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David Sharon, PhD
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Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Sara Mirali, BSc, Botham Aaron, Veronique Voisin, PhD, Changjiang Xu, Jonathan St-Germain, David Sharon, PhD, Fieke W Hoff, BSc, Yihua Qiu, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G Wei Xu, Boaz Nachmias, MD PhD, Neil MacLean, Xiaoming Wang, Andrea Arruda, Mark D. Minden, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Brian Raught, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 729.
https://doi.org/10.1182/blood-2019-122784
Published: 2019
Journal Articles

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Changjiang Xu, Veronique Voisin, PhD, Gary D Bader, Jean Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3932.
https://doi.org/10.1182/blood-2018-99-120258
Published: 2018
Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Rashim Pal Singh, MSc,PhD, Danny V. Jeyaraju, PhD, Veronique Voisin, PhD, Changjiang Xu, Samir H Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman,, PhD MSC, Neil MacLean, Mark D. Minden, MD PhD, Steven M Chan, MD PhD, John E. Dick, Gary D Bader, Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2018-99-111015
Published: 2018
Journal Articles

Combination of Enasidenib and Venetoclax Shows Superior Anti-Leukemic Activity Against IDH2 Mutated AML in Patient-Derived Xenograft Models

Severine Cathelin, PhD, David Sharon, PhD, Amit Subedi, PhD, Dan Cojocari, PhD BSc, Darren C. Phillips, PhD, Joel D. Leverson, PhD, Kyle MacBeth, PhD, Brandon Nicolay, Rohini Narayanaswamy, Sebastien Ronseaux, Guowen Liu, PhD, Steven M Chan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 562.
https://doi.org/10.1182/blood-2018-99-119688
Published: 2018
Journal Articles

The Origin and Functional Impact of Mitochondrial DNA Mutations in Acute Myeloid Leukemia

Severine Cathelin, PhD, David Sharon, PhD, Michael Ryan Corces-Zimmerman, PhD, Bruno C Medeiros, MD, Ravi Majeti, MD PhD, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2496.
https://doi.org/10.1182/blood.V130.Suppl_1.2496.2496
Published: 2017
Journal Articles

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

David Sharon, PhD, Severine Cathelin, PhD, Amit Subedi, PhD, Ryan Williams, Mariana Benicio, PhD, Troy Ketela, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 297.
https://doi.org/10.1182/blood.V130.Suppl_1.297.297
Published: 2017
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017