Page 1 | Search Results | Blood | American Society of Hematology

1-18 of 18

Sort by

Sort Order Select

Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 480.

https://doi.org/10.1182/blood.V124.21.480.480

Published: 2014

Journal Articles

Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, PhD, Alexei Tulin, Sabine Cerny-Reiterer, D.V.M, Peter Valent, Markus Muschen, Stephen M. Sykes, PhD, Tomasz Skorski, MD, PhD

Blood (2013) 122 (21): 810.

https://doi.org/10.1182/blood.V122.21.810.810

Published: 2013

Journal Articles

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

Kimberly Cramer, Ph.D., Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Sliwinski, David Irvine, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 3.

https://doi.org/10.1182/blood.V120.21.3.3

Published: 2012

Journal Articles

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Artur Slupianek, PhD, Rafal Falinski, PhD, Pawel Znojek, Tomasz Stoklosa, MD, PhD, Sylwia Flis, Valentina Doneddu, Ewelina Synowiec, Janusz Blasiak, Alfonso Bellacosa, Tomasz Skorski, MD, PhD

Blood (2012) 120 (21): 520.

https://doi.org/10.1182/blood.V120.21.520.520

Published: 2012

Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Blood (2011) 118 (21): 2736.

https://doi.org/10.1182/blood.V118.21.2736.2736

Published: 2011

Journal Articles

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

Piotr Kopinski, Margaret Nieborowska-Skorska, MD, PhD, Grazyna Hoser, PhD, Danielle Ngaba, Regina Ray, Mateusz Koptyra, PhD, Elisabeth Bolton, Ilona Seferynska, MD, PhD, Tomasz Stoklosa, MD, PhD, Artur Slupianek, PhD, Mamatha R. Reddy, Martin Sattler, PhD, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 1211.

https://doi.org/10.1182/blood.V116.21.1211.1211

Published: 2010

Journal Articles

Targeting Phosphotyrosine-315 In RAD51 Recombinase to Prevent BCR-ABL1 - Mediated Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shu-yue Ren, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD

Blood (2010) 116 (21): 1190.

https://doi.org/10.1182/blood.V116.21.1190.1190

Published: 2010

Journal Articles

ROS-Induced DNA Damage Causing Genomic Instability in CML Stem and/or Progenitor Cells and in Quiescent and/or Proliferating Cells: Role of Mitochondrial Respiratory Chain Complex III.

Margaret Nieborowska-Skorska, Ph.D., Mateusz Koptyra, PhD, Elisabeth Bolton, Regina Ray, Danielle Ngaba, Grazyna Hoser, PhD, Tomasz Stoklosa, M.D., Ph.D., Artur Slupianek, PhD, Piotr Kopinski, Tomasz Skorski, MD, PhD

Blood (2009) 114 (22): 3268.

https://doi.org/10.1182/blood.V114.22.3268.3268

Published: 2009

Journal Articles

Targeting BCR/ABL-RAD51 Interaction to Prevent Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shuyue Ren, MD, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD

Blood (2009) 114 (22): 3272.

https://doi.org/10.1182/blood.V114.22.3272.3272

Published: 2009

Journal Articles

Selective Anti-Leukemia Targeting of the Interaction Between BCR/ABL and Mammalian RecA Homologs

Artur Slupianek, PhD, Shuyue Ren, MD, PhD, Tomasz Skorski, MD, PhD

Blood (2008) 112 (11): 195.

https://doi.org/10.1182/blood.V112.11.195.195

Published: 2008

Journal Articles

BCR/ABL Kinase Elevates ROS-Mediated Oxidative DNA Damage in CML Stem/Progenitor Cells and Affects the Efficiency and Fidelity of DNA Repair To Induce Genetic Instability.

Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Stoklosa, MD, Tomasz Poplawski, PhD, Kimberly Cramer, Tomasz Skorski

Blood (2007) 110 (11): 34.

https://doi.org/10.1182/blood.V110.11.34.34

Published: 2007

Journal Articles

BCR/ABL Kinase Inhibits Mismatch Repair To Reduce Apoptosis and Induce Point Mutations.

Tomasz Stoklosa, MD, PhD, Tomasz Poplawski, PhD, Grzegorz Basak, MD, PhD, Artur Slupianek, PhD, Janusz Blasiak, PhD, Ilona Seferynska, MD, PhD, Tomasz Skorski, MD, PhD

Blood (2007) 110 (11): 32.

https://doi.org/10.1182/blood.V110.11.32.32

Published: 2007

Journal Articles

Enhanced Phosphorylation of Nbs1, a Member of DNA Repair/Checkpoint Complex RAD50-Mre11-Nbs1, Can Be Targeted Simultaneously with BCR/ABL Kinase To Eliminate Leukemia Cells.

Lori Rink, PhD, Tomasz Stoklosa, MD, PhD, Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Ilona Seferynska, MD, Tomasz Skorski, MD, PhD

Blood (2006) 108 (11): 2127.

https://doi.org/10.1182/blood.V108.11.2127.2127

Published: 2006

Journal Articles

Imatinib Mesylate (STI571) Abrogates the Resistance to Doxorubicin in K562 Chronic Myeloid Leukemia Cells by Inhibition of BCR/ABL Kinase-Mediated DNA Repair.

Ireneusz Majsterek, PhD, Janusz Blasiak, PhD, Artur Slupianek, PhD, Tomasz Skorski, PhD

Blood (2005) 106 (11): 1525.

https://doi.org/10.1182/blood.V106.11.1525.1525

Published: 2005

Journal Articles

BCR/ABL Modifies the Kinetics and Fidelity of DNA Double-Strand Breaks Repair in Leukemia Cells.

Artur Slupianek, PhD, Michal O. Nowicki, Tomasz Skorski, MD, PhD

Blood (2005) 106 (11): 1982.

https://doi.org/10.1182/blood.V106.11.1982.1982

Published: 2005

Journal Articles

BCR/ABL Kinase Disrupts Formation of Mismatch Repair Complex To Induce Genomic Instability.

Tomasz Stoklosa, MD, PhD, Artur Slupianek, PhD, Grzegorz Basak, Tomasz Skorski, MD, PhD

Blood (2005) 106 (11): 2864.

https://doi.org/10.1182/blood.V106.11.2864.2864

Published: 2005

Journal Articles

BCR/ABL Regulates the Expression and Interacts with Werner Syndrome Helicase/Exonuclease To Modulate Its Biochemical Properties.

Artur Slupianek, PhD, Stanislaw Jozwiakowski, Ewa Gurdek, Michal O. Nowicki, Tomasz Skorski, MD, PhD

Blood (2005) 106 (11): 2873.

https://doi.org/10.1182/blood.V106.11.2873.2873

Published: 2005

Journal Articles

BCR/ABL Oncogenic Kinase Promotes Unfaithful Repair of the Reactive Oxygen Species - Dependent DNA Double-Strand Breaks.

Tomasz Skorski, MD, PhD, Michal O. Nowicki, MS, Rafal Falinski, MS, Mateusz Koptyra, MS, Artur Slupianek, PhD, Tomasz Stoklosa, MD, Ewa Gloc, Margaret Nieborowska-Skorska, MD, PhD, Janusz Blasiak, PhD

Blood (2004) 104 (11): 712.

https://doi.org/10.1182/blood.V104.11.712.712

Published: 2004

NARROW

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Mitochondrial Respiratory Chain Complex III Causes Genomic Instability In CML-CP.

Targeting Phosphotyrosine-315 In RAD51 Recombinase to Prevent BCR-ABL1 - Mediated Unfaithful Homeologous Recombination Repair.

ROS-Induced DNA Damage Causing Genomic Instability in CML Stem and/or Progenitor Cells and in Quiescent and/or Proliferating Cells: Role of Mitochondrial Respiratory Chain Complex III.

Targeting BCR/ABL-RAD51 Interaction to Prevent Unfaithful Homeologous Recombination Repair.

Selective Anti-Leukemia Targeting of the Interaction Between BCR/ABL and Mammalian RecA Homologs

BCR/ABL Kinase Elevates ROS-Mediated Oxidative DNA Damage in CML Stem/Progenitor Cells and Affects the Efficiency and Fidelity of DNA Repair To Induce Genetic Instability.

BCR/ABL Kinase Inhibits Mismatch Repair To Reduce Apoptosis and Induce Point Mutations.

Enhanced Phosphorylation of Nbs1, a Member of DNA Repair/Checkpoint Complex RAD50-Mre11-Nbs1, Can Be Targeted Simultaneously with BCR/ABL Kinase To Eliminate Leukemia Cells.

Imatinib Mesylate (STI571) Abrogates the Resistance to Doxorubicin in K562 Chronic Myeloid Leukemia Cells by Inhibition of BCR/ABL Kinase-Mediated DNA Repair.

BCR/ABL Modifies the Kinetics and Fidelity of DNA Double-Strand Breaks Repair in Leukemia Cells.

BCR/ABL Kinase Disrupts Formation of Mismatch Repair Complex To Induce Genomic Instability.

BCR/ABL Regulates the Expression and Interacts with Werner Syndrome Helicase/Exonuclease To Modulate Its Biochemical Properties.

BCR/ABL Oncogenic Kinase Promotes Unfaithful Repair of the Reactive Oxygen Species - Dependent DNA Double-Strand Breaks.

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only