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Daniel E. Bauer, MD PhD
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Journal Articles

ZNF410 Represses Fetal Globin By Devoted Control of CHD4/NuRD

Divya S Vinjamur, PhD, Qiuming Yao, PhD, Mitchel A. Cole, BS, Connor McGuckin, Chunyan Ren, PhD, Jing Zeng, MD, Mir Hossain, PhD, Luca Pinello, PhD, Daniel E Bauer, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-142134
Published: 2020
Journal Articles

Therapeutic Base Editing of Human Hematopoietic Stem Cells

Jing Zeng, MD, Yuxuan Wu, PhD, Chunyan Ren, PhD, Jasmine Bonanno, Anne H. Shen, Devlin Shea, Jason M Gehrke, PhD, John P Manis, MD, J. Keith Gehrke, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 612.
https://doi.org/10.1182/blood-2019-129173
Published: 2019
Journal Articles

CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53 -Mutated AML

Yuichiro Semba, MD PhD, Takuji Yamauchi, MD PhD, Fumihiko Nakao, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Luca Pinello, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3784.
https://doi.org/10.1182/blood-2019-129623
Published: 2019
Journal Articles

Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia

Shuquan Rao, PhD, Josias Brito-Frazao, Anna V. Serbin, Qiuming Yao, PhD, Kevin Luk, Yuxuan Wu, PhD, Jing Zeng, MD, Chunyan Ren, PhD, Ruth Watkinson, Myriam Armant, PhD, Luca Pinello, PhD, Akiko Shimamura, MD PhD, Benhur Lee, Scot A. Wolfe, PhD, Peter E. Newburger, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3.
https://doi.org/10.1182/blood-2019-131073
Published: 2019
Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Jean-Yves Metais, PhD, Phillip A Doerfler, PhD, Thiyagaraj Mayuranathan, Daniel E. Bauer, MD PhD, Stephanie Fowler, Matthew Hsieh, MD, Varun Katta, Sagar Keriwala, Cicera Lazzarotto, Kevin Luk, Michael Neel, Scott Perry, Shaina Porter, Byoung Y. Ryu, PhD, Akshay Sharma, MBBS, Devlin Shea, Samuel Peters, John F. Tisdale, MD, Scot A. Wolfe, PhD, Kaitly Jensen Woodard, BS, Naoya Uchida, MD, Yuxuan Wu, PhD, Yu Yao, MD, Jing Zeng, MD, Shondra M. Pruett-Miller, PhD, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2066.
https://doi.org/10.1182/blood-2019-131318
Published: 2019
Journal Articles

Paics, a De Novo Purine Synthetic Enzyme, Is a Novel Target for AML Therapy

Takuji Yamauchi, MD PhD, Kohta Miyawaki, MD, Yuichiro Semba, MD PhD, Fumihiko Nakao, MD, Takeshi Sugio, MD PhD, Kensuke Sasaki, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Simon Osborne, PhD, Luca Pinello, PhD, Deborah Taylor, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1390.
https://doi.org/10.1182/blood-2019-127047
Published: 2019
Journal Articles

Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing

Selami Demirci, PhD, Jing Zeng, MD, Yuxuan Wu, PhD, Naoya Uchida, MD, Jackson Gamer, Morgan Yapundich, Claire Drysdale, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, VMD, Anne H. Shen, Juan J. Haro-Mora, PhD, Alexis Leonard, MD, Tina Nassehi, Kevin Luk, Scot A. Wolfe, Cicera R. Lazzarotto, Shengdar Q. Tsai, PhD, Mitchell J. Weiss, MD, PhD, Daniel E. Bauer, MD PhD, John F. Tisdale, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4632.
https://doi.org/10.1182/blood-2019-129394
Published: 2019
Journal Articles

Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations

Yuxuan Wu, PhD, Mitchel A. Cole, BS, Abdou Mousas, Jing Zeng, MD, Qiuming Yao, PhD, Divya Vinjamur, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Guillame Lettre, PhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 532.
https://doi.org/10.1182/blood-2018-99-120229
Published: 2018
Journal Articles

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, PhD, Sacher Joshua, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Daniel E. Bauer, MD PhD, Florence Wagner, PhD, Kimberly Stegmaier, MD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 891.
https://doi.org/10.1182/blood-2018-99-113794
Published: 2018
Journal Articles

Target of Erythropoietin, Fam210b , Regulates Erythroid Heme Synthesis By Control of Mitochondrial Iron Import and Regulation of Fech Activity

Yvette Y Yien, PhD, Jiahai Shi, PhD, Caiyong Chen, PhD, Jesmine Cheung, Anthony Grillo, PhD, Rishna Shrestha, Liangtao Li, PhD, Xuedi Zhang, Martin Daniel Kafina, MS, BA, Paul D. Kingsley, PhD, Matthew King, Julien Ablain, PhD, Leonard I. Zon, MD, James Palis, MD, Martin Burke, Daniel E. Bauer, MD PhD, Stuart H. Orkin, MD, Carla Koehler, PhD, John D. Phillips, PhD, Jerry Kaplan, PhD, Diane Ward, PhD, Harvey Lodish, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 849.
https://doi.org/10.1182/blood-2018-99-120299
Published: 2018
Journal Articles

Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease

Tolulope O Rosanwo, BA, Melissa Kinney, PhD, Martha A Clark, PhD, Linda T Vo, PhD, R. Grant Rowe, MD PhD, Natasha M. Archer, MD, Matthew M Heeney, MD, Thorsten Schlaeger, PhD, Daniel E. Bauer, MD PhD, Mark D. Fleming, MD DPhil, Manoj T Duraisingh, PhD, Stuart H. Orkin, MD, Carlo Brugnara, MD, Trista North, PhD, George Q. Daley, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2359.
https://doi.org/10.1182/blood-2018-99-114136
Published: 2018
Journal Articles

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Jing Zeng, MD, Daniel E. Bauer, MD PhD, Yuxuan Wu, PhD, Benjamin P Roscoe, Pengpeng Liu, Qiuming Yao, PhD, Cicera Lazzarrotto, M. Kendell Clement, Mitchel A. Cole, BS, Kevin Luk, Cristina Baricordi, Erica B. Esrick, MD, John P Manis, MD, David Dorfma, David A. Williams, MD, Alessandra Biffi, MD PhD, Carlo Brugnara, MD, Luca Biasco, Christian Brendel, PhD, Luca Pinello, PhD, Shengdar Tsai, PhD, Scot A. Wolfe
Journal: Blood
Blood (2018) 132 (Supplement 1): 3482.
https://doi.org/10.1182/blood-2018-99-119365
Published: 2018
Journal Articles

Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits

Avik Choudhuri, PhD, Eirini Trompouki, PhD, Brian J. Abraham, PhD, Leandro Colli, MD, William Mallard, Min-Lee Yang, PhD, Divya Vinjamur, PhD, Alireza Ghamari, PhD, Satish Nandakumar, PhD, Kanen Hoi, Barbara Hummel, Sonja Boatman, Victoria Chan, Teresa V. Bowman, PhD, Song Yang, Yi Zhou, Sinichiro Takahashi, MD PhD, Alan B. Cantor, MD PhD, Vijay G. Sankaran, MD PhD, Santhi Ganesh, MD, Daniel E. Bauer, MD PhD, John Rinn, PhD, Stephen J Chanock, MD, Richard A. Young, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1277.
https://doi.org/10.1182/blood-2018-99-118637
Published: 2018
Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2018-99-117043
Published: 2018
Journal Articles

Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival

Takuji Yamauchi, MDPhD, Takeshi Masuda, PhD, Matthew C. Canver, BS, Michael Seiler, PhD, Mohammad Shboul, Manami Maeda, MDPhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Yuichiro Semba, MD, Yuichi Ishikawa, MD PhD, Michitaka Nakano, MD, Fumio Arai, PhD, Stuart Orkin, Bruno Reversade, Silvia Buonamici, PhD, Luca Pinello, PhD, Koichi Akashi, MD PhD, Daniel E. Bauer, MD PhD, Takahiro Maeda, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 782.
https://doi.org/10.1182/blood.V130.Suppl_1.782.782
Published: 2017
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

An Essential Erythroid-Specific Enhancer of ATP2B4 Associated with Red Blood Cell Traits and Malaria Susceptibility

Emily N Stern, B.S., Samuel Lessard, B.S., Patrick G. Schupp, B.S., Falak Sher, PhD, Guillaume Lettre, PhD, Daniel E. Bauer, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1250.
https://doi.org/10.1182/blood.V128.22.1250.1250
Published: 2016
Journal Articles

Erythropoietin Signaling Regulates Heme Biosynthesis

Jacky Chung, PhD, Johannes G. Wittig, Alireza Ghamari, Manami Maeda, MD, PhD, Harvey Lodish, PhD, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Alan B. Cantor, MD, PhD, Takahiro Maeda, MD PhD, Harry A. Dailey, PhD, Barry H. Paw, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 543.
https://doi.org/10.1182/blood.V128.22.543.543
Published: 2016
Journal Articles

Hematopoietic Stem Cells Develop in the Absence of Endothelial Cadherin 5 Expression

Heidi Anderson, Taylor Patch, Pavan Reddy, Elliott Hagedorn, Owen J. Tamplin, PhD, Daniel E. Bauer, MD, PhD, Barry H. Paw, MD, PhD, Dietmar Vestweber, Leonard I. Zon, MD, Stuart H. Orkin, MD, George Q. Daley, MD PhD, Dhvanit I. Shah, PhD
Journal: Blood
Blood (2015) 126 (23): 1165.
https://doi.org/10.1182/blood.V126.23.1165.1165
Published: 2015