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Issue Archive

Volume 3, Issue 17
September 10 2019
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Inherited predisposition to myeloid malignancies
Lucy A. Godley
View Articletitled, Inherited predisposition to myeloid malignancies
Supplemental data

EXCEPTIONAL CASE REPORTS

Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier
Clinical Trials & Observations
Christian P. Bradley,Cai Chen,Karolyn A. Oetjen,Cheng Yan,Reema Panjwani,Sara Hauffe,Katherine R. Calvo,Constance Yuan,Prapti Arvind Patel,Nathan D. Montgomery,Matthew C. Foster,Minoo Battiwalla,A. John Barrett,Richard J. Gibbons,Sawa Ito
View Articletitled, Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier
Supplemental data
Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome
Clinical Trials & Observations
Anne Angelillo-Scherrer,Behrouz Mansouri Taleghani,Frauke Förger,Gabriela M. Baerlocher,Thomas Pabst,Alexander Pöllinger,Yara Banz,Thomas Geiser,Johanna A. Kremer Hovinga,Alicia Rovó
View Articletitled, Immunoadsorption and autologous transplantation for life-threatening primary antiphospholipid syndrome

STIMULUS REPORT

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia
Brian M. Barth,Weiyuan Wang,Paul T. Toran,Todd E. Fox,Charyguly Annageldiyev,Regina M. Ondrasik,Nicole R. Keasey,Timothy J. Brown,Viola G. Devine,Emily C. Sullivan,Andrea L. Cote,Vasiliki Papakotsi,Su-Fern Tan,Sriram S. Shanmugavelandy,Tye G. Deering,David B. Needle,Stephan T. Stern,Junjia Zhu,Jason Liao,Aaron D. Viny,David J. Feith,Ross L. Levine,Hong-Gang Wang,Thomas P. Loughran, Jr,Arati Sharma,Mark Kester,David F. Claxton
View Articletitled, Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia
Supplemental data

REVIEW ARTICLE

Decoding the role of SOD2 in sickle cell disease
Atinuke M. Dosunmu-Ogunbi,Katherine C. Wood,Enrico M. Novelli,Adam C. Straub
View Articletitled, Decoding the role of SOD2 in sickle cell disease

SYSTEMATIC REVIEW

HLA-haploidentical vs matched-sibling hematopoietic cell transplantation: a systematic review and meta-analysis
Mohamad A. Meybodi,Wenhao Cao,Leo Luznik,Asad Bashey,Xu Zhang,Rizwan Romee,Wael Saber,Mehdi Hamadani,Daniel J. Weisdorf,Haitao Chu,Armin Rashidi
View Articletitled, HLA-haploidentical vs matched-sibling hematopoietic cell transplantation: a systematic review and meta-analysis
Supplemental data

GENE THERAPY

Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates
David Salas,Karin L. Kwikkers,Nerea Zabaleta,Andrea Bazo,Harald Petry,Sander J. van Deventer,Gloria Gonzalez Aseguinolaza,Valerie Ferreira
View Articletitled, Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates
Supplemental data
Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue
Wojciech Jankowski,Joseph McGill,H. A. Daniel Lagassé,Stepan Surov,Gary Bembridge,Campbell Bunce,Edward Cloake,Mark H. Fogg,Katarzyna I. Jankowska,Abdul Khan,Joseph Marcotrigiano,Mikhail V. Ovanesov,Zuben E. Sauna
View Articletitled, Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue
Supplemental data

LYMPHOID NEOPLASIA

KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis
Yusuke Isshiki,Yaeko Nakajima-Takagi,Motohiko Oshima,Kazumasa Aoyama,Mohamed Rizk,Shuhei Kurosawa,Atsunori Saraya,Takashi Kondo,Emiko Sakaida,Chiaki Nakaseko,Koutaro Yokote,Haruhiko Koseki,Atsushi Iwama
View Articletitled, KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis
Supplemental data
Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
Clinical Trials & Observations
Iris de Weerdt,Tom Hofland,Renate de Boer,Johan A. Dobber,Julie Dubois,Denise van Nieuwenhuize,Mehrdad Mobasher,Fransien de Boer,Mels Hoogendoorn,Gerjo A. Velders,Marjolein van der Klift,Ester B. M. Remmerswaal,Frederike J. Bemelman,Carsten U. Niemann,Sabina Kersting,Mark-David Levin,Eric Eldering,Sanne H. Tonino,Arnon P. Kater
View Articletitled, Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
Supplemental data

PLATELETS AND THROMBOPOIESIS

Mechanism of platelet α-granule biogenesis: study of cargo transport and the VPS33B-VPS16B complex in a model system
Andrea L. Ambrosio,Santiago M. Di Pietro
View Articletitled, Mechanism of platelet α-granule biogenesis: study of cargo transport and the VPS33B-VPS16B complex in a model system
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo
Timothy J. McMahon,Siqing Shan,Daniel A. Riccio,Milena Batchvarova,Hongmei Zhu,Marilyn J. Telen,Rahima Zennadi
View Articletitled, Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo
Supplemental data
Reticulocyte and red blood cell deformation triggers specific phosphorylation events
Pedro L. Moura,Maria A. Lizarralde Iragorri,Olivier Français,Bruno Le Pioufle,Johannes G. G. Dobbe,Geert J. Streekstra,Wassim El Nemer,Ashley M. Toye,Timothy J. Satchwell
View Articletitled, Reticulocyte and red blood cell deformation triggers specific phosphorylation events
Supplemental data

TRANSPLANTATION

Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
Clinical Trials & Observations
Celalettin Ustun,Soyoung Kim,Min Chen,Amer M. Beitinjaneh,Valerie I. Brown,Parastoo B. Dahi,Andrew Daly,Miguel Angel Diaz,Cesar O. Freytes,Siddhartha Ganguly,Shahrukh Hashmi,Gerhard C. Hildebrandt,Hillard M. Lazarus,Taiga Nishihori,Richard F. Olsson,Kristin M. Page,Genovefa Papanicolaou,Ayman Saad,Sachiko Seo,Basem M. William,John R. Wingard,Baldeep Wirk,Jean A. Yared,Miguel-Angel Perales,Jeffery J. Auletta,Krishna V. Komanduri,Caroline A. Lindemans,Marcie L. Riches
View Articletitled, Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children
Clinical Trials & Observations
Jennifer S. Whangbo,Haesook T. Kim,Nikola Mirkovic,Lauren Leonard,Samuel Poryanda,Sophie Silverstein,Soomin Kim,Carol G. Reynolds,Sharmila C. Rai,Kelly Verrill,Michelle A. Lee,Steven Margossian,Christine Duncan,Leslie Lehmann,Jennifer Huang,Sarah Nikiforow,Edwin P. Alyea, III,Philippe Armand,Corey S. Cutler,Vincent T. Ho,Bruce R. Blazar,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz,John Koreth
View Articletitled, Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children
Supplemental data
Related and unrelated donor transplantation for β-thalassemia major: results of an international survey
Clinical Trials & Observations
Chunfu Li,Vikram Mathews,Soyoung Kim,Biju George,Kyle Hebert,Hua Jiang,Changgang Li,Yiping Zhu,Daniel A. Keesler,Jaap Jan Boelens,Christopher C. Dvorak,Rajni Agarwal,Jeffery J. Auletta,Rakesh K. Goyal,Rabi Hanna,Kimberly Kasow,Shalini Shenoy,Angela R. Smith,Mark C. Walters,Mary Eapen
View Articletitled, Related and unrelated donor transplantation for β-thalassemia major: results of an international survey
“Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients
Clinical Trials & Observations
Ifigeneia Tzannou,Ayumi Watanabe,Swati Naik,Rachel Daum,Manik Kuvalekar,Kathryn S. Leung,Caridad Martinez,Ghadir Sasa,Mengfen Wu,Adrian P. Gee,Robert A. Krance,Stephen Gottschalk,Helen E. Heslop,Bilal Omer
View Articletitled, “Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients
Supplemental data
Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70
Clinical Trials & Observations
Philip H. Imus,Hua-Ling Tsai,Leo Luznik,Ephraim J. Fuchs,Carol Ann Huff,Douglas E. Gladstone,Patrick Lowery,Richard F. Ambinder,Ivan M. Borrello,Lode J. Swinnen,Nina Wagner-Johnston,Christian B. Gocke,Syed Abbas Ali,F. Javier Bolaños-Meade,Ravi Varadhan,Richard J. Jones
View Articletitled, Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70
Supplemental data

COMMENTARY

Additional analysis of pediatric pulmonary embolism using the Pediatric Health Information System database
Madhvi Rajpurkar,Yuan-shung V. Huang,Leslie Raffini
View Articletitled, Additional analysis of pediatric pulmonary embolism using the Pediatric Health Information System database
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Röth A, Broome CM, Barcellini W, et al. Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up. Blood Adv. 2023;7(19):5890-5897.
Hemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria
Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL
An indirect comparison of acalabrutinib with and without obinutuzumab vs zanubrutinib in treatment-naive CLL
Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival

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