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Daniel Nixdorf
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Journal Articles

Two Players, One Goal: BiTE ® Vs CART Targeting FLT3 in AML

Lisa Rohrbacher, Daniel Nixdorf, Helena Stadler, Bettina Brauchle, Florian Märkl, Nora Philipp, Gerulf Hänel, Anetta Marcinek, Maryam Kazerani, Alica Joana Emhardt, Giulia Magno, Rebecca L. Goldstein, Tobias Straub, Sebastian Kobold, Tara L. Chapman-Arvedson, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 3444.
https://doi.org/10.1182/blood-2023-177922
Published: 2023
Journal Articles

Beyond Mitigating Immune-Related Adverse Events: Glucocorticoids Ameliorate Bispecific Antibody-Mediated T-Cell Exhaustion I n Vitro

Amelie Muth, Nora Philipp, Anetta Marcinek, Tobias Straub, Lis Winter, Gerulf Hänel, Daniel Nixdorf, Lisa Rohrbacher, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 5389.
https://doi.org/10.1182/blood-2023-174258
Published: 2023
Journal Articles

Sting Activation Improves T-Cell Engaging Immunotherapy of Acute Myeloid Leukemia

Andreas Linder, Daniel Nixdorf, Niklas Kuhl, Ignazio Piseddu, TengTeng Xu, Gunnar Kuut, Simon Veth, Thomas Carell, Roman Kischel, Veit Hornung, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2055.
https://doi.org/10.1182/blood-2023-179115
Published: 2023
Journal Articles

Accomplices in Cure: Blinatumomab + Dasatinib Reduces TCR Signaling and Effector Function Stronger Than Ponatinib and Ameliorates T-Cell Exhaustion

Nora Philipp, Anetta Marcinek, Gerulf Hänel, Daniel Nixdorf, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 1511.
https://doi.org/10.1182/blood-2023-179286
Published: 2023
Journal Articles

Single-Cell Transcriptomic Profiling of T Cells from Blinatumomab-Treated Patients with B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Reveals Circulating CD8 T Cell Subsets Associated with Treatment Response

Francesco Corrado, Jan Wulf, Tobias Straub, Daniel Nixdorf, Anetta Marcinek, Nora Philipp, Chang-Feng Chu, Christina Zielinski, Michael von Bergwelt-Baildon, Viktoria Blumenberg, Maryam Kazerani, Marion Subklewe, Veit L. Buecklein
Journal: Blood
Blood (2023) 142 (Supplement 1): 600.
https://doi.org/10.1182/blood-2023-188970
Published: 2023
Journal Articles

CD33-TIM3 Dual CAR T Cells: Enhancing Specificity While Maintaining Efficacy Against AML

Yingshuai Wang, Wenjie Lu, Lisa Rohrbacher, Heinrich Flaswinkel, Alica Joana Emhardt, Giulia Magno, Sascha Haubner, Sebastian Kobold, Heinrich Leonhardt, Karl-Peter Hopfner, Dirk H Busch, Veit L. Buecklein, Daniel Nixdorf, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 3449.
https://doi.org/10.1182/blood-2023-180890
Published: 2023
Journal Articles

Rational Combinatorial Targeting By Adapter CAR T Cells (AdCAR-T) Prevents Antigen Escape in Acute Myeloid Leukemia (AML)

Daniel Atar, Lara Ruoff, Anna-Sophia Mast, Simon Krost, Moustafa Moustafa-Oglou, Sophia Scheuermann, Beate Kristmann, Maximilian Feige, Aysegül Canak, Katrin Wolsing, Karin Schilbach, Latifa Zekri, Martin Ebinger, Daniel Nixdorf, Marion Subklewe, Johannes Schulte, Claudia Lengerke, Niels Werchau, Joerg Mittelstaet, Peter Lang, Rupert Handgretinger, Patrick Schlegel, Christian Martin Seitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 6834.
https://doi.org/10.1182/blood-2023-185093
Published: 2023
Journal Articles

Uncovering the Enemy: Single-Cell Transcriptional Profiling of Measurable Residual Disease (MRD) Cells

Maryam Kazerani, Lucas Wange, Benjamin Tast, Maria Solovey, Daniel Nixdorf, Lisa Rohrbacher, Christina Heitmüller, Thomas Koehnke, Frauke Schnorfeil, Victoria V Grunwald, Karsten Spiekermann, Klaus H. Metzeler, Karl-Peter Hopfner, Wolfgang Enard, Veit L Buecklein, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 6321–6322.
https://doi.org/10.1182/blood-2022-167788
Published: 2022
Journal Articles

The Race Is on: BiTE Vs CART As FLT3-Directed Immunotherapies in AML

Lisa Rohrbacher, Daniel Nixdorf, Helena Stadler, Bettina Brauchle, Florian Märkl, Nora Phillip, Gerulf Hänel, Anetta Marcinek, Maryam Kazerani, Rebecca Goldstein, Michael von Bergwelt, Sebastian Kobold, Veit L Buecklein, Tara Chapman-Arvedson, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 10233–10234.
https://doi.org/10.1182/blood-2022-158452
Published: 2022
Journal Articles

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Nora Philipp, Maryam Kazerani, Alyssa Nicholls, Binje Vick, Jan Wulf, Tobias Straub, Michaela Scheurer, Amelie Muth, Gerulf Hänel, Daniel Nixdorf, Monika Sponheimer, Malte Ohlmeyer, Sonja M. Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Kai Rejeski, Oliver Weigert, Michael von Bergwelt-Baildon, Sebastian Theurich, Roman Kischel, Irmela Jeremias, Veit Bücklein, Marion Subklewe
Journal: Blood
Blood (2022) 140 (10): 1104–1118.
https://doi.org/10.1182/blood.2022015956
Published: 2022
Includes: Supplemental data
Journal Articles

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Nora Zieger, Maryam Kazerani Pasikhani, Tobias Straub, Alyssa Nicholls, Gerulf Hänel, Jan Wulf, Michaela Scheurer, Daniel Nixdorf, Monika Sponheimer, Sonja M Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Michael von Bergwelt, Karsten Spiekermann, Oliver Weigert, Sebastian Theurich, Veit L Buecklein, Roman Kischel, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 513.
https://doi.org/10.1182/blood-2021-150178
Published: 2021
Journal Articles

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Nora Zieger, Alyssa Nicholls, Jan Wulf, Gerulf Hänel, Maryam Kazerani Pasikhani, Veit Buecklein, MD, Bettina Brauchle, Anetta Marcinek, Daniel Nixdorf, Lisa Rohrbacher, Michaela Scheurer, Roman Kischel, MD, Karsten Spiekermann, MD, Oliver Weigert, MD, Sebastian Theurich, MD, Michael von Bergwelt, MD PhD, Marion Subklewe, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-137421
Published: 2020