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Journal Articles

The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice

Caroline A. Enns, Shall Jue, An-Sheng Zhang

Blood (2020) 136 (8): 989–1001.

https://doi.org/10.1182/blood.2020005222

Published: 2020

Includes: Supplemental data

Journal Articles

Cutting not the key to TMPRSS6 activity?

Thomas Benedict Bartnikas

Blood (2020) 136 (8): 922–923.

https://doi.org/10.1182/blood.2020006608

Published: 2020

Journal Articles

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Matthew Wake, PhD, Jonathan Papworth, BSc, Luke Bayliss, BSc, Benjamin Grimshaw, PhD, Natalie Rynkiewicz, PhD, Jemima Paterson, BSc, Alicia Poindron, MSc, Erin Spearing, Emily Carter, Robyne Hudson, BSc, Verena Petzer, MD, Amelie Largounez, BSc, Audrey Belot, BSc, Anais Palin, BSc, Igor Theurl, MD PhD, Volker Germaschewski, Delphine Meynard, PhD

Blood (2019) 134 (Supplement_1): 3532.

https://doi.org/10.1182/blood-2019-124075

Published: 2019

Journal Articles

Effect of Oral Iron Treatment in Tmprss6 Knock-out Mouse Model

Elisa Brilli, PhD, Michela Asperti, PhD, Annalisa Castagna, B.S., PhD, Claudio Cerchione, MD PhD, Domenico Girelli, MD, PhD, Maura Poli, PhD, Germano Tarantino

Blood (2019) 134 (Supplement_1): 2235.

https://doi.org/10.1182/blood-2019-122416

Published: 2019

Journal Articles

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Mariateresa Pettinato, Mariam Aghajan, PhD, Violante Olivari, MSc, Alessandro Dulja, MSc, Antonella Nai, PhD, Jessica Bordini, PhD, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, PhD, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2019) 134 (Supplement_1): 955.

https://doi.org/10.1182/blood-2019-126496

Published: 2019

Journal Articles

Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

Juliana Xavier-Ferrucio, Vanessa Scanlon, Xiuqi Li, Ping-Xia Zhang, Larisa Lozovatsky, Nadia Ayala-Lopez, Toma Tebaldi, Stephanie Halene, Chang Cao, Mark D. Fleming, Karin E. Finberg, Diane S. Krause

Blood (2019) 134 (18): 1547–1557.

https://doi.org/10.1182/blood.2019002039

Published: 2019

Includes: Supplemental data

Journal Articles

Novel Insights Into Systemic Iron Regulation

Laura Silvestri, PhD, Alessia Pagani, PhD, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): SCI-1.

https://doi.org/10.1182/blood-2018-99-109518

Published: 2018

Journal Articles

Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and Mice

Juliana Xavier-Ferrucio, PhD, Xiuqi Li, Vanessa Scanlon, PhD, Ping-Xia Zhang, PhD, Nadia Ayala-Lopez, PhD MT(ASCP), Toma Tebaldi, PhD, Stephanie Halene, MD, Karin E. Finberg, MD PhD, Diane S. Krause, MD PhD

Blood (2018) 132 (Supplement 1): 2.

https://doi.org/10.1182/blood-2018-99-115124

Published: 2018

Journal Articles

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Sandro Altamura, PhD, Sandro Altamura, PhD, Martina U. Muckenthaler, PhD, Sibylle Dames, MSc, Christian Frauendorf, PhD, Steffen Schubert, PhD, Manuela Aleku, MSc, Jim Vadolas, PhD, George Grigoriadis, MBBS PhD FRACP FRCPA, Ulrich Zügel, PhD

Blood (2018) 132 (Supplement 1): 2340.

https://doi.org/10.1182/blood-2018-99-110163

Published: 2018

Journal Articles

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Michael McCaleb, PhD, Jason Lickliter, MBBS, PhD, Andrew Dibble, PhD, Eugene Schneider, MD, Mariam Aghajan, Shuling Guo, Steve Hughes, MD MBA, Richard S Geary, PhD, Brett P. Monia, PhD

Blood (2018) 132 (Supplement 1): 3634.

https://doi.org/10.1182/blood-2018-99-115339

Published: 2018

Journal Articles

Heeney MM, Guo D, De Falco L, et al. Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. Blood. 2018;132(4):448-452.

Blood (2018) 132 (12): 1355.

https://doi.org/10.1182/blood-2018-08-867523

Published: 2018

Journal Articles

Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency

Matthew M. Heeney, Dongjing Guo, Luigia De Falco, Dean R. Campagna, Gordana Olbina, Paige P.-C. Kao, Klaus Schmitz-Abe, Fedik Rahimov, Patrick Gutschow, Keith Westerman, Vaughn Ostland, Tracy Jackson, Robert J. Klaassen, Kyriacos Markianos, Karin E. Finberg, Achille Iolascon, Mark Westerman, Wendy B. London, Mark D. Fleming

Blood (2018) 132 (4): 448–452.

https://doi.org/10.1182/blood-2017-03-773028

Published: 2018

Includes: Supplemental data

Journal Articles

The Tmprss6 -/- Mouse Model of Iron Refractory Iron Deficiency Anemia (IRIDA) Exhibits Disrupted Phosphate Homeostasis, Elevated Circulating FGF23 Levels, and Increased Fgf23 Expression in Bone Marrow

Xiuqi Li, BS, Larisa Lozovatsky, MS, Abitha Sukumaran, PhD, Steven Tommasini, PhD, Jackie A. Fretz, PhD, Karin E. Finberg, MD PhD

Blood (2017) 130 (Supplement 1): 228.

https://doi.org/10.1182/blood.V130.Suppl_1.228.228

Published: 2017

Journal Articles

A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2

Alessia Pagani, Silvia Colucci, Renata Bocciardi, Marta Bertamino, Carlo Dufour, Roberto Ravazzolo, Laura Silvestri, Clara Camaschella

Blood (2017) 129 (25): 3392–3395.

https://doi.org/10.1182/blood-2017-03-773481

Published: 2017

Includes: Supplemental data

Journal Articles

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Mariam Aghajan, PhD, Carla Casu, PhD, Vania lo Presti, Sheri Booten, Brett P. Monia, PhD, Stefano Rivella, PhD, Shuling Guo, PhD

Blood (2016) 128 (22): 1013.

https://doi.org/10.1182/blood.V128.22.1013.1013

Published: 2016

Journal Articles

Biallelic Mutations in Hamp in Type 2b Hemochromatosis

Serge Pissard, MDPhD, Ka Chandran, Florence Houriez, Ichrache Benmaad, Martial Saunier, Thibault Lefebvre, Patricia Aguilar-Martinez, MD PhD, Patricia A. Bignell, Gerald Le Gac, MDPhD, Jacques Rochette, MB, DSc

Blood (2016) 128 (22): 1279.

https://doi.org/10.1182/blood.V128.22.1279.1279

Published: 2016

Journal Articles

Erythroferrone Regulates Hepcidin Expression Independently of Matriptase 2

Leon Kautz, PhD, Sharraya Aschemeyer, Victoria Gabayan, Tomas Ganz, PhD MD, Elizabeta Nemeth, PhD

Blood (2016) 128 (22): 3616.

https://doi.org/10.1182/blood.V128.22.3616.3616

Published: 2016

Journal Articles

Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice

Daniel Garcia-Santos, PhD, Amel Hamdi, PhD, Zuzana Zidova, MSc, Monika Horvathova, PhD, Prem Ponka, MD PhD FCMA

Blood (2016) 128 (22): 2462.

https://doi.org/10.1182/blood.V128.22.2462.2462

Published: 2016

Journal Articles

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Antonella Nai, Aude Rubio, Alessandro Campanella, Ophélie Gourbeyre, Irene Artuso, Jessica Bordini, Aurélie Gineste, Chloé Latour, Céline Besson-Fournier, Herbert Y. Lin, Hélène Coppin, Marie-Paule Roth, Clara Camaschella, Laura Silvestri, Delphine Meynard

Blood (2016) 127 (19): 2327–2336.

https://doi.org/10.1182/blood-2015-11-681494

Published: 2016

Includes: Supplemental data

Journal Articles

Inactivation of Tmprss6 Hampers Hepcidin Inhibition By Erythroferrone through Upregulation of the BMP-SMAD Pathway

Laura Silvestri, PhD, Antonella Nai, PhD, Alessandro Campanella, PhD, Irene Artuso, BSc, Jessica Bordini, BSc, Clara Camaschella, MD

Blood (2015) 126 (23): 408.

https://doi.org/10.1182/blood.V126.23.408.408

Published: 2015

NARROW

The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice

Cutting not the key to TMPRSS6 activity?

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Effect of Oral Iron Treatment in Tmprss6 Knock-out Mouse Model

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

Novel Insights Into Systemic Iron Regulation

Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and Mice

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Heeney MM, Guo D, De Falco L, et al. Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. Blood. 2018;132(4):448-452.

Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency

The Tmprss6 -/- Mouse Model of Iron Refractory Iron Deficiency Anemia (IRIDA) Exhibits Disrupted Phosphate Homeostasis, Elevated Circulating FGF23 Levels, and Increased Fgf23 Expression in Bone Marrow

A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Biallelic Mutations in Hamp in Type 2b Hemochromatosis

Erythroferrone Regulates Hepcidin Expression Independently of Matriptase 2

Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Inactivation of Tmprss6 Hampers Hepcidin Inhibition By Erythroferrone through Upregulation of the BMP-SMAD Pathway

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American Society of Hematology

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ASH Publications

American Society of Hematology

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