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Journal Articles

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Hiroyuki Takamatsu, MDPhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-136893

Published: 2020

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia

Atsushi Narita, Hideki Muramatsu, MD PhD, Yinyan Xu, Motoharu Hamada, MD PhD, Daisuke Ichikawa, MD, Eri Nishikawa, MD PhD, Nozomu Kawashima, MD, Yusuke Okuno, MD PhD, Nobuhiro Nishio, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD, Seiji Kojima, MD PhD, Yoshiyuki Takahashi, MD PhD

Blood (2019) 134 (Supplement_1): 2505.

https://doi.org/10.1182/blood-2019-124945

Published: 2019

Journal Articles

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Tanabe Mikoto, MD, Nguyen Hoang Maianh, MD, Kohei Hosokawa, MD PhD, Noriharu Nakagawa, MD, Luis Espinoza, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3736.

https://doi.org/10.1182/blood-2019-126677

Published: 2019

Journal Articles

Randomized Trial of Two Dosages of Rabbit Antithymocyte Globulin in Patients with Aplastic Anemia

Atsushi Narita, MD PhD, Xiaofan Zhu, PhD, Hideki Muramatsu, MD PhD, Xiaojuan Chen, Ye Guo, Wenyu Yang, Jingliao Zhang, MD, Fang Liu, Jun Ho Jang, MD PhD, Hoon Kook, MD PhD, Hawk Kim, MD PhD, Kensuke Usuki, MD PhD, Hirohito Yamazaki, MD PhD, Yoshiyuki Takahashi, MD, PhD, Shinji Nakao, MD PhD, Jong-Wook Lee, MD PhD, Seiji Kojima, MD PhD

Blood (2018) 132 (Supplement 1): 3873.

https://doi.org/10.1182/blood-2018-99-111323

Published: 2018

Journal Articles

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Tanabe Mikoto, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MD PhD, Luis Espinoza, MD PhD, Kana Maruyama, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3874.

https://doi.org/10.1182/blood-2018-99-118741

Published: 2018

Journal Articles

Mixed Chimerism and Secondary Engraftment Failure in Allogeneic Transplantation for Aplastic Anemia

Shinichi Kako, MD, Hirohito Yamazaki, MD PhD, Kazuteru Ohashi, MD PhD, Yukiyasu Ozawa, MD PhD, Shuichi Ota, MD, Yoshinobu Kanda, MD PhD, Tetsuo Maeda, MD, Jun Kato, MD, Ken Ishiyama, MD PhD, Ken-Ichi Matsuoka, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Fukuda, MD PhD, Tatsuo Ichinohe, MD PhD, Yoshiko Atsuta, MD PhD, Takehiko Mori, MD PhD

Blood (2018) 132 (Supplement 1): 4631.

https://doi.org/10.1182/blood-2018-99-111175

Published: 2018

Journal Articles

A Moderate Increase in the WT1 mRNA Copy Number in Peripheral Blood of Patients with Long-Standing Acquired Aplastic Anemia without Apparent Signs of Myelodysplastic Syndrome

Ken Ishiyama, MD PhD, Takeshi Yoroidaka, MD, Noriharu Nakagawa, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD, Kohei Hosokawa, Hirohito Yamazaki, MD PhD, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2462.

https://doi.org/10.1182/blood.V130.Suppl_1.2462.2462

Published: 2017

Journal Articles

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

Hiroki Mizumaki, MD, Hirohito Yamazaki, MD PhD, Kazuyoshi Hosomichi, PhD, Noriharu Nakagawa, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Hiromi Iwasaki, MD PhD, Mika Kuroiwa, Ryosuke Ogawa, MDPhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 1176.

https://doi.org/10.1182/blood.V130.Suppl_1.1176.1176

Published: 2017

Journal Articles

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

Tatsuya Imi, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MDPhD, Ken Ishiyama, Hirohito Yamazaki, MD PhD, Koichi Kashiwase, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 1168.

https://doi.org/10.1182/blood.V126.23.1168.1168

Published: 2015

Journal Articles

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

Noriharu Nakagawa, MD, Hiroyuki Maruyama, MD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Chizuru Saito, MD, Takamasa Katagiri, PhD, Kohei Hosokawa, MD PhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 2418.

https://doi.org/10.1182/blood.V126.23.2418.2418

Published: 2015

Journal Articles

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

An T. T. Dao, MD, Kohei Hosokawa, MDPhD, Chiharu Sugimori, MD PhD, Luis J. Espinoza, MD PhD, Kana Maruyama, MD, Yoshitaka Zaimoku, MD, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Hiroyuki Takamatsu, MD PhD, Chizuru Saito, MD, Noriko Iwaki, MD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 4384.

https://doi.org/10.1182/blood.V124.21.4384.4384

Published: 2014

Journal Articles

Evidence That HLA-B40:02 and HLA-Α31:01 Are Strongly Involved in the Presentation of Autoantigens to CTLs Responsible for the Development of Acquired Aplastic Anemia

Yoshitaka Zaimoku, MD, Hiroyuki Maruyama, MD, Kana Maruyama, MD, Takamasa Katagiri, PhD, An T. T. Dao, MD, Hiroyuki Takamatsu, MD PhD, Hirohito Yamazaki, MD PhD, Koichi Kashiwase, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 2948.

https://doi.org/10.1182/blood.V124.21.2948.2948

Published: 2014

Journal Articles

Donor-Type Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism

Kana Maruyama, MD, Hiroyuki Maruyama, MD, Yoshitaka Zaimoku, MD, An T. T. Dao, MD, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 2411.

https://doi.org/10.1182/blood.V124.21.2411.2411

Published: 2014

Journal Articles

Prevalence, Clone Size and Lineage Diversity Of HLA-A Allele-Lacking Leukocytes In Patients With Acquired Aplastic Anemia

Hiroyuki Maruyama, MD, Takamasa Katagiri, Ph.D., Yoshitaka Zaimoku, MD, Chizuru Saito, MD, Kohei Hosokawa, MD, PhD, Hirohito Yamazaki, MD, PhD, Seishi Ogawa, MD, PhD, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 2475.

https://doi.org/10.1182/blood.V122.21.2475.2475

Published: 2013

Journal Articles

Increased Gene Expression Of The Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia

Kohei Hosokawa, MD, PhD, Takumi Nishiuchi, PhD, Takamasa Katagiri, Ph.D., Chizuru Saito, MD, Hiroyuki Maruyama, MD, Naomi Sugimori, MD, PhD, Hirohito Yamazaki, MD, PhD, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 1238.

https://doi.org/10.1182/blood.V122.21.1238.1238

Published: 2013

Journal Articles

CD109 Deficiency Induces Preferential Proliferation of the Piga Mutant Leukemia Cell Line TF-1 in the Presence of TGF-β

Kohei Hosokawa, MD, Takamasa Katagiri, PhD, Chizuru Saito, MD, Luis J. Espinoza, MD, PhD, Yumi Sasaki, MS, Yu Seiki, MD, Yasuhiko Yamamoto, MD, PhD, Hirohito Yamazaki, MD, PhD, Shinji Nakao, MD, PhD

Blood (2012) 120 (21): 4399.

https://doi.org/10.1182/blood.V120.21.4399.4399

Published: 2012

Journal Articles

SLIT1 Mutation in Patients with Acquired Aplastic Anemia: Its Relevance in Immune Pathophysiology

Chizuru Saito, MD, Kohei Hosokawa, MD, Takamasa Katagiri, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD, Toshiya Inaba, MD, PhD, Masafumi Taniwaki, MD, PhD, Hirohito Yamazaki, MD, PhD, Shinji Nakao, MD, PhD

Blood (2012) 120 (21): 645.

https://doi.org/10.1182/blood.V120.21.645.645

Published: 2012

Journal Articles

Thymoglobuline Is As Effective As Lymphoglobuline in Japanese Patients with Aplastic Anemia Possessing Increased Glycosylphosphatidylinositol-Anchored Protein (GPI-AP) Deficient Cells

Hirohito Yamazaki, MD, PhD, Chizuru Saito, MD, Naomi Sugimori, MD, PhD, Kohei Hosokawa, MD, Yu Kiyu, MD, Kanako Mochizuki, MD, PhD, Hiroyuki Takamatsu, MD, PhD, Shinji Nakao, MD, PhD

Blood (2011) 118 (21): 1339.

https://doi.org/10.1182/blood.V118.21.1339.1339

Published: 2011

Journal Articles

Loss of HLA Class-I Expression In Leukemic Cells That Relapsed After HLA-Matched and -Mismatched SCT

Yukio Kondo, MD, PhD, Takamasa Katagiri, Bsc, Kohei Hosokawa, MD, Kinya Ohata, MD, Hirohito Yamazaki, MD, PhD, Seishi Ogawa, MD, PhD, Shinji Nakao, MD, PhD

Blood (2010) 116 (21): 2541.

https://doi.org/10.1182/blood.V116.21.2541.2541

Published: 2010

NARROW

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Randomized Trial of Two Dosages of Rabbit Antithymocyte Globulin in Patients with Aplastic Anemia

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Mixed Chimerism and Secondary Engraftment Failure in Allogeneic Transplantation for Aplastic Anemia

A Moderate Increase in the WT1 mRNA Copy Number in Peripheral Blood of Patients with Long-Standing Acquired Aplastic Anemia without Apparent Signs of Myelodysplastic Syndrome

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

Evidence That HLA-B40:02 and HLA-Α31:01 Are Strongly Involved in the Presentation of Autoantigens to CTLs Responsible for the Development of Acquired Aplastic Anemia

Donor-Type Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism

Prevalence, Clone Size and Lineage Diversity Of HLA-A Allele-Lacking Leukocytes In Patients With Acquired Aplastic Anemia

Increased Gene Expression Of The Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia

CD109 Deficiency Induces Preferential Proliferation of the Piga Mutant Leukemia Cell Line TF-1 in the Presence of TGF-β

SLIT1 Mutation in Patients with Acquired Aplastic Anemia: Its Relevance in Immune Pathophysiology

Thymoglobuline Is As Effective As Lymphoglobuline in Japanese Patients with Aplastic Anemia Possessing Increased Glycosylphosphatidylinositol-Anchored Protein (GPI-AP) Deficient Cells

Loss of HLA Class-I Expression In Leukemic Cells That Relapsed After HLA-Matched and -Mismatched SCT

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American Society of Hematology

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American Society of Hematology

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