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Journal Articles

Leukemia-Associated HSC Vascular Niche Is Negatively Regulated By PERK of Unfolded Protein Response (UPR)

Lan Zhou, MD, Cui Liu, MBBS, PhD, Stanley A Adoro, PhD BSc, MSc, Lechuang Chen, PhD, Diana Ramirez, PhD, Ge Jin, PhD

Blood (2019) 134 (Supplement_1): 2486.

https://doi.org/10.1182/blood-2019-127607

Published: 2019

Journal Articles

Proteostasis and Myeloid Stem Cell Production

Robert Signer, PhD

Blood (2019) 134 (Supplement_1): SCI-42.

https://doi.org/10.1182/blood-2019-121085

Published: 2019

Journal Articles

Single Cell Approaches - Drilling Down Deeper Using Technology and Integrated Data Analyses

Dan A. Landau, MD

Blood (2019) 134 (Supplement_1): SCI-28.

https://doi.org/10.1182/blood-2019-121046

Published: 2019

Journal Articles

Effect of the Unfolded Protein Response and Oxidative Stress on Mutagenesis of CSF3R a Model of Evolution of Severe Congenital Neutropenia to Myelodysplastic Syndrome/Acute Myeloid Leukemia

Adya Sapra, MS, Roman Jaksik, PhD, Sara Biesiadny, Hrishikesh M Mehta, PhD, Marek Kimmel, PhD DSc, Seth J. Corey, MD

Blood (2019) 134 (Supplement_1): 3752.

https://doi.org/10.1182/blood-2019-127401

Published: 2019

Journal Articles

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

Ran Zhao, BS, Sarah Zarabi, MD, Takenobu Nii, PhD, Ondrej Halgas, PhD, Yulia Jitkova, PhD, Vivian Ruvolo, Lauren Heese, Yuki Nishida, MD PhD, Gautam M. Borthakur, MD, Kensuke Kojima, MD PhD, Martin Stogniew, Wolfgang Oster, MD, Emil Pai, PhD, Eric Davis, MD, Hagop M. Kantarjian, MD, Aaron D Schimmer, MD PhD, Michael Andreeff, MD PhD, Jo Ishizawa, MD PhD

Blood (2019) 134 (Supplement_1): 2562.

https://doi.org/10.1182/blood-2019-127101

Published: 2019

Journal Articles

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Oluwatoyosi Muse, PhD, Rushad Patell, MD, Christian Peters, PhD, Sol Schulman, MD PhD, Emale Darzi, MS, Calvin Schuster, BA, Ling Huang, PhD, Shibani Mukherjee, PhD, Senthil Muthuswamy, PhD, Jeffrey I. Zwicker, MD, Robert C. Flaumenhaft, MD PhD

Blood (2019) 134 (Supplement_1): 632.

https://doi.org/10.1182/blood-2019-123544

Published: 2019

Journal Articles

Analysis of Mechanisms Underlying Clonal Evolution of AML By a New Single-Cell Sequencing Platform

Ryosaku Inagaki, MSc, Masahiro Marshall Nakagawa, MD PhD, Yasuhito Nannya, MD PhD, Qi Xingxing, PhD, Lanying Zhao, MD, PhD, June Takeda, MD, Akinori Yoda, PhD, Ayana Kon, MD PhD, Hisashi Tsurumi, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD

Blood (2019) 134 (Supplement_1): 542.

https://doi.org/10.1182/blood-2019-126444

Published: 2019

Journal Articles

Machine Learning Unveils Proteotypic Mimicry in Genetically Defined SCN Variants

Sebastian Hesse, MD, Christoph Klein, MD PhD, Rappsilber Juri, Prof., Yoko Mizoguchi, Monika Linder, PhD, Piotr Grabowski, PhD, Zahra Alizadeh, PhD, Zahra Pourpak, MD PhD, Nima Rezaei, MD PhD, Sorin Iurian, MD PhD, Ekrem Unal, MD, Fabian Hauck, MD PhD, Ralf Zimmer, Prof., Gergely Csaba, PhD

Blood (2019) 134 (Supplement_1): 3580.

https://doi.org/10.1182/blood-2019-131136

Published: 2019

Journal Articles

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

Bhavuk Garg, PhD, Hrishikesh M Mehta, PhD, Ralph Kamel, Marshall S. Horwitz, MD PhD, Seth J. Corey, MD

Blood (2019) 134 (Supplement_1): 103.

https://doi.org/10.1182/blood-2019-127409

Published: 2019

Journal Articles

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Kotaro Shide, MD PhD, Takuro Kameda, MD PhD, Ayako Kamiunten, MD, Yoshinori Ozono, MD, Yuki Tahira, MD, Masaaki Sekine, MD, Masaya Ono, MD PhD, Takako Yokomizo, PhD, Sho Kubota, Keiichi Akizuki, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD

Blood (2019) 134 (Supplement_1): 309.

https://doi.org/10.1182/blood-2019-130034

Published: 2019

Journal Articles

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Hans C. Lee, Zuzana Berkova, Allison Berger, Marc Hyer, Nibedita Chattopadhyay, Sakeena Syed, Judy Qiuju Shi, Jie Yu, Vaishali Shinde, Stephen Tirrell, Richard Julian Jones, Zhiqiang Wang, R. Eric Davis, Robert Z. Orlowski

Blood (2019) 133 (14): 1572–1584.

https://doi.org/10.1182/blood-2018-06-859686

Published: 2019

Includes: Supplemental data

Journal Articles

Calreticulin Ins5 and Del52 Mutations Impair Unfolded Protein and Oxidative Stress Responses in Hematopoietic Cells

Simona Salati, PhD, Elena Genovese, BSc, Zelia Prudente, BSc, PhD, Chiara Carretta, Niccolò Bartalucci, PhD BSc, Valentina Pennucci, PhD, Samantha Ruberti, BSc, PhD, Chiara Rossi, PharmD, Sebastiano Rontauroli, BSc, Carmela Mannarelli, PhD, Roberta Zini, BSc, PhD, Elisa Bianchi, BSc, PhD, Paola Guglielmelli, MD PhD, Enrico Tagliafico, MDPhD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhD

Blood (2018) 132 (Supplement 1): 4332.

https://doi.org/10.1182/blood-2018-99-112550

Published: 2018

Journal Articles

Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis

Aaron Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): SCI-11.

https://doi.org/10.1182/blood-2018-99-109470

Published: 2018

Journal Articles

Angiogenesis Induced By Aminoacyl-tRNA Synthetase Deficiency Is Dependent on Amino Acid Response (AAR) but Not Unfolded Protein Response (UPR) Pathways

Fan Zhang, Yi Chen, Yi Jin, Chun-Hui Xu, Dian-Jia Liu, Ai-Ning Xu, Yuan-Liang Zhang, Yin-Yin Xie, Jing-Yi Shi, Lan Wang, MD, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, PhD

Blood (2018) 132 (Supplement 1): 77.

https://doi.org/10.1182/blood-2018-99-117909

Published: 2018

Journal Articles

The NAD+ Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Blood (2018) 132 (Supplement 1): 641.

https://doi.org/10.1182/blood-2018-99-117388

Published: 2018

Journal Articles

AXL Expression in Pediatric AML Is Associated with Putative LSC and Correlates with a Distinct Set of Proteins Associated with Cell Metabolism, Cell Cycle, and Unfolded Protein Response

Fieke W Hoff, BSc, Peter P. Ruvolo, PhD, Yihua Qiu, Michael Andreeff, MD PhD, Eveline S. de Bont, MD, Terzah M. Horton, MD PhD, Steven M. Kornblau, MD

Blood (2018) 132 (Supplement 1): 2686.

https://doi.org/10.1182/blood-2018-99-112555

Published: 2018

Journal Articles

Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1 + Acute Lymphoblastic Leukemia to Dexamethasone

Margherita Vieri, MSc, Christian Preisinger, Mirle Schemionek, Azam Salimi, John B. Patterson, Afshin Samali, Tim H Brümmendorf, MD, Iris Appelmann, MD, Behzad Kharabi Masouleh, MD

Blood (2018) 132 (Supplement 1): 4674.

https://doi.org/10.1182/blood-2018-99-110967

Published: 2018

Journal Articles

JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia

Stephen M. Sykes, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, BS, Jacqueline Huhn, BS, Anushk Gupta, Ritika Mistry

Blood (2018) 132 (Supplement 1): 1327.

https://doi.org/10.1182/blood-2018-99-119742

Published: 2018

Journal Articles

Dual Targeting of Cell-Cycle Checkpoint Kinase and Unfolded Protein Response As a Novel Therapeutic Approach for High-Risk Multiple Myeloma with TP53 Deletion or Mutations

Yuka Tanaka, MD, Takayuki Tabayashi, MD PhD, Yasuyuki Takahashi, MD PhD, Yuta Kimura, MD, Tatsuki Tomikawa, MD PhD, Junichi Watanabe, MD PhD, Tomoe Anan-Nemoto, MD PhD, Morihiko Sagawa, MD PhD, Reiko Watanabe, MD PhD, Michihide Tokuhira, Masahiro Kizaki, MD PhD

Blood (2018) 132 (Supplement 1): 5613.

https://doi.org/10.1182/blood-2018-99-116247

Published: 2018

Journal Articles

The Unfolded Protein Response As a Predictor of Chemosensitivity in Pediatric Acute Myeloid Leukemia

Saman Khalid Hashmi, MD, Mia Hofstad, Nenggang Zhang, PhD, Gaye Jenkins, BS, Terzah M. Horton, MD PhD

Blood (2017) 130 (Supplement 1): 5106.

https://doi.org/10.1182/blood.V130.Suppl_1.5106.5106

Published: 2017

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Leukemia-Associated HSC Vascular Niche Is Negatively Regulated By PERK of Unfolded Protein Response (UPR)

Proteostasis and Myeloid Stem Cell Production

Single Cell Approaches - Drilling Down Deeper Using Technology and Integrated Data Analyses

Effect of the Unfolded Protein Response and Oxidative Stress on Mutagenesis of CSF3R a Model of Evolution of Severe Congenital Neutropenia to Myelodysplastic Syndrome/Acute Myeloid Leukemia

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Analysis of Mechanisms Underlying Clonal Evolution of AML By a New Single-Cell Sequencing Platform

Machine Learning Unveils Proteotypic Mimicry in Genetically Defined SCN Variants

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Calreticulin Ins5 and Del52 Mutations Impair Unfolded Protein and Oxidative Stress Responses in Hematopoietic Cells

Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis

Angiogenesis Induced By Aminoacyl-tRNA Synthetase Deficiency Is Dependent on Amino Acid Response (AAR) but Not Unfolded Protein Response (UPR) Pathways

The NAD+ Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

AXL Expression in Pediatric AML Is Associated with Putative LSC and Correlates with a Distinct Set of Proteins Associated with Cell Metabolism, Cell Cycle, and Unfolded Protein Response

Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1 + Acute Lymphoblastic Leukemia to Dexamethasone

JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia

Dual Targeting of Cell-Cycle Checkpoint Kinase and Unfolded Protein Response As a Novel Therapeutic Approach for High-Risk Multiple Myeloma with TP53 Deletion or Mutations

The Unfolded Protein Response As a Predictor of Chemosensitivity in Pediatric Acute Myeloid Leukemia

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