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Journal Articles

Overcoming NK Cell-Mediated Allograft Rejection By Anti-3 rd Party Central Memory Veto CD8 T Cells through Down-Regulation of the Activating Receptor DNAM-1 on Alloreactive NK Cells

Wei-Hsin Liu, Aloukick Singh, Sandeep Yadav, Esther Bachar Lustig, Yair Reisner

Blood (2024) 144 (Supplement 1): 3401.

https://doi.org/10.1182/blood-2024-203601

Published: 2024

Journal Articles

Allogeneic Veto-CAR CD8 T Cells Enabling Prolonged Graft Survival, Anti-Tumor Specificity, and Low Risk of Graft Versus Host Disease

Wei-Hsin Liu, Anat Globerson Levin, Assaf Lask, Galit Horn, Tova Waks, Bar Nathansohn Levy, Maksim Mamonkin, Zelig Eshhar, Richard E. Champlin, Yair Reisner, Esther Bachar Lustig

Blood (2023) 142 (Supplement 1): 4833.

https://doi.org/10.1182/blood-2023-175033

Published: 2023

Journal Articles

First in Human Study of Anti-Viral Veto Cells Enabling Successful Engraftment without Severe Gvhd in Non-Myeloablative T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)

Blood (2022) 140 (Supplement 1): 2120–2122.

https://doi.org/10.1182/blood-2022-159183

Published: 2022

Journal Articles

Towards Safer Allogeneic HSCT in Autoimmunity: Proof of Concept in Diabetes-Prone Mice

Rakefet Sidlik Muskatel, MD, Bar Nathansohn-Levi, PhD, Esther BACHAR Lustig, PhD, Yair Reisner, PhD

Blood (2019) 134 (Supplement_1): 3212.

https://doi.org/10.1182/blood-2019-124905

Published: 2019

Journal Articles

Proof of Concept for Repair of Sickle Cell Disease By Non-Myeloablative MHC Disparate T Cell Depleted HSCT Combined with Donor-Derived Veto Cells

Aloukick Kumar Singh, PhD, Elias Schetzen, PhD, Esther BACHAR Lustig, PhD, Wei-Hsin Liu, M.Sc, Raj Kumar Yadav, PhD, Sandeep Kumar Yadav, PhD, Kathryn McGinnis, M.Sc, Yair Reisner, PhD

Blood (2019) 134 (Supplement_1): 1919.

https://doi.org/10.1182/blood-2019-124594

Published: 2019

Journal Articles

High Levels of Hematopoietic Progenitors in the Fetal Lung Enable Induction of Immune Tolerance and Co-Transplantation of Epithelial Progenitors for Repair of Lung Injury Across MHC Barriers

Carmit Hillel Karniel, MSc, Chava Rosen, MD PhD, Esther Bachar Lustig, PhD, Elias Shezen, PhD, Yair Reisner, PhD

Blood (2016) 128 (22): 1477.

https://doi.org/10.1182/blood.V128.22.1477.1477

Published: 2016

Journal Articles

Next Generation Veto Cells for Non-Myeloablative Haploidentical HSCT: Combining Anti-Viral and Graft Facilitating Activity

Esther Bachar Lustig, PhD, Noga Or Geva, PhD, Assaf Lask, PhD, Rotem Gidron, MD, Sivan Kagan, PhD, Aloukick Kumar Sinqh, PhD, Yair Reisner, PhD

Blood (2016) 128 (22): 3345.

https://doi.org/10.1182/blood.V128.22.3345.3345

Published: 2016

Journal Articles

Chimerism Induction Without GVHD Following Low Intensity Conditioning In MHC Disparate Recipients: Combining The Benefit Of Cyclophosphamide Post Transplant With The Tolerogenicity Of Megadose T Cell Depleted HSCT

Esther Bachar-Lustig, PhD, Noga Or-Geva, MSc, Yael Zlotnikov Klionsky, MSc, Yair Reisner, PhD

Blood (2013) 122 (21): 3238.

https://doi.org/10.1182/blood.V122.21.3238.3238

Published: 2013

Journal Articles

Murine anti–third-party central-memory CD8 + T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells

Eran Ophir, Noga Or-Geva, Irina Gurevich, Orna Tal, Yaki Eidelstein, Elias Shezen, Raanan Margalit, Assaf Lask, Guy Shakhar, David Hagin, Esther Bachar-Lustig, Shlomit Reich-Zeliger, Andreas Beilhack, Robert Negrin, Yair Reisner

Blood (2013) 121 (7): 1220–1228.

https://doi.org/10.1182/blood-2012-07-441493

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7

Lior Zangi, Yael Zlotnikov Klionsky, Liran Yarimi, Esther Bachar-Lustig, Yaki Eidelstein, Elias Shezen, David Hagin, Yumi Ito, Toshiyuki Takai, Shlomit Reich-Zeliger, Assaf Lask, Oren Milstein, Steffen Jung, Vera Shinder, Yair Reisner

Blood (2012) 120 (8): 1647–1657.

https://doi.org/10.1182/blood-2012-02-410803

Published: 2012

Includes: Supplemental data

Journal Articles

Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.

Esther Bachar-Lustig, PhD, Dalit Tchorsh-Yutsis, PhD, Eran Ophir, MSc, Yael Zlotnikov Klionsky, MSc, Noga Or-Geva, BSc, Yair Reisner, PhD

Blood (2010) 116 (21): 3726.

https://doi.org/10.1182/blood.V116.21.3726.3726

Published: 2010

Journal Articles

Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo–induced central memory CD8 T cells

Eran Ophir, Yaki Eidelstein, Ran Afik, Esther Bachar-Lustig, Yair Reisner

Blood (2010) 115 (10): 2095–2104.

https://doi.org/10.1182/blood-2009-10-248716

Published: 2010

Includes: Supplemental data

Journal Articles

Tolerance Induction by Immature Dendritic Cells Is Mediated by Distinct MHC Dependent and Independent Mechanisms: A Novel Role for Perforin, Granzyme A and Toll Like Receptor 7.

Lior Zangi, Yaki Edelshtein, Yael Klionsky, Esther Bachar-Lustig, Elias Shezen, Shlomit Reich-Zeliger, PhD, Assaf Lask, Oren Milstein, Vera Shinder, Yair Reisner

Blood (2009) 114 (22): 65.

https://doi.org/10.1182/blood.V114.22.65.65

Published: 2009

Journal Articles

Ex-Vivo Acquisition of Central Memory Phenotype Is Critical for Tolerance Induction by Donor Anti-3 rd party CD8 T Cells in Allogeneic Bone Marrow Transplantation.

Yaki Edelshtein, Eran Ophir, Esther Bachar-Lustig, Ran Afik, Yair Reisner

Blood (2008) 112 (11): 2323.

https://doi.org/10.1182/blood.V112.11.2323.2323

Published: 2008

Journal Articles

Overcoming Rejection of Bone Marrow Allografts by Treg Cells in a Stringent Mouse Model for T Cell Mediated Rejection: Tolerance Induction by Third Party “Off-the-Shelf” Cells.

David Steiner, PhD, Noga Brunicki, MSc, Esther Bachar-Lustig, PhD, Yair Reisner, PhD

Blood (2005) 106 (11): 576.

https://doi.org/10.1182/blood.V106.11.576.576

Published: 2005

Journal Articles

Immune regulatory activity of CD34 + progenitor cells: evidence for a deletion-based mechanism mediated by TNF-α

Hilit Gur, Rita Krauthgamer, Esther Bachar-Lustig, Helena Katchman, Rinat Arbel-Goren, Alain Berrebi, Tirza Klein, Arnon Nagler, Antonio Tabilio, Massimo F. Martelli, Yair Reisner

Blood (2005) 105 (6): 2585–2593.

https://doi.org/10.1182/blood-2002-11-3463

Published: 2005

Journal Articles

Effective Deletion of Anti-Donor Host Memory Effector Cells by Anti-3rd Party Veto CTLs: Implications to Tolerance Induction in Presensitized Bone Marrow Recipients.

Shlomit Reich-Zeliger, PhD, Esther Bachar-Lustig, PhD, Yair Reisner, PhD

Blood (2004) 104 (11): 44.

https://doi.org/10.1182/blood.V104.11.44.44

Published: 2004

Journal Articles

Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose

Esther Bachar-Lustig, Shlomit Reich-Zeliger, Yair Reisner

Blood (2003) 102 (6): 1943–1950.

https://doi.org/10.1182/blood-2003-03-0759

Published: 2003

Journal Articles

Induction of Donor-Type Chimerism and Transplantation Tolerance Across Major Histocompatibility Barriers in Sublethally Irradiated Mice by Sca-1 + Lin − Bone Marrow Progenitor Cells: Synergism With Non-Alloreactive (Host × Donor)F 1 T Cells

Esther Bachar-Lustig, Hong Wei Li, Hilit Gur, Rita Krauthgamer, Hadar Marcus, Yair Reisner

Blood (1999) 94 (9): 3212–3221.

https://doi.org/10.1182/blood.V94.9.3212

Published: 1999

NARROW

Overcoming NK Cell-Mediated Allograft Rejection By Anti-3 rd Party Central Memory Veto CD8 T Cells through Down-Regulation of the Activating Receptor DNAM-1 on Alloreactive NK Cells

Allogeneic Veto-CAR CD8 T Cells Enabling Prolonged Graft Survival, Anti-Tumor Specificity, and Low Risk of Graft Versus Host Disease

First in Human Study of Anti-Viral Veto Cells Enabling Successful Engraftment without Severe Gvhd in Non-Myeloablative T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)

Towards Safer Allogeneic HSCT in Autoimmunity: Proof of Concept in Diabetes-Prone Mice

Proof of Concept for Repair of Sickle Cell Disease By Non-Myeloablative MHC Disparate T Cell Depleted HSCT Combined with Donor-Derived Veto Cells

High Levels of Hematopoietic Progenitors in the Fetal Lung Enable Induction of Immune Tolerance and Co-Transplantation of Epithelial Progenitors for Repair of Lung Injury Across MHC Barriers

Next Generation Veto Cells for Non-Myeloablative Haploidentical HSCT: Combining Anti-Viral and Graft Facilitating Activity

Chimerism Induction Without GVHD Following Low Intensity Conditioning In MHC Disparate Recipients: Combining The Benefit Of Cyclophosphamide Post Transplant With The Tolerogenicity Of Megadose T Cell Depleted HSCT

Murine anti–third-party central-memory CD8 + T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells

Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7

Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.

Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo–induced central memory CD8 T cells

Tolerance Induction by Immature Dendritic Cells Is Mediated by Distinct MHC Dependent and Independent Mechanisms: A Novel Role for Perforin, Granzyme A and Toll Like Receptor 7.

Ex-Vivo Acquisition of Central Memory Phenotype Is Critical for Tolerance Induction by Donor Anti-3 rd party CD8 T Cells in Allogeneic Bone Marrow Transplantation.

Overcoming Rejection of Bone Marrow Allografts by Treg Cells in a Stringent Mouse Model for T Cell Mediated Rejection: Tolerance Induction by Third Party “Off-the-Shelf” Cells.

Immune regulatory activity of CD34 + progenitor cells: evidence for a deletion-based mechanism mediated by TNF-α

Effective Deletion of Anti-Donor Host Memory Effector Cells by Anti-3rd Party Veto CTLs: Implications to Tolerance Induction in Presensitized Bone Marrow Recipients.

Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose

Induction of Donor-Type Chimerism and Transplantation Tolerance Across Major Histocompatibility Barriers in Sublethally Irradiated Mice by Sca-1 + Lin − Bone Marrow Progenitor Cells: Synergism With Non-Alloreactive (Host × Donor)F 1 T Cells

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American Society of Hematology

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American Society of Hematology

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