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Journal Articles

Precision Assessment of on- and Off-Target Effects of mTOR Kinase Inhibitors in a Mouse Model

Cuiqing Fan, PhD, Xiongwei Cai, PhD, Feng Zhang, PhDcandidate, Cindy Hochstetler, PhDcandidate, Xiaoyi Chen, PhD, Fukun Guo, PhD, Weidong Tian, PhD, Yi Zheng, PhD

Blood (2018) 132 (Supplement 1): 2632.

https://doi.org/10.1182/blood-2018-99-115225

Published: 2018

Journal Articles

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Cuiqing Fan, PhD, Chuntao Zhao, PhD, Feng Zhang, Xiongwei Cai, PhD, Lingli Xu, Shan Lin, PhD, Xiaoyi Chen, PhD, Fukun Guo, PhD, Richard Q Lu, PhD, Weidong Tian, PhD, Yi Zheng, PhD

Blood (2017) 130 (Supplement 1): 2416.

https://doi.org/10.1182/blood.V130.Suppl_1.2416.2416

Published: 2017

Journal Articles

Novel Method to Study Mouse Bone Marrow Endothelial Cells in Vivo and in Vitro

Yuxin Feng, Ming Liu, Fukun Guo, Wei Liu, Leesa Sampson, Li-Ru You, Chia-Yi Kuan, Yi Zheng, PhD

Blood (2012) 120 (21): 617.

https://doi.org/10.1182/blood.V120.21.617.617

Published: 2012

Journal Articles

Rho Gtpase Cdc42 Is Essential for Endothelial Niche Maintenance in the Bone Marrow and Hematopoiesis

Yuxin Feng, Xuan Zhou, Wei Liu, Fukun Guo, Ming Liu, Leesa Sampson, Li-Ru You, Chia-Yi Kuan, Yi Zheng

Blood (2012) 120 (21): 508.

https://doi.org/10.1182/blood.V120.21.508.508

Published: 2012

Journal Articles

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

Sachin Kumar, Juying Xu, Charles Perkins, Fukun Guo, Scott Snapper, Fred D. Finkelman, Yi Zheng, Marie-Dominique Filippi

Blood (2012) 120 (17): 3563–3574.

https://doi.org/10.1182/blood-2012-04-426981

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Targeting mTOR by a New Generation of Kinase Inhibitors Sensitizes Leukemia Cells for Chemotherapy Via Suppressing FANCD2 Expression

Jie Li, Fukun Guo, Jared Sipple, Sara Kozma, George Thomas, Yi Zheng, PhD, Qishen Pang, PhD

Blood (2011) 118 (21): 1514.

https://doi.org/10.1182/blood.V118.21.1514.1514

Published: 2011

Journal Articles

mTOR Regulates DNA Damage Response of Hematopoietic Stem and Progenitor Cells Through Modulation of Fanconi Anemia Core Complex

Fukun Guo, Jie Li, PhD, Wei Du, MD, PhD, Shuangmin Zhang, Wei Liu, M.D., M.S., George Thomas, Sara Kozma, Qishen Pang, PhD, Yi Zheng, PhD

Blood (2011) 118 (21): 864.

https://doi.org/10.1182/blood.V118.21.864.864

Published: 2011

Journal Articles

Gene Targeting of RhoA Reveals Its Essential Role In Lymphopoiesis

Shuangmin Zhang, Yi Zheng, Richard Lang, Fukun Guo

Blood (2010) 116 (21): 282.

https://doi.org/10.1182/blood.V116.21.282.282

Published: 2010

Journal Articles

Rac1 targeting suppresses p53 deficiency–mediated lymphomagenesis

Emily E. Bosco, Wenjun Ni, Lei Wang, Fukun Guo, James F. Johnson, Yi Zheng

Blood (2010) 115 (16): 3320–3328.

https://doi.org/10.1182/blood-2009-02-202440

Published: 2010

Includes: Supplemental data

Journal Articles

Rho GTPases in hematopoiesis and hemopathies

James C. Mulloy, Jose A. Cancelas, Marie-Dominique Filippi, Theodosia A. Kalfa, Fukun Guo, Yi Zheng

Blood (2010) 115 (5): 936–947.

https://doi.org/10.1182/blood-2009-09-198127

Published: 2010

Journal Articles

Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation.

Fukun Guo, PhD, Wei Liu, MD, MS, Kankana Chava, Jose Cancelas, MD, PhD, George Thomas, Sara C Kozma, PhD, Yi Zheng, PhD

Blood (2009) 114 (22): 1490.

https://doi.org/10.1182/blood.V114.22.1490.1490

Published: 2009

Journal Articles

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation

Fukun Guo, Chinavenmeni S. Velu, H. Leighton Grimes, Yi Zheng

Blood (2009) 114 (14): 2909–2916.

https://doi.org/10.1182/blood-2009-04-214676

Published: 2009

Journal Articles

The Rho GTPase Cdc42 is essential for B lyphocyte development and Activation

Fukun Guo, PhD, Yi Zheng

Blood (2008) 112 (11): 704.

https://doi.org/10.1182/blood.V112.11.704.704

Published: 2008

Journal Articles

Mobilization of Hematopoitic Stem/Progenitor Cells by a Cdc42 Activity-Specific Inhibitor

Wei Liu, MD, MS, Lei Wang, PhD, Xun Shang, PhD, Fukun Guo, PhD, Marnie A. Ryan, PhD, Hartmut Geiger, PhD, Yi Zheng, PhD

Blood (2008) 112 (11): 68.

https://doi.org/10.1182/blood.V112.11.68.68

Published: 2008

Journal Articles

A Cell-Autonomous Defect of Bone Marrow Hematopoietic Stem/Progenitor Cells and Impaired Stromal Function in FA-a Patients

Xiaoling Zhang, Xun Shang, Fukun Guo, Kim Murphy, Michelle Kirby, Patrick Kelly, Lilith Reeves, Franklin O Smith, David A. Williams, Yi Zheng, Qishen Pang

Blood (2008) 112 (11): 1364.

https://doi.org/10.1182/blood.V112.11.1364.1364

Published: 2008

Journal Articles

Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A

Xiaoling Zhang, Xun Shang, Fukun Guo, Kim Murphy, Michelle Kirby, Patrick Kelly, Lilith Reeves, Franklin O. Smith, David A. Williams, Yi Zheng, Qishen Pang

Blood (2008) 112 (5): 1683–1686.

https://doi.org/10.1182/blood-2008-03-147090

Published: 2008

Includes: Supplemental data

Journal Articles

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development

Fukun Guo, Jose A. Cancelas, David Hildeman, David A. Williams, Yi Zheng

Blood (2008) 112 (5): 1767–1775.

https://doi.org/10.1182/blood-2008-01-132068

Published: 2008

Journal Articles

R-Ras Regulates Hematopoietic Stem/Progenitor Cell Adhesion, Migration, and Mobilization through Rac GTPase-Mediated Signals.

Xun Shang, PhD, Lina Li, MD, Jose Concelas, MD PhD, Fukun Guo, PhD, Deidre Daria, MS, Hartmut Geiger, MD, Nancy Ratner, MD, Yi Zheng, PhD

Blood (2007) 110 (11): 221.

https://doi.org/10.1182/blood.V110.11.221.221

Published: 2007

Journal Articles

Gene Targeting of Cdc42 Reveals Its Essential Role in T Cell Development and Homeostasis.

Fukun Guo, PhD, David Hildeman, Ph.D., Jun Mo, M.D., Yi Zheng, Ph.D.

Blood (2007) 110 (11): 794.

https://doi.org/10.1182/blood.V110.11.794.794

Published: 2007

Journal Articles

Defective Adhesion, Migration and Homing Are Associated with Altered Rho GTPase Activity in Cells from Fanconi Anemia Patients.

Xiaoling Zhang, MD, Xun Shang, PhD, Lei Wang, PhD, Fukun Guo, PhD, Yi Zheng, PhD, Qishen Pang, PhD

Blood (2006) 108 (11): 350.

https://doi.org/10.1182/blood.V108.11.350.350

Published: 2006

NARROW

Precision Assessment of on- and Off-Target Effects of mTOR Kinase Inhibitors in a Mouse Model

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Novel Method to Study Mouse Bone Marrow Endothelial Cells in Vivo and in Vitro

Rho Gtpase Cdc42 Is Essential for Endothelial Niche Maintenance in the Bone Marrow and Hematopoiesis

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

Targeting mTOR by a New Generation of Kinase Inhibitors Sensitizes Leukemia Cells for Chemotherapy Via Suppressing FANCD2 Expression

mTOR Regulates DNA Damage Response of Hematopoietic Stem and Progenitor Cells Through Modulation of Fanconi Anemia Core Complex

Gene Targeting of RhoA Reveals Its Essential Role In Lymphopoiesis

Rac1 targeting suppresses p53 deficiency–mediated lymphomagenesis

Rho GTPases in hematopoiesis and hemopathies

Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation.

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation

The Rho GTPase Cdc42 is essential for B lyphocyte development and Activation

Mobilization of Hematopoitic Stem/Progenitor Cells by a Cdc42 Activity-Specific Inhibitor

A Cell-Autonomous Defect of Bone Marrow Hematopoietic Stem/Progenitor Cells and Impaired Stromal Function in FA-a Patients

Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development

R-Ras Regulates Hematopoietic Stem/Progenitor Cell Adhesion, Migration, and Mobilization through Rac GTPase-Mediated Signals.

Gene Targeting of Cdc42 Reveals Its Essential Role in T Cell Development and Homeostasis.

Defective Adhesion, Migration and Homing Are Associated with Altered Rho GTPase Activity in Cells from Fanconi Anemia Patients.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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