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Issue Archive

Volume 9, Issue 20
October 28 2025
Blood Advances Cover Image for Volume 9, Issue 20

Table of Contents

INSIDE BLOOD ADVANCES

Post-HCT gilteritinib outweighs conditioning in NPM1m FLT3-ITD AML
Clinical Trials & Observations
Aaron James Stonestrom,Maria R. Baer
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Embarrassment of riches: which donor for allo-transplant?
Clinical Trials & Observations
Eric Irons,Koen van Besien
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Olutasidenib: an Achilles’ heel for IDH1-mutated MDS?
Clinical Trials & Observations
Laura Wiser,Curtis Lachowiez
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CART in MCL: risk and reward?
Toby A. Eyre
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REVIEW ARTICLE

Molecular and immunological determinants of long-term survival in multiple myeloma
Khanmi Kasomva,Kritika Yadav,Siegfried Janz,Binod Dhakal,Sridhar Rao
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CLINICAL TRIALS AND OBSERVATIONS

Pilot study of an inpatient physical activity intervention for older adults treated intensively for acute myeloid leukemia
Clinical Trials & Observations
Heidi D. Klepin,Janet A. Tooze,Walter J. Rejeski,Shannon Mihalko,Timothy S. Pardee,Leslie Ellis,Dianna Howard,Wendy Demark-Wahnefried,Bayard L. Powell,Stephen Kritchevsky
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Supplemental data
Long-term results from the AGILE study of azacitidine plus ivosidenib vs placebo in newly diagnosed IDH1-mutated AML
Clinical Trials & Observations
Pau Montesinos,Dylan M. Marchione,Christian Recher,Michael Heuser,Susana Vives,Ewa Zarzycka,Jianxiang Wang,Marta Riva,Rodrigo T. Calado,Andre C. Schuh,Su-Peng Yeh,Adriana E. Tron,Jianan Hui,Diego A. Gianolio,Sung Choe,Prapti Patel,Stéphane De Botton,Courtney D. DiNardo,Hartmut Döhner
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Supplemental data
Olutasidenib alone or combined with azacitidine in patients with mutant IDH1 myelodysplastic syndrome
Clinical Trials & Observations
Jorge E. Cortes,Jay Yang,Gail J. Roboz,Shira N. Dinner,Eunice S. Wang,Andrew H. Wei,Hua Tian,Francois di Trapani,Maria R. Baer,William Donnellan,Justin M. Watts
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Supplemental data
Olutasidenib: an Achilles’ heel for IDH1-mutated MDS?
Clinical Trials & Observations
Laura Wiser,Curtis Lachowiez
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Targeting S100A9-mediated inflammation: a novel therapeutic approach for CLL
Angimar Uriepero-Palma,Maria Elena Márquez,Eugenia Payque,Melanie Mediavilla-Varela,Wael Gamal,Kamira Maharaj,John Powers,Julio Chavez,Erika Eksioglu,Sandra Sernbo,Florencia Palacios,Juliana Querol-Rivas,Claudia Ortega,Rita Uria,Gimena Dos Santos,Carolina Oliver,Ana Inés Landoni,Eva Sahakian,Pablo Oppezzo,Javier Pinilla-Ibarz
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Supplemental data
Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring
Mariolina Bruno,Charlotte Kröger,Anaísa V. Ferreira,Bowen Zhang,Rutger J. Röring,Ruiqi Liu,Caspar I. van der Made,Norman van Rhijn,Laszlo Groh,Viola Klück,Nico A. F. Janssen,Wenchao Li,Diletta Rosati,Ahmed Alaswad,Helin Tercan,Jorge Saiz,Carolina Gonzalez-Riano,Martina van Uelft,Orsolya Ildiko Gaal,Sophie Müller,Humberto J. Ferreira,Stefanie Warnat-Herresthal,Matthias Becker,Lisa Holsten,Michael Kraut,Jonas Schulte-Schrepping,Lorenzo Bonaguro,Kristian Händler,Cristina Cunha,Manfred Schmolz,Joachim L. Schultze,Leo A. B. Joosten,Coral Barbas,Mihai G. Netea,Yang Li,Anna C. Aschenbrenner,Agostinho Carvalho,Frank L. van de Veerdonk
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Supplemental data

LYMPHOID NEOPLASIA

Monitoring ctDNA in aggressive B-cell lymphoma: a prospective correlative study of ctDNA kinetics and PET-CT metrics
Gayaththri Vimalathas,Marcus Høy Hansen,Oriane Cédile,Mads Thomassen,Michael Boe Møller,Sara Kamuk Dahlmann,Marie Louise Grube Kjeldsen,Malene Grubbe Hildebrandt,Anne Lerberg Nielsen,Mohammad Naghavi-Behzad,Lars Edenbrandt,Charlotte Guldborg Nyvold,Thomas Stauffer Larsen
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Supplemental data
Real-world data for tisagenlecleucel in patients with R/R B-ALL: subgroup analyses from the CIBMTR registry
Samuel John,Kevin J. Curran,Erin M. Hall,Amy K. Keating,Susanne H.C. Baumeister,Sarah Nikiforow,Timothy Driscoll,Amy Moskop,Kevin O. McNerney,Christine L. Phillips,Michael A. Pulsipher,Emily M. Hsieh,Rayne H. Rouce,Marcelo C. Pasquini,Ranjan Tiwari,Jennifer Willert,Roberto Ramos,Joerg Krueger,Erin Guest,Stephan A. Grupp
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Supplemental data
T-cell dysregulation informs radiotherapy-immunotherapy response in B-cell lymphoma: results from a phase 1 trial
Clinical Trials & Observations
Eliza A. Hawkes,Jodie B. Palmer,Richard Khor,Sze Ting Lee,Melinda Burgess,Soi C. Law,Maher K. Gandhi,Geoffrey Chong,Jake Shortt,Rakin Chowdhury,Fiona Swain,Leonid Churilov,Michael MacManus,Charmaine Smith,Fiona E. Scott,Arina Martynchyk,Allison Barraclough,Kate Manos,Andrew M. Scott,Colm Keane
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Supplemental data
Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas
Nicole Schmidt,Kevin Kornrumpf,Lena Ries,Katharina Markus,Nora Anna Maria Ksionsko,Paolo Mazzeo,Melanie Lohrberg,Maren Sitte,Gabriela Salinas,Till Braun,Annika Dechow,Marco Herling,Aleksandr Ianevski,Tero Aittokallio,Björn Chapuy,Holger Bastians,Gerald Wulf,Tim Beißbarth,Jürgen Dönitz,Raphael Koch
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Supplemental data
Immunoglobulin use, survival, and infection outcomes in patients with chronic lymphocytic leukemia
Sara Carrillo de Albornoz,Xin Zhang,Rainier Arnolda,Aleece MacPhail,Adam Irving,Alisa M. Higgins,Erica M. Wood,Zoe K. McQuilten,Dennis Petrie
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Supplemental data
Real-world outcomes of brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma: a CIBMTR analysis
Nausheen Ahmed,Swetha Kambhampati Thiruvengadam,Mehdi Hamadani,Zhen-Huan Hu,Natalie Grover,Mazyar Shadman,Frederick L. Locke,James Gerson,Matthew J. Frank,Lihua E. Budde,Michael Wang,Soyoung Kim,Matthew Bye,Mohamed A. Kharfan-Dabaja,Craig Sauter,Peiman Hematti,Cameron J. Turtle,Sairah Ahmed,Amy Moskop,Brent Logan,Ana Nunes,David Dalton,Ioana Kloos,Daniel Lee,Hairong Xu,Marcelo C. Pasquini,Alex F. Herrera
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Supplemental data
CART in MCL: risk and reward?
Toby A. Eyre
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MYELOID NEOPLASIA

Impact of transplant conditioning, NPM1 mutations, and measurable residual disease in FLT3-ITD acute myeloid leukemia
Clinical Trials & Observations
Mark J. Levis,Mehdi Hamadani,Brent R. Logan,Richard J. Jones,Anurag K. Singh,Mark R. Litzow,John R. Wingard,Esperanza B. Papadopoulos,Alexander E. Perl,Robert J. Soiffer,Celalettin Ustun,Masumi Ueda Oshima,Geoffrey L. Uy,Edmund K. Waller,Sumithira Vasu,Melhem Solh,Asmita Mishra,Lori S. Muffly,Hee-Je Kim,Matthias Stelljes,Yuho Najima,Masahiro Onozawa,Kirsty Thomson,Caroline Chen,Nahla Hasabou,Matt Rosales,Jason E. Hill,Stanley C. Gill,Rishita Nuthethi,Denise King,Adam Mendizabal,Steven M. Devine,Mary M. Horowitz,Yi-Bin Chen
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Supplemental data
Post-HCT gilteritinib outweighs conditioning in NPM1m FLT3-ITD AML
Clinical Trials & Observations
Aaron James Stonestrom,Maria R. Baer
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Cost-effectiveness of upfront vs delayed allogeneic hematopoietic stem cell transplant for intermediate risk AML
Abdulrahman Alhajahjeh,Kishan K. Patel,Nikolai A. Podoltsev,Tariq Kewan,Jessica M. Stempel,Lourdes Mendez,Stuart Seropian,Lohith Gowda,Scott F. Huntington,Maximilian Stahl,Amer M. Zeidan,George Goshua,Jan Philipp Bewersdorf
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Supplemental data
Somatic mutations in STAG2 are associated with separated megakaryocyte nuclear lobes in myelodysplastic syndromes
Waihay J. Wong,Rebecca L. Zon,Christopher J. Gibson,Caleb Ho,Olga Pozdnyakova,Donna Neuberg,Elisabeth M. Battinelli,Marlise R. Luskin,Zuzana Tothova,Elizabeth A. Morgan,Benjamin L. Ebert
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Supplemental data

PLATELETS AND THROMBOPOIESIS

Posttransfusion recovery, quality, and metabolism of short- and long-term stored platelets during controlled inflammation
Stefan F. van Wonderen,Floor L. F. van Baarle,Philippa G. Phelp,Esther B. Bulle,Amy Argabright,Sanne de Bruin,Anita M. Tuip-de Boer,Chantal A. Polet,Rombout B. E. van Amstel,Endry H. T. Lim,Jimmy Schenk,Anna-Linda Peters,Robin van Bruggen,Julie A. Reisz,Christie Vermeulen,Thomas R. L. Klei,Bart J. Biemond,Marcella C. A. Müller,Angelo D'Alessandro,Alexander P. J. Vlaar
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Supplemental data

THROMBOSIS AND HEMOSTASIS

Trp1250, Lys1252, and Arg1367 of ADAMTS13 comprise a hot spot for anti-CUB domain antibodies in patients with iTTP
Tim Postmus,Robin Jansen,Paul Kaijen,Floris van Alphen,Carmen van der Zwaan,Arie J. Hoogendijk,Paul Coppo,Bérangère S. Joly,Agnès Veyradier,Karen Vanhoorelbeke,Gerry Nicolaes,Jan Voorberg
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Supplemental data

TRANSPLANTATION

Older matched sibling donor vs young haploidentical donor for older patients with acute myeloid leukemia
Clinical Trials & Observations
Xavier Poiré,Myriam Labopin,Emmanuelle Polge,Didier Blaise,Patrice Chevallier,Johan Maertens,Nicolaus Kröger,Caroline Besley,Stéphanie Nguyen,Cristina Castilla-Llorente,Gérard Socié,Edouard Forcade,Anne Huynh,Igor Wolfgang Blau,Arnon Nagler,Jaime Sanz,Simona Piemontese,Mohamad Mohty,Fabio Ciceri
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Embarrassment of riches: which donor for allo-transplant?
Clinical Trials & Observations
Eric Irons,Koen van Besien
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Bone marrow and blood demonstrate distinct immune reconstitution patterns and correlations with relapse posttransplant
Susan DeWolf,Jason Kuttiyara,Paola Vinci,Teng Fei,John Slingerland,Zoe Katsamakis,Joshua A. Fein,Brianna Gipson,Rachel Lorenc,Victoria Zinsmeyer,LeeAnn Marcello,Paul Giardina,William Donohoe,Gunjan Shah,Richard Lin,Esperanza Papadopoulos,Boglarka Gyurkocza,Brian Shaffer,Martin Tallman,Ioannis Politikos,Sergio A. Giralt,Juliet Barker,Miguel-Angel Perales,Roni Tamari,Omar Abdel-Wahab,Christina Cho,Katharine Hsu,Jonathan U. Peled,Marcel R. M. van den Brink,Alan M. Hanash
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Supplemental data

RESEARCH LETTERS

Comparative outcomes of HSCT with posttransplant cyclophosphamide in older adults: the impact of donor type
Yosra M. Aljawai,Jeremy Ramdial,Portia Smallbone,George Chen,Partow Kebriaei,Oren Pasvolsky,Uday Popat,Betul Oran,Katayoun Rezvani,Richard E. Champlin,Elizabeth J. Shpall,Rohtesh S. Mehta
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Supplemental data
Incomplete harms reporting in systematic reviews of direct oral factor Xa inhibitors
Clinical Trials & Observations
Jack Rea,Chase Lee,Micah Kee,Brayden Rucker,Holly Flores,Corbin Walters,Taryn Haney,Alicia Tomlin,Adam Khan,Matt Vassar
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Supplemental data
Prognostic impact of the PredicT-ALL classifier in the AALL0434 trial: a model combining NGS, MRD, and WBC at diagnosis
Clinical Trials & Observations
Mathieu Simonin,Nicolas Boissel,Arnaud Petit,Charles G. Mullighan,Stephen P. Hunger,Mignon L. Loh,Stuart S. Winter,Elizabeth Macintyre,David T. Teachey,André Baruchel,Vahid Asnafi
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Supplemental data
Assessment of classical hematologists and classical hematology fellowship programs at NCI-designated cancer centers
Lewis T. Go,Lucas T. Go,Madugodaralalage D. S. K. Gunaratne,Alexandra P. Wolanskyj-Spinner,Aneel A. Ashrani,Michelle A. Elliott,Richard L. Godby,Christopher C. Hook,Leslie J. Padrnos,Rajiv K. Pruthi,Candido E. Rivera,Rachelle L. Rouse,Surbhi Shah,Marwan E. Shaikh,Mustaqeem A. Siddiqui,Meera Sridharan,Ewa M. Wysokinska,Ronald S. Go,Jithma P. Abeykoon
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Updating clinical guidelines with limited evidence: case study of ASH/ISTH pediatric VTE treatment guidelines
Ali Choaib,Aseel AlKhader,Muayad Azzam,Hassan Kawtharany,Marisol Betensky,Leslie Raffini,Rachel Bercovitz,Sara K. Vesely,Paul Monagle,Reem A. Mustafa
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Survival after anti-CD19 CAR T-cell therapy for B-cell non-Hodgkin lymphoma and CLL with 10 years of follow-up
Clinical Trials & Observations
Tatyana Gavrilova,Lori McIntyre,Stephanie L. Goff,James C. Yang,Danielle A. Natrakul,Steven A. Rosenberg,James N. Kochenderfer,Jennifer N. Brudno
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COMMENTARY

Ethical considerations for hematologic precursor conditions
Clinical Trials & Observations
Eric C. Blackstone,Lachelle D. Weeks,Amy E. DeZern,Gregory A. Abel
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LETTERS TO THE EDITOR

HLA vaccine effect in double cord blood transplant: a Chinese cohort
Chi Hang Wong,Wilson Y. K. Chan,Pamela P. W. Lee,Daniel K. L. Cheuk,Wing Leung
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Too soon to reject immunoglobulin replacement in CLL
Clinical Trials & Observations
Stephen Opat,Ross Salvaris
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  • Cover Image

    Cover Image

    issue cover

    Image showing immune restoration in long-term survivors of multiple myeloma. Enhanced cytotoxic CD8+ T cells, activated natural killer cells, and normal B cells counter suppressive cells, thereby restoring interferon gamma signaling, memory persistence, and cytotoxic function for durable myeloma control. See the article by Kasomva et al.

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