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Journal Articles

Tripartite RAR fusions explain RA resistance

Hsin-Chieh Wu, Hugues de Thé

Blood (2024) 144 (14): 1461–1462.

https://doi.org/10.1182/blood.2024026117

Published: 2024

Journal Articles

In APL, noncoding mutations and SNP converge on WT1

Hsin-Chieh Wu, Hugues de Thé

Blood (2022) 140 (10): 1060–1061.

https://doi.org/10.1182/blood.2022017214

Published: 2022

Journal Articles

Clonal Hematopoiesis Driven By MDM4 Amplification Defines a Canonical Route Towards Secondary MDS/AML in Fanconi Anemia Patients

Blood (2021) 138 (Supplement 1): 860.

https://doi.org/10.1182/blood-2021-147811

Published: 2021

Journal Articles

Retinoids in hematology: a timely revival?

Marie-Claude Geoffroy, Cécile Esnault, Hugues de Thé

Blood (2021) 137 (18): 2429–2437.

https://doi.org/10.1182/blood.2020010100

Published: 2021

Journal Articles

Primitive macrophages are dispensable for HSPC mobilization and definitive hematopoiesis

Hao Yuan, Shuo Gao, Huiqiao Chen, Xiaohui Liu, Jun Zhou, Hugues de The, Jun Zhu

Blood (2019) 134 (9): 782–784.

https://doi.org/10.1182/blood.2018893974

Published: 2019

Includes: Supplemental data

Journal Articles

FLT3 -ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Cécile Esnault, Ramy Rahmé, Kim L. Rice, Caroline Berthier, Coline Gaillard, Samuel Quentin, Anne-Lise Maubert, Scott Kogan, Hugues de Thé

Blood (2019) 133 (13): 1495–1506.

https://doi.org/10.1182/blood-2018-07-866095

Published: 2019

Includes: Supplemental data

Journal Articles

Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic

Nabih Maslah1, PharmD, Tracy Dagher, PhDstudent, Valérie Edmond, PhD, Bruno Cassinat, PharmD, PhD, Valérie Lallemand-Breitenbach, PhD, Emmanuelle Verger, PhD, Isabelle Plo, PhD, Jean-Jacques Kiladjian, MD PhD, Jean-Luc Villeval, PhD, Hugues de Thé, MD PhD

Blood (2018) 132 (Supplement 1): 52.

https://doi.org/10.1182/blood-2018-99-112518

Published: 2018

Journal Articles

Arsenic Trioxide and Interferon-Alpha Eradicate Adult T Cell Leukemia Initiating Cells through PML/p53 Senescence and Activation of Innate Immunity

Hiba El Hajj, Dr, Rita Hleihel, Zaatari Ghazi, Julie Bruneau, Hideki Hasegawa, William Hall, Olivier Hermine, MD PhD, Hugues de The, MD PhD, Ali Bazarbachi, MD PhD

Blood (2017) 130 (Supplement 1): 1233.

https://doi.org/10.1182/blood.V130.Suppl_1.1233.1233

Published: 2017

Journal Articles

Whole Exome Analysis of Relapsing Patients with Acute Promyelocytic Leukemia

Cecile Bally, Jacqueline Lehmann-Che, Bruno Cassinat, PharmD, PhD, Lionel Ades, MD PhD, Eric Letouze, Pierre Hirsch, Marie-Joelle Mozziconacci, Sophie Raynaud, MD, Eric Delabesse, PharmD, PhD, Madalina Uzunov, MD, Mathilde Hunault, MD PhD, Eric Lippert, PhD, Hélène Lapillonne, MD PhD, Christophe Ferrand, PhD, Carine Gervais, MD, Nathalie Gachard, PhD, Agnès Guerci, MD PhD, Pierre Fenaux, MD PhD, Hugues de The, MD PhD

Blood (2016) 128 (22): 2892.

https://doi.org/10.1182/blood.V128.22.2892.2892

Published: 2016

Journal Articles

Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia

Sangeetha Surianarayanan, Coline M Gaillard, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, PhD, Emmanuelle Passegue, PhD, Hugues de Thé, MD PhD, Scott C. Kogan, MD

Blood (2016) 128 (22): 1518.

https://doi.org/10.1182/blood.V128.22.1518.1518

Published: 2016

Journal Articles

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

Hiba El Hajj, Zeina Dassouki, Caroline Berthier, Emmanuel Raffoux, Lionel Ades, Olivier Legrand, Rita Hleihel, Umut Sahin, Nadim Tawil, Ala Salameh, Kazem Zibara, Nadine Darwiche, Mohamad Mohty, Hervé Dombret, Pierre Fenaux, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (22): 3447–3454.

https://doi.org/10.1182/blood-2014-11-612416

Published: 2015

Includes: Supplemental data

Journal Articles

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Zeina Dassouki, Umut Sahin, Hiba El Hajj, Florence Jollivet, Youmna Kfoury, Valérie Lallemand-Breitenbach, Olivier Hermine, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (3): 474–482.

https://doi.org/10.1182/blood-2014-04-572750

Published: 2015

Includes: Supplemental data

Journal Articles

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation

Adeline Vitaliano-Prunier, Juliane Halftermeyer, Julien Ablain, Aurélien de Reynies, Laurent Peres, Morgane Le Bras, Daniel Metzger, Hugues de Thé

Blood (2014) 124 (25): 3772–3780.

https://doi.org/10.1182/blood-2014-03-561852

Published: 2014

Includes: Supplemental data

Journal Articles

Detection of TP53 Mutations in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). a Comparison Between a Functional Method (FASAY) and Next Generation Sequencing (NGS)

Cécile Bally, Aline Renneville, Lionel Adès, MD PhD, Claude Preudhomme, Hugues de Thé, MD PhD, Pierre Fenaux, MD PhD, Jacqueline Lehmann-Che, PharmD, PhD

Blood (2014) 124 (21): 3266.

https://doi.org/10.1182/blood.V124.21.3266.3266

Published: 2014

Journal Articles

Effective Targeting Of Chronic Myeloid Leukemia Initiating Activity With The Combination Of Arsenic Trioxide and Interferon Alpha

Rabab El Eit, MS, Iskandarani Ahmad, Jessica Saliba, Mark Jabbour, Rami Mahfouz, MD, MPH, Nizar Bitar, MB, DSc, MD, Hanadi ElAyoubi, Ghazi Zaatari, MD, Francois-Xavier Mahon, MD, PhD, Hugues de Thé, MD, PhD, Ali Bazarbachi, MD, PhD, Rihab Nasr

Blood (2013) 122 (21): 5171.

https://doi.org/10.1182/blood.V122.21.5171.5171

Published: 2013

Journal Articles

The Combination Of Arsenic, Interferon-Alpha, and Zidovudine Restores An “Immunocompetent-like” Micro-Environment In Patients With Adult T-Cell Leukemia/Lymphoma

Ghada Kchour, S. A. Rahim Rezaee, Reza Farid, Akram Ghantous, Houshang Rafatpana, Mahdi Tarhini, Mohamad-Mehdi Kooshyar, Hiba El Hajj, PhD, Fadwa Berry, Roudaina Nasser, Abbas Shirdel, Zeina Dassouki, Mohamad Ezzedine, Hossein Rahimi, Ardeshir Ghavamzadeh, Hugues de Thé, MD, PhD, Olivier Hermine, MD, PhD, Mahmoud Mahmoudi, Ali Bazarbachi, MD, PhD

Blood (2013) 122 (21): 5100.

https://doi.org/10.1182/blood.V122.21.5100.5100

Published: 2013

Journal Articles

Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?

Valérie Lallemand-Breitenbach, Hugues de Thé

Blood (2013) 122 (12): 2008–2010.

https://doi.org/10.1182/blood-2013-06-505115

Published: 2013

Journal Articles

Prognostic Value of TP53 Gene Mutations in Higher Risk MDS Treated with Azacitidine

Cecile Bally, Lionel Ades, MD, PhD, Aline Renneville, MD, Claude Preudhomme, Marie-Joelle Mozziconacci, MD, PhD, Hugues de The, MD, PhD, Jacqueline Lehmann-Che, Pierre Fenaux, MD, PhD

Blood (2012) 120 (21): 1706.

https://doi.org/10.1182/blood.V120.21.1706.1706

Published: 2012

Journal Articles

Incidence and Prognostic Value of TP53 Mutations in Lower Risk MDS with Del 5q.

Cecile Bally, Lionel Ades, MD, PhD, Aline Renneville, MD, Sophie Raynaud, Virginie Eclache, MD, Thomas Cluzeau, MD, PhD, Mathilde Hunault-Berger, MD, PhD, Aspasia Stamatoullas, MD, Christian Bastard, MD, Michaela Fontenay, MD, PhD, Marie-Joelle Mozziconacci, MD, PhD, Claude Preudhomme, Hugues de The, MD, PhD, Pierre Fenaux, MD, PhD, Jacqueline Lehmann-Che, PharmD, PhD

Blood (2012) 120 (21): 2809.

https://doi.org/10.1182/blood.V120.21.2809.2809

Published: 2012

Journal Articles

Sumoylation of CCAAT/enhancer–binding protein α promotes the biased primitive hematopoiesis of zebrafish

Hao Yuan, Jun Zhou, Min Deng, Yong Zhang, Yi Chen, Yi Jin, Jiang Zhu, Sai Juan Chen, Hugues de The, Zhu Chen, Ting Xi Liu, Jun Zhu

Blood (2011) 117 (26): 7014–7020.

https://doi.org/10.1182/blood-2010-12-325712

Published: 2011

Includes: Supplemental data

NARROW

Tripartite RAR fusions explain RA resistance

In APL, noncoding mutations and SNP converge on WT1

Clonal Hematopoiesis Driven By MDM4 Amplification Defines a Canonical Route Towards Secondary MDS/AML in Fanconi Anemia Patients

Retinoids in hematology: a timely revival?

Primitive macrophages are dispensable for HSPC mobilization and definitive hematopoiesis

FLT3 -ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic

Arsenic Trioxide and Interferon-Alpha Eradicate Adult T Cell Leukemia Initiating Cells through PML/p53 Senescence and Activation of Innate Immunity

Whole Exome Analysis of Relapsing Patients with Acute Promyelocytic Leukemia

Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation

Detection of TP53 Mutations in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). a Comparison Between a Functional Method (FASAY) and Next Generation Sequencing (NGS)

Effective Targeting Of Chronic Myeloid Leukemia Initiating Activity With The Combination Of Arsenic Trioxide and Interferon Alpha

The Combination Of Arsenic, Interferon-Alpha, and Zidovudine Restores An “Immunocompetent-like” Micro-Environment In Patients With Adult T-Cell Leukemia/Lymphoma

Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?

Prognostic Value of TP53 Gene Mutations in Higher Risk MDS Treated with Azacitidine

Incidence and Prognostic Value of TP53 Mutations in Lower Risk MDS with Del 5q.

Sumoylation of CCAAT/enhancer–binding protein α promotes the biased primitive hematopoiesis of zebrafish

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American Society of Hematology

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American Society of Hematology

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