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Issue Archive

Volume 5, Issue 19
October 12 2021
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Fatal late-onset CAR T-cell–mediated encephalitis after axicabtagene-ciloleucel in a patient with large B-cell lymphoma
Clinical Trials & Observations
Susanne Jung,Jochen Greiner,Stephanie von Harsdorf,Pavle Popovic,Roland Moll,Jens Schittenhelm,Kosmas Kandilaris,Volker Daniel,Alexander Kunz,Michael Schmitt,Peter Dreger
View Articletitled, Fatal late-onset CAR T-cell–mediated encephalitis after axicabtagene-ciloleucel in a patient with large B-cell lymphoma
Supplemental data
Systemic bevacizumab for refractory bleeding and transfusion-dependent anemia in Heyde syndrome
Clinical Trials & Observations
Andrew B. Song,Rahul Sakhuja,Nancy M. Gracin,Ronald Weinger,Raj S. Kasthuri,Hanny Al-Samkari
View Articletitled, Systemic bevacizumab for refractory bleeding and transfusion-dependent anemia in Heyde syndrome

STIMULUS REPORT

Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MM
Marietta S. Truger,Johannes Duell,Xiang Zhou,Larissa Heimeshoff,Anna Ruckdeschel,Mara John,Angela Riedel,Sebastian Hüper,Jessica Peter,Wencke Walter,Larissa Haertle,Manja Meggendorfer,Max S. Topp,Andreas Rosenwald,Matteo Claudio Da Via,Niccolo Bolli,Niels Weinhold,Hermann Einsele,Claudia Haferlach,K. Martin Kortüm,Leo Rasche
View Articletitled, Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MM
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 study of venetoclax plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma
Clinical Trials & Observations
Luciano J. Costa,Faith E. Davies,Gregory P. Monohan,Tibor Kovacsovics,Nicholas Burwick,Andrzej Jakubowiak,Jonathan L. Kaufman,Wan-Jen Hong,Monique Dail,Ahmed Hamed Salem,Xiaoqing Yang,Abdullah A. Masud,Wijith Munasinghe,Jeremy A. Ross,Orlando F. Bueno,Shaji K. Kumar,Edward A. Stadtmauer
View Articletitled, Phase 2 study of venetoclax plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma
Supplemental data
Hematopoietic stem cell transplantation for infants with high-risk KMT2A gene–rearranged acute lymphoblastic leukemia
Clinical Trials & Observations
Takayuki Takachi,Tomoyuki Watanabe,Takako Miyamura,Akiko Moriya Saito,Takao Deguchi,Toshinori Hori,Tomomi Yamada,Shigeru Ohmori,Masami Haba,Yuki Aoki,Sae Ishimaru,Shinya Sasaki,Junjiro Ohshima,Akihiro Iguchi,Yoshiyuki Takahashi,Nobuyuki Hyakuna,Atsushi Manabe,Keizo Horibe,Eiichi Ishii,Katsuyoshi Koh,Daisuke Tomizawa
View Articletitled, Hematopoietic stem cell transplantation for infants with high-risk <em>KMT2A</em> gene–rearranged acute lymphoblastic leukemia
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

The selection of variable regions affects effector mechanisms of IgA antibodies against CD20
Mitchell Evers,Thies Rösner,Anna Dünkel,J. H. Marco Jansen,Niklas Baumann,Toine ten Broeke,Maaike Nederend,Klara Eichholz,Katja Klausz,Karli Reiding,Denis M. Schewe,Christian Kellner,Matthias Peipp,Jeanette H. W. Leusen,Thomas Valerius
View Articletitled, The selection of variable regions affects effector mechanisms of IgA antibodies against CD20
Supplemental data

LYMPHOID NEOPLASIA

Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype
Ruben A.L. de Groen,Ronald van Eijk,Stefan Böhringer,Tom van Wezel,Richard Raghoo,Dina Ruano,Patty M. Jansen,Inge Briaire-de Bruijn,Fleur A. de Groot,Karin Kleiverda,Liane te Boome,Valeska Terpstra,Henriette Levenga,Alina Nicolae,Eduardus F.M. Posthuma,Isabelle Focke-Snieders,Lizan Hardi,Wietske C.E. den Hartog,Lara H. Bohmer,Pancras C.W. Hogendoorn,Anke van den Berg,Arjan Diepstra,Marcel Nijland,Pieternella J. Lugtenburg,Marie José Kersten,Steven T. Pals,Hendrik Veelken,Judith V.M.G. Bovée,Arjen H.G. Cleven,Joost S.P. Vermaat
View Articletitled, Frequent mutated <em>B2M, EZH2</em>, <em>IRF8</em>, and <em>TNFRSF14</em> in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype
Supplemental data
IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms
Liang Zhou,Yu Zhang,Mark B. Meads,Yun Dai,Yanxia Ning,Xiaoyan Hu,Lin Li,Kanika Sharma,Jewel Nkwocha,Rebecca Parker,Danny Bui,Jacquelyn McCarter,Lora Kramer,Cullen Purcell,Praneeth R. Sudalagunta,Rafael R. Canevarolo,Maria D. Coelho Siqueira Silva,Gabriel De Avila,Raghunandan Reddy Alugubelli,Ariosto S. Silva,Maciej Kmeiciak,Andrea Ferreira-Gonzalez,Kenneth H. Shain,Steven Grant
View Articletitled, IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms
Supplemental data
Outcomes after first-line immunochemotherapy for primary mediastinal B-cell lymphoma: a LYSA study
Clinical Trials & Observations
Vincent Camus,Cédric Rossi,Pierre Sesques,Justine Lequesne,David Tonnelet,Corinne Haioun,Eric Durot,Alexandre Willaume,Martin Gauthier,Marie-Pierre Moles-Moreau,Chloé Antier,Julien Lazarovici,Hélène Monjanel,Sophie Bernard,Magalie Tardy,Caroline Besson,Laure Lebras,Sylvain Choquet,Katell Le Du,Christophe Bonnet,Sarah Bailly,Ghandi Damaj,Kamel Laribi,Hervé Maisonneuve,Roch Houot,Adrien Chauchet,Fabrice Jardin,Alexandra Traverse-Glehen,Pierre Decazes,Stéphanie Becker,Alina Berriolo-Riedinger,Hervé Tilly
View Articletitled, Outcomes after first-line immunochemotherapy for primary mediastinal B-cell lymphoma: a LYSA study
Supplemental data
Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
Jason H. Rogers,Rohit Gupta,Jaime M. Reyes,Michael C. Gundry,Geraldo Medrano,Anna Guzman,Rogelio Aguilar,Shannon E. Conneely,Tidie Song,Cade Johnson,Sean Barnes,Carlo D.D. Cristobal,Kristen Kurtz,Lorenzo Brunetti,Margaret A. Goodell,Rachel E. Rau
View Articletitled, Modeling <em>IKZF1</em> lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
Supplemental data

PLATELETS AND THROMBOPOIESIS

Spotlight on eltrombopag in pediatric ITP in China: a long-term observational study in real-world practice
Clinical Trials & Observations
Xiaoling Cheng,LingLing Fu,Jingyao Ma,Hao Gu,Zhenping Chen,Libo Zhao,Xiaoling Wang,Runhui Wu
View Articletitled, Spotlight on eltrombopag in pediatric ITP in China: a long-term observational study in real-world practice

RED CELLS, IRON, AND ERYTHROPOIESIS

Impact of a grant program to spur advances in sickle cell disease research
Sindy N. Escobar Alvarez,Elizabeth R. Myers
View Articletitled, Impact of a grant program to spur advances in sickle cell disease research
Supplemental data

THROMBOSIS AND HEMOSTASIS

Characteristics of upper- and lower-extremity deep vein thrombosis and predictors of postthrombotic syndrome in children
Clinical Trials & Observations
Laura Avila,Nour Amiri,Riddhita De,Jennifer Vincelli,Eleanor Pullenayegum,Suzan Williams,Leonardo R. Brandão
View Articletitled, Characteristics of upper- and lower-extremity deep vein thrombosis and predictors of postthrombotic syndrome in children
Supplemental data
Management of acquired hemophilia A: results from the Spanish registry
Clinical Trials & Observations
María-Eva Mingot-Castellano,Josep Pardos-Gea,Saturnino Haya,José-María Bastida-Bermejo,Dolors Tàssies,Ana Marco-Rico,Ramiro Núñez,Faustino García-Candel,María-Carmen Fernández-Sanchez de Mora,Inmaculada Soto,María-Teresa Álvarez-Román,Susana Asenjo,Marina Carrasco,Rafael Lluch-García,José-Manuel Martín-Antorán,Agustín Rodríguez-Alén,Elena Roselló,Laura Torres-Miñana,Shally Marcellini-Antonio,Ana Moretó-Quinana,José-Antonio Rodríguez-García,Reyes Aguinaco-Culebras,Nieves Alonso-Escobar,Carlos Cervero-Santiago,Núria Fernández-Mosteirín,María-Paz Martínez-Badás,Montserrat Pérez-Sánchez,Rocío Pérez-Montes,Ramón Rodríguez-González,Marisol Uribe-Barrientos,Isabel Socorro Caparrós-Miranda,Miriam Iglesias-Fernández,Ángela Baena,Manuel Rodríguez-López,Ana Sebrango-Sandia,Irene Vázquez-Fernández,Pascual Marco,on behalf of the Acquired Haemophilia Spanish Registry of the Spanish Society of ThrombosisHaemostasis (SETH)
View Articletitled, Management of acquired hemophilia A: results from the Spanish registry
Supplemental data
A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder
Makoto Osada,Keiko Maruyama,Koichi Kokame,Ryunosuke Denda,Kohei Yamazaki,Hisako Kunieda,Maki Hirao,Seiji Madoiwa,Nobuo Okumura,Mitsuru Murata,Yasuo Ikeda,Kentaro Watanabe,Yuiko Tsukada,Takahide Kikuchi
View Articletitled, A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder

TRANSFUSION MEDICINE

Storage temperature determines platelet GPVI levels and function in mice and humans
Jeffrey Miles,S. Lawrence Bailey,Ava M. Obenaus,Molly Y. Mollica,Chomkan Usaneerungrueng,Daire Byrne,Lydia Fang,Jake R. Flynn,Jill Corson,Barbara Osborne,Katie Houck,Yi Wang,Yu Shen,Xiaoyun Fu,Jing-Fei Dong,Nathan J. Sniadecki,Moritz Stolla
View Articletitled, Storage temperature determines platelet GPVI levels and function in mice and humans
Supplemental data

TRANSPLANTATION

5-Azacytidine depletes HSCs and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice
Andriyana K. Bankova,Wendy W. Pang,Brenda J. Velasco,Janel R. Long-Boyle,Judith A. Shizuru
View Articletitled, 5-Azacytidine depletes HSCs and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice
Supplemental data

COMMENTARY

Optimizing outcomes in primary mediastinal B-cell lymphoma: is R-CHOP enough?
Clinical Trials & Observations
Michael R. Cook,Kieron Dunleavy
View Articletitled, Optimizing outcomes in primary mediastinal B-cell lymphoma: is R-CHOP enough?
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