau, MD, Susan O’Brien, MD, Donald A. Bergstrom, MD,PhD, David A. Rizzieri, MD

Blood (2006) 108 (11): 1967.

https://doi.org/10.1182/blood.V108.11.1967.1967

Published: 2006

Journal Articles

Translational In Vivo and In Vitro Studies in Patients (pts) with Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML) and Myeloproliferative Disease (MPD) Treated with MK-0457 (MK), a Novel Aurora Kinase, Flt3, JAK2, and Bcr-Abl Inhibitor.

Raoul Tibes, MD, Francis Giles, M.D., Teresa McQueen, Donald A. Bergstrom, M.D., Ph.D., Steven J. Freedman, M.D., Ph.D., Michael Andreeff, M.D., Ph.D.

Blood (2006) 108 (11): 1362.

https://doi.org/10.1182/blood.V108.11.1362.1362

Published: 2006

Journal Articles

MK-0457, a Novel Multikinase Inhibitor, Inhibits BCR-ABL Activity in Patients with Chronic Myeloid Leukemia (CML) and Acute Lymphocytic Leukemia (ALL) with the T315I BCR-ABL Mutation.

Donald A. Bergstrom, MD, PhD, Jason B. Clark, PhD, Alan Xiao, PhD, Matthew Griffiths, PhD, Susannah Falcon, PhD, John Pollard, PhD, Steven J. Freedman, MD,PhD, Francis Giles, MD

Blood (2006) 108 (11): 637.

https://doi.org/10.1182/blood.V108.11.637.637

Published: 2006

Journal Articles

MK-0457 Is a Novel Aurora Kinase and Janus Kinase 2 (JAK2) Inhibitor with Activity in Transformed JAK2-Positive Myeloproliferative Disease (MPD).

Francis Giles, MD, Donald A. Bergstrom, MD,PhD, Guillermo Garcia-Manero, MD, Steven Kornblau, MD, Michael Andreeff, MD,PhD, Hagop Kantarjian, MD, Dan Jones, MD,PhD, Steven J. Freedman, MD,PhD, Srdan Verstovsek, MD,PhD

Blood (2006) 108 (11): 4893.

https://doi.org/10.1182/blood.V108.11.4893.4893

Published: 2006

NARROW

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Novel AKT Inhibitor GSK2110183 Shows Favorable Safety, Pharmacokinetics, and Clinical Activity in Multiple Myeloma. Preliminary Results From a Phase I First-Time-In-Human Study

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Plasma Fibronectin In Thrombosis and Hemostasis: Exploring the Fibrin Dependent and Independent Mechanisms

The Role of ABO Blood Group In TTP Prevalence and Disease Outcome

Pregnancy-associated Thrombotic Thrombocytopenic Purpura: A Single Institution's Experience

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Platelet Apoptosis in Fluid-Phase and Adherent Platelets and Thrombi-Like Platelet Aggregates.

MK-0457, a Novel Aurora Kinase and BCR-ABL Inhibitor, Is Active Against BCR-ABL T315I Mutant Chronic Myelogenous Leukemia (CML).

MK-0457, a Novel Multikinase Inhibitor, Is Active in Patients with Chronic Myeloid Leukemia (CML) and Acute Lymphocytic Leukemia (ALL) with the T315I BCR-ABL Resistance Mutation and Patients with Refractory JAK-2 Positive Myeloproliferative Diseases (MPD).

MK-0457, a Novel Multikinase Inhibitor, Has Activity in Refractory AML, Including Transformed JAK2 Positive Myeloproliferative Disease (MPD), and in Philadelphia-Positive ALL.

Translational In Vivo and In Vitro Studies in Patients (pts) with Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML) and Myeloproliferative Disease (MPD) Treated with MK-0457 (MK), a Novel Aurora Kinase, Flt3, JAK2, and Bcr-Abl Inhibitor.

MK-0457, a Novel Multikinase Inhibitor, Inhibits BCR-ABL Activity in Patients with Chronic Myeloid Leukemia (CML) and Acute Lymphocytic Leukemia (ALL) with the T315I BCR-ABL Mutation.

MK-0457 Is a Novel Aurora Kinase and Janus Kinase 2 (JAK2) Inhibitor with Activity in Transformed JAK2-Positive Myeloproliferative Disease (MPD).

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American Society of Hematology

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