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Journal Articles

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Nora Philipp, Maryam Kazerani, Alyssa Nicholls, Binje Vick, Jan Wulf, Tobias Straub, Michaela Scheurer, Amelie Muth, Gerulf Hänel, Daniel Nixdorf, Monika Sponheimer, Malte Ohlmeyer, Sonja M. Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Kai Rejeski, Oliver Weigert, Michael von Bergwelt-Baildon, Sebastian Theurich, Roman Kischel, Irmela Jeremias, Veit Bücklein, Marion Subklewe
Journal: Blood
Blood (2022) 140 (10): 1104–1118.
https://doi.org/10.1182/blood.2022015956
Published: 2022
Includes: Supplemental data
Journal Articles

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Nora Zieger, Maryam Kazerani Pasikhani, Tobias Straub, Alyssa Nicholls, Gerulf Hänel, Jan Wulf, Michaela Scheurer, Daniel Nixdorf, Monika Sponheimer, Sonja M Lacher, Bettina Brauchle, Anetta Marcinek, Lisa Rohrbacher, Alexandra Leutbecher, Michael von Bergwelt, Karsten Spiekermann, Oliver Weigert, Sebastian Theurich, Veit L Buecklein, Roman Kischel, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 513.
https://doi.org/10.1182/blood-2021-150178
Published: 2021
Journal Articles

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Nora Zieger, Alyssa Nicholls, Jan Wulf, Gerulf Hänel, Maryam Kazerani Pasikhani, Veit Buecklein, MD, Bettina Brauchle, Anetta Marcinek, Daniel Nixdorf, Lisa Rohrbacher, Michaela Scheurer, Roman Kischel, MD, Karsten Spiekermann, MD, Oliver Weigert, MD, Sebastian Theurich, MD, Michael von Bergwelt, MD PhD, Marion Subklewe, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-137421
Published: 2020
Journal Articles

Predictors of Efficacy for Blinatumomab in BCP-ALL Patients: Non-Responders Show Impaired CD19-BiTE®-Mediated Cytotoxicity in Vitro

Veit Bücklein, MD, Michaela Scheurer, Bettina Brauchle, MSc, Roman Kischel, MD, Michael von Bergwelt, Karsten Spiekermann, MD, Marion Subklewe, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2632.
https://doi.org/10.1182/blood-2019-129057
Published: 2019