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Issue Archive

Volume 6, Issue 5
March 8 2022
Issue Cover

Table of Contents

POINT-COUNTERPOINT

Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation
Siok-Keen Tey,Steven W. Lane
View Articletitled, Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation
Not all patients with AML over 60 years of age should be offered early allogeneic stem cell transplantation 
H. Joachim Deeg
View Articletitled, Not all patients with AML over 60 years of age should be offered early allogeneic stem cell transplantation 

SYSTEMATIC REVIEW

Impact of vitamin D level at diagnosis and transplantation on the prognosis of hematological malignancy: a meta-analysis
Yusuke Ito,Akira Honda,Mineo Kurokawa
View Articletitled, Impact of vitamin D level at diagnosis and transplantation on the prognosis of hematological malignancy: a meta-analysis
Supplemental data
Chimeric antigen receptor T-cell therapy in adults with B-cell acute lymphoblastic leukemia
Punita Grover,Olivier Veilleux,Lu Tian,Ryan Sun,Melissa Previtera,Emily Curran,Lori Muffly
View Articletitled, Chimeric antigen receptor T-cell therapy in adults with B-cell acute lymphoblastic leukemia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Outcomes of relapsed B-cell acute lymphoblastic leukemia after sequential treatment with blinatumomab and inotuzumab
Clinical Trials & Observations
Kitsada Wudhikarn,Amber C. King,Mark B. Geyer,Mikhail Roshal,Yvette Bernal,Boglarka Gyurkocza,Miguel-Angel Perales,Jae H. Park
View Articletitled, Outcomes of relapsed B-cell acute lymphoblastic leukemia after sequential treatment with blinatumomab and inotuzumab
Supplemental data
Peritransplantation ruxolitinib administration is safe and effective in patients with myelofibrosis: a pilot open-label study
Clinical Trials & Observations
Haris Ali,Ni-Chun Tsai,Timothy Synold,Sally Mokhtari,Weimin Tsia,Joycelynne Palmer,Tracey Stiller,Monzr Al Malki,Ibrahim Aldoss,Amandeep Salhotra,Syed Rahmanuddin,Vinod Pullarkat,Ji-Lian Cai,Anthony Stein,Stephen J. Forman,Guido Marcucci,Matthew Mei,David S. Snyder,Ryotaro Nakamura
View Articletitled, Peritransplantation ruxolitinib administration is safe and effective in patients with myelofibrosis: a pilot open-label study
Supplemental data
Dose-finding study of ibrutinib and venetoclax in relapsed or refractory mantle cell lymphoma
Clinical Trials & Observations
Craig A. Portell,Nolan A. Wages,Brad S. Kahl,Lihua E. Budde,Robert W. Chen,Jonathon B. Cohen,Nikole E. Varhegyi,Gina R. Petroni,Michael E. Williams
View Articletitled, Dose-finding study of ibrutinib and venetoclax in relapsed or refractory mantle cell lymphoma
Supplemental data
Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients
Clinical Trials & Observations
Sabine Haggenburg,Birgit I. Lissenberg-Witte,Rob S. van Binnendijk,Gerco den Hartog,Michel S. Bhoekhan,Nienke J. E. Haverkate,Dennis M. de Rooij,Johan van Meerloo,Jacqueline Cloos,Neeltje A. Kootstra,Dorine Wouters,Suzanne S. Weijers,Ester M. M. van Leeuwen,Hetty J. Bontkes,Saïda Tonouh-Aajoud,Mirjam H. M. Heemskerk,Rogier W. Sanders,Elianne Roelandse-Koop,Quincy Hofsink,Kazimierz Groen,Lucia Çetinel,Louis Schellekens,Yvonne M. den Hartog,Belle Toussaint,Iris M. J. Kant,Thecla Graas,Emma de Pater,Willem A. Dik,Marije D. Engel,Cheyenne R. N. Pierie,Suzanne R. Janssen,Edith van Dijkman,Meliawati Poniman,Judith A. Burger,Joey H. Bouhuijs,Gaby Smits,Nynke Y. Rots,Sonja Zweegman,Arnon P. Kater,Tom van Meerten,Pim G. N. J. Mutsaers,Jaap A. van Doesum,Annoek E. C. Broers,Marit J. van Gils,Abraham Goorhuis,Caroline E. Rutten,Mette D. Hazenberg,Inger S. Nijhof
View Articletitled, Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients
Supplemental data
Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant
Clinical Trials & Observations
David J. Chung,Sneh Sharma,Madhumitha Rangesa,Susan DeWolf,Yuval Elhanati,Karlo Perica,James W. Young
View Articletitled, Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant
Supplemental data
Antiplatelet medications and risk of intracranial hemorrhage in patients with metastatic brain tumors
Clinical Trials & Observations
Eric J. Miller,Rushad Patell,Erik J. Uhlmann,Siyang Ren,Hannah Southard,Pavania Elavalakanar,Griffin M. Weber,Donna Neuberg,Jeffrey I. Zwicker
View Articletitled, Antiplatelet medications and risk of intracranial hemorrhage in patients with metastatic brain tumors

HEALTH SERVICES AND OUTCOMES

The economic burden of NIPC and BOS following allogeneic HSCT in patients with commercial insurance in the United States
Naomi C. Sacks,Bridget E. Healey,Sajjad Raza,Philip L. Cyr,Gerhard Boerner,Ajay Sheshadri
View Articletitled, The economic burden of NIPC and BOS following allogeneic HSCT in patients with commercial insurance in the United States
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice
Roberto Avellino,Roger Mulet-Lazaro,Marije Havermans,Remco Hoogenboezem,Leonie Smeenk,Nathan Salomonis,Rebekka K. Schneider,Elwin Rombouts,Eric Bindels,Lee Grimes,Ruud Delwel
View Articletitled, Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in <em>Cebpa</em> enhancer-null mice
Supplemental data
Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
Clinical Trials & Observations
Kana Mizuno,Christopher E. Dandoy,Ashley Teusink-Cross,Stella M. Davies,Alexander A. Vinks,Sonata Jodele
View Articletitled, Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
Supplemental data
GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
Kirby D. Johnson,Alexandra A. Soukup,Emery H. Bresnick
View Articletitled, GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
Supplemental data
M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands
Martina Hason,Tereza Mikulasova,Olga Machonova,Antonio Pombinho,Tjakko J. van Ham,Uwe Irion,Christiane Nüsslein-Volhard,Petr Bartunek,Ondrej Svoboda
View Articletitled, M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands
Supplemental data

LYMPHOID NEOPLASIA

Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas
Min Jung Koh,Mwanasha H. Merrill,Min Ji Koh,Robert Stuver,Carolyn D. Alonso,Francine M. Foss,Angel M. Mayor,John Gill,Marta Epeldegui,Edward Cachay,Jennifer E. Thorne,Michael J. Silverberg,Michael A. Horberg,Keri N. Althoff,Ank E. Nijhawan,Kathleen A. McGinnis,Jennifer S. Lee,Charles S. Rabkin,Sonia Napravnik,Jun Li,Jessica L. Castilho,Changyu Shen,Salvia Jain
View Articletitled, Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas
Supplemental data
The molecular hallmarks of primary and secondary vitreoretinal lymphoma
Irina Bonzheim,Philip Sander,Julia Salmerón-Villalobos,Daniela Süsskind,Peter Szurman,Florian Gekeler,Martin S. Spitzer,Julia Steinhilber,Esther Kohler,Melanie Büssgen,Jens Schittenhelm,Itziar Salaverria,Elias Campo,Sarah E. Coupland,Leticia Quintanilla-Martinez,Falko Fend
View Articletitled, The molecular hallmarks of primary and secondary vitreoretinal lymphoma
Supplemental data

MYELOID NEOPLASIA

Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia
Clinical Trials & Observations
Sydney Fobare,Jessica Kohlschmidt,Hatice Gulcin Ozer,Krzysztof Mrózek,Deedra Nicolet,Alice S. Mims,Ramiro Garzon,James S. Blachly,Shelley Orwick,Andrew J. Carroll,Richard M. Stone,Eunice S. Wang,Jonathan E. Kolitz,Bayard L. Powell,Christopher C. Oakes,Ann-Kathrin Eisfeld,Erin Hertlein,John C. Byrd
View Articletitled, Molecular, clinical, and prognostic implications of <em>PTPN11</em> mutations in acute myeloid leukemia
Supplemental data
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study
Clinical Trials & Observations
Jan M. Middeke,Klaus H. Metzeler,Christoph Röllig,Michael Krämer,Jan-Niklas Eckardt,Sebastian Stasik,Philipp A. Greif,Karsten Spiekermann,Maja Rothenberg-Thurley,Utz Krug,Jan Braess,Alwin Krämer,Andreas Hochhaus,Tim H. Brümmendorf,Ralph Naumann,Björn Steffen,Hermann Einsele,Markus Schaich,Andreas Burchert,Andreas Neubauer,Dennis Görlich,Cristina Sauerland,Kerstin Schäfer-Eckart,Christoph Schliemann,Stefan W. Krause,Mathias Hänel,Norbert Frickhofen,Richard Noppeney,Ulrich Kaiser,Martin Kaufmann,Desiree Kunadt,Bernhard Wörmann,Katja Sockel,Malte von Bonin,Tobias Herold,Carsten Müller-Tidow,Uwe Platzbecker,Wolfgang E. Berdel,Hubert Serve,Claudia D. Baldus,Gerhard Ehninger,Johannes Schetelig,Wolfgang Hiddemann,Martin Bornhäuser,Friedrich Stölzel,Christian Thiede
View Articletitled, Differential impact of <em>IDH1</em>/<em>2</em> mutational subclasses on outcome in adult AML: results from a large multicenter study
Supplemental data
CAMK2G is identified as a novel therapeutic target for myelofibrosis
Masashi Miyauchi,Ken Sasaki,Yuki Kagoya,Kazuki Taoka,Yosuke Masamoto,Sho Yamazaki,Shunya Arai,Hideaki Mizuno,Mineo Kurokawa
View Articletitled, CAMK2G is identified as a novel therapeutic target for myelofibrosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice
Jada Selma,Hannah Song,Christian Rivera,Simone Douglas,Abhiramgopal Akella,Keval Bollavaram,Nishone Thompson,Manu O. Platt,Edward A. Botchwey
View Articletitled, Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice
Supplemental data

TRANSPLANTATION

Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy
Clinical Trials & Observations
Robert Chiesa,Jaap Jan Boelens,Christine N. Duncan,Jörn-Sven Kühl,Caroline Sevin,Neena Kapoor,Vinod K. Prasad,Caroline A. Lindemans,Simon A. Jones,Hernan M. Amartino,Mattia Algeri,Nancy Bunin,Cristina Diaz-de-Heredia,Daniel J. Loes,Esther Shamir,Alison Timm,Elizabeth McNeil,Andrew C. Dietz,Paul J. Orchard
View Articletitled, Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy
Supplemental data
The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT
Roni Shouval,Joshua A. Fein,Christina Cho,Scott T. Avecilla,Josel Ruiz,Ana Alarcon Tomas,Miriam Sanchez-Escamilla,Nerea Castillo Flores,Lucrecia Yáñez,Juliet N. Barker,Parastoo Dahi,Sergio A. Giralt,Alexander I. Geyer,Boglarka Gyurkocza,Ann A. Jakubowski,Richard J. Lin,Richard J. O’Reilly,Esperanza B. Papadopoulos,Ioannis Politikos,Doris M. Ponce,Craig S. Sauter,Michael Scordo,Brian Shaffer,Gunjan L. Shah,James P. Sullivan,Roni Tamari,Marcel R. M. van den Brink,James W. Young,Arnon Nagler,Sean Devlin,Avichai Shimoni,Miguel-Angel Perales
View Articletitled, The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT
Supplemental data

RESEARCH LETTER

SARS-CoV-2–specific T-cell responses to recurrent COVID-19 pneumonitis in a patient with post-CART B-cell aplasia
Angus Hodder,Lindsey Williams,Jan Chu,Alasdair Bamford,Charlene Rodrigues,Kimberley Gilmour,Arnold Awuah,Fariba Tahami,Caroline Dalton,Orlagh McGarrity,Ajay Vora
View Articletitled, SARS-CoV-2–specific T-cell responses to recurrent COVID-19 pneumonitis in a patient with post-CART B-cell aplasia
SARS-CoV-2–neutralizing antibody treatment in patients with COVID-19 and immunodeficiency due to B-cell non-Hodgkin lymphoma
Clinical Trials & Observations
Jakob J. Malin,Veronica Di Cristanziano,Carola Horn,Elisabeth Pracht,Jorge Garcia Borrega,Eva Heger,Elena Knops,Rolf Kaiser,Boris Böll,Clara Lehmann,Norma Jung,Peter Borchmann,Gerd Fätkenheuer,Florian Klein,Michael Hallek,Jan Rybniker
View Articletitled, SARS-CoV-2–neutralizing antibody treatment in patients with COVID-19 and immunodeficiency due to B-cell non-Hodgkin lymphoma
Supplemental data

ERRATUM

Tiong IS, Dillon R, Ivey A, et al. Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia. Blood Adv. 2021;5(23):5107-5111.
View Articletitled, Tiong IS, Dillon R, Ivey A, et al. Clinical impact of <em>NPM1</em>-mutant molecular persistence after chemotherapy for acute myeloid leukemia. <em>Blood Adv.</em> 2021;5(23):5107-5111.
Weisdorf D, Cooley S, Wang T, et al. KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation. Blood Adv. 2020;4(4):740-754.
View Articletitled, Weisdorf D, Cooley S, Wang T, et al. <em>KIR B</em> donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation. <em>Blood Adv.</em> 2020;4(4):740-754.
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