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Journal Articles

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Ayiesha Barnes, MS, Ann Rux, Serge Yarovoi, Sooho S Myoung, Alexandra Johnson, Grace M Lee, MD, Madelaine Duarte, BA, Mortimer Poncz, MD, Gowthami M. Arepally, MD, Douglas B. Cines, MD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-138631

Published: 2020

Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 10.

https://doi.org/10.1182/blood-2019-123132

Published: 2019

Journal Articles

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Hyunsook Ahn, MSc, John Tkaczynski, BS, Khalil Bdeir, PhD, Victoria Stepanova, Douglas B. Cines, MD, Mortimer Poncz, MD, Sergei Zaitsev

Blood (2019) 134 (Supplement_1): 3627.

https://doi.org/10.1182/blood-2019-124501

Published: 2019

Journal Articles

Fibrinolysis of Contracted Blood Clots Depends on Whether Plasminogen Activator Acts from inside or Outside

Valerie Tutwiler, PhD, Alina D. Peshkova, MS, Giang Le Minh, Sergei Zaitsev, Rustem I. Litvinov, Douglas B. Cines, MD, John W. Weisel, PhD

Blood (2018) 132 (Supplement 1): 3773.

https://doi.org/10.1182/blood-2018-99-119659

Published: 2018

Journal Articles

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Randolph Lyde, PhD, Hyunsook Ahn, Vincent Hayes, Sergei Zaistev, PhD, Shu-Wha Lin, PhD, Zaverio M. Ruggeri, MD, Renhao Li, PhD, Vladimir Muzykantov, Douglas B. Cines, MD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 990.

https://doi.org/10.1182/blood-2018-99-115262

Published: 2018

Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD

Blood (2018) 132 (Supplement 1): 271.

https://doi.org/10.1182/blood-2018-99-111381

Published: 2018

Journal Articles

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Michael Frank, MD, Douglas B. Cines, MD, Gowthami Arepally, MD

Blood (2017) 130 (Supplement 1): 3617.

https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617

Published: 2017

Journal Articles

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

Ian Johnston, BS, Jose A. Lopez, MD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2310.

https://doi.org/10.1182/blood.V130.Suppl_1.2310.2310

Published: 2017

Journal Articles

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Ian Johnston, BS, Lubica Rauova, MD PhD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 1023.

https://doi.org/10.1182/blood.V128.22.1023.1023

Published: 2016

Journal Articles

Synthetic Partially Reduced Human Neutrophil Peptide (HNP)-1 Inhibits Platelet Adhesion and Aggregation on Von Willebrand Factor-Collagen Surfaces Under Arterial Shear Stress through a Disulfide Bond Reduction Mechanism

Jenny K. McDaniel, MD, Khalil Bdeir, PhD, Douglas B. Cines, MD, X. Long Zheng, MD, PhD

Blood (2016) 128 (22): 3722.

https://doi.org/10.1182/blood.V128.22.3722.3722

Published: 2016

Journal Articles

Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy

Carlos Hipolito Villa, MD PhD, Daniel Pan, PhD, Ian Johnston, BS, Colin F Greineder, MD PhD, Marion E. Reid, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Don L. Siegel, MD, PhD,, Vladimir R Muzykantov, MD PhD

Blood (2016) 128 (22): 701.

https://doi.org/10.1182/blood.V128.22.701.701

Published: 2016

Journal Articles

Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation

Colin F Greineder, MDPhD, Ian Johnston, BS, Carlos Hipolito Villa, MD PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Vladimir R Muzykantov, MD PhD

Blood (2016) 128 (22): 2613.

https://doi.org/10.1182/blood.V128.22.2613.2613

Published: 2016

Journal Articles

Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia

Izabella Andrianova, Vincent M Hayes, BS, Daria Madeeva, MD, Rustem I. Litvinov, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, John W. Weisel, PhD, Lubica Rauova, MD PhD

Blood (2015) 126 (23): 2244.

https://doi.org/10.1182/blood.V126.23.2244.2244

Published: 2015

Journal Articles

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Vikram G. Pillai, PhD, Jialing Bao, PhD, Jenny McDaniel, MD, Catherine B. Zander1, PhD, Wenjing Cao, MD, PhD, Khalil Bdeir, PhD, Douglas B. Cines, MD, X. Long Zheng, MD PhD

Blood (2015) 126 (23): 105.

https://doi.org/10.1182/blood.V126.23.105.105

Published: 2015

Journal Articles

A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics

Colin F Greineder, MDPhD, Ian Johnston, BS, Carlos Hipolito Villa, MD PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Vladimir R Muzykantov, MDPhD

Blood (2015) 126 (23): 3454.

https://doi.org/10.1182/blood.V126.23.3454.3454

Published: 2015

Journal Articles

Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity

Carlos Hipolito Villa, MD PhD, Colin F Greineder, MDPhD, Ian Johnston, BS, Daniel Pan, PhD, Ronald Carnemolla, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Don L. Siegel, MD, PhD,, Vladimir R Muzykantov, MDPhD

Blood (2015) 126 (23): 3493.

https://doi.org/10.1182/blood.V126.23.3493.3493

Published: 2015

Journal Articles

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT)

Zheng Cai, PhD, Serge V. Yarovoi, PhD, Zhiquiang Zhu, PhD, Lubica Rauova, MD,PhD, Tatiana Lebedeva, PhD, Mortimer Poncz, MD, Gowthami M Arepally, MD, Douglas B. Cines, MD, Mark I. Greene, MD

Blood (2014) 124 (21): 465.

https://doi.org/10.1182/blood.V124.21.465.465

Published: 2014

Journal Articles

Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis

Jialing Bao, PhD, Khalil Bdeir, PhD, Don L. Siegel, MD, PhD, Douglas B. Cines, MD, X. Long Zheng, MD, PhD

Blood (2014) 124 (21): 599.

https://doi.org/10.1182/blood.V124.21.599.599

Published: 2014

Journal Articles

New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation

Vincent Hayes, Ian Johnston, BS, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 574.

https://doi.org/10.1182/blood.V124.21.574.574

Published: 2014

Journal Articles

FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT

Daria Madeeva, MD, Valerie Tutwiler, Douglas B. Cines, MD, Mortimer Poncz, MD, Lubica Rauova, MD PhD

Blood (2014) 124 (21): 575.

https://doi.org/10.1182/blood.V124.21.575.575

Published: 2014

NARROW

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Fibrinolysis of Contracted Blood Clots Depends on Whether Plasminogen Activator Acts from inside or Outside

A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Synthetic Partially Reduced Human Neutrophil Peptide (HNP)-1 Inhibits Platelet Adhesion and Aggregation on Von Willebrand Factor-Collagen Surfaces Under Arterial Shear Stress through a Disulfide Bond Reduction Mechanism

Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy

Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation

Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics

Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT)

Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis

New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation

FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT

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American Society of Hematology

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ASH Publications

American Society of Hematology

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