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Issue Archive

Volume 6, Issue 9
May 10 2022
Issue Cover

Table of Contents

STIMULUS REPORT

RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea
Clinical Trials & Observations
Habib Zouali,Juliette Lemasson,Andreea Calugareanu,Christophe Battail,David Michonneau,Hélène le Buanec,Chloé Grolleau,Charles Cassius,Marie Robin,Marine Merandet,Gabor Dobos,Thibault Mahevas,Michel Rybojad,Adèle de Masson,Reyhan Amode,Anne Boland,Laurence Michel,Flore Sicre de Fontbrune,Régis Peffault de Latour,Patrick Bruneval,Hafid Ait-Oufella,Maxime Battistella,Marie Jachiet,Martine Bagot,Jean-François Deleuze,Gérard Socié,Jean-David Bouaziz
View Articletitled, RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea
Supplemental data
Day 30 SUVmax predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy
Ajlan Al Zaki,Lei Feng,Grace Watson,Sairah A. Ahmed,Haleigh Mistry,Loretta J. Nastoupil,Misha Hawkins,Ranjit Nair,Swaminathan P. Iyer,Hun J. Lee,Raphael E. Steiner,Christopher R. Flowers,Elizabeth J. Shpall,Partow Kebriaei,Sattva S. Neelapu,Jason R. Westin,Paolo Strati
View Articletitled, Day 30 SUV<sub>max</sub> predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity
Clinical Trials & Observations
Sigrun Einarsdottir,Anna Martner,Jesper Waldenström,Malin Nicklasson,Johan Ringlander,Mohammad Arabpour,Andreas Törnell,Hanna Grauers Wiktorin,Staffan Nilsson,Rudy Bittar,Malin Nilsson,Mikael Lisak,Malin Veje,Vanda Friman,Samer Al-Dury,Tomas Bergström,Per Ljungman,Mats Brune,Kristoffer Hellstrand,Martin Lagging
View Articletitled, Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity
Supplemental data

LYMPHOID NEOPLASIA

Distinct clinical and genetic features of hepatitis B virus–associated follicular lymphoma in Chinese patients
Weicheng Ren,Xianhuo Wang,Mingyu Yang,Hui Wan,Xiaobo Li,Xiaofei Ye,Bing Meng,Wei Li,Jingwei Yu,Mengyue Lei,Fanfan Xie,Wenqi Jiang,Eva Kimby,Huiqiang Huang,Dongbing Liu,Zhi-Ming Li,Kui Wu,Huilai Zhang,Qiang Pan-Hammarström
View Articletitled, Distinct clinical and genetic features of hepatitis B virus–associated follicular lymphoma in Chinese patients
Supplemental data
Improving eligibility criteria for first-line trials for patients with DLBCL using a US-based Delphi-method survey
Clinical Trials & Observations
R. Andrew Harkins,Sharvil P. Patel,Michelle J. Lee,Jeffrey M. Switchenko,Stephen M. Ansell,Nancy L. Bartlett,Kristie A. Blum,Amanda F. Cashen,Carla Casulo,Jonathan W. Friedberg,Patrick B. Johnston,Brad S. Kahl,John P. Leonard,Brian K. Link,Izidore S. Lossos,Peter Martin,Matt J. Maurer,Neha Mehta-Shah,Patrick M. Reagan,Jason R. Westin,Jean L. Koff,Christopher R. Flowers
View Articletitled, Improving eligibility criteria for first-line trials for patients with DLBCL using a US-based Delphi-method survey
Supplemental data
A multicenter retrospective study of polatuzumab vedotin in patients with large B-cell lymphoma after CAR T-cell therapy
Sushanth Gouni,Allison C. Rosenthal,Jennifer L. Crombie,Andrew Ip,Manali K. Kamdar,Brian Hess,Lei Feng,Grace Watson,Amy Ayers,Sattva S. Neelapu,Arushi Khurana,Yi Lin,Madiha Iqbal,Reid W. Merryman,Paolo Strati
View Articletitled, A multicenter retrospective study of polatuzumab vedotin in patients with large B-cell lymphoma after CAR T-cell therapy
Utility of PET/CT in assessing early treatment response in patients with newly diagnosed multiple myeloma
Clinical Trials & Observations
Charalampos Charalampous,Utkarsh Goel,Stephen M. Broski,David Dingli,Prashant Kapoor,Morie A. Gertz,Martha Q. Lacy,Angela Dispenzieri,Suzanne R. Hayman,Francis Buadi,Lisa Hwa,Nelson Leung,Yi Lin,Wilson I. Gonsalves,Taxiarchis V. Kourelis,Rahma Warsame,Amie Fonder,Miriam Hobbs,Moritz Binder,Robert A. Kyle,S. Vincent Rajkumar,Shaji K. Kumar
View Articletitled, Utility of PET/CT in assessing early treatment response in patients with newly diagnosed multiple myeloma

MYELOID NEOPLASIA

Single-cell analysis reveals selection of TP53-mutated clones after MDM2 inhibition
Nabih Maslah,Emmanuelle Verger,Stéphane Giraudier,Mathias Chea,Ronald Hoffman,John Mascarenhas,Bruno Cassinat,Jean-Jacques Kiladjian
View Articletitled, Single-cell analysis reveals selection of <em>TP53</em>-mutated clones after MDM2 inhibition
Supplemental data
Changes in body mass index, weight, and height in children with acute myeloid leukemia and the associations with outcome
Clinical Trials & Observations
Mayuko Iijima,Melanie Stall,Lei Wang,John C. Panetta,Brandon M. Triplett,Ching-Hon Pui,Raul C. Ribeiro,Jeffrey E. Rubnitz,Stanley B. Pounds,Hiroto Inaba
View Articletitled, Changes in body mass index, weight, and height in children with acute myeloid leukemia and the associations with outcome
Supplemental data
Prediction of life-threatening and disabling bleeding in patients with AML receiving intensive induction chemotherapy
Jurjen Versluis,Manu Pandey,Yael Flamand,J. Erika Haydu,Roger Belizaire,Mark Faber,Rahul S. Vedula,Anne Charles,Kevin M. Copson,Shai Shimony,Alon Rozental,Pavan K. Bendapudi,Ofir Wolach,Elizabeth A. Griffiths,James E. Thompson,Richard M. Stone,Daniel J. DeAngelo,Donna Neuberg,Marlise R. Luskin,Eunice S. Wang,R. Coleman Lindsley
View Articletitled, Prediction of life-threatening and disabling bleeding in patients with AML receiving intensive induction chemotherapy
Supplemental data
TP53 mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML
Clinical Trials & Observations
Olga K. Weinberg,Alexa Siddon,Yazan F. Madanat,Jeffrey Gagan,Daniel A. Arber,Paola Dal Cin,Damodaran Narayanan,Madhu M. Ouseph,Jason H. Kurzer,Robert P. Hasserjian
View Articletitled, <em>TP53</em> mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML
Supplemental data
Historical expectations with DNA methyltransferase inhibitor monotherapy in MDS: when is combination therapy truly “promising”?
Clinical Trials & Observations
Andrew M. Brunner,Geoffrey Fell,David P. Steensma
View Articletitled, Historical expectations with DNA methyltransferase inhibitor monotherapy in MDS: when is combination therapy truly “promising”?

PLATELETS AND THROMBOPOIESIS

Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry
Samuel Kemble,Amanda Dalby,Gillian C. Lowe,Phillip L. R. Nicolson,Steve P. Watson,Yotis Senis,Steven G. Thomas,Paul Harrison
View Articletitled, Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry
Supplemental data

THROMBOSIS AND HEMOSTASIS

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD
Qizhen Shi,Scot A. Fahs,Jeremy G. Mattson,Hongyin Yu,Crystal L. Perry,Patricia A. Morateck,Jocelyn A. Schroeder,Jessica Rapten,Hartmut Weiler,Robert R. Montgomery
View Articletitled, A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD
Supplemental data
Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model
Dongjune A. Kim,David N. Ku
View Articletitled, Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model
Supplemental data
Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort
Marc Blondon,Alexandre Bodmer,Laure Thouvenin,Thomas Lecompte,Marc Righini,Pierre Fontana,Alessandro Casini
View Articletitled, Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort
Supplemental data
Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
Orla Rawley,Laura L. Swystun,Christine Brown,Kate Nesbitt,Margaret Rand,Taneya Hossain,Robert Klaassen,Paula D. James,Manuel D. Carcao,David Lillicrap
View Articletitled, Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects
Supplemental data

TRANSPLANTATION

Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD
Clint Piper,Emma Hainstock,Cheng Yin-Yuan,Yao Chen,Achia Khatun,Moujtaba Y. Kasmani,John Evans,James A. Miller,Jack Gorski,Weiguo Cui,William R. Drobyski
View Articletitled, Single-cell immune profiling reveals a developmentally distinct CD4<sup>+</sup> GM-CSF<sup>+</sup> T-cell lineage that induces GI tract GVHD
Supplemental data
Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant
Jeremy D. Rubinstein,Carolyn Lutzko,Thomas Leemhuis,Xiang Zhu,Giang Pham,Lorraine Ray,Shawn Thomas,Celeste Dourson,Jamie Wilhelm,Adam Lane,Jose A. Cancelas,Dakota Lipps,Justin Ferrell,Patrick J. Hanley,Michael D. Keller,Catherine M. Bollard,YunZu M. Wang,Stella M. Davies,Adam S. Nelson,Michael S. Grimley
View Articletitled, Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant
Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease
Kristin M. Page,Margie A. Ream,Hemalatha G. Rangarajan,Rafael Galindo,Ali Y. Mian,Mai-Lan Ho,James Provenzale,Kathryn E. Gustafson,Jennifer Rubin,Shalini Shenoy,Joanne Kurtzberg
View Articletitled, Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease
Supplemental data

RESEARCH LETTER

Prognostic impact of ABCA3 expression in adult and pediatric acute myeloid leukemia: an ALFA-ELAM02 joint study
Antony Ceraulo,Hélène Lapillonne,Meyling H Cheok,Claude Preudhomme,Hervé Dombret,Christine Terré,Juliette Lambert,Guy Leverger,Yves Bertrand,Franck Mortreux,Eric Wattel
View Articletitled, Prognostic impact of <em>ABCA3</em> expression in adult and pediatric acute myeloid leukemia: an ALFA-ELAM02 joint study
Supplemental data
Rapid next-generation sequencing aids in diagnosis of transient abnormal myelopoiesis in a phenotypically normal newborn
Rahela Aziz-Bose,Franziska Wachter,Roberto Chiarle,Neal I. Lindeman,Annette S. Kim,Barbara A. Degar,Kimberly Davies,Yana Pikman
View Articletitled, Rapid next-generation sequencing aids in diagnosis of transient abnormal myelopoiesis in a phenotypically normal newborn
Results of a United Kingdom real-world study of polatuzumab vedotin, bendamustine, and rituximab for relapsed/refractory DLBCL
Clinical Trials & Observations
Michael Northend,William Wilson,Wendy Osborne,Christopher P. Fox,Andrew J. Davies,Dima El-Sharkawi,Elizabeth H. Phillips,Hau Wui Sim,Shalal Sadullah,Nimish Shah,Ying Ying Peng,Iman Qureshi,Juanah Addada,Rocio Figueroa Mora,Neil Phillips,Andrea Kuhnl,Elizabeth Davies,David Wrench,Pamela McKay,Indrani Karpha,Anna Cowley,Richard Karim,Sarah Challenor,Vikram Singh,Cathy Burton,Rebecca Auer,Chris Williams,Joel Cunningham,Angus Broom,Anita Arasaretnam,Claire Roddie,Tobias Menne,William Townsend
View Articletitled, Results of a United Kingdom real-world study of polatuzumab vedotin, bendamustine, and rituximab for relapsed/refractory DLBCL
Supplemental data
ASXL1 mutations are prognostically significant in PMF, but not MF following essential thrombocythemia or polycythemia vera
Clinical Trials & Observations
Paola Guglielmelli,Giacomo Coltro,Francesco Mannelli,Giada Rotunno,Giuseppe G. Loscocco,Carmela Mannarelli,Chiara Maccari,Chiara Paoli,Simone Romagnoli,Niccolò Bartalucci,Alessandro M. Vannucchi
View Articletitled, <em>ASXL1</em> mutations are prognostically significant in PMF, but not MF following essential thrombocythemia or polycythemia vera
Supplemental data

ERRATUM

Aiello S, Gastoldi S, Galbusera M, et al. C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19. Blood Adv. 2022;6(3):866-881.
View Articletitled, Aiello S, Gastoldi S, Galbusera M, et al. C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19. <em>Blood Adv.</em> 2022;6(3):866-881.
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