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Journal Articles

Ex Vivo Drug Sensitivity and Functional Genomics Platform Identifies Novel Combinations Targeting Intrinsic and Extrinsic Apoptotic Signaling Pathways in Multiple Myeloma

Ariosto Siqueira Silva, PhD, Rafael Renatino-Canevarolo, PhD, Mark B. Meads, PhD, Maria D Coelho Siqueira Silva, MSc, Praneeth Reddy Sudalagunta, PhD, Christopher Cubitt, Gabriel De Avila, BS, Raghunandan Reddy Alugubelli, Amit Kulkarni, PhD, Melissa Mitchell, Hongyue Dai, Qi Zhang, PhD, Oliver Hampton, Xin Lu, Dimple A. Modi, PhD, Monica Motwani, PhD, Jason Harb, PhD, Jeremy A. Ross, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-134924
Published: 2020
Journal Articles

Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker

Michael J Mason, PhD, Carolina D. Schinke, MD, Christine Eng, PhD, Fadi Towfic, PhD, Fred Gruber, PhD, Brian S. White, Yi Cui, PhD, Bailiang Li, PhD, Thomas Yu, BS, William S. Dalton, PhDMD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, MD PhD, Mehmet Samur, PhD, Maria Ortiz, Matthew Trotter, PhD, Boris Hayete, PhD, Andrew Dervan, Erin Flynt, Hongyue Dai, PhD, Douglas Bassett, PhD, Pieter Sonneveld, Kenneth H. Shain, MD PhD, Nikhil C. Munshi, MD, Daniel Auclair, Dirk Hose, MD, Gareth Morgan, MDPhDFRCP, Jonathan Göke, PhD, Brian A Walker, PhD, Anjan Thakurta, Justin Guinney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4370.
https://doi.org/10.1182/blood-2019-127362
Published: 2019
Journal Articles

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance

Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Alexandre Tungesvik, MD, Gabriel De Avila, Alugubelli Raghunandan Reddy, Minerva Nong, Jamie Teer, PhD, Eric A. Welsh, PhD, Tint Lwin, MD PhD, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5544.
https://doi.org/10.1182/blood-2019-128442
Published: 2019
Journal Articles

Reinforcement Learning to Optimize the Treatment of Multiple Myeloma

Kenneth H. Shain, MD PhD, Daniel Hart, Ariosto Siqueira Silva, PhD, Raghunandanreddy Alugubelli, MS, Gabriel De Avila, BS, Praneeth Reddy Sudalagunta, PhD, Alexandre Tungesvik, MD, Amit Kulkarni, PhD, Carmelo Blancuicett, PhD MD, Hongyue Dai, PhD, Taiga Nishihori, MD, Jason B. Brayer, PhDMD, Brandon Blue, MD, Melissa Alsina, MD, Rachid Baz, MD, William S. Dalton, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5511.
https://doi.org/10.1182/blood-2019-132234
Published: 2019
Journal Articles

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Anders Berglund, Paula S. Oliveira, Allison Distler, Praneeth Reddy Sudalagunta, PhD, Timothy Jacobson, Jamie Teer, PhD, Eric A. Welsh, PhD, Hongyue Dai, PhD, John M. Koomen, PhD, Alugubelli Raghunandan Reddy, Gabriel De Avila, Alexandre Tungesvik, MD, William Roush, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD, John Cleveland, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5537.
https://doi.org/10.1182/blood-2019-130830
Published: 2019
Journal Articles

A Systems Biology Approach to Identify Mechanisms of Therapy Resistance in Multiple Myeloma

Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Mark B. Meads, PhD, Priscilla Granados, Anders Berglund, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, Kenneth H. Shain, MD PhD, Ariosto Siqueira Silva, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3266.
https://doi.org/10.1182/blood-2018-99-118784
Published: 2018
Journal Articles

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Mark B. Meads, PhD, Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Paula S. Oliveira, Dario M. Magaletti, Bin Fang, PhD, Maria D Coelho Siqueira Silva, MSc, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, John M. Koomen, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 950.
https://doi.org/10.1182/blood-2018-99-120269
Published: 2018
Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4411.
https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411
Published: 2017
Journal Articles

Crowdsourcing a High-Risk Classifier for Multiple Myeloma Patients

Andrew P Dervan, Michael Mason, PhD, Fadi Towfic, PhD, Michael Amatangelo, PhD, Daniel Auclair, PhD, Douglas Bassett, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Samuel Danziger, PhD, Erin Flynt, PhD, Hartmut Goldschmidt, MD, Justin Guinney, PhD, Dirk Hose, MD, Konstantimos Mavrommatis, PhD, Gareth J. Morgan, MD PhD, Nikhil Munshi, MD, Alexander Ratushny, PhD, Dan Rozelle, PhD, Mehmet Kemal Samur, PhD, Frank Schmitz, MD PhD, Kenneth H Shain, MD PhD, Matthew Trotter, PhD, Brian A Walker, PhD, Brian S. White, PhD, Thomas Yu, BS, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 265.
https://doi.org/10.1182/blood.V130.Suppl_1.265.265
Published: 2017
Journal Articles

A CK1δ/CK1ε-to-β-Catenin Circuit Is a Therapeutic Vulnerability for Primary and Drug Resistant Multiple Myeloma

Karen L Burger, PhD, Mark B. Meads, PhD, Ariosto Siqueira Silva, PhD, Paula Oliveira, Tuan Nguyen, Allison Distler, Maria Coelho Siqueira Silva, Timothy Jacobson, Jamie Teer, PhD, Hongyue Dai, PhD, William Roush, PhD, John Cleveland, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 591.
https://doi.org/10.1182/blood.V130.Suppl_1.591.591
Published: 2017