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Journal Articles

NOTCH1 signaling during CD4 + T-cell activation alters transcription factor networks and enhances antigen responsiveness

Alec B. Wilkens, Elena C. Fulton, Margot J. Pont, Gabriel O. Cole, Isabel Leung, Sylvia M. Stull, Matthew R. Hart, Irwin D. Bernstein, Scott N. Furlan, Stanley R. Riddell

Blood (2022) 140 (21): 2261–2275.

https://doi.org/10.1182/blood.2021015144

Published: 2022

Includes: Supplemental data

Journal Articles

Clonal Analysis Reveals Functional and Transcriptional Heterogeneity of Self-Renewing Fetal Liver Hematopoietic Stem Cells

Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland

Blood (2022) 140 (Supplement 1): 8574–8575.

https://doi.org/10.1182/blood-2022-156513

Published: 2022

Journal Articles

Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo

Tessa Dignum, BS, Barbara Varnum-Finney, PhD, Sanjay Srivatsan, Stacey Dozono, Olivia Waltner, Adam Heck, PhD, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD, Brandon Hadland, MD PhD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-142607

Published: 2020

Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD

Blood (2019) 134 (Supplement_1): 3699.

https://doi.org/10.1182/blood-2019-126109

Published: 2019

Journal Articles

The Role of Notch in Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Quy Le, PhD, Brandon Hadland, MD PhD, Soheil Meshinchi, MD PhD, Irwin D. Bernstein, MD

Blood (2018) 132 (Supplement 1): 3947.

https://doi.org/10.1182/blood-2018-99-119735

Published: 2018

Journal Articles

Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis

Brandon Hadland, MD PhD, Barbara Varnum-Finney, Stacey Dozono, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD

Blood (2018) 132 (Supplement 1): 5086.

https://doi.org/10.1182/blood-2018-99-118772

Published: 2018

Journal Articles

Drug Transporter ABCB1 SNP Predicts Outcome in Patients with Acute Myeloid Leukemia Treated with Gemtuzumab Ozagamicin: A Report from Children's Oncology Group AAML0531 Trial

Lata Chauhan, PhD, Todd A Alonzo, PhD, Jim Wang, Michael R. Loken, PhD, Jessica A. Pollard, MD, Richard Aplenc, MD, Susana C. Raimondi, PhD, Roland B. Walter, MD PhD, Betsy A Hirsch, PhD, Irwin D. Bernstein, MD, Alan S Gamis, MD MPH, Soheil Meshinchi, MD PhD, Jatinder Lamba, PhD

Blood (2017) 130 (Supplement 1): 2526.

https://doi.org/10.1182/blood.V130.Suppl_1.2526.2526

Published: 2017

Journal Articles

CD33-Single Nucleotide Polymorphism (CD33-SNP) Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: Report from Children's Oncology Group AAML0531 Trial

Jatinder Lamba, PhD, Lata Chauhan, PhD, Miyoung Shin, PhD, Michael R. Loken, PhD, Jessica A. Pollard, MD, Jim Wang, Richard Aplenc, MD, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Roland B. Walter, MD PhD, Irwin D. Bernstein, MD, Alan S Gamis, MD MPH, Todd A Alonzo, PhD, Soheil Meshinchi, MD PhD

Blood (2017) 130 (Supplement 1): 3826.

https://doi.org/10.1182/blood.V130.Suppl_1.3826.3826

Published: 2017

Journal Articles

Talen Mediated Therapeutic Gene Editing Strategy for ß-Hemoglobinopathies

Christopher Lux, MDPhD, Kyle Jacoby, PhD, Sowmya Pattabhi, PhD, Julia Yang, BS, Olivier Humbert, PhD, Brian Gordon, MS, Irwin D. Bernstein, MD, David J. Rawlings, MD, Andrew M. Scharenberg, MD

Blood (2017) 130 (Supplement 1): 3340.

https://doi.org/10.1182/blood.V130.Suppl_1.3340.3340

Published: 2017

Journal Articles

Gemtuzumab ozogamicin for acute myeloid leukemia

Frederick R. Appelbaum, Irwin D. Bernstein

Blood (2017) 130 (22): 2373–2376.

https://doi.org/10.1182/blood-2017-09-797712

Published: 2017

Journal Articles

Hypoxia Potentiates Notch-Induced Expansion of Human Hematopoietic Stem/Progenitor Cells

Jianfei Fu, MD, Heather D. Huntsman, PhD, Ayla Cash, B.Sc., Patali S. Cheruku, B.Sc., Richard H. Smith, PhD, Aibin Liang, MD PhD, Irwin D. Bernstein, MD, Andre Larochelle, MD PhD

Blood (2016) 128 (22): 2640.

https://doi.org/10.1182/blood.V128.22.2640.2640

Published: 2016

Journal Articles

CD33 Splicing Polymorphism Is a Strong Predictor of Therapeutic Efficacy of Gemtuzumab Ozogamicin in De Novo AML: Report from COG-AAML0531 Study

Jatinder K Lamba, PhD, Lata Chauhan, PhD, Michael R. Loken, PhD, Jessica Pollard, MD, Yi-Cheng Wang, MS, Ries E Rhonda, Richard Aplenc, MD PhD, Betsy A. Hirsch, PhD, Susana C. Raimondi, PhD, Roland B. Walter, MD PhD, Irwin D. Bernstein, MD, Alan S. Gamis, MD MPH, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD

Blood (2016) 128 (22): 2743.

https://doi.org/10.1182/blood.V128.22.2743.2743

Published: 2016

Journal Articles

The Role of Notch in Vascular Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Quy Le, PhD, Soheil Meshinchi, Brandon Kenneth Hadland, MD PhD, Roland B. Walter, MD PhD, Irwin D. Bernstein, MD

Blood (2016) 128 (22): 2750.

https://doi.org/10.1182/blood.V128.22.2750.2750

Published: 2016

Journal Articles

Treatment of 11q23/ MLL + AML with Gemtuzumab Ozogamicin: Results from the Randomized Phase III Children's Oncology Group Trial AAML0531

Jessica Pollard, MD, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Lillian Sung, MD PhD, Richard Aplenc, MD PhD, Erin M. Guest, MD, Irwin D. Bernstein, MD, Michael R. Loken, PhD, Soheil Meshinchi, MD PhD, Alan S. Gamis, MD MPH

Blood (2015) 126 (23): 799.

https://doi.org/10.1182/blood.V126.23.799.799

Published: 2015

Journal Articles

Prevalence and Prognostic Significance of KIT Mutations in Pediatric Core Binding Factor AML Patients Treated with Gemtuzumab Ozogamicin: Results from the Randomized Phase III Children's Oncology Group Trial AAML0531

Jessica Pollard, MD, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Yi-Cheng Wang, MS, Jason Joaquin, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Lillian Sung, MD PhD, Richard Aplenc, MD PhD, Irwin D. Bernstein, MD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD

Blood (2015) 126 (23): 800.

https://doi.org/10.1182/blood.V126.23.800.800

Published: 2015

Journal Articles

Genetic Variations in Calicheamicin Pathway Genes Are Predictors of Gemtuzumab Ozogamicin Response in AML Patients: Results from COG-AAML0531 Study

Jatinder K Lamba, PhD, Lata Chauhan, PhD, Richard Aplenc, MD PhD, Maggie Skrypek, MD, Jessica Pollard, MD, Todd A. Alonzo, PhD, Y-C Wang, Irwin D. Bernstein, MD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD

Blood (2015) 126 (23): 1260.

https://doi.org/10.1182/blood.V126.23.1260.1260

Published: 2015

Journal Articles

Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro

Brandon K Hadland, MD PhD, Barbara Varnum-Finney, Randall T Moon, PhD, Michael Gustave Poulos, PhD, Jason M. Butler, PhD, Shahin Rafii, MD, Irwin D. Bernstein, MD

Blood (2014) 124 (21): 2897.

https://doi.org/10.1182/blood.V124.21.2897.2897

Published: 2014

Journal Articles

Infusion of a Non HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cell Product Following Myeloablative Cord Blood Transplantation Is Safe, Decreases the Time to Hematopoietic Recovery, and Results in Excellent Overall Survival

Filippo Milano, MD PhD, Shelly Heimfeld, PhD, Ivy B. Riffkin, Ian Nicoud, PhD, Frederick R. Appelbaum, MD, Irwin D. Bernstein, MD, Colleen Delaney, MD

Blood (2014) 124 (21): 46.

https://doi.org/10.1182/blood.V124.21.46.46

Published: 2014

Journal Articles

Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling

Elizabeth Csaszar, Weijia Wang, Tatiana Usenko, Wenlian Qiao, Colleen Delaney, Irwin D. Bernstein, Peter W. Zandstra

Blood (2014) 123 (5): 650–658.

https://doi.org/10.1182/blood-2013-08-520445

Published: 2014

Includes: Supplemental data

Journal Articles

Dose Dependent Enhancement Of Neutrophil Recovery By Infusion Of Notch Ligand Ex Vivo Expanded Cord Blood Progenitors: Results Of a Multi-Center Phase I Trial

Colleen Delaney, MD, MSC, Filippo Milano, MD, PhD, Ian Nicoud, PhD, Shelly Heimfeld, PhD, Chatchada Karanes, MD, Jonathan A Gutman, MD, John E. Wagner, MD, Frederick R. Appelbaum, MD, Irwin D. Bernstein, MD

Blood (2013) 122 (21): 297.

https://doi.org/10.1182/blood.V122.21.297.297

Published: 2013

NARROW

NOTCH1 signaling during CD4 + T-cell activation alters transcription factor networks and enhances antigen responsiveness

Clonal Analysis Reveals Functional and Transcriptional Heterogeneity of Self-Renewing Fetal Liver Hematopoietic Stem Cells

Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

The Role of Notch in Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis

Drug Transporter ABCB1 SNP Predicts Outcome in Patients with Acute Myeloid Leukemia Treated with Gemtuzumab Ozagamicin: A Report from Children's Oncology Group AAML0531 Trial

CD33-Single Nucleotide Polymorphism (CD33-SNP) Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: Report from Children's Oncology Group AAML0531 Trial

Talen Mediated Therapeutic Gene Editing Strategy for ß-Hemoglobinopathies

Gemtuzumab ozogamicin for acute myeloid leukemia

Hypoxia Potentiates Notch-Induced Expansion of Human Hematopoietic Stem/Progenitor Cells

CD33 Splicing Polymorphism Is a Strong Predictor of Therapeutic Efficacy of Gemtuzumab Ozogamicin in De Novo AML: Report from COG-AAML0531 Study

The Role of Notch in Vascular Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy

Treatment of 11q23/ MLL + AML with Gemtuzumab Ozogamicin: Results from the Randomized Phase III Children's Oncology Group Trial AAML0531

Prevalence and Prognostic Significance of KIT Mutations in Pediatric Core Binding Factor AML Patients Treated with Gemtuzumab Ozogamicin: Results from the Randomized Phase III Children's Oncology Group Trial AAML0531

Genetic Variations in Calicheamicin Pathway Genes Are Predictors of Gemtuzumab Ozogamicin Response in AML Patients: Results from COG-AAML0531 Study

Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro

Infusion of a Non HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cell Product Following Myeloablative Cord Blood Transplantation Is Safe, Decreases the Time to Hematopoietic Recovery, and Results in Excellent Overall Survival

Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling

Dose Dependent Enhancement Of Neutrophil Recovery By Infusion Of Notch Ligand Ex Vivo Expanded Cord Blood Progenitors: Results Of a Multi-Center Phase I Trial

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American Society of Hematology

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American Society of Hematology

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