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Journal Articles

Development TACI and Bcma Dual-Antigen Targeted Immunotherapy for Multiple Myeloma

Jooeun Bae, PhD, Teru Hideshima, MD PhD, Mehmet Kemal Samur, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 3138.

https://doi.org/10.1182/blood-2019-128689

Published: 2019

Journal Articles

Activating KRAS , NRAS , and BRAF Mutants Enhance Proteasome Capacity and Reduce Endoplasmic Reticulum Stress in Multiple Myeloma, Thereby Promoting Plasma Cell Survival and Proteasome Inhibitor Resistance

Fazal Shirazi, PhD, Richard J. Jones, PhD, Isere Kuiatse, PhD, Zuzana Berkova, PhD, Hua Wang, PhD, Hans C. Lee, MD, Samuel Hong, PhD, Ram Kumar Singh, PhD, Lawrence Robert Dick, PhD, Nibedita Chattopadhyay, PhD, Robert Z. Orlowski, MD PhD

Blood (2018) 132 (Supplement 1): 406.

https://doi.org/10.1182/blood-2018-99-117577

Published: 2018

Journal Articles

Predicting Treatment Response and Survival of Multiple Myeloma with the Xbp-1 Co-Expression Gene Module

Xuzhang Lu, PhD, Fan Xiaolong, Jia Zhuxia, PhD, He Jinyuan, PhD, Cai Xiaohui, MD

Blood (2018) 132 (Supplement 1): 5590.

https://doi.org/10.1182/blood-2018-99-111695

Published: 2018

Journal Articles

Selective Targeting of Multiple Myeloma By Bcma-Specific Central Memory CD8 + cytotoxic T Lymphocytes: A Potential Immunotherapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders

Jooeun Bae, PhD, Teru Hideshima, MD PhD, Nikhil Munshi, MD, Kenneth C. Anderson, MD

Blood (2018) 132 (Supplement 1): 3196.

https://doi.org/10.1182/blood-2018-99-117282

Published: 2018

Journal Articles

The Implications of Endoplasmic Reticulum Stress Response in the Prognosis and Pathogenesis of Myelodysplastic Syndrome

Ming-En Lin, MD, Wen-Chien Chou, MD, PhD, Yu-Chiao Chiu, PhD, Mei-Hsuan Tseng, M.Sc., Ming-Chih Liu, Chia-Wen Liu, Jih-Luh Tang, MD,PhD, Ming Yao, MD, Chi-Cheng Li, MD, Shang-Yi Huang, MD, PhD, Chien-Yuan Chen, MD, PhD, Bor-Sheng Ko, MD, PhD, Szu-Chun Hsu, MD, Hsin-An Hou, MD, PhD, Shang-Ju Wu, MD, PhD, Chien-Ting Lin, MD, Woei Tsai, MD, PhD, Yidong Chen, PhD, Hwei-Fang Tien, MD, PhD

Blood (2017) 130 (Supplement 1): 4249.

https://doi.org/10.1182/blood.V130.Suppl_1.4249.4249

Published: 2017

Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD

Blood (2017) 130 (Supplement 1): 4290.

https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290

Published: 2017

Journal Articles

The Novel Protein HSF1 Stress Pathway Inhibitor Bisamide CCT361814 Demonstrates Pre-Clinical Anti-Tumor Activity in Myeloma

Karen Menezes, PhD BSc, MSc, Grace Aram, MSc, Fabio Mirabella, PhD, David C Johnson, PhD, Amy L Sherborne, PhD, Richard S Houlston, MD PhD, Matthew D Cheeseman, PhD, Elisa Pasqua, PhD, Paul Clarke, PhD, Paul Workman, PhD, Keith Jones, PhD, Martin F Kaiser, MD

Blood (2017) 130 (Supplement 1): 3072.

https://doi.org/10.1182/blood.V130.Suppl_1.3072.3072

Published: 2017

Journal Articles

Identification and Validation of HLA-A24 XBP1 us , XBP1 sp , CD138, and CS1 Peptides to Generate Antigens Specific-Cytotoxic T Lymphocytes: Preclinical Basis for Vaccine Therapy in HLA-A24 Patients with Multiple Myeloma and Other Cancers

Jooeun Bae, PhD, Brandon Nguyen, Matthew Ho, Yan Song, PhD, Noopur Raje, MD, Paul G. Richardson, MD, Teru Hideshima, MD PhD, Dharminder Chauhan, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 5689.

https://doi.org/10.1182/blood.V128.22.5689.5689

Published: 2016

Journal Articles

Prevention of Chronic Gvhd By Targeting Xbp-1 Genetically or Pharmacologically in Mice

Steven D Schutt, BS, Chih-Hang Anthony Tang, MD PhD, Yongxia Wu, PhD, David A Bastian, BS, Juan Del Valle, BS, PhD, Chih-Chi Andrew Hu, PhD, Xue-Zhong Yu, PhD

Blood (2016) 128 (22): 4541.

https://doi.org/10.1182/blood.V128.22.4541.4541

Published: 2016

Journal Articles

Whole Exome Sequencing of Pediatric Acute Lymphoblastic Leukemia Patients Identify Mutations in 11 Pathways: A Report from the Children's Oncology Group

Blood (2016) 128 (22): 455.

https://doi.org/10.1182/blood.V128.22.455.455

Published: 2016

Journal Articles

Translational Focus on Targeting HDAC6 with Ricolinostat Confirms Potent Activity in Preclinical Models of Lymphoma and a Favorable Toxicity Profile in Patients with Relapsed or Refractory Lymphoma

Jennifer E Amengual, MD, Lichtenstein Renee, Celeste Rojas, Kelly Zullo, MS, Maximilian Lombardo, Emily Lichtenstein, RN, Ellen Neylon, NP, Changchun Deng, MD PhD, Ahmed Sawas, MD, Bijal D Shah, Catherine Wheeler, MD, Simon S Jones, PhD, Owen A. O'Connor, MD PhD

Blood (2015) 126 (23): 1280.

https://doi.org/10.1182/blood.V126.23.1280.1280

Published: 2015

Journal Articles

Proteasome Inhibitor-Adapted Myeloma Cells That Lack Proteasome Gene Mutations Resist Highly Efficient Proteasome Inhibition and Show Proteomic Alterations That Suggest Complex Metabolic Changes

Lenka Besse, PhD, Guillem Soriano, Nan Li, Andrej Besse, Marianne Kraus, Juergen Bader, Tobias Christian Silzle, MD, Nico Meeuwenoord, Hans den Dulk, Herman S Overkleeft, Bogdan Florea, Christoph Driessen, MD

Blood (2015) 126 (23): 1278.

https://doi.org/10.1182/blood.V126.23.1278.1278

Published: 2015

Journal Articles

Mechanisms of Acquired Drug Resistance to the Isoform Selective HDAC6 Inhibitor Ricolinostat Reveals Markedly Upregulated Elements of the BTK Pathway Revealing Rational Drug : Drug Combinations

Jennifer E Amengual, MD, Maximilian Lombardo, Kelly M Zullo, Paul M. Johannet, BA, Sathyen A Prabhu, Gonzalez Yulissa, Luigi Scotto, PhD, Ying Wei, Jimmy Duong, Owen A. O'Connor, MD PhD

Blood (2015) 126 (23): 3708.

https://doi.org/10.1182/blood.V126.23.3708.3708

Published: 2015

Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart

Blood (2015) 126 (23): 450.

https://doi.org/10.1182/blood.V126.23.450.450

Published: 2015

Journal Articles

Interfering with Arginine Metabolism As a New Treatment Strategy for Multiple Myeloma

Bjoern Jacobi, MD, Lea Stroeher, MS, Nadine Leuchtner, Hakim Echchannaoui, PhD, Alexander Desuki, MD, Lara Kuerzer, Alice Habermeier, Edite Antunes, Eva Amann, John Bomalaski, MD, Closs Ellen, PhD Prof., Matthias Theobald, MD PhD, Markus Munder, MD

Blood (2015) 126 (23): 3005.

https://doi.org/10.1182/blood.V126.23.3005.3005

Published: 2015

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Jo Ishizawa, MD PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Archana Dilip, MS, Hong Mu, MD PhD, Zhihong Zeng, MD, Polina Matre, PhD, Joshua E. Allen, PhD, Sattva S Neelapu, MD, Timothy J. McDonnell, MD PhD, Roberto N. Miranda, MD, Larry W. Kwak, MD PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 3122.

https://doi.org/10.1182/blood.V124.21.3122.3122

Published: 2014

Journal Articles

Hypoferremia of Fasting in Mice Is Associated with Increased Hepcidin and Decreased Erythroferrone Expression

Yihang Li, PhD, Gregory R Booth, MD, Qi Feng, MD, Robert E Fleming, MD

Blood (2014) 124 (21): 4026.

https://doi.org/10.1182/blood.V124.21.4026.4026

Published: 2014

Journal Articles

PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal

Yuichiro Inagaki, MD, Fumihiko Hayakawa, MD PhD, Yuki Kojima, MD, Takanobu Morishita, MD, Naoto Imoto, MD, Tomoki Naoe, MDPhD, Hitoshi Kiyoi, MD PhD

Blood (2014) 124 (21): 4349.

https://doi.org/10.1182/blood.V124.21.4349.4349

Published: 2014

Journal Articles

Mast Cell Activation in Sickle Mice Stimulates Endothelial Dysfunction

Kathryn Luk, Julia Nguyen, BS, Jinny Paul, PhD, Barbara Benson, BS, Yann Y Lamarre, PhD, Kalpna Gupta, PhD

Blood (2014) 124 (21): 453.

https://doi.org/10.1182/blood.V124.21.453.453

Published: 2014

Journal Articles

Overcoming Resistance to Apoptosis in Multiple Myeloma By Simultaneous Inhibition of Bcl2 and IAP Families of Anti-Apoptotic Proteins

Marcus Gomez, Vijay G. Ramakrishnan, PhD, Vivek Prasad, Teresa K. Kimlinger, Utkarsh Painuly, MD, Lintao Bi, PhD, Vincent Rajkumar, MD, Shaji Kumar, MD

Blood (2014) 124 (21): 2088.

https://doi.org/10.1182/blood.V124.21.2088.2088

Published: 2014

NARROW

Development TACI and Bcma Dual-Antigen Targeted Immunotherapy for Multiple Myeloma

Activating KRAS , NRAS , and BRAF Mutants Enhance Proteasome Capacity and Reduce Endoplasmic Reticulum Stress in Multiple Myeloma, Thereby Promoting Plasma Cell Survival and Proteasome Inhibitor Resistance

Predicting Treatment Response and Survival of Multiple Myeloma with the Xbp-1 Co-Expression Gene Module

Selective Targeting of Multiple Myeloma By Bcma-Specific Central Memory CD8 + cytotoxic T Lymphocytes: A Potential Immunotherapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders

The Implications of Endoplasmic Reticulum Stress Response in the Prognosis and Pathogenesis of Myelodysplastic Syndrome

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

The Novel Protein HSF1 Stress Pathway Inhibitor Bisamide CCT361814 Demonstrates Pre-Clinical Anti-Tumor Activity in Myeloma

Identification and Validation of HLA-A24 XBP1 us , XBP1 sp , CD138, and CS1 Peptides to Generate Antigens Specific-Cytotoxic T Lymphocytes: Preclinical Basis for Vaccine Therapy in HLA-A24 Patients with Multiple Myeloma and Other Cancers

Prevention of Chronic Gvhd By Targeting Xbp-1 Genetically or Pharmacologically in Mice

Whole Exome Sequencing of Pediatric Acute Lymphoblastic Leukemia Patients Identify Mutations in 11 Pathways: A Report from the Children's Oncology Group

Translational Focus on Targeting HDAC6 with Ricolinostat Confirms Potent Activity in Preclinical Models of Lymphoma and a Favorable Toxicity Profile in Patients with Relapsed or Refractory Lymphoma

Proteasome Inhibitor-Adapted Myeloma Cells That Lack Proteasome Gene Mutations Resist Highly Efficient Proteasome Inhibition and Show Proteomic Alterations That Suggest Complex Metabolic Changes

Mechanisms of Acquired Drug Resistance to the Isoform Selective HDAC6 Inhibitor Ricolinostat Reveals Markedly Upregulated Elements of the BTK Pathway Revealing Rational Drug : Drug Combinations

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Interfering with Arginine Metabolism As a New Treatment Strategy for Multiple Myeloma

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Hypoferremia of Fasting in Mice Is Associated with Increased Hepcidin and Decreased Erythroferrone Expression

PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal

Mast Cell Activation in Sickle Mice Stimulates Endothelial Dysfunction

Overcoming Resistance to Apoptosis in Multiple Myeloma By Simultaneous Inhibition of Bcl2 and IAP Families of Anti-Apoptotic Proteins

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American Society of Hematology

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