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Journal Articles

Phase I/II Clinical Trial on CD19-Chimeric Antigen Receptor (CAR) T Cells Generated with an Automated Process, from Fresh Apheresis, and Reinfused As Fresh Drug Product for Pediatric/Young Adult Patients with Relapsed/Refractory (r/r) B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Francesca Del Bufalo, Mattia Algeri, Daria Pagliara, Linda Hanssens, Valentina Bertaina, Monica Gunetti, Giuseppina Li Pira, Chiara Rosignoli, Michele Massa, Matilde Sinibaldi, Giovanna Leone, Marco Becilli, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli

Blood (2024) 144 (Supplement 1): 4834.

https://doi.org/10.1182/blood-2024-206901

Published: 2024

Journal Articles

Allogeneic, donor-derived, second-generation, CD19-directed CAR-T cells for the treatment of pediatric relapsed/refractory BCP-ALL

Blood (2023) 142 (2): 146–157.

https://doi.org/10.1182/blood.2023020023

Published: 2023

Includes: Supplemental data

Journal Articles

CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

Blood (2022) 140 (Supplement 1): 7369–7370.

https://doi.org/10.1182/blood-2022-166107

Published: 2022

Journal Articles

A New Promising Third Generation CAR-CD30 T-Cell Therapy for CD30+ Lymphoma

Blood (2019) 134 (Supplement_1): 2069.

https://doi.org/10.1182/blood-2019-127969

Published: 2019

Journal Articles

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

Francesca Del Bufalo, MD, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Ignazio Caruana, PhD, Matilde Sinibaldi, PhD, Luciana Vinti, MD, Pietro Merli, MD, Mattia Algeri, MD, Annalisa Ruggeri, MD, Federica Galaverna, MD, Valentina Cirillo, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Giovanna Leone, MD, Valentina Bertaina, PhD, Franca Fassio, PhD, Monica Gunetti, PhD, Stefano Iacovelli, PhD, Franco Locatelli, MD PhD

Blood (2019) 134 (Supplement_1): 1341.

https://doi.org/10.1182/blood-2019-129821

Published: 2019

Journal Articles

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Concetta Quintarelli, PhD, Simona Sivori, PhD, Simona Caruso, PhD, Simona Carlomagno, PhD, Iolanda Boffa, PhDstudent, Domenico Orlando, PhDstudent, Marika Guercio, Biancamaria Cembrola, PhD, Angela Pitisci, Stefano Di Cecca, PhD, Giuseppina Li Pira, PhD, Luciana Vinti, MD, Biagio De Angelis, PhD, Lorenzo Moretta, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 3491.

https://doi.org/10.1182/blood-2018-99-118005

Published: 2018

Journal Articles

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Concetta Quintarelli, PhD, Iolanda Boffa, PhDstudent, Matilde Sinibaldi, Domenico Orlando, PhDstudent, Marika Guercio, Stefano Di Cecca, PhD, Simona Caruso, PhD, Angela Pitisci, Valentina Bertaina, Francesca Del Bufalo, MD, Pietro Merli, MD, Mattia Algeri, MD, Federica Galaverna, MD, Luciana Vinti, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2204.

https://doi.org/10.1182/blood-2018-99-119413

Published: 2018

Journal Articles

Zoledronic Acid Boosts γδ T-Cell Activity in Children Receiving αβ + T and CD19 + CELL-Depleted Grafts from a Haplo-Identical DONOR

Giulia Barbarito, Irma Airoldi, PhD, Alessia Zorzoli, Alice Bertaina, MDPhD, Andrea Petretto, Elvira Inglese, Chiara Lavarello, Letizia Pomponia Brescia, MD, Biagio De Angelis, PhD, Gino Tripodi, Pietro Merli, MD, Lorenzo Moretta, MD, Franco Locatelli, MD

Blood (2016) 128 (22): 5771.

https://doi.org/10.1182/blood.V128.22.5771.5771

Published: 2016

Journal Articles

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

Alice Bertaina, MDPhD, Pietro Merli, MD, Daria Pagliara, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Francesca Del Bufalo, MD, Mauro Montanari, MD, Barbarella Lucarelli, MD, Mattia Algeri, MD, Martha French, PhD, Annemarie Moseley, MDPhD, Franco Locatelli, MD

Blood (2016) 128 (22): 2286.

https://doi.org/10.1182/blood.V128.22.2286.2286

Published: 2016

Journal Articles

Bone Marrow (BM) Microenviroment Factors As Early Markers of Response in Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Treated with Nilotinib

Blood (2015) 126 (23): 1570.

https://doi.org/10.1182/blood.V126.23.1570.1570

Published: 2015

Journal Articles

A Novel Score to Predict Interferon-Alpha Therapy Responsiveness in Patients with Essential Thrombocythemia

Novella Pugliese, MD Graduate student, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Laura Cella, PhD, Santa Errichiello, PhD, Luana Marano, Simona Caruso, Graduate student, Nicola Esposito, Barbara Izzo, PhD, Marco Picardi, MD, Vincenzo Martinelli, MD, Fabrizio Pane, MD

Blood (2014) 124 (21): 1850.

https://doi.org/10.1182/blood.V124.21.1850.1850

Published: 2014

Journal Articles

Evaluation of Cepheid Xpert® BCR-ABL Monitor Assay in Three Italian Reference Centers for Monitoring of BCR-ABL Transcript Levels in CML Patients

Maria Teresa Bochicchio, Barbara Izzo, Enrico Gottardi, Biagio De Angelis, Roberta Lorenzatti, Claudia Venturi, Francesca Crasto, Caterina De Benedittis, Filomena Daraio, Emanuela Ottaviani, Alessandro Volpengo, Giuseppe Saglio, MD, Fabrizio Pane, MD, Giovanni Martinelli, MD

Blood (2014) 124 (21): 1809.

https://doi.org/10.1182/blood.V124.21.1809.1809

Published: 2014

Journal Articles

The Interferon Score Towards Interferon Alpha Tailored Therapy In Essential Thrombocythemia

Novella Pugliese, MD, Novella Pugliese, MD, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Luana Marano, Santa Errichiello, PhD, Nicola Esposito, Maddalena Raia, Claudio Cerchione, Luigi Del Vecchio, MD, Marco Picardi, MD, Vincenzo Martinelli, MD, Fabrizio Pane

Blood (2013) 122 (21): 4073.

https://doi.org/10.1182/blood.V122.21.4073.4073

Published: 2013

Journal Articles

Analysis of Bone Marrow Microenviroment Factors As Early Markers of Response in Patients with Newly Diagnosed Bcr-Abl Positive CML in Chronic Phase Treated with Nilotinib.

Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Santa Errichiello, PhD, Simona Caruso, Nicola Esposito, PhD, Luigia Luciano, MD, Simona Paratore, PhD, Claudia Galimberti, PhD, Simona Soverini, PhD, Carolina Terragna, PhD, Daniela Cilloni, MD, Giuseppe Saglio, MD, Giovanni Martinelli, Frank Giles, MD, Andreas Hochhaus, MD, Fabrizio Pane

Blood (2012) 120 (21): 2795.

https://doi.org/10.1182/blood.V120.21.2795.2795

Published: 2012

Journal Articles

High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells

Concetta Quintarelli, Gianpietro Dotti, Sayyeda T. Hasan, Biagio De Angelis, Valentina Hoyos, Santa Errichiello, Martha Mims, Luigia Luciano, Jessica Shafer, Ann M. Leen, Helen E. Heslop, Cliona M. Rooney, Fabrizio Pane, Malcolm K. Brenner, Barbara Savoldo

Blood (2011) 117 (12): 3353–3362.

https://doi.org/10.1182/blood-2010-08-300376

Published: 2011

Includes: Supplemental data

Journal Articles

Generation of Epstein-Barr virus–specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

Biagio De Angelis, Gianpietro Dotti, Concetta Quintarelli, Leslie E. Huye, Lan Zhang, Ming Zhang, Fabrizio Pane, Helen E. Heslop, Malcolm K. Brenner, Cliona M. Rooney, Barbara Savoldo

Blood (2009) 114 (23): 4784–4791.

https://doi.org/10.1182/blood-2009-07-230482

Published: 2009

Includes: Supplemental data

Journal Articles

IL15 Enhances Proliferation and Effector Function of Antigen-Specific Cytotoxic T Lymphocytes (CTLs) and Mitigates the Suppressive Action of Regulatory T Cells (Tregs).

Serena Kimi Perna, MD, Biagio De Angelis, PhD, Daria Pagliara, MD, Lan Zhan, Cliona M Rooney, PhD, Helen E. Heslop, MD, Malcolm K Brenner, MB, PhD, FRCP, FRCPath, Gianpietro Dotti, MD, Barbara Savoldo, MD, PhD

Blood (2009) 114 (22): 4088.

https://doi.org/10.1182/blood.V114.22.4088.4088

Published: 2009

Journal Articles

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

Antonio Di Stasi, Biagio De Angelis, Cliona M. Rooney, Lan Zhang, Aruna Mahendravada, Aaron E. Foster, Helen E. Heslop, Malcolm K. Brenner, Gianpietro Dotti, Barbara Savoldo

Blood (2009) 113 (25): 6392–6402.

https://doi.org/10.1182/blood-2009-03-209650

Published: 2009

Journal Articles

Generation of Epstein Barr Virus Specific Cytotoxic T Lymphocytes (EBVCTLs) Resistant to the Immunosuppressive Drug Tacrolimus (FK506)

Biagio De Angelis, PhD, Gianpietro Dotti, MD, Concetta Quintarelli, PhD, Leslie E Huye, PhD, Lan Zhang, Ming Zhang, Helen E. Heslop, MD, Malcolm K Brenner, MD, PhD, Cliona M Rooney, PhD, Barbara Savoldo, MD

Blood (2008) 112 (11): 3536.

https://doi.org/10.1182/blood.V112.11.3536.3536

Published: 2008

Journal Articles

Polyclonal PRAME-Specific Cytotoxic T Lymphocytes Generated Using Protein-Spanning Pools of Overlapping Pentadecapeptides Target Chronic Myeloid Leukemia

Concetta Quintarelli, PhD, Gianpietro Dotti, MD, Biagio De Angelis, PhD, Valentina Hoyos, MD, Fabrizio Pane, MD, Martha P. Mims, MD, PhD, Helen E. Heslop, MD, Cliona M Rooney, PhD, Malcolm K Brenner, MD, PhD, Barbara Savoldo, MD

Blood (2008) 112 (11): 3899.

https://doi.org/10.1182/blood.V112.11.3899.3899

Published: 2008

NARROW

Phase I/II Clinical Trial on CD19-Chimeric Antigen Receptor (CAR) T Cells Generated with an Automated Process, from Fresh Apheresis, and Reinfused As Fresh Drug Product for Pediatric/Young Adult Patients with Relapsed/Refractory (r/r) B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Allogeneic, donor-derived, second-generation, CD19-directed CAR-T cells for the treatment of pediatric relapsed/refractory BCP-ALL

CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

A New Promising Third Generation CAR-CD30 T-Cell Therapy for CD30+ Lymphoma

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Zoledronic Acid Boosts γδ T-Cell Activity in Children Receiving αβ + T and CD19 + CELL-Depleted Grafts from a Haplo-Identical DONOR

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

Bone Marrow (BM) Microenviroment Factors As Early Markers of Response in Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Treated with Nilotinib

A Novel Score to Predict Interferon-Alpha Therapy Responsiveness in Patients with Essential Thrombocythemia

Evaluation of Cepheid Xpert® BCR-ABL Monitor Assay in Three Italian Reference Centers for Monitoring of BCR-ABL Transcript Levels in CML Patients

The Interferon Score Towards Interferon Alpha Tailored Therapy In Essential Thrombocythemia

Analysis of Bone Marrow Microenviroment Factors As Early Markers of Response in Patients with Newly Diagnosed Bcr-Abl Positive CML in Chronic Phase Treated with Nilotinib.

High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells

Generation of Epstein-Barr virus–specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

IL15 Enhances Proliferation and Effector Function of Antigen-Specific Cytotoxic T Lymphocytes (CTLs) and Mitigates the Suppressive Action of Regulatory T Cells (Tregs).

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

Generation of Epstein Barr Virus Specific Cytotoxic T Lymphocytes (EBVCTLs) Resistant to the Immunosuppressive Drug Tacrolimus (FK506)

Polyclonal PRAME-Specific Cytotoxic T Lymphocytes Generated Using Protein-Spanning Pools of Overlapping Pentadecapeptides Target Chronic Myeloid Leukemia

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