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Journal Articles

MARCKS affects cell motility and response to BTK inhibitors in CLL

Laura Beckmann, Valeska Berg, Clarissa Dickhut, Clare Sun, Olaf Merkel, Johannes Bloehdorn, Sandra Robrecht, Marc Seifert, Alexandra da Palma Guerreiro, Julia Claasen, Stefan Loroch, Matteo Oliverio, Chingiz Underbayev, Lauren Vaughn, Daniel Thomalla, Malte F. Hülsemann, Eugen Tausch, Kirsten Fischer, Anna Maria Fink, Barbara Eichhorst, Albert Sickmann, Clemens M. Wendtner, Stephan Stilgenbauer, Michael Hallek, Adrian Wiestner, René P. Zahedi, Lukas P. Frenzel
Journal: Blood
Blood (2021) 138 (7): 544–556.
https://doi.org/10.1182/blood.2020009165
Published: 2021
Includes: Supplemental data
Journal Articles

Global Rnaseq/Proteomic-Phoshoproteomic Analysis Unveil Mir-21 As a Central Player in Driving Th17 Mediated Bone Disease in MM

Marco Rossi, MD, Emanuela Altomare, PhD, Cirino Botta, MD, Maria Eugenia Gallo Cantafio, Marco Gaspari, Domenico Taverna, Sarvide Sarai, Daniele Caracciolo, MD, Paola Critelli, MD, Francesco Conforti, Maria Teresa Di Martino, PhD, Bruno Paiva, PhD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 505.
https://doi.org/10.1182/blood-2019-122429
Published: 2019
Journal Articles

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, BSc, Hannah Huckstep, BSc, Jarrod Sandow, PhD, Ray C Bartolo, PhD, Nadia Davidson, PhD, Breon Schmidt, BSc, Stefan Bjelosevic, BSc, Ricky W Johnstone, PhD, Alicia Oshlack, PhD, Melissa Davis, PhD, Paul G Ekert
Journal: Blood
Blood (2018) 132 (Supplement 1): 2628.
https://doi.org/10.1182/blood-2018-99-117844
Published: 2018
Journal Articles

Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1 + Acute Lymphoblastic Leukemia to Dexamethasone

Margherita Vieri, MSc, Christian Preisinger, Mirle Schemionek, Azam Salimi, John B. Patterson, Afshin Samali, Tim H Brümmendorf, MD, Iris Appelmann, MD, Behzad Kharabi Masouleh, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4674.
https://doi.org/10.1182/blood-2018-99-110967
Published: 2018
Journal Articles

Integrated Proteomic and Phosphoproteomic Analysis Reveal Novel Targets and Suggest Rationale for Ibrutinib Efficacy in UM-CLL

Laura Beckmann, MD, Valeska Berg, PhD, Clarissa Dickhut, Johannes Bloehdorn, MD, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Malte Hülsemann, MD, Stefan Loroch, Olaf Merkel, Kirsten Fischer, MD, Clemens-Martin Wendtner, Stephan Stilgenbauer, Albert Sickmann, PhD, Michael Hallek, René Zahedi, PhD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 583.
https://doi.org/10.1182/blood-2018-99-118235
Published: 2018
Journal Articles

The Two SH2 Domains of SHP-2 Bridge Two PD-1 Molecules Resulting in SHP-2 Activation and PD-1-Mediated Inhibition

Nikolaos Patsoukis, PhD, Jonathan Duke-Cohan, PhD, Apoorvi Chaudhri, Eunyoung Park, PhD, Council Asia, Anders Berg, MD PhD, Gordon J Freeman, PhD, Michael Eck, Vassiliki A Boussiotis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 862.
https://doi.org/10.1182/blood-2018-99-117486
Published: 2018
Journal Articles

Map3k8/COT1/Tpl2 Drives Resistance to Bcr-Abl1 Inhibition through Activation of MEK-ERK and NF-Kb Pathways

Anna Dorota Chorzalska, PhD, Nagib Ahsan, PhD, Alexander Tepper, Steven Hines, Diana Olguta Treaba, MD, Adam J Olszewski, MD, John L. Reagan, MD, Philip Gruppuso, MD, Patrycja Dubielecka, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2529.
https://doi.org/10.1182/blood.V130.Suppl_1.2529.2529
Published: 2017
Journal Articles

Unbiased Phosphoproteomics Reveals a Therapeutically Relevant Connection between Pre-mRNA Splicing and Proteasome Inhibition in Multiple Myeloma

Hector H Huang, PhD, Christine YT Lam, BA, Alexis Thornton, BA, Margarette Mariano, MS, Ian Ferguson, BA, Byron C Hann, MD PhD, Angela Brooks, PhD, Arun P. Wiita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3069.
https://doi.org/10.1182/blood.V130.Suppl_1.3069.3069
Published: 2017
Journal Articles

Impact of Tyrosine Kinase Inhibitors Used in Chronic Myeloid Leukemia on Signaling and Epigenetics in Endothelial Cells

Srila Gopal, Qing Lu, MD PhD, Wendy Baur, Sitara Rao, Lev Litichevskiy, Malvina Papanastasiou, Amanda Creech, Adam Officer, Shawn Egri, Desiree Davison, Jacob D Jaffe, PhD, Iris Zamir Jaffe, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2296.
https://doi.org/10.1182/blood.V130.Suppl_1.2296.2296
Published: 2017
Journal Articles

Characterization of Kinase Activity By Phosphoproteomics in Myeloid Cell Lines for Identification of Driving Oncogenic Pathways

Mahmoud Hallal, Manfred Heller, PhD, Rémy Bruggmann, PhD, Ramanjaneyulu Allam, PhD MSc, BSc, Raphael Jeancourt, PhD, Elisabeth Oppliger Leibundgut, PharmD, Cédric Simillion, PhD, Nicolas Bonadies, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2515.
https://doi.org/10.1182/blood.V130.Suppl_1.2515.2515
Published: 2017
Journal Articles

Ups and downs of the ADP phosphoproteome

Zoltan Nagy, Yotis A. Senis
Journal: Blood
Blood (2017) 129 (2): 135–136.
https://doi.org/10.1182/blood-2016-11-751917
Published: 2017
Journal Articles

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

e-blood
Florian Beck, Jörg Geiger, Stepan Gambaryan, Fiorella A. Solari, Margherita Dell’Aica, Stefan Loroch, Nadine J. Mattheij, Igor Mindukshev, Oliver Pötz, Kerstin Jurk, Julia M. Burkhart, Christian Fufezan, Johan W. M. Heemskerk, Ulrich Walter, René P. Zahedi, Albert Sickmann
Journal: Blood
Blood (2017) 129 (2): e1–e12.
https://doi.org/10.1182/blood-2016-05-714048
Published: 2017
Includes: Supplemental data
Journal Articles

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

Srila Gopal, MD, Amanda Creech, Adam Officer, Shawn Egri, Desiree Davison, Jacob D Jaffe, PhD, Iris Z Jaffe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1353.
https://doi.org/10.1182/blood.V128.22.1353.1353
Published: 2016
Journal Articles

Proteomic Analysis Directs Effective Drug Selection in Relapsed AML By Quantifying Drug Targets

David J Britton, PhD, Edmund Wilkes, BSc, PhD, Pedro Casado, PhD, Vinothini Rajeeve, PhD, Jude Fitzgibbon, John Gribben, Pedro R Cutillas, BSc, PhD
Journal: Blood
Blood (2016) 128 (22): 5265.
https://doi.org/10.1182/blood.V128.22.5265.5265
Published: 2016
Journal Articles

Differentiation Status Revealed By Shotgun Phosphoproteomics Determines Sensitivity of Primary AML Cells to Kinase Inhibitors

Pedro Casado, PhD, Edmund Wilkes, PhD, Marym M Hadi, Vinothini Rajeeve, PhD, Farideh Miraki-Moud, PhD, Rebecca Pike, PhD, Ana Del Rio-Machin, PhD, Sameena Iqbal, Jude Fitzgibbon, PhD, John Gribben, Pedro R Cutillas, BSc, PhD
Journal: Blood
Blood (2016) 128 (22): 840.
https://doi.org/10.1182/blood.V128.22.840.840
Published: 2016
Journal Articles

Identification of Kinase-Dependent Signaling Pathways Regulated By Rap1b in Murine Platelets

Luis Paniagua, Xiaogang Wu, PhD, Michael Pereckas, Kathleen Noon, Gilbert White, II, MD
Journal: Blood
Blood (2016) 128 (22): 3717.
https://doi.org/10.1182/blood.V128.22.3717.3717
Published: 2016
Journal Articles

Grb2 Directly Interacts with HGAL and Ameliorates Its Effects on B-Cell Receptor Signaling

Xiaoyu Jiang, PhD, Xiaoqing Lu, Brett J Schuchardt, David C Mikles, Amjad Farooq, Vincent Moy, PhD, Izidore S Lossos, MD
Journal: Blood
Blood (2015) 126 (23): 702.
https://doi.org/10.1182/blood.V126.23.702.702
Published: 2015
Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Fiona Brown, PhD, Eric Still, Paolo Cifani, PhD, Scott Ficarro, PhD, Gayle Pouliot, MD PhD, Esther Drill, PhD, Mithat Gonen, PhD, Jie He, PhD, Sohail Balasubramanian, M.S., Shan Zhong, PhD, Dean Pavlick, Bahar Yilmazel, Andrei V. Krivtsov, PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD, Steven M. Kornblau, MD, Richard M. Stone, MD, Guido Marcucci, MD, John C. Byrd, MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 88.
https://doi.org/10.1182/blood.V126.23.88.88
Published: 2015
Journal Articles

Comparative Phosphoproteomics Study Between Obinutuzumab (GA101) Vs. Rituximab (RTX) Against RTX Sensitive/Resistant Burkitt Lymphoma (BL): Differentially Phosphorylated B Cell Receptor, Fc-Gamma Receptor, Phagocytosis and Natural Killer Cell-Mediated Cytotoxicity Signaling Pathway Proteins

Aradhana Tiwari, Delphine CM Rolland, PharmD, PhD, Mona Elmacken, MD, Janet Ayello, MS, Carmella van de Ven, MA, Venkatesha Basrur, PhD, Kevin Conlon, MS, Damine Fermin, PhD, Matthew J. Barth, MD, Christian Klein, PhD, Kojo Elenitoba-Johnson, Megan S Lim, MD PhD, Mitchell S. Cairo, MD
Journal: Blood
Blood (2015) 126 (23): 1550.
https://doi.org/10.1182/blood.V126.23.1550.1550
Published: 2015
Journal Articles

A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment

Michael J Krueger, BS, Matthew Minus, BS, Wei Liu, PhD, Xin Long, PhD, Alexandra M. Stevens, MD, Mikhail I. Kolosov, BS, Edward Allan R. Sison, MD, David John Tweardy, MD, Zachary T. Ball, PhD, Michele S. Redell, MD PhD
Journal: Blood
Blood (2015) 126 (23): 569.
https://doi.org/10.1182/blood.V126.23.569.569
Published: 2015