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Journal Articles

Acid Ceramidase (ASAH1) Is a Key Mediator of Drug Resistance in Refractory Multiple Myeloma

Ryan T Bishop, Tao Li, Raghunandan Reddy Alugubelli, Mark Meads, Bin Fang, Gabriel De Avila, Oliver Hampton, Steven Grant, John M. Koomen, Ariosto Siqueira Silva, Kenneth H. Shain, Conor Lynch
Journal: Blood
Blood (2022) 140 (Supplement 1): 5977–5978.
https://doi.org/10.1182/blood-2022-170103
Published: 2022
Journal Articles

Oxidative Phosphorylation Regulated By PGC-1α Promotes Multiple Myeloma Progression

Yu Xiang, MD, Bin Fang, MD, Yilin Liu, MD, Siqi Yan, MD, Yicheng Zhang, Tao Guo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5524.
https://doi.org/10.1182/blood-2019-127807
Published: 2019
Journal Articles

Integrated Multi-Level Omics to Characterize Bortezomib Resistance in Multiple Myeloma

David C. Koomen, BS, Mark B. Meads, PhD, Dario M. Magaletti, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Victoria Izumi, MS, Rafael Renatino-Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Maria Silva, Raghunandanreddy Alugubelli, MS, Gabe De Avilla, Alex Tungeskiv, Eric A. Welsh, PhD, Laurel E. Meke, Wei Zhang, PhD, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, Ariosto Siqueira Silva, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5534.
https://doi.org/10.1182/blood-2019-132001
Published: 2019
Journal Articles

Systems Biology Analysis Identifies Targetable Vulnerability Networks to Proteasome Inhibitors in Multiple Myeloma

Mark B. Meads, PhD, Rafael Renatino Canevarolo, PhD, Praneeth Reddy Sudalagunta, PhD, Paula S. Oliveira, Dario M. Magaletti, Bin Fang, PhD, Maria D Coelho Siqueira Silva, MSc, Amit Kulkarni, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Ion Petre, PhD, John M. Koomen, PhD, Ariosto Siqueira Silva, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 950.
https://doi.org/10.1182/blood-2018-99-120269
Published: 2018
Journal Articles

Proteometabolomics of Melphalan Resistance in Multiple Myeloma

David C. Koomen, BS, Joy D. Guingab, PhD, Paula S. Oliveira, Bin Fang, PhD, Min Liu, PhD, Eric A. Welsh, PhD, Mark B. Meads, PhD, Tuan Nguyen, Laurel E. Meke, Steven A. Eschrich, PhD, Timothy J. Garrett, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5619.
https://doi.org/10.1182/blood-2018-99-117747
Published: 2018
Journal Articles

Pharmacoproteomics Identifies PLK1 As Vulnerability for Aggressive B-Cell Lymphomas

Yuan Ren, PhD, Chengfeng Bi, MD PhD, Xiaohong Zhao, MD PhD, Tint Lwin, MD PhD, Wang Cheng, MD, Ji Yuan, Ariosto Siqueira Silva, PhD, Bijal D. Shah, MD, Bin Fang, PhD, Tao Li, John M. Koomen, PhD, Huijuan Jiang, MD, Julio C. Chavez, MD, Lan V. Pham, PhD, Praneeth Reddy Sudalagunta, PhD, Lixin Wan, Xuefeng Wang, PhD, William S. Dalton, PhD MD, Lynn C. Moscinski, MD, Kenneth H. Shain, MD PhD, Julie M. Vose, MD MBA, John Cleveland, PhD, Eduardo Sotomayor, MD, Kai Fu, MD PhD, Jianguo Tao, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2018-99-118004
Published: 2018
Journal Articles

20(S)-Protopanaxatriol Promotes Fatty Acid-Induced ER Stress and Apoptosis in Multiple Myeloma By Down-Regulating SCD1 Expression

Qiuguo Wang, Siqi Yan, Xiaoran Zhou, Huiling Mei, Yu Xiang, Bin Fang, Leilei Zhang, Yu Hu, MD PhD, Qiuguo Wang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3219.
https://doi.org/10.1182/blood-2018-99-118181
Published: 2018
Journal Articles

Identification of Target Pathways of Acquired IMiD and Proteasome Inhibitor Resistance in Multiple Myeloma

Mark B. Meads, PhD, Paula Oliveira, Bin Fang, Praneeth Sudalagunta, PhD, Maria D Coelho Siqueira Silva, MSc, Tuan Nguyen, Allison Distler, Salah-Eddin Komrokji, Aunshka Collins, Hongyue Dai, PhD, John M. Koomen, Ariosto Siqueira Silva, PhD, Kenneth H Shain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4411.
https://doi.org/10.1182/blood.V130.Suppl_1.4411.4411
Published: 2017
Journal Articles

Identification of Target Pathways Induced By the Multiple Myeloma Tumor Microenvironment Using Activity-Based Protein Profiling and Ex Vivo Protein Kinase Inhibitor Screening

Mark B Meads, PhD, Paula Oliveira, BS, Allison Distler, B.S., Maria Silva, M.Sc, Karen Burger, PhD, Bin Fang, PhD, Aunshka Collins, BS, John L. Cleveland, PhD, John M. Koomen, PhD, Ariosto Silva, PhD, Dmitri Rebatchouk, PhD, Kenneth H. Shain, MD PhD, William R. Roush, PhD
Journal: Blood
Blood (2016) 128 (22): 3288.
https://doi.org/10.1182/blood.V128.22.3288.3288
Published: 2016
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, MS, Liang Nong, MD, Ismael Rosado-Lopez, Tuan Nguyen, Jennifer E. Ring, William Matsui, MD, Robert MacLeod, PhD, David T. Weaver, PhD, Jonathan A. Pachter, PhD, Lori A. Hazlehurst, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3008.
https://doi.org/10.1182/blood.V126.23.3008.3008
Published: 2015
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, MD, Ismael Rosado-Lopez, BS, Jennifer E. Ring, Robert MacLeod, PhD, Lori Hazlehurst, PhD, Conor Lynch, PhD, Jonathan A. Pachter, PhD, William Matsui, MD, John Koomen, PhD, Tuan Nguyen
Journal: Blood
Blood (2014) 124 (21): 2081.
https://doi.org/10.1182/blood.V124.21.2081.2081
Published: 2014
Journal Articles

PYK2 Mediates Microenvironment-Specific Myeloma Survival

Mark Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, M.D., Lori A Hazlehurst, Ph.D, Robert MacLeod, PhD, John Koomen, Ph.D., Kenneth Shain, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4443.
https://doi.org/10.1182/blood.V122.21.4443.4443
Published: 2013
Journal Articles

Combination Immunotherapy After ASCT for Multiple Myeloma (MM) Using MAGE-A3/Poly-ICLC Immunizations Followed by Vaccine-Primed and Activated Autologous T-Cells

Aaron P. Rapoport, MD, Nicole A. Aqui, MD, Edward A. Stadtmauer, MD, Ashraf Z. Badros, MD, Dan T. Vogl, MD, MSCE, YinYan Xu, Brendan M Weiss, MD, Ling Cai, PhD, Hong-Bin Fang, PhD, Elizabeth Veloso, RN, JD, Zhaohui Zheng, MA, Saul Yanovich, MD, Gorgun Akpek, MD, MHS, Sunita Philip, Kathleen Ruehle, RN, Kelly-Marie Betts, MS, Anne Chew, PhD, Holly McConville, RN, BSN, Sandra Westphal, Scott Strome, Andres Salazar, MD, Bruce L. Levine, PhD, Carl H. June, MD
Journal: Blood
Blood (2012) 120 (21): 352.
https://doi.org/10.1182/blood.V120.21.352.352
Published: 2012
Journal Articles

Pyk2 Mediates Enhanced STAT3 Phosphorylation Following Collaborative Signaling Between gp130 and beta1 Integrins in Adhered Myeloma Cells

Kenneth Shain, MD, PhD, Mark Meads, PhD, Liang Nong, M.D., Jennifer Gemmer, Linda Mathews, Bin Fang, PhD, Robert MacLeod, Ph.D., John Koomen, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 4021.
https://doi.org/10.1182/blood.V120.21.4021.4021
Published: 2012
Journal Articles

Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma

Clinical Trials & Observations
Aaron P. Rapoport, Nicole A. Aqui, Edward A. Stadtmauer, Dan T. Vogl, Hong-Bin Fang, Ling Cai, Stephen Janofsky, Anne Chew, Jan Storek, Gorgun Akpek, Ashraf Badros, Saul Yanovich, Ming T. Tan, Elizabeth Veloso, Marcela F. Pasetti, Alan Cross, Sunita Philip, Heather Murphy, Rita Bhagat, Zhaohui Zheng, Todd Milliron, Julio Cotte, Andrea Cannon, Bruce L. Levine, Robert H. Vonderheide, Carl H. June
Journal: Blood
Blood (2011) 117 (3): 788–797.
https://doi.org/10.1182/blood-2010-08-299396
Published: 2011
Includes: Supplemental data
Journal Articles

Schedule Dependent Effects of Adoptively Transferred Autologous T Cells After AutoSCT for Myeloma: Accelerated Immune Recovery Is Associated with Improved Event-Free Survival.

Aaron P. Rapoport, MD, Nicole A. Aqui, MD, Edward A. Stadtmauer, MD, Dan T. Vogl, MD, Hong-Bin Fang, PhD, Stephen Janofsky, BS, Jan Storek, MD, PhD, Anne Chew, PhD, Elizabeth Veloso, JD, Gorgun Akpek, MD, MS, Saul Yanovich, MD, Ming T. Tan, PhD, Yin Wu, MD, Alan Cross, MD, Sunita Philip, MPH, Heather Murphy, Rita Bhagat, RN, Yiping Liu, Bruce Levine, PhD, Robert H. Vonderheide, MD, DPhil, Carl H. June, MD
Journal: Blood
Blood (2009) 114 (22): 784.
https://doi.org/10.1182/blood.V114.22.784.784
Published: 2009