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Issue Archive

Volume 9, Issue 16
August 26 2025
Blood Advances Cover Image for Volume 9, Issue 16

Table of Contents

INSIDE BLOOD ADVANCES

Avoid burning bridges before CAR-T therapy in myeloma
Swetha Reddi,Rahul Banerjee
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Asciminib in late-line CML treatment
Clinical Trials & Observations
Kendra Sweet,Javier Pinilla-Ibarz
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SYSTEMATIC REVIEW

Cortisol in sickle cell disease: a systematic review and meta-analysis
Kemar V. Prussien,Margaret Mary Burke,Kandace Gollomp,Rosalind J. Wright,Alexis A. Thompson
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CLINICAL TRIALS AND OBSERVATIONS

Pivotal results of SELECT-MDS-1 phase 3 study of tamibarotene with azacitidine in newly diagnosed higher-risk MDS
Clinical Trials & Observations
Amy E. DeZern,Sylvain Thepot,Stephane de Botton,Andrea Patriarca,Dries Deeren,Jose-Miguel Torregrossa-Diaz,Giovanni Marconi,Teresa Bernal,Juan Bergua Burgues,Blanca Xicoy,Anna Jonášová,Amer M. Zeidan,Sophie Dimicoli-Salazar,Célestine Simand,David Valcarcel,Maria Diez Campelo,Wanxing Chai-Ho,Lalit Saini,Alice Garnier,Klaus Geissler,Yishai Ofran,Zsolt Nagy,Pramila Krishnamurthy,Michael Lübbert,Grzegorz Basak,Hetty E. Carraway,David A. Sallman,Uma Borate,Valeria Santini,Victoria Campbell,Pierre Fenaux,Thorsten Braun,Francesco Lanza,Jan Maciej Zaucha,David A. Roth,Sofia Paul,Pourab Roy,Michael J. Kelly,Angela Volkert,Jaime Chisholm,Tanya Abdul Malak,Virginia M. Klimek,Thomas Cluzeau,on behalf of the Tamibarotene MDS Investigator Group
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Zanubrutinib is well tolerated and effective in patients with CLL/SLL intolerant of ibrutinib/acalabrutinib: updated results
Clinical Trials & Observations
Mazyar Shadman,John M. Burke,Jennifer Cultrera,Habte A. Yimer,Syed F. Zafar,Jamal Misleh,Subramanya S. Rao,Charles M. Farber,Aileen Cohen,Hui Yao,Adam Idoine,Qi An,Ian W. Flinn,Jeff P. Sharman
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Prebiotic fiber enteral supplementation after allogeneic transplantation: feasibility and impact on the microbiome
Clinical Trials & Observations
Sarah Andersen,Glen Kennedy,Merrilyn Banks,Bernadine Flanagan,Andrea Henden
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ADORE: an open platform study of ruxolitinib in combination with other novel therapies in patients with myelofibrosis
Clinical Trials & Observations
David M. Ross,Florian H. Heidel,Andrew Charles Perkins,Andreas Reiter,Carl Crodel,Caroline Riley,María Teresa Gómez-Casares,Istvan Takacs,Heiko Becker,Thomas Lehmann,Olga Vinogradova,Kate Burbury,Alessandro M. Vannucchi,Vikas Gupta,Marielle Wondergem,Jean-Jacques Kiladjian,Grace Cleary,Angela Zhang,Jagannath Kota,Anirudh Prahallad,Monika Wroclawska,Min Lu,Claire N. Harrison
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Impact of concomitant azoles on ruxolitinib treatment in patients with GVHD: post hoc analyses of REACH2 and REACH3
Clinical Trials & Observations
Zahra Mahmoudjafari,Emily Kintsch,Zhenyi Xue,Valkal Bhatt,John Galvin,Franco Locatelli,Robert Zeiser
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Long-term outcomes of patients with refractory cytopenia of childhood under observation only
Clinical Trials & Observations
Beatrice Drexler,Stephan Schwarz-Furlan,Irith Baumann,Martina Rudelius,Peter Nöllke,Dirk Lebrecht,Senthilkumar Ramamoorthy,Natalia Rotari,Axel Karow,Shinsuke Hirabayashi,Fabian Beier,Yvonne Lisa Behrens,Gudrun Göhring,Reinhard Kalb,Marcin W. Wlodarski,Brigitte Strahm,Miriam Erlacher,Charlotte M. Niemeyer,Ayami Yoshimi
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From CyBorD to dara-CyBorD, ASCT utilization trends in AL amyloidosis: a 15-year analysis
Clinical Trials & Observations
Eli Muchtar,Angela Dispenzieri,Francis K. Buadi,Prashant Kapoor,David Dingli,Taxiarchis V. Kourelis,Wilson Gonsalves,Nelson Leung,Suzanne R. Hayman,Martha Q. Lacy,Mustaqeem Siddiqui,Joselle Cook,Nadine Abdallah,Moritz Binder,Saurabh Zanwar,William Hogan,Rahma Warsame,S. Vincent Rajkumar,Shaji K. Kumar,Morie A. Gertz
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A prospective clinical trial of GVHD prophylaxis with posttransplant cyclophosphamide and abatacept
Clinical Trials & Observations
Divya Koura,Kaitlyn Dykes,Aaron Goodman,Caitlin Costello,Carolyn Mulroney,James K. Mangan,Tiffany N. Tanaka,Edward D. Ball,Ayad Hamdan,Ah-Reum Jeong,James Mirocha,Qingyang Zhang,Paula Ogrodnik,Kimberly McConnell,Joseph J. Maroge,Michelle Padilla,Gerald P. Morris,Dimitrios Tzachanis
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Outcomes of brexucabtagene autoleucel in patients with relapsed/refractory acute lymphoblastic leukemia with CNS involvement
Ibrahim N. Muhsen,Gregory W. Roloff,Rawan Faramand,Tamer Othman,Yannis Valtis,Noam E. Kopmar,Simone E. Dekker,Matthew Connor,Santiago Mercadal,Timothy E. O'Connor,Kaitlyn C. Dykes,Mohamed Ahmed,Nikeshan Jeyakumar,Amy Zhang,Katharine Miller,Katherine C. Sutherland,Caitlin Guzowski,Vishal K. Gupta,Navneet Majhail,Minoo Battiwalla,Melhem M. Solh,Shahbaz A. Malik,John Mathews,Caspian H. Oliai,Paul Shaughnessy,Luke Mountjoy,Catherine J. Lee,Aaron C. Logan,Stephanie B. Tsai,Jessica T. Leonard,Marc Schwartz,Joshua P. Sasine,Muthu Kumaran,Noelle Frey,Jae H. Park,Divya Koura,Ryan D. Cassaday,Bijal D. Shah,Ibrahim Aldoss,Lori S. Muffly,LaQuisa C. Hill
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Bridging intensity is associated with impaired hematopoietic recovery after BCMA CAR-T therapy for multiple myeloma
Jan H. Frenking,Xiang Zhou,Kai Rejeski,Vivien Wagner,Patrick Costello,Thomas Hielscher,Lilan Gatti,Joseph Kauer,Omar Nadeem,Elias K. Mai,Christian S. Michel,Mirco J. Friedrich,David Sedloev,Niels Weinhold,Hartmut Goldschmidt,Klaus Herfarth,Anita Schmitt,Michael Hundemer,Michael Schmitt,Carsten Müller-Tidow,Max Topp,Hermann Einsele,Peter Dreger,Nikhil C. Munshi,Adam S. Sperling,Leo Rasche,Sandra Sauer,Marc S. Raab
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Supplemental data
Avoid burning bridges before CAR-T therapy in myeloma
Swetha Reddi,Rahul Banerjee
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LYMPHOID NEOPLASIA

Impact of SARS-CoV-2 infection on bispecific antibody treatment in patients with B-cell lymphoproliferative disorders
Ángel Serna,Víctor Navarro,Moraima Jiménez,Josu Iraola-Truchuelo,Marc Bosch,Cristina García,Anna Falcó,Adaia Albasanz,Isabel Ruiz-Camps,Cristina Andrés,Andrés Antón,Juliana Esperalba,Ainara Ferrero,Tomás García,Cecilia Carpio,Marta Crespo,Gloria Iacoboni,Ana Marín-Niebla,Francesc Bosch,Pau Abrisqueta
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Expression of HERV-K and embryonic genes in chronic lymphocytic leukemia and their association with therapy regimens
Claudia Matteucci,Vita Petrone,Alessandro Giovinazzo,Roberta Laureana,Massimiliano Postorino,Livio Pupo,Chiara Cipriani,Nicola Toschi,Marialaura Fanelli,Antonella Minutolo,Giovangiacinto Paterno,Elisa Buzzatti,Paola Sinibaldi Vallebona,Antonella Zucchetto,Federico Pozzo,Valter Gattei,Giovanni Del Poeta,Adriano Venditti,Emanuela Balestrieri,Maria Ilaria Del Principe
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Real-world evidence of duvelisib and romidepsin in relapsed/refractory peripheral and cutaneous T-cell lymphomas
Josie G. Ford,Min Jung Koh,Alexandra W. Lenart,Caroline MacVicar,Kusha Chopra,Arushi Meharwal,Mark N. Sorial,Mwanasha Merrill,Anna B. Rider,Aliyah R. Sohani,Sean M. McCabe,Ronnie A. Nemec,Makoto Iwasaki,Dhruv Mistry,Khyati Maulik Kariya,Steven Chen,Jeffrey Barnes,Steven McAfee,Yi-Bin Chen,Corben Yuwai Wong,Kristiana Nasto,Eric Jacobsen,Salvia Jain
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MYELOID NEOPLASIA

IGSF9-targeted therapy inhibits the progression of acute myeloid leukemia
Lijun Hui,Jing Xiao,Zhiling Zhao,Juan Zhang,Huiwen Luan,Jiashen Zhang,Yuxiao Sun,Xianhui Meng,Hongying Wang,Chunling Li,Fangmin Li,Shuhao Ji,Shuping Wei,Fang Li,Hong Yu,Chengyun Zheng,Yang Jiang,Yaopeng Wang,Zunling Li
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Genome-wide association study of somatic GATA1s mutations in newborns with Down syndrome
Yunqi Li,Natalina Elliott,Patricia Lein,Paresh Vyas,Irene Roberts,Adam J. de Smith
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Asciminib remained superior vs bosutinib in late-line CML-CP after nearly 4 years of follow-up in ASCEMBL
Clinical Trials & Observations
Michael J. Mauro,Yosuke Minami,Andreas Hochhaus,Elza Lomaia,Sergey Voloshin,Anna Turkina,Dong-Wook Kim,Jane F. Apperley,Jorge E. Cortes,Andre Abdo,Laura Maria Fogliatto,Dennis Dong Hwan Kim,Philipp le Coutre,Susanne Saussele,Mario Annunziata,Timothy P. Hughes,Naeem Chaudhri,Lynette Chee,Valentin García-Gutiérrez,Koji Sasaki,Carla Boquimpani,Shruti Kapoor,Noemi Espurz,Vishal Dhamal,Delphine Rea
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Asciminib in late-line CML treatment
Clinical Trials & Observations
Kendra Sweet,Javier Pinilla-Ibarz
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THROMBOSIS AND HEMOSTASIS

Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets
Alexis N. Smith,Hammodah R. Alfar,Smita Joshi,Daniëlle M. Coenen,Joshua Lykins,Isabelle C. Becker,Brittany E. Dong,Harry Chanzu,Chi Peng,Kanakanagavalli Shravani Prakhya,Linda Omali,Irina D. Pokrovskaya,Brian Storrie,Joseph Italiano,Sidney W. Whiteheart
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Platelet-activating histone/antihistone IgG complexes in anti-PF4–negative thrombosis and thrombocytopenia syndrome
Clinical Trials & Observations
Max Esefeld,Stefan Handtke,Rainer Kaiser,Leo Nicolai,Lea Di Fina,Dario Rossaro,Jan Wesche,Justina Rath,Ann-Christin Wienrich,Till Hoffmann,Lukas Harasser,Clemens Feistritzer,Lorin Loacker,Kourosh Lotfi,Margareta Holmström,Jovan Antovic,Leif Steil,Uwe Völker,Lena Ulm,Karsten Becker,Nils Olaf Hübner,Andreas Greinacher,Thomas Thiele
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TRANSPLANTATION

Allogeneic hematopoietic stem cell transplantation for STAT3 hyper-IgE syndrome: a worldwide study
Christo Tsilifis,Johannes Raedler,Joanna Renke,Michael Medinger,Alexandra Laberko,Ásgeir Haraldsson,Niraj Patel,Peter Ciznar,Melanie Wong,Steven J. Keogh,Paul Gray,Richard Mitchell,Venetia Bigley,Suzanne Elcombe,Fabian Hauck,Michael H. Albert,Eleni Tholouli,Archana Herwadkar,Shuayb Elkhalifa,Chris Kosmidis,Giorgio Callisti,Lauri M. Burroughs,Karin Chen,Ben Carpenter,Thomas A. Fox,Emma C. Morris,Ramya Uppuluri,Revathi Raj,Masakatsu Yanagimachi,Emilie P. Buddingh,Christina Oikonomopoulou,Corina Gonzalez,Dimana Dimitrova,Jennifer A. Kanakry,Danielle Arnold,Sung-Yun Pai,Mary A. Slatter,Mark S. Pearce,Austen Worth,Alexandra F. Freeman,Andrew R. Gennery
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RESEARCH LETTERS

Invasive fungal disease is rare in patients with relapsed/refractory multiple myeloma treated with BCMA CAR T-cell therapy
Clinical Trials & Observations
Jessica S. Little,Angelica Medina Pena,E. Bridget Kim,Andrew J. Yee,Omar Nadeem,Shonali Midha,Adam S. Sperling,Nikhil C. Munshi,Noopur Raje,Matthew J. Frigault,Diana D. Cirstea,Sarah P. Hammond
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RBC transfusion dependency refines the Molecular International Prognostic Scoring System for myelodysplastic syndrome
Thomas Wiseman,Michaela Spooner,Shreyas Khanna,Kevin Hung,Carla R. Toop,Monika Kutyna,Joanne Yu,Anna Brown,Hamish Scott,Christopher Hahn,Chung Hoow Kok,Devendra Hiwase
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One for the ages: impact of age on international prognostic indices in lymphoid cancer
Christian Brieghel,Emelie Curovic Rotbain,Jelena Jelicic,Sigrun Thorsteinsdottir,Peter de Nully Brown,Carsten Utoft Niemann
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Blood-derived cell-free DNA is a superior biomarker for noninvasive DNA methylation profiling in multiple myeloma
Robbe Heestermans,Catharina Olsen,Shervine Ameli,Jana Succari,Toon Janssen,Wouter De Brouwer,Ann De Becker,Isabelle Vande Broek,Marleen Bakkus,Rik Schots,Elke De Bruyne,Ivan Van Riet
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LETTERS TO THE EDITOR

Peripheral neuropathy and BTKis in Waldenström: a response?
Chiara Briani,Bruno Ferrero,Alessandro Salvalaggio,Simone Ragaini,Enrico Amaducci,Irene Dogliotti,Andrea Visentin,Simone Ferrero
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SGLT2i-associated erythrocytosis: closing the evidence gap
Benjamin Chin-Yee,Cyrus C. Hsia
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  • Cover Image

    Cover Image

    issue cover

    Fluorescence image showing IGSF9 (green) which was exclusively localized to the cellular membrane of acute myeloid leukemia (AML) cells with the red portion representing lysosomes. This image validates the therapeutic potential of anti-IGSF9 therapy in AML treatment. The image not only confirms surface expression as a targetable site, but it also establishes benchmarks for antibody-drug conjugate pharmacokinetics, providing support for the development of precision therapies in AML cells. See the article by Hui et al.

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Late effects after thymectomy
Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS
HLA-E[pHLA-G] complex–specific monoclonal antibody enhancing NK activity in multiple myeloma
Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis
Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate

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