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Journal Articles

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, David M. Harris, PhD, Ping Li, PhD, Zhiming Liu, BS, Taghi Manshouri, PhD, Ivo Veletic, MD, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, Srdan Verstovsek, MD PhD, William G. Wierda, MD PhD, Michael J Keating, MBBS, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 3018.

https://doi.org/10.1182/blood-2019-124014

Published: 2019

Journal Articles

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Taghi Manshouri, PhD, Ivo Veletic, MD, Ying Zhang, MD MS, Joseph E. Bove, IV, BS, Ping Li, PhD, David M. Harris, PhD, Zhiming Liu, BS, Evan N. Cohen, PhD, Srdan Verstovsek, MD PhD, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 2961.

https://doi.org/10.1182/blood-2019-132054

Published: 2019

Journal Articles

Ixazomib Modulates Bone Remodeling and Actives Sonic Hedgehog Pathways

Daniele Tibullo, PhD, Anna Longo, PhD, Alessandra Romano, MD PhD, Alessandro Barbato, Cesarina Giallongo, PhD, Michelino Di Rosa, PhD, Carmelina Daniela Anfuso, Gabriella Lupo, Concetta Conticello, MD, Nunzio Vicario, PhD, Rosario Gulino, PhD, Rosalba Parenti, PhD, Giuseppe A. Palumbo, MD PhD, Giovanni Li Volti, MD PhD, Francesco Di Raimondo, MD

Blood (2019) 134 (Supplement_1): 4345.

https://doi.org/10.1182/blood-2019-129927

Published: 2019

Journal Articles

Novel Role of Raft-Associated Smoothened (SMO) in AKT Signal Regulation in Diffuse Large B Cell Lymphoma

Nitin Agarwal, PhD, Kranthi Kunkalla, Daniel Bilbao, PhD, Ralf Landgraf, PhD, Francisco Vega, MD PhD

Blood (2019) 134 (Supplement_1): 3972.

https://doi.org/10.1182/blood-2019-121847

Published: 2019

Journal Articles

Mebendazole Mediates Its Anti-Leukemic Effects By Proteasomal Degradation of GLI Transcription Factors Via Inhibition of HSP70/90-Chaperone Activity in Acute Myeloid Leukemia in a Preclinical and Clinical Setting

Fabian Freisleben, Hauke Stamm, PhD, Jana Muschhammer, Vanessa Thaden, Franziska Modemann, MD, Alexander Krispien, Franziska Brauneck, Jasmin Wellbrock, PhD, Walter Fiedler, MD

Blood (2019) 134 (Supplement_1): 5050.

https://doi.org/10.1182/blood-2019-129973

Published: 2019

Journal Articles

Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia

Emanuela M. Ghia, Laura Z. Rassenti, Donna S. Neuberg, Alejandro Blanco, Fouad Yousif, Erin N. Smith, John D. McPherson, Thomas J. Hudson, the HALT Pan-Leukemia Gene Panel Consortium, Olivier Harismendy, Kelly A. Frazer, Thomas J. Kipps

Blood (2019) 133 (25): 2651–2663.

https://doi.org/10.1182/blood-2018-09-873695

Published: 2019

Includes: Supplemental data

Journal Articles

TGF-Beta Signaling in Mesenchymal Stromal Cells Contributes to Myelofibrosis but Not Hematopoietic Phenotypes in Myeloproliferative Neoplasms

Juo-Chin Yao, Grazia Abou Ezzi, PhD, Joseph R. Krambs, BS, Eric J. Duncavage, MD, Daniel C. Link, MD

Blood (2018) 132 (Supplement 1): 3053.

https://doi.org/10.1182/blood-2018-99-113745

Published: 2018

Journal Articles

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Marianne T. Santaguida, BSc, PhD, Christos Gekas, PhD, Todd A Alonzo, PhD, Robert B Gerbing, MA, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, E. Anders Kolb, MD, Tiffany Hylkema, BS, Lisa Eidenschink Brodersen, PhD, Michael R. Loken, PhD, Hamid Bolouri, PhD, Soheil Meshinchi, MD PhD

Blood (2018) 132 (Supplement 1): 881.

https://doi.org/10.1182/blood-2018-99-115544

Published: 2018

Journal Articles

Mebendazole Exerts Potent Anti-Leukemic Effects By Downregulating Protein Levels of Hedgehog Transcription Factors GLI1 and GLI2

Fabian Freisleben, Hauke Stamm, PhD, Jana Muschhammer, Alexander Krispien, Vanessa Thaden, Jasmin Wellbrock, PhD, Walter Fiedler, MD

Blood (2018) 132 (Supplement 1): 5145.

https://doi.org/10.1182/blood-2018-99-118189

Published: 2018

Journal Articles

Genetic Modulation of Adenosine-to-Inosine RNA Editing Selectively Disrupts Inflammasome and Extracellular Matrix Genes in Multiple Myeloma

Leslie A Crews, PhD, Phoebe Mondala, BS, Elisa Lazzari, PhD, Gabriel Pineda, PhD, Christina Wu, PhD, Caitlin L. Costello, MD, Catriona Jamieson, MD PhD

Blood (2018) 132 (Supplement 1): 1324.

https://doi.org/10.1182/blood-2018-99-120326

Published: 2018

Journal Articles

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Rafael Kramann, Rebekka K. Schneider

Blood (2018) 131 (19): 2111–2119.

https://doi.org/10.1182/blood-2018-02-834820

Published: 2018

Journal Articles

Upregulation of Alternatively Glycosylated Smoothened (SMO) Is Involved in Doxorubicin (DXR) Resistance in Diffuse Large B-Cell Lymphoma

Nitin Agarwal, PhD, Kranthi Kunkalla, MS, Sandra Sanchez, MD, Amineh Vaghefi, MD, Darius Juskevicius, PhD, Alexandar Tzankov, Ramiro E Verdun, PhD, Ralf Landgraf, PhD, Francisco Vega, MD PhD

Blood (2017) 130 (Supplement 1): 3839.

https://doi.org/10.1182/blood.V130.Suppl_1.3839.3839

Published: 2017

Journal Articles

ADAR1-MediatedGLI1 Editing Promotes Malignant Self-Renewal in Multiple Myeloma

Leslie Crews, PhD, Elisa Lazzari, PhD, Phoebe Mondala, BS, Nathan Delos Santos, BS, Amber Miller, PhD BA, Gabriel Pineda, PhD, Qingfei Jiang, PhD, Heather Leu, BS, Shawn Ali, BA, Anusha Preethi Ganesan, MD PhD, Christina Wu, PhD, Caitlin L. Costello, MD, Mark D. Minden, MD PhD, Raffaella Chiaramonte, PhD, A. Keith Stewart, MBChB, MBA, Catriona Jamieson, MD PhD

Blood (2017) 130 (Supplement 1): 1204.

https://doi.org/10.1182/blood.V130.Suppl_1.1204.1204

Published: 2017

Journal Articles

Smoothened Stabilizes and Protects TRAF6 from Proteosomal Degradation: A Novel Non-Canonical Role of Smoothened with Implications in Lymphoma Biology

Changju QU, MDPhD, Amineh Vaghefi, MD, Kranthi Kunkalla, MS, Jennifer R Chapman, MD, Yadong Liu, MD, Marzenna Blonska, PhD, Juan Pablo Alderuccio, MD, Leon Bernal-Mizrachi, MD, Izidore S Lossos, MD, Ralf Landgraf, PhD, Francisco Vega, MD PhD

Blood (2017) 130 (Supplement 1): 646.

https://doi.org/10.1182/blood.V130.Suppl_1.646.646

Published: 2017

Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD

Blood (2017) 130 (Supplement 1): 2654.

https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654

Published: 2017

Journal Articles

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Bonnie W Lau, MD PhD, Kyounghee Huh, MS, Rafael Madero-Marroquin, MD, Federico De Marchi, MD, Yiting Lim, PhD, Francisco Lobo, PhD, Luigi Marchionni, PhD, Peter D. Aplan, MD, William Matsui, MD, Lukasz P. Gondek, MD PhD

Blood (2017) 130 (Supplement 1): 1676.

https://doi.org/10.1182/blood.V130.Suppl_1.1676.1676

Published: 2017

Journal Articles

Modulating Hedgehog Signaling Reduces MAPK, TGF-β, and Marrow Fibrosis in a Transgenic Mouse Model of JAK2V617F Associated Myeloproliferative Disease

Parvesh Chaudhry, PhD, Mohan Singh, PhD, Imran Siddiqi, MDPhD, Casey L. O'Connell, MD, Zhizhuang Joe Zhao, PhD, Akil Merchant, MD

Blood (2017) 130 (Supplement 1): 4216.

https://doi.org/10.1182/blood.V130.Suppl_1.4216.4216

Published: 2017

Journal Articles

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML

Parvesh Chaudhry, Mohan Singh, Timothy J. Triche, Monica Guzman, Akil A. Merchant

Blood (2017) 129 (26): 3465–3475.

https://doi.org/10.1182/blood-2016-05-718585

Published: 2017

Includes: Supplemental data

Journal Articles

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis, Sofie Demeyer, Jolien De Bie, Enrico Radaelli, Daphnie Pauwels, Sandrine Degryse, Olga Gielen, Carmen Vicente, Roel Vandepoel, Ellen Geerdens, Anne Uyttebroeck, Nancy Boeckx, Charles E. de Bock, Jan Cools

Blood (2016) 128 (23): 2642–2654.

https://doi.org/10.1182/blood-2016-03-703454

Published: 2016

Includes: Supplemental data

Journal Articles

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

Kelly A. Turner, BSc, Katharina Rothe, PhD, Adrian Woolfson, MD PhD, Xiaoyan Jiang, MD PhD

Blood (2016) 128 (22): 4236.

https://doi.org/10.1182/blood.V128.22.4236.4236

Published: 2016

NARROW

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Ixazomib Modulates Bone Remodeling and Actives Sonic Hedgehog Pathways

Novel Role of Raft-Associated Smoothened (SMO) in AKT Signal Regulation in Diffuse Large B Cell Lymphoma

Mebendazole Mediates Its Anti-Leukemic Effects By Proteasomal Degradation of GLI Transcription Factors Via Inhibition of HSP70/90-Chaperone Activity in Acute Myeloid Leukemia in a Preclinical and Clinical Setting

Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia

TGF-Beta Signaling in Mesenchymal Stromal Cells Contributes to Myelofibrosis but Not Hematopoietic Phenotypes in Myeloproliferative Neoplasms

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options — a COG and Target Pediatric AML Study

Mebendazole Exerts Potent Anti-Leukemic Effects By Downregulating Protein Levels of Hedgehog Transcription Factors GLI1 and GLI2

Genetic Modulation of Adenosine-to-Inosine RNA Editing Selectively Disrupts Inflammasome and Extracellular Matrix Genes in Multiple Myeloma

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Upregulation of Alternatively Glycosylated Smoothened (SMO) Is Involved in Doxorubicin (DXR) Resistance in Diffuse Large B-Cell Lymphoma

ADAR1-MediatedGLI1 Editing Promotes Malignant Self-Renewal in Multiple Myeloma

Smoothened Stabilizes and Protects TRAF6 from Proteosomal Degradation: A Novel Non-Canonical Role of Smoothened with Implications in Lymphoma Biology

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Modulating Hedgehog Signaling Reduces MAPK, TGF-β, and Marrow Fibrosis in a Transgenic Mouse Model of JAK2V617F Associated Myeloproliferative Disease

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Drug-Insensitive CML Stem/Progenitor Cells Highly Express Key Regulators of the Hedgehog Pathway and Inhibition of the Hedgehog Pathway Enhances Their Response to TKI Treatment

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American Society of Hematology

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ASH Publications

American Society of Hematology

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