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Jean-Francois Spinella
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Identification of Acute Myeloid Leukemia Cell Surface Therapeutic Targets Using Single Cell RNA Sequencing Supported By Surface Proteomics

Véronique Lisi, Banafsheh Khakipoor, Azer Farah, Marie-Eve Bordeleau, Eric Audemard, Arnaud Metois, Louis Theret, Jean-François Spinella, Jalila Chagraoui, Ossama Moujaber, Laure Mallinger, Isabel Boivin, Nadine Mayotte, Azadeh Hajmirza, Eric Bonneil, Francois Béliveau, Albert Feghali, Geneviève Boucher, Patrick Gendron, Frederic Barabe, Sebastien Lemieux, Guillaume Richard-Carpentier, Josée Hébert, Philippe Roux, Guy Sauvageau, Vincent-Philippe Lavallee
Journal: Blood
Blood (2023) 142 (Supplement 1): 163.
https://doi.org/10.1182/blood-2023-186367
Published: 2023
Journal Articles

Targeting PLZF Enhances Glucocorticoid Sensitivity in Acute Myeloid Leukemia

Azadeh Hajmirza, Laura Simon, Jalila Chagraoui, Nadine Mayotte, Jean-François Spinella, Tara Macrae, Bernhard Lehnertz, Thierry Bertomeu, Jasmin Coulombe-Huntington, Geneviève Boucher, Sébastien Lemieux, Mike Tyers, Josee Hebert, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 8825–8826.
https://doi.org/10.1182/blood-2022-163685
Published: 2022
Journal Articles

Identification of a Novel Cyclin K Degrader Molecule with Selective Anti-AML Activity

Deanne Gracias, Céline Moison, Rodrigo Mendoza-Sanchez, Simon Fortier, Simon Girard, Jean-Francois Spinella, Tara Macrae, Bounkham Thavonekham, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 10684.
https://doi.org/10.1182/blood-2022-166517
Published: 2022
Journal Articles

Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML

Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Simon Fortier, Isabel Boivin, Jean-Francois Spinella, Tara Macrae, Rejean Ruel, Josee Hebert, Anne Marinier, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 10680–10681.
https://doi.org/10.1182/blood-2022-165235
Published: 2022
Journal Articles

Identification of Novel Antigens for Normal Karyotype Triple Mutated Acute Myeloid Leukemia

Arnaud Metois, Marie-Eve Bordeleau, Louis Theret, Azadeh Hajmirza, Ossama Moujaber, Jean-François Spinella, Jalila Chagraoui, Nadine Mayotte, Isabel Boivin, Eric Audemard, Azer Farah, Véronique Lisi, Eric Bonneil, Pierre Thibault, Guillaume Richard-Carpentier, Vincent-Philippe Lavallée, Josee Hebert, Philippe P Roux, Guy Sauvageau
Journal: Blood
Blood (2022) 140 (Supplement 1): 11791–11792.
https://doi.org/10.1182/blood-2022-166857
Published: 2022
Journal Articles

Identification of Novel Cell Surface Therapeutic Targets for KMT2A -Rearranged Acute Myeloid Leukemia

Louis Theret, Marie-Eve Bordeleau, Azadeh Hajmirza, Arnaud Metois, Ossama Moujaber, Eric Audemard, Jean-Francois Spinella, Jalila Chagraoui, Léo Aubert, Azer Farah, Véronique Lisi, Eric Bonneil, Isabel Boivin, Nadine Mayotte, Tara MacRae, Pierre Thibault, Sébastien Lemieux, Vincent-Philippe Lavallée, Josee Hebert, Guy Sauvageau, Philippe P Roux
Journal: Blood
Blood (2022) 140 (Supplement 1): 6316–6317.
https://doi.org/10.1182/blood-2022-166769
Published: 2022
Journal Articles

IL1R1 Expression Predicts the Benefit from Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia and Intermediate-Risk Cytogenetics

Guillaume Richard-Carpentier, Francois Beliveau, Sandrine Lacoste, Jean-Francois Spinella, Michael Vladovsky, Patrick Gendron, Sébastien Lemieux, Vincent-Philippe Lavallee, Guy Sauvageau, Josee Hebert
Journal: Blood
Blood (2022) 140 (Supplement 1): 6333–6334.
https://doi.org/10.1182/blood-2022-170230
Published: 2022
Journal Articles

High frequency of germline RUNX1 mutations in patients with RUNX1 -mutated AML

Brief Report
Laura Simon, Jean-François Spinella, Chi-Yuan Yao, Vincent-Philippe Lavallée, Isabel Boivin, Geneviève Boucher, Eric Audemard, Marie-Eve Bordeleau, Sébastien Lemieux, Josée Hébert, Guy Sauvageau
Journal: Blood
Blood (2020) 135 (21): 1882–1886.
https://doi.org/10.1182/blood.2019003357
Published: 2020
Includes: Supplemental data
Journal Articles

Chemogenomic Profiling of Complex Karyotype AML Reveals a Novel Susceptibility to G2/M Checkpoint Inhibition Mediated By HMGA2 Overexpression

Céline Moison, PhD, Vincent-Philippe Lavallee, MD, Clarisse Thiollier, PhD, Jean-Francois Spinella, PhD, Isabel Boivin, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3925.
https://doi.org/10.1182/blood-2018-99-111304
Published: 2018
Journal Articles

Coordination of Pro- and Anti-Inflammatory Signals Determine Human Hematopoietic Stem and Progenitor Cell Expansion

Jalila Chagraoui, PhD, Elisa Tomellini, PhD, Leo Aubert, Iman Fares, PhD, Jean-Francois Spinella, PhD, Simon Girard, Nadine Mayotte, Philippe P Roux, PhD, Guy Sauvageau, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2555.
https://doi.org/10.1182/blood-2018-99-111917
Published: 2018
Journal Articles

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia

Irene Baccelli, PhD, Yves Gareau, Bernhard Lehnertz, PhD, Gingras Stephane, Jean-Francois Spinella, PhD, Alexandre Beautrait, PhD, Sophie Corneau, Nadine Mayotte, Isabel Boivin, Simon Girard, Tara MacRae, Melanie Frechette, Koryne Leveille, Jana Krosl, PhD, Clarisse Thiollier, PhD, Evgeny Kanshin, PhD, Thierry Bertomeu, PhD, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, PhD, Geneviève Boucher, Philippe P Roux, PhD, Sébastien Lemieux, PhD, Mike Tyers, PhD, Pierre Thibault, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 910.
https://doi.org/10.1182/blood-2018-99-114525
Published: 2018
Journal Articles

Chemogenomic Approach Unveils the Increased Susceptibility of RUNX1 -Mutated AML to Glucocorticoids

Laura Simon, BSc, MSc, Vincent-Philippe Lavallee, MD, Marie-Eve Bordeleau, PhD, Bernhard Lehnertz, PhD, Tara MacRae, Jalila Chagraoui, PhD, Jean-Francois Spinella, PhD, Geneviève Boucher, Thierry Bertomeu, PhD, Jasmin Coulombe-Huntington, PhD, Mike Tyers, PhD, Sébastien Lemieux, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4675.
https://doi.org/10.1182/blood-2018-99-111030
Published: 2018