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Isabel Ben Batalla
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Journal Articles

Phase Ib/II Study (NCT02488408 / BGBC003) of Bemcentinib Monotherapy or in Combination with Cytarabine or Decitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS): FINAL Results

Sonja Loges, Michael Heuser, Jolanta Chromik, Grerk Sutamtewagul, Silke Kapp-Schwoerer, Monica Crugnola, Nicola Di Renzo, Roberto Massimo Lemoli, Daniele Giovanni Mattei, Isabel Ben Batalla, Jonas Waizenegger, Melanie Janning, Lisa-Marie Rieckmann, Charles Imbusch, Niklas Beumer, David Micklam, Claudia Gorcea-Carson, Cristina Oliva, Walter Fiedler, Yesid Alvarado-Valero, Nigel McCracken, Bjorn T. Gjertsen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4287.
https://doi.org/10.1182/blood-2023-181833
Published: 2023
Journal Articles

AML Treatment By the AXL Inhibitor Bemcentinib in Combination with Cytarabine Shows Clinical Efficacy Related to TNFα and Cytotoxic Immune Cells: A Single-Cell Translational Study from the BGBC003 Trial

Niklas Beumer, Jonas S. Waizenegger, Michael Heuser, Jörg Chromik, Grerk Sutamtewagul, Silke Kapp-Schwoerer, Monica Crugnola, Nicola Di Renzo, Roberto M. Lemoli, Daniele G. Mattei, Walter Fiedler, Yesid Alvarado-Valero, David Micklem, Linn H. Nilsson, Noelly Madeleine, Nigel McCracken, Cristina Oliva, Claudia Gorcea-Carson, Lisa-Marie Rieckmann, Jenny Krause, Victoria Gensch, Isabel Ben Batalla, Melanie Janning, Nicola Gagliani, Benedikt Brors, Charles D. Imbusch, Bjorn T. Gjertsen, Sonja Loges
Journal: Blood
Blood (2023) 142 (Supplement 1): 1540.
https://doi.org/10.1182/blood-2023-185499
Published: 2023
Journal Articles

Bemcentinib (Oral AXL Inhibitor) in Combination with Low-Dose Cytarabine Is Well Tolerated and Efficacious in Older Relapsed AML Patients.Updates from the Ongoing Phase II Trial (NCT02488408) and Preliminary Translational Results Indicating Bemcentinib Elicits Anti-AML Immune Responses

Sonja Loges, Grerk Sutamtewagul, Michael Heuser, Jörg Chromik, Silke Kapp-Schwoerer, Monica Crugnola, Nicola Di Renzo, Roberto M. Lemoli, Daniele Giovanni Mattei, Isabel Ben Batalla, Monica Hellesøy, Jonas Waizenegger, Melanie Janning, Charles D. Imbusch, Niklas Beumer, Austin Rayford, Jaya Nautiyal, Tzivia Berkman-Gottlieb, David Micklem, Hani Gabra, Claudia Gorcea-Carson, James B. Lorens, Walter Fiedler, Yesid Alvarado, Bjorn T. Gjertsen, Lisa-Marie Rieckmann
Journal: Blood
Blood (2021) 138 (Supplement 1): 3410.
https://doi.org/10.1182/blood-2021-147225
Published: 2021
Journal Articles

The Combination of AXL Inhibitor Bemcentinib and Low Dose Cytarabine Is Well Tolerated and Efficacious in Elderly Relapsed AML Patients: Update from the Ongoing BGBC003 Phase II Trial (NCT02488408)

Sonja Loges, MD PhD, Michael Heuser, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, MD, Nicola Di Renzo, MD, Roberto M. Lemoli, Daniele Giovanni Mattei, MD, Isabel Ben-Batalla, PhD, Monica Hellesoy, PhD, Katherine Lorens, MD, Joseph Birkett, PhD, Stuart McPherson, BSc, Jaya Nautiyal, PhD, David Micklem, PhD, Hani Gabra, MD PhD FRCPE, FRCP, James B. Lorens, PhD, Walter Fiedler, MD, Yesid Alvarado, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-136566
Published: 2020
Journal Articles

Durable Responses Observed in Elderly AML Patients Unfit for Intensive Chemotherapy with First-in Class Selective AXL Inhibitor Bemcentinib (BGB324) in Combination with LDAC: Phase II Open-Label Study

Sonja Loges, MD, PhD, Michael Heuser, MD, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, Nicola Di Renzo, MD, Roberto Massimo Lemoli, MD, Daniele Giovanni Mattei, MD, Isabel Ben Batalla, PhD, Monica Hellesoy, PhD, David Micklem, PhD, Robert J. Holt, PhD, James B. Lorens, PhD, Muhammad Shoaib, MD, Hassan Aly, MD PhD, Wouter Hanekom, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3943.
https://doi.org/10.1182/blood-2019-128683
Published: 2019
Journal Articles

Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refractory AML and MDS

Sonja Loges, MD, PhD, Michael Heuser, MD, Joerg Chromik, Carlos E Vigil, MD, Peter Paschka, MD, Isabel Ben-Batalla, PhD, Nuray Akyüz, David Micklem, Robert Holt, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn Gjertsen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2672.
https://doi.org/10.1182/blood-2018-99-120380
Published: 2018
Journal Articles

Therapeutic Potential of Axl Blockade in BCR-ABL Negative Myeloproliferative Neoplasms (MPN)

Antonia Beitzen-Heineke, MD, Isabel Ben Batalla, PhD, Nikolaus Berenbrok, Sarina Paesler, Victoria Gensch, Gunhild von Amsberg, Philippe Schafhausen, MD, Kristoffer Riecken, PhD, Thomas Fischer, MD, Klaus Pantel, MD, PhD, Carsten Bokemeyer, MD, PhD, Sonja Loges, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3063.
https://doi.org/10.1182/blood-2018-99-118175
Published: 2018
Journal Articles

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Janik Engelmann, Isabel Ben Batalla, PhD, Hanna Taipaleenmäki, PhD, Kristoffer Riecken, PhD, Victoria Gensch, Sarina Paesler, Nikolaus Berenbrok, Maria Elena Vargas, Jonas Waizenegger, MD, Boris Fehse, PhD, Klaus Pantel, MD, PhD, Ihab S Darwish, PhD, Somasekhar Bhamidipati, PhD, Esteban Masuda, PhD, Carsten Bokemeyer, MD, PhD, Eric Hesse, MD, PhD, Sonja Loges, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1922.
https://doi.org/10.1182/blood-2018-99-118273
Published: 2018
Journal Articles

BET-Inhibition By JQ1 Promotes Proliferation and Self-Renewal Capacity of Hematopoietic Stem Cells

Mark Wroblewski, PhD, Marina Scheller-Wendorff, PhD, Raimund Bauer, PhD, Florian Udonta, Jara Schlichting, Lin Zhao, MD, Isabel Ben Batalla, PhD, Victoria Gensch, Marek Wanior, Hanna Taipaleenmäki, PhD, Simona Bolamperti, PhD, Zeynab Najafova, PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD PhD, Eric Hesse, MD PhD, Stefan Knapp, PhD, Steven Johnsen, PhD, Sonja Loges, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1900.
https://doi.org/10.1182/blood.V130.Suppl_1.1900.1900
Published: 2017
Journal Articles

The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles

Sonja Loges, MD PhD, Bjørn Tore Gjertsen, Michael Heuser, MD, Joerg Chromik, Isabel Ben-Batalla, Nuray Akyüz, David Micklem, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1375.
https://doi.org/10.1182/blood.V130.Suppl_1.1375.1375
Published: 2017
Journal Articles

BGB324, an Orally Available Selective Axl Inhibitor Exerts Anti-Leukemic Activity in the First-in-Patient Trial BGBC003 and Induces Unique Changes in Biomarker Profiles

Loges Sonja, Bjorn T. Gjertsen, Michael Heuser, Jörg Chromik, Isabel Ben Batalla, Nuray Akyüz, PhD, David Micklem, Anthony Brown, Jim Lorens, Maxim Kebenko, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2016) 128 (22): 592.
https://doi.org/10.1182/blood.V128.22.592.592
Published: 2016
Journal Articles

BGB324 Inhibits BCR-ABL TKI-Resistant Chronic Myeloid Leukemia

Isabel Ben Batalla, PhD, Robert Erdmann, PhD, Heather Jørgensen, PhD, Rebecca Mitchell, Thomas Ernst, MD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Stephen Rankin, MD, Richard E. Clark, Prof MD, Steffen Koschmieder, MD, Alexander Schultze, MD, Subir Mitra, MD, Peter Vandenberghe, Prof MD PhD, Tim H. Brümmendorf, Prof MD, Peter Carmeliet, Prof MD PhD, Gudmundur Helgason, PhD, Andreas Hochhaus, MD, Klaus Pantel, Prof MD PhD, Carsten Bokemeyer, MD, Tessa L Holyoake, Prof PhD, Sonja Loges, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1569.
https://doi.org/10.1182/blood.V126.23.1569.1569
Published: 2015
Journal Articles

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

Sarah Krause, Christian Pfeiffer, Susanne Strube, Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Sonja Loges, Jonas Waizenegger, Isabel Ben-Batalla, Gunnar Cario, Anja Möricke, Martin Stanulla, Martin Schrappe, Denis M. Schewe
Journal: Blood
Blood (2015) 125 (5): 820–830.
https://doi.org/10.1182/blood-2014-06-583062
Published: 2015
Includes: Supplemental data
Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Robert Erdmann, PhDMSc, Heather Jorgensen, PhD, Isabel Ben-Batalla, PhD, Nils Kruse, PhD, David Micklem, PhD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Alexander Schultze, MD MSc, Mark Wroblewski, MSc, Mascha Binder, Miguel Cubas-Cordova, MSc, Tobias Hadlich, MD, Melanie Janning, MD MSc, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, BSc, Jennifer Cassells, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MD, Steffen Koschmieder, MD, Peter Vandenberghe, MD PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD PhD, Tessa L. Holyoake, MD PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD, Sonja Loges, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4512.
https://doi.org/10.1182/blood.V124.21.4512.4512
Published: 2014
Journal Articles

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

Isabel Ben-Batalla, Alexander Schultze, Mark Wroblewski, Robert Erdmann, Michael Heuser, Jonas S. Waizenegger, Kristoffer Riecken, Mascha Binder, Denis Schewe, Stefanie Sawall, Victoria Witzke, Miguel Cubas-Cordova, Melanie Janning, Jasmin Wellbrock, Boris Fehse, Christian Hagel, Jürgen Krauter, Arnold Ganser, James B. Lorens, Walter Fiedler, Peter Carmeliet, Klaus Pantel, Carsten Bokemeyer, Sonja Loges
Journal: Blood
Blood (2013) 122 (14): 2443–2452.
https://doi.org/10.1182/blood-2013-03-491431
Published: 2013
Includes: Supplemental data
Journal Articles

Prognostic Significance and Target Potential of Axl in Acute Myeloid Leukemia

Alexander Schultze, M.D., M.Sc., Isabel Ben-Batalla, Ph.D., Michael Heuser, M.D., Kristoffer Weber, Ph.D., Robert Erdmann, Ph.D., Sacha Holland, Ph.D., Stefanie Sawall, Helena Fritz, M.Sc., Marc Tjwa, M.D., Ph.D., Thomas Schmidt, M.D., Walter Fiedler, M.D., Boris Fehse, Ph.D., Bjorn Dahlback, M.D., Klaus Pantel, M.D., Ph.D., Jürgen Krauter, Arnold Ganser, MD, Carsten Bokemeyer, M.D., Sonja Loges, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 940.
https://doi.org/10.1182/blood.V118.21.940.940
Published: 2011