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Journal Articles

Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML

Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Simon Fortier, Isabel Boivin, Jean-Francois Spinella, Tara Macrae, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 10680–10681.
https://doi.org/10.1182/blood-2022-165235
Published: 2022
Journal Articles

Identification of a Novel Cyclin K Degrader Molecule with Selective Anti-AML Activity

Deanne Gracias, Céline Moison, Rodrigo Mendoza-Sanchez, Simon Fortier, Simon Girard, Jean-Francois Spinella, Tara Macrae, Bounkham Thavonekham, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 10684.
https://doi.org/10.1182/blood-2022-166517
Published: 2022
Journal Articles

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia

Irene Baccelli, PhD, Yves Gareau, Bernhard Lehnertz, PhD, Gingras Stephane, Jean-Francois Spinella, PhD, Alexandre Beautrait, PhD, Sophie Corneau, Nadine Mayotte, Isabel Boivin, Simon Girard, Tara MacRae, Melanie Frechette, Koryne Leveille, Jana Krosl, PhD, Clarisse Thiollier, PhD, Evgeny Kanshin, PhD, Thierry Bertomeu, PhD, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, PhD, Geneviève Boucher, Philippe P Roux, PhD, Sébastien Lemieux, PhD, Mike Tyers, PhD, Pierre Thibault, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 910.
https://doi.org/10.1182/blood-2018-99-114525
Published: 2018
Journal Articles

Chemogenomic Profiling of Complex Karyotype AML Reveals a Novel Susceptibility to G2/M Checkpoint Inhibition Mediated By HMGA2 Overexpression

Céline Moison, PhD, Vincent-Philippe Lavallee, MD, Clarisse Thiollier, PhD, Jean-Francois Spinella, PhD, Isabel Boivin, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3925.
https://doi.org/10.1182/blood-2018-99-111304
Published: 2018
Journal Articles

Genetic Characterization of ABT-199 Sensitivity in Human AML

Marie-Eve Bordeleau, PhD, Richard Bisaillon, PhD, Clarisse Thiollier, PhD, Jana Krosl, PhD, Bernhard Lehnertz, PhD, Vincent-Philippe Lavallee, MD, Tara MacRae, Labelle Caroline, Geneviève Boucher, Isabel Boivin, Giovanni D'Angelo, Sylvie Lavallée, Anne Marinier, PhD, Sébastien Lemieux, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 283.
https://doi.org/10.1182/blood-2018-99-113062
Published: 2018
Journal Articles

Chemogenomic Approach Unveils the Increased Susceptibility of RUNX1 -Mutated AML to Glucocorticoids

Laura Simon, BSc, MSc, Vincent-Philippe Lavallee, MD, Marie-Eve Bordeleau, PhD, Bernhard Lehnertz, PhD, Tara MacRae, Jalila Chagraoui, PhD, Jean-Francois Spinella, PhD, Geneviève Boucher, Thierry Bertomeu, PhD, Jasmin Coulombe-Huntington, PhD, Mike Tyers, PhD, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4675.
https://doi.org/10.1182/blood-2018-99-111030
Published: 2018
Journal Articles

Single UM171 Expanded Cord Blood Permits Transplantation of Better HLA Matched Cords with Excellent Gvhd Relapse Free Survival

Sandra Cohen, MD FRCP(C), Jean Roy, MD, Silvy Lachance, MD FRCP, Anne Marinier, PhD, Jean-Sébastien Delisle, MD PhD, Denis-Claude Roy, MD, Lambert Busque, MD, Imran Ahmad, MD MPH, Nadia M. Bambace, MD, Frederic Barabe, MD, Léa Bernard, MD, Thomas L. Kiss, MD, Philippe Bouchard, BPharm, Pierre Caudrelier, MD, Fannie Larochelle, Sébastien Lemieux, PhD, Mégane Tanguay, Jalila Chagraoui, PhD, Peter W. Zandstra, PhD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4658.
https://doi.org/10.1182/blood-2018-99-110188
Published: 2018
Journal Articles

Single UM171 Expanded Cord Blood Transplant Is Feasible, Safe, and Permits Transplantation of Better HLA Matched Cords with Very Low Transplant Related Mortality

Sandra Cohen, MD, Jean Roy, MD, Silvy Lachance, MDFRCPC, Anne Marinier, PhD, Denis-Claude Roy, MD, Jean-Sébastien Delisle, MD PhD, Lambert Busque, MD, Pierre Caudrelier, MD, Fannie Larochelle, Philippe Bouchard, BPharm, Jean Roy, MD, Nadia M. Bambace, MD, Léa Bernard, MD, Thomas L Kiss, MD, Sébastien Lemieux, PhD, Peter W. Zandstra, PhD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 658.
https://doi.org/10.1182/blood.V130.Suppl_1.658.658
Published: 2017
Journal Articles

Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia

Bastien Gerby, PhD, Diogo F.T Veiga, PhD, Jana Krosl, PhD, Julianne Ouellette, André Haman, Geneviève Lavoie, PhD, Iman Fares, MSc, Mathieu Tremblay, PhD, Véronique Litalien, Elizabeth Ottoni, Milena Kosic, Dominique Geoffrion, Joël Ryan, Paul Maddox, PhD, Jalila Chagraoui, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD, Benjamin H Kwok, PhD, Philippe P Roux, PhD, Trang Hoang, PhD
Journal: Blood
Blood (2016) 128 (22): 527.
https://doi.org/10.1182/blood.V128.22.527.527
Published: 2016
Journal Articles

Chemo-Transcriptomic Analysis of Complex Karyotype AML Reveals Increased Expression of Cell Cycle Components and Exquisite Dependency on Polo-like Kinase 1

Vincent-Philippe Lavallée, MD, Clarisse Thiollier, PhD, Céline Moison, PhD, Marie-Ève Bordeleau, PhD, Isabel Boivin, M.Sc, Geneviève Boucher, M.Sc, Patrick Gendron, M.Sc, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 769.
https://doi.org/10.1182/blood.V128.22.769.769
Published: 2016
Journal Articles

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

Vincent-Philippe Lavallée, Jana Krosl, Sébastien Lemieux, Geneviève Boucher, Patrick Gendron, Caroline Pabst, Isabel Boivin, Anne Marinier, Cynthia J. Guidos, Sylvain Meloche, Josée Hébert, Guy Sauvageau
Journal: Blood
Blood (2016) 127 (24): 3054–3061.
https://doi.org/10.1182/blood-2016-03-705053
Published: 2016
Includes: Supplemental data
Journal Articles

Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal

Iman Fares, Jalila Chagaroui, Yves Gareau, Stéphane Gingras, Nadine Mayotte, Elizabeth Csaszar, Hans-Peter Kiem, Norman N. Iscove, R. Keith Humphries, Connie J. Eaves, Sandra Cohen, Anne Marinier, PhD, Peter W. Zandstra, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2014) 124 (21): 650.
https://doi.org/10.1182/blood.V124.21.650.650
Published: 2014